Clinical trials: Brain Activity
Disability Physical, Stroke
Comparing the Responsiveness of Barthel Index and Longshi Scale in Assessing the ADL of Stroke Survivors
The aim of this research was to compare the responsiveness of Barthel Index (BI) and Longshi Scale (LS) for assessing activities of daily living (ADL) in stroke survivors at different stage and we also aimed to observe changes of…
- Trial name
- NCT05150743
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Shenzhen Second People's Hospital
Parkinson Disease
Consolidation of Motor Learning of Writing Skills and Its Related Brain Activity Changes in Parkinson's Disease
The basal ganglia play an important role in motor learning, especially during the consolidation phase of motor learning. This raises the question whether it is possible to sustain learning increments in a neurodegenerative…
- Trial name
- NCT02288052
- Testing
- Writing program, Stretch & Relaxation program
- Where
- Belgium
- Volunteers
- 42 people
- Sponsor
- KU Leuven
Alzheimer's Disease
Visuospatial Attention, Eye Movements and Instrumental Activities of Daily Living (IADLs) in Alzheimer's Disease
The aim is to understand which components of attentional deployment and selection are impaired in AD during searching in realistic scenes on a computer screen (Experiment 1) and in a natural setting (Experiment 2).The…
- Trial name
- ARVA-MA (NCT02941289)
- Testing
- Performance of everyday objects in realistic scenes
- Where
- France
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Cerebral Palsy, Spastic
Sensory Perceptual Training on Activities of Daily Living and Hand Functions
Many risk factors can come to the fore in CP. With the new studies on CP, new risk factors are defined and existing risks are better understood.
- Trial name
- NCT06554990
- Testing
- physical therapy excersies, sensory perceptual motor exercises
- Where
- 2 sites in Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Badr University
NSCLC, Brain Metastases
Repotrectinib in ROS1-positive Non-small Cell Lung Cancer Patients With Active Brain Metastasis
REPOSE is a phase II clinical trial exploring the safety and efficacy of repotrectinib in patients with non-small cell lung cancer (NSCLC) characterized by the presence of brain metastasis (BM) and whose tumors have mutated ROS…
- Conditions
- NSCLC, Brain Metastases, ROS1 Gene Rearrangement
- Trial name
- REPOSE (NCT06315010)
- Testing
- Repotrectinib
- Where
- 17 sites in Austria, Germany and 1 more
- Volunteers
- 20 people
- Sponsor
- MedSIR
Acquired Brain Injury
OPTImized RESTing Environments in Rehabilitation
This study investigates whether an individually designed environment can support and improve the quality of daytime resting periods in in-hospital neurorehabilitation of patients suffering severe acquired brain injury.
- Trial name
- OPTIREST (NCT04500951)
- Testing
- Optimized resting environment, Standard resting environment
- Where
- Denmark
- Volunteers
- 29 people
- Sponsor
- University of Aarhus
Brain Metastases
EXCLAIM: Exploring Combined Local and Systemic Approaches In Brain Metastasis: a Multi-cohort Randomized Phase II Study Evaluating Initial Response to Systemic Therapy and Subsequent Integration of Stereotactic Radiosurgery in Patients With Low-risk Brain Metastases and Central Nervous System-active
To learn if consolidative stereotactic radiosurgery (cSRS) can help to control central nervous system (CNS) disease in patients who have brain metastases and have a partial response or stable brain metastases after systemic…
- Trial name
- NCT06649058
- Testing
- Systemic Therapy, Stereotactic Radiosurgery
- Where
- United States
- Volunteers
- 316 people
- Sponsor
- M.D. Anderson Cancer Center
Cognitive Dysfunction
Cognitive Leisure and Preclinical Alzheimer's Disease: Exploring Neural Mechanisms
The goal of this clinical trial is aims to: 1. Translate and culturally adapt the Cognitive Leisure Activity Scale (CLAS) into Chinese and Conduct reliability and validity tests for the Chinese version of CLAS. 2.
- Trial name
- NCT06215274
- Testing
- Relationship of the cognitive leisure activity levels, cognitive function, and MRI characteristics.
- Where
- China
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Yuanjiao Yan
Subarachnoid Hemorrhage (SAH) From Ruptured Aneurysm
Metabolomic Profile and Proteasic Activity as Biomarkers for Early Detection of Arterial Vasospas in Arterial Vasospasm After Aneurysmal Subarachnoid Hemorrhage
The subarachnoid hemorrhage (SAH) from ruptured aneurysm is a situation that is life-threatening, which is largely dependent on the occurrence of vasospasm from the 4th day after the bleeding.
- Trial name
- NCT02397759
- Testing
- Blood draw and cerebrospinal fluid draw
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Pediatric Cancer, Pediatric Brain Tumor
Playful Sensorimotor Training in Pediatric Brain Tumor Patients
Chemotherapy-induced peripheral neuropathy (CIPN) is a highly prevalent and clinically relevant side-effect of cancer treatment.
