Clinical trials: Bra
Snakebite
Trial of Oral Community SVMP INhibitors for Snakebite
Bites by venomous snakes can cause disability and can be life-threatening. We are doing research in adult patients to try and find medications that can be administered orally and can help to reduce disability and death due to…
- Trial name
- TOCSINS (NCT07500233)
- Testing
- 2,3-dimercapto-1-propanesulfonic acid, marimastat, Antivenom Snakes
- Volunteers
- 504 people
- Sponsor
- Liverpool School of Tropical Medicine
Visceral Leishmaniasis
Amphotericin B to Treat Visceral Leishmaniasis in Brazilian Children
The purpose of this study is to determine if amphotericin B is effective against visceral leishmaniasis in Brazilian children. Amphotericin B will be compared to meglumine antimoniate which is the current approved drug used for…
- Trial name
- LVTO (NCT01032187)
- Testing
- Meglumine antimoniate, Amphotericin B-deoxycholate
- Where
- 2 sites in Brazil
- Volunteers
- 101 people
- Sponsor
- University of Brasilia
Breast Cancer, Medical Device
Smart Bra for Diagnosing Breast Cancer
This project aims to assess the ability of a portable and connected medical device to detect breast abnormalities, for breast cancer screening. It will accelerate technological progress in the face of breast cancer.
- Trial name
- CBRA (NCT05294016)
- Testing
- BRA CONNECT device
- Where
- 2 sites in France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Hopital Nord Franche-Comte
Crack Abuse or Dependence
Case Management for Crack Users Who Seek Treatment in CAPSad in Brazil
The purpose of this study is to evaluate the effectiveness of a Case Management (CM) intervention in crack users applied in Psychosocial Care Centers - Alcohol and Drugs (CAPSad) by trained social workers, in comparison to CAPSad…
- Trial name
- NCT01558726
- Testing
- Case Management (Strength-Based), Usual Treatment
- Where
- Brazil
- Volunteers
- 600 people
- Sponsor
- Federal University of Rio Grande do Sul
Pregnancy
Nutritional Status and Mental Health During Pregnancy and Postpartum: a Cohort Study in Rio de Janeiro, Brazil
There is increasing evidence that psychosocial factors may affect health by means of biological effects and changes in behavioral health.
- Trial name
- NCT01660165
- Where
- Brazil
- Volunteers
- 299 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Malaria, Vivax, Therapeutics
DHA-PQP vs Chloroquine and Primaquine for Radical Cure of Vivax Malaria in Brazil
Plasmodium vivax can be cause of severe malaria and mortality. There are serious public health implications associated with cases of P.
- Trial name
- CuraVivax (NCT03208907)
- Testing
- CQ coadministered with PQ, DHA-PQP coadministered with PQ, CQ and PQ starting on Day 42
- Where
- Brazil
- Volunteers
- 419 people
- Sponsor
- Fundação de Medicina Tropical Dr. Heitor Vieira Dourado
Healthy
Bioequivalence Study of Tramadol Hydrochloride /Paracetamol Tablets Versus Ultracet Tablets
The sponsor, Pfizer has developed a formulation of tramadol hydrochloride/ paracetamol 37.5 mg/ 325 mg (test drug) as a generic alternative to the reference listed product Ultracet®.
- Trial name
- NCT03803371
- Testing
- Ultracet Tablets, Tramadol hydrochloride 37.5 mg/Paracetamol 325 mg tablets - tablet (Pfizer)
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pfizer
Sugar Intake, Beverage Intake
Reducing Beverages and Sugar and Increasing Physical Activity in Public School Adolescents From Brazil
The main objective is to evaluate the effect on BMI of a school-based program that discourages the consumption of all sweetened beverages, encourages the reduction in sugar intake, and encourages the increase in physical activity…
- Conditions
- Sugar Intake, Beverage Intake, Fruit Intake, Beans Intake
- Trial name
- PAPAS (NCT01046474)
- Testing
- lifestyle
- Where
- Brazil
- Volunteers
- 600 people
- Sponsor
- Rio de Janeiro State University
Sepsis
Sepse: Critical Analysis of New Sepse Definitions and Retrospective Evaluation of Sepse Protocol at a Tertiary Hospital in Brazil
Research in the databases Lilacs, BIREME, SciELO by the terms: systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis and septic shock and their equivalents in the English language.
- Trial name
- HUVR (NCT03217981)
- Testing
- Sepsis protocol
- Where
- Brazil
- Volunteers
- 506 people
- Sponsor
- Unimed Volta Redonda
Malaria
Efficacy of Artemisinin Combination Therapies for the Treatment of Uncomplicated P. Falciparum in Pregnancy in Brazil
Data on the burden of MIP in low transmission areas, such as Latin America, are very limited; there is even less information on the efficacy of case management of MiP.
