Clinical trials: Brain Activity
Parkinson Disease
Evaluation of Ronnie Gardiner Method in Individuals With Parkinson's Disease
Parkinson's disease (PD) is typically associated with cognitive and movement related functional disabilities. One commonly described cognitive complaint is the ability to do several things simultaneously, defined as dual or…
- Trial name
- RGM/PD (NCT02999997)
- Testing
- Ronnie Gardiner Method (RGM)
- Where
- Sweden
- Volunteers
- 51 people
- Sponsor
- University Hospital, Linkoeping
Dementia, Neurodegenerative Disease
VR-based Physical Activity and Reminiscence Therapy
The goal of this clinical trial is to learn if active Physical activity + virtual reality cognitive therapy (aPAVRCT) works to slow the progression of AD cognitive decline in older adults.
- Conditions
- Dementia, Neurodegenerative Disease, Mild Cognitive Impairment (MCI), Virtual Reality
- Trial name
- NCT06934720
- Testing
- aPAVRCT
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hong Kong University of Science and Technology
Fibromyalgia
Effects of tDCS on People With Fibromyalgia
People with fibromyalgia could experience physical and cognitive impairment as well as higher dual-task cost than healthy people when two tasks are performed simultaneously.
- Trial name
- NCT05266989
- Testing
- Transcranial Direct Current Stimulation
- Where
- Spain
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Extremadura
Developmental Articulation Disorder, Stuttering
Study of Brain Activity During Speech Production and Speech Perception
The purpose of this study is to gain a better understanding of the brain's activity and organization in the development of speech disorders.
- Trial name
- NCT00004991
- Where
- United States
- Volunteers
- 411 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Acute Stroke, Psychomotor Agitation
Effect of Virtual Reality on Agitation in Acute Stroke
This randomized controlled, single-blind study evaluates the effect of a Virtual Reality (VR) application on agitation levels and physiological vital signs in patients with acute stroke.
- Trial name
- NCT07787910
- Testing
- Virtual Reality Application, Standard Care (in control arm)
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Ankara Etlik City Hospital
Brain Activity
Neurocognitive Correlates of the Influence of Number Word Syntax on Magnitude Processing
Linguistic irregularities in number naming systems, such as the inversion of number words, affect the processing of Arabic numerals. Recently, it has been claimed that there is even a syntactic representation of number words.
- Trial name
- NUMWORD (NCT07133230)
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Centre Hospitalier St Anne
Pediatric Cancer
Efficacy of Cognitive and Physical Trainings in Pediatric Cancer Survivors
Cancer survival comes at a price: pediatric cancer survivors have a high risk for a wide range of cognitive difficulties, particularly survivors of cancer involving the central nervous system (CNS, e.g., brain tumors [BT]) are…
- Trial name
- NCT02749877
- Testing
- Working Memory Training, Physical Training
- Where
- Switzerland
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Parkinson Disease, Physical Inactivity
Integrating AI in Postural Rehabilitation for Parkinson's Disease
Postural abnormalities are highly disabling complications of Parkinson's disease (PD). These include camptocormia, anterocollis, and Pisa Syndrome (PS).
- Conditions
- Parkinson Disease, Physical Inactivity, Physical Disability, Pisa Syndrome
- Trial name
- NCT07010328
- Testing
- Neurorehabilitation, AI-based home rehabilitation for postural disorders
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Premature Birth
Studying Newborns' Brain Activity in the NICU Through a Musical Intervention: the Role of Fundamental Frequency
This research project stands to the intersection of neonatology, neuroscience, and music based interventions (MBIs), exploring the impact of structured sound on the brain activity of premature newborns in Neonatal Intensive Care…
- Trial name
- FunFreqNICU (NCT06398912)
- Testing
- Music Based Intervention
- Where
- Greece
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Athens General Children's Hospital "Pan. & Aglaia Kyriakou"
Parkinson Disease
Estimates of the Efficacy of Talineuren (TLN) and Placebo in Patients With Parkinson Disease
This study is double-blinded placebo controlled followed by an open-label extension placebo-to-active switch to estimate the efficacy of Talineuren.