- Conditions
- Pediatric Cancer, Pediatric Brain Tumor, Chemotherapy-induced Peripheral Neuropathy, Sensorimotor Polyneuropathy
- Trial name
- RESET (NCT03334162)
- Testing
- Sensorimotor training
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Basel
Mild Cognitive Impairment
Intervention to Reduce Sedentary Time
The purpose of this study is to determine whether the researchers can help people change the amount of time they spend in sitting activities and whether this change might improve health outcomes.
- Trial name
- ReST-MCI (NCT02878486)
- Testing
- Jawbone Up, Physical Activity Education, ActivPAL
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Kansas Medical Center
Migraine, Headaches
Efficacy and Safety of 20 mg Sumatriptan Powder Delivered Intranasally With the Bi-directional Device Compared With 100 mg Sumatriptan Tablets in Adults With Acute Migraine With or Without Aura
This study is being conducted to determine if OPTINOSE SUMATRIPTAN delivered nasally (through the nose) using the OPTINOSE SUMATRIPTAN DEVICE can reduce the pain associated with migraine headaches in 30 minutes after use.
- Trial name
- COMPASS (NCT01667679)
- Where
- 13 sites in United States
- Volunteers
- 275 people
- Sponsor
- Avanir Pharmaceuticals
Stroke, Acute
Effectiveness of High-intensity Aerobic Interval Training on Impairments and Activity Limitations in the Acute Phase of Stroke in Benin
This clinical trial aims to examine the effects of combining HIIT on a semi-recumbent cycle ergometer (HIIT-RCE) with conventional physiotherapy on impairments and activity limitations in early subacute stroke.
- Trial name
- NCT06179173
- Testing
- HIIT-RCE, Conventional physiotherapy
- Where
- Benin
- Volunteers
- 40 people
- Sponsor
- Hasselt University
Alzheimer Disease
Neural Mechanisms of Clinically Designed Improvisatory Music for Alzheimer's Disease
Clinically Designed Improvisatory Music (CDIM) is a form of improvised music based on calm-inducing sound parameters which brought relief to our cohort of neurology patients.
- Trial name
- NCT05477862
- Testing
- Clinically Designed Improvisatory Music
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Parkinson's Disease
Cognitive-motor Training for PD
This study will evaluate gait when individuals with Parkinson's disease (PD) are walking and how walking changes when challenged to perform a functional cognitive task simultaneously.
- Trial name
- NCT01917903
- Testing
- Gait-cognitive training, Identification of at risk variables
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Stony Brook University
Aggression
The Effect of Rapid Transcranial Magnetic Stimulation (rTMS) on Aggression in Forensic Patients
Forensic patients will undergo 30 rTMS treatments, once per day each business day using a 1Hz frequency at the right dorso-lateral pre frontal cortex, located using modified BEAM F3.
- Trial name
- NCT02990442
- Testing
- rTMS
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Cervicogenic Headache
Manual Therapy and Exercise in Patients With Cervicogenic Headache
Hypothesis: The group of cervicogenic headache patients receiving upper cervical and upper thoracic thrust manipulation will demonstrate significant and clinically important changes in outcomes when compared to the mobilization…
- Trial name
- NCT01580280
- Testing
- Thrust Manipulation, Non-thrust Mobilization and Exercise
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Alabama Physical Therapy & Acupuncture
Brain Injuries
Mobility and Activity Patterns in Hospitalised Severe Brain Injury
The purpose of this observational study is to quantify physical activity patterns in patients with severe acquired brain injury admitted for in-hospital rehabilitation.
- Trial name
- MAP-ABI (NCT05571462)
- Testing
- Activity monitor group
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Christian Riberholt
Diplegic Cerebral Palsy With Spasticity
Effects of Ankle Mobilization on Body Structure, Function, Activities and Participation of Children With Cerebral Palsy
Cerebral palsy is the most common motor disability of childhood (Suvanand et al 1997). By definition CP is a static encephalopathy, but the musculoskeletal pathology is a major concern .
- Trial name
- NCT05500924
- Testing
- Intervention group
- Where
- Palestinian Territories
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Eastern Mediterranean University
Movement Disorders, Parkinson Disease
Sedation During Microelectrode Recordings Before Deep Brain Stimulation for Movement Disorders.
The purpose of this study is to detect possible changes in the electrical activity of the Basal Ganglia related to sedation during deep brain stimulation surgery.
- Conditions
- Movement Disorders, Parkinson Disease, Parkinsonian Disorders, Dystonia
- Trial name
- NCT00355927
- Testing
- Sedation with IV propofol
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Hadassah Medical Organization