- Trial name
- PAACT-PF (NCT01082731)
- Testing
- Artemether-Lumefantrine, Mefloquine- Artesunate
- Where
- 2 sites in Brazil
- Volunteers
- 6 people
- Sponsor
- Centers for Disease Control and Prevention
Suspected or Known Squamous Cell Neoplasia, Prior History of Squamous Cell Dysplasia and /or Neoplasia
Acceptability and Performance of a Mobile Optical Biopsy Technology for Gastrointestinal Cancer Screening
The investigators have a current trial in China and the US which provides significant support for the safety, cost-effectiveness, accuracy and efficiency of a high resolution microendoscope (HRME)-guided approach in the hands of…
- Trial name
- NCT05396781
- Testing
- Proflavine, Mobile, Augmented High Resolution Microendoscope
- Where
- 2 sites in United States, Brazil
- Volunteers
- 41 people
- Sponsor
- Anandasabapathy, Sharmila, M.D.
Atopic Dermatitis (AD)
A Study of Oral Upadacitinib Tablets to Assess Change in Disease State in Participants Aged 12-75 Years With Moderate to Severe Atopic Dermatitis in Brazil
Atopic Dermatitis (AD) is a chronic inflammatory skin disease that is characterized by intense itching, oozing and crusting, redness, skin erosion and dry skin.
- Trial name
- NCT04666675
- Testing
- Upadacitinib
- Sponsor
- AbbVie
Infections, Papillomavirus
Safety Study of GSK Biologicals' Human Papillomavirus Vaccine in 580299/008 Subjects From Brazil, Taiwan or Thailand
This phase 3b study is designed to assess the safety of GlaxoSmithKline Biological's HPV vaccine GSK580299 in female subjects who took part in study 008/580299 and received the control vaccine (Hepatitis A vaccine).
- Trial name
- NCT00849381
- Testing
- GSK580299, GSK Biological's HPV vaccine
- Where
- 9 sites in Brazil, Taiwan and 1 more
- Volunteers
- 1,239 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Diabetes Mellitus
Pharmaceutical Care in the Reduction of Readmission Rates in Diabetes Melitus
Diabetes mellitus (DM) is associated with the frequent use of polypharmacy at different times of administration and requires special attention from the patient or caregivers in order to properly treatment performed.
- Trial name
- NCT03786978
- Testing
- Structured pharmaceutical care, Comparator
- Volunteers
- 100 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Infections, Bacterial
Amoxicillin Bioequivalence Study Brazil - Fast
This study is prospective, open-label, randomized, crossover, single dose, with 02 treatments, 02 sequences and 02 periods. The volunteers received, in each period, the reference or the test formulation, according to the…
- Trial name
- NCT01431989
- Testing
- Amoxicillin powder for oral suspension (Clamoxyl®) 500mg/5mL, Amoxil® 500mg/5mL powder for oral suspension
- Where
- Brazil
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Asthma
Impact of a Curriculum Intervention on Asthma Knowledge in Adolescents of a Public School in Salvador-Bahia-Brazil
The purpose of this study is to estimate the impact of a curriculum intervention on asthma knowledge in adolescents of a public school in Salvador-Bahia-Brazil.
- Trial name
- KARE (NCT02142179)
- Testing
- Knowledge about Asthma and Respiratory Education (KARE)
- Where
- Brazil
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- Federal University of Bahia
Third Molar Extraction
Fixed-dose Combination of Etoricoxib + Cyclobenzaprine for Pain Relief After Third Molar Extraction in Brazil
Etoricoxib and cyclobenzaprine hydrochloride are active pharmaceutical ingredients (APIs) already registered in the country as mono-drugs.
- Trial name
- BENCOX (NCT05683574)
- Where
- Brazil
- Sponsor
- Eurofarma Laboratorios S.A.
Infections, Papillomavirus
Efficacy Study of HPV-16/18 Vaccine (GSK 580299) to Prevent HPV-16 and/or -18 Cervical Infection in Young Healthy Women
The purpose of this phase IIB MedImmune-sponsored study was to evaluate the efficacy of the HPV-16/18 VLP vaccine in the prevention of infection with HPV-16 and/or HPV-18 in adolescent and young adult women.
- Trial name
- NCT00689741
- Testing
- Cervarix
- Volunteers
- 1,113 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Moderate Asthma
Non-Inferiority,Combination Formoterol/FluticasonexAlenia®Formoterol/Budesonide for Asthma in Brazil
Eurofarma Laboratórios S.A. markets a FDC containing formoterol 12 mcg/fluticasone 250 mcg, in a single capsule for inhalation (Lugano®; reference product).
- Trial name
- FORASMA (NCT05735431)
- Testing
- Administration of investigation drug, Administration of comparator
- Where
- Brazil
- Sponsor
- Eurofarma Laboratorios S.A.
Pulmonary Arterial Hypertension
Local Open-Label Access Study For Patients Who Completed A1481244 Study In Brazil
The purpose of this study is to provide sildenafil therapy to patients who completed the A1481244 study for the treatment of PAH, and reside in Brazilian States where Revatio™ is not supplied by Health Secretary, and are judged…
- Trial name
- NCT00866983
- Testing
- sildenafil (Revatio) 20 mg TID
- Where
- 2 sites in Brazil
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.