Clinical trials: Brain Activity
Hemiplegia, Stroke
Impact of Physiotherapy on Spasticity, Upper Limb Function, Daily Activities, and Kinesiophobia in Hemiplegic Patients
This study investigated the effects of rehabilitation exercises on spasticity levels, upper extremity functions, activities of daily living, and kinesiophobia in patients with hemiplegia following a stroke.
- Trial name
- NCT06542848
- Testing
- Physiotherapy and Rehabilitation Practices
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- University of Beykent
Stroke
Effects of Early Exercise in Patients With Moderate to Severe Stroke.
Purpose: to investigate the efficacy of early exercise in patients with moderate to severe stroke regarding functional outcome and walking ability.
- Trial name
- NCT04241952
- Testing
- Exercise
- Volunteers
- 52 people
- Sponsor
- Klas Sandberg
Stroke, Knowledge, Attitudes, Practice
Effects of an Educational Intervention on Rehabilitation Clinicians' Practices for Health-related Outcomes After Stroke
The overall aim of this pilot study is to evaluate the feasibility of a study protocol for a future stepped wedge cluster randomized clinical trial (c-RCT) that will investigate the effects of an innovative KT intervention on 1)…
- Conditions
- Stroke, Knowledge, Attitudes, Practice, Physical Disability, Motor Skills Disorders
- Trial name
- NCT03807115
- Testing
- Implementation of stroke mobility guidelines
- Where
- 6 sites in Canada
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- McGill University
Healthy
Study of the Optimal Number of Repetitions to Investigate the Cerebral Activity by fNIRS During a Voluntary Movement and an Illusory Movement Induced by Vibration
The purpose of this study is to investigate the cerebral activation of healthy participants during a voluntary movement and an illusory movement induced by vibration.
- Trial name
- MoViBloc (NCT07203807)
- Testing
- Voluntary movement and illusory movement of the right upper limb induced by TVS.
- Where
- France
- Volunteers
- 29 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Old Age; Dementia, Old Age; Debility
Significant Activities in the Integrated Person-centered Care Model
The increasing life expectancy and global aging population necessitate changes in long-term gerontological services based on Person-Centred Care approaches.
- Trial name
- IO/20240924 (NCT06623864)
- Testing
- meaningful activities, other activities
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Universidad de Burgos
Cerebral Palsy (CP)
Intensive Video-Based Game Therapy Applications in Cerebral Palsy
This study investigates the effectiveness of intensive video game-based rehabilitation and intensive bimanual activity-based therapy for improving motor skills and daily living activities in individuals with spastic cerebral…
- Trial name
- NCT06821815
- Testing
- Video Game Based Therapy, Bimanual Intensive Therapy
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 16 people
- Sponsor
- Medipol University
Acromegaly
Comparison of Oral Octreotide Capsules to Injectable Somatostatin Analogs in Acromegaly
Octreotide capsule is a novel, orally-administered formulation of the commercially-available injectable drug octreotide. In a recent phase 3 trial (OPTMAL; NCT03252353), oral octreotide capsules demonstrated sustained biochemical…
- Trial name
- MPOWERED (NCT02685709)
- Testing
- Octreotide capsules
- Where
- 53 sites in United States, Austria and 11 more
- Volunteers
- 146 people
- Sponsor
- Chiasma, Inc.
Parkinson Disease
Efficacy and Tolerability of Nebicapone in Parkinson's Disease Patients With "Wearingoff" Phenomenon
The purpose of this study was to investigate the effect on the "wearing-off" phenomenon of 3 different doses of nebicapone (NEB 50 mg, 100 mg and 150 mg), compared with entacapone and placebo when dministered concomitantly with…
- Trial name
- NCT03103399
- Testing
- Comtan®, Nebicapone, Levodopa/DDCI
- Volunteers
- 254 people
- Sponsor
- Bial - Portela C S.A.
Pompe Disease
Screening Protocol to Evaluate Acid Alpha-Glucosidase (GAA) Activity and GAA Gene Mutations in Patients With Late Onset Pompe Disease
Pompe disease (also known as glycogen storage disease type II) is caused by a deficiency of a critical enzyme in the body called acid alpha-glucosidase (GAA).
- Trial name
- NCT00113035
- Where
- 5 sites in United States
- Volunteers
- 60 people
- Sponsor
- Genzyme, a Sanofi Company
Alzheimer Disease, Early Onset
The Resting-state EEG Gamma Oscillations in Alzheimer's Disease
The literature suggests a strong association between amyloid accumulation and gamma alterations, emerging gamma activity as a biomarker candidate for Alzheimer's pathology.