- Trial name
- LIBRA (NCT06431971)
- Testing
- Talineuren
- Where
- 6 sites in Switzerland
- Volunteers
- 40 people
- Sponsor
- InnoMedica Schweiz AG
NSCLC, Brain Metastases
Repotrectinib in ROS1-positive Non-small Cell Lung Cancer Patients With Active Brain Metastasis
REPOSE is a phase II clinical trial exploring the safety and efficacy of repotrectinib in patients with non-small cell lung cancer (NSCLC) characterized by the presence of brain metastasis (BM) and whose tumors have mutated ROS…
- Conditions
- NSCLC, Brain Metastases, ROS1 Gene Rearrangement
- Trial name
- REPOSE (NCT06315010)
- Testing
- Repotrectinib
- Where
- 17 sites in Austria, Germany and 1 more
- Volunteers
- 20 people
- Sponsor
- MedSIR
Obesity and Overweight
Neurological Impact of Weight Reduction and Fitness Interventions
This study will test how significant weight loss through bariatric surgery, combined with a personalised exercise program, affects brain inflammation.
- Trial name
- NeuroFit (NCT06830252)
- Testing
- Exercise
- Where
- Australia
- Volunteers
- 50 people
- Sponsor
- University of Sydney
Cerebrovascular Accident
Hybrid Approach to Mirror Therapy and Transcranial Direct Current Stimulation for Stroke Recovery
We hypothesize that (1) the hybrid therapy will induce greater improvements on some health-related outcomes compared to other therapies; (2) such benefits will retain at 6-month follow-up; (3) better motor control and brain…
- Trial name
- NCT02254616
- Testing
- Mirror Therapy with tDCS, Mirror Therapy, Control Intervention
- Where
- 4 sites in Taiwan
- Volunteers
- 24 people
- Sponsor
- Chang Gung Memorial Hospital
Scapulocostal Syndrome
Traditional Thai Massage and Brain Electrical Activity
The purpose of this study is to evaluate the immediate effect of traditional Thai massage on brain electrical activity in the patients with scapulocostal syndrome
- Trial name
- NCT01201733
- Testing
- Traditional Thai massage, Ultrasound therapy and hot pack
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Khon Kaen University
Dementia
Lifestyle Integrated Functional Exercise for People With Dementia: a Home-based Physical Activity Program
Physical activity improves cognitive function and the ability to perform activities of daily living in people with dementia and reduces caregivers' burden thus, enhancing quality of life of people with dementia and their…
- Trial name
- LiFE4D (NCT03757806)
- Testing
- Experimental group
- Where
- Portugal
- Volunteers
- 56 people
- Sponsor
- Aveiro University
Alzheimer's Disease, Dementia
Reducing Disabilities in Alzheimer's Disease (RDAD) Translation in Area Agencies on Aging (AAAs)
The University of Washington's Northwest Research Group on Aging is partnering with Area Agencies on Aging (AAA) in Washington and Oregon to complete this translational investigation of RDAD (Reducing Disabilities in Alzheimer's…
- Conditions
- Alzheimer's Disease, Dementia, Memory Impairment, Cognitive Impairment
- Trial name
- RDAD (NCT01708304)
- Testing
- RDAD
- Where
- United States
- Volunteers
- 510 people
- Sponsor
- University of Washington
Stroke, Spasticity
Phase III Study of Botulax® to Treat Post Stroke Upper Limb Spasticity
The purpose of this study is to evaluate the safety and efficacy of Botulax® compared to Botox® reducing upper limb muscle tone in post stroke patients.
- Trial name
- NCT01915459
- Testing
- Botulinum toxin type A(Botulax®), Botulinum toxin type A(Botox®)
- Where
- 6 sites in South Korea
- Volunteers
- 186 people
- Sponsor
- Hugel
Amyotrophic Lateral Sclerosis
GM604 Phase 2A Randomized Double-blind Placebo Controlled Pilot Trial in Amyotrophic Lateral Disease (ALS)
GM604 is an endogenous human embryonic stage neural regulatory and signaling peptide that controls the development, monitoring and correction of the human nervous system.
- Trial name
- GALS (NCT01854294)
- Testing
- GM604
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Genervon Biopharmaceuticals, LLC
Stroke
Focal Muscle Vibration and tDCS on Motor Recovery in Stroke
Although tDCS and FV have shown some benefit as stand-alone treatment, researcher suggest that combining intervention with complementary mechanism can lead to additive or synergistic benefits which might yield more significant…
- Trial name
- NCT06893653
- Testing
- Focal muscle vibration, tDCS, Physical Therapy
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Riphah International University
Trauma, Brain
Risk Assessment of Mild Traumatic Brain Injury in Military Training
The SNIPER-TBI study aims to identify and quantify the risk of mild traumatic brain injury (mTBI) in soldiers of the Czech Armed Forces during specific high-risk training activities, including parachute jumps, high-caliber…
- Trial name
- NCT06992570
- Testing
- Quantification of mild trauma brain injury risk, Biomechanical Analysis of Head Impact Forces
- Where
- Czechia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
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