- Trial name
- EEG (NCT05989087)
- Testing
- CSF
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Görsev Yener, MD, PhD
Aging
Cognitive Enhancement and Risk-reduction Through Exercise for Brain-Related Outcomes
As the population ages, it is also growing more diverse. Twelve percent of older Latinos are currently diagnosed with Alzheimer's disease (AD), and it is estimated that the number of Latinos with AD will increase by 832% by 2060.
- Trial name
- CEREBRO (NCT05588778)
- Testing
- BAILAMOS™ @home/en casa, ¡En Forma y Fuerte! @home/en casa
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Stroke, Non-communicable Disease
Make My Day - a Stroke Prevention Program
The purpose of this study is to evaluate the effects of a person-centered stroke prevention program implemented in primary healthcare.
- Trial name
- NCT05279508
- Testing
- Make My Day - stroke prevention program
- Where
- Sweden
- Volunteers
- 122 people
- Sponsor
- Karolinska Institutet
Hypoactive Sexual Desire Disorder
Role of the Melanocortin-4 Receptor in Hypoactive Sexual Desire Disorder
A randomised, double-blind, placebo-controlled, two-way crossover physiological study. Designed to evaluate the effects of melanocortin-4 receptor (MC4R) activation on brain activity patterns and behavioural psychometric measures…
- Trial name
- NCT04179734
- Testing
- Bremelanotide
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Imperial College Healthcare NHS Trust
Stroke
Increasing Physical Activity in Stroke Survivors Using STARFISH
There is good evidence of the effectiveness of regular physical activity in the primary and secondary prevention of stroke. STARFISH is a smartphone-based application designed as a behavioural change intervention to encourage the…
- Trial name
- NCT01792349
- Testing
- STARFISH intervention
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- NHS Greater Glasgow and Clyde
Mental Imagery, Dementia of Alzheimer Type
Imagery in Early Stages of Dementia
The purpose of the present study is to investigate the effectiveness of mental imagery (MI) in subjects with early stage of dementia.
- Trial name
- NCT05232526
- Testing
- Mental imagery (MI) and exercise program, Mental Imagery and Exercise program
- Where
- Greece
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of West Attica
Spinal Cord Injury, Stroke
Brain/Neural Hand Exoskeleton Control for Restoration of Bimanual Tasks
This study investigates whether spinal cord injury and stroke survivors (n=10) are able to operate a brain/neural hand exoskeleton (B/NHE) based on electroencephalography (EEG) and electrooculography (EOG) for restoration of…
- Trial name
- NCT04440709
- Testing
- Brain/neural hand exoskeleton (B/NHE)
- Where
- 2 sites in Germany
- Volunteers
- 10 people
- Sponsor
- University Hospital Tuebingen
Epilepsy
The Effect of Anti-epileptic Drugs on Mitochondrial Activity
This study is based on the hypothesis that antiepileptic drugs (other than Valproic acid) have an effect on the mitochondrial oxidative phosphorylation.
- Trial name
- NCT01218321
- Testing
- antiepileptic treatment
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Hadassah Medical Organization
Magnetic Resonance Imaging, Neuronal Activity
Cracking the Code of Crying Babies: How Familiarity Changes the Interpretation of Cries
Understanding babies' signals is essential to meet their needs. Recent works suggest that crying provides useful information, not only allowing parents to recognize their baby among others (static information), but also to…
- Trial name
- BEBEDOL (NCT05170178)
- Testing
- inclusion and familiarization, fMRI acquisition and closure
- Where
- 2 sites in France
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Physical Fatigue, Return to Sport
The Effect of Physical Fatigue on Different Balance Tests and Brain Activity in a Healthy Population
The main objective of this project is: 1. To assess the influence of physical fatigue on brain functioning during a balance and reaction time task in a healthy population.
- Conditions
- Physical Fatigue, Return to Sport, Injury Prevention, EEG
- Trial name
- NCT04030390
- Testing
- Physical Fatigue, Control
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Healthy
Effect of Talampanel (an AMPA Receptor Blocker) on Brain Activity
This study will use transcranial magnetic stimulation (TMS) and electroencephalography (EEG) to test the safety of an experimental anti-epileptic drug called Talampanel and learn how it affects brain activity.
- Trial name
- NCT00057460
- Testing
- Talampanel
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
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