Clinical trials: Brain Age
Obesity, Vascular Dementia
Urolithin A Supplementation in Middle-aged Adults With Obesity
The goal of this clinical trial is to learn about the effect of urolithin A, a dietary supplement, on blood flow in middle-aged adults with obesity.
- Conditions
- Obesity, Vascular Dementia, Cognitive Impairment
- Trial name
- NCT05921266
- Testing
- Urolithin A
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Oklahoma
Stroke, Ischemic, Cognitive Impairment
Stroke in Working Age and Job Accommodation in Facilitating Transition Back to Work
The aim of this randomized controlled trial (RCT) is to investigate whether cognitive job accommodation intervention enhances return to work, work ability and performance after ischemic stroke in working-age population.
- Conditions
- Stroke, Ischemic, Cognitive Impairment, Fatigability Post Stroke, Mood Disturbances
- Trial name
- SWIFT (NCT06709898)
- Testing
- Cognitive job accommodation
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Finnish Institute of Occupational Health
Parkinson Disease, Age Related Macular Degeneration
Prevalence of Age Related Macular Degeneration (ARMD) in Parkinson's Patients and Assesment of the Role of L-DOPA
Age related macular degeneration (ARMD) is a major and irreversible cause of blindness among the elderly. The sub-retinal space, located between the retinal pigmentary epithelium (RPE) and the external segments of the retinal…
- Trial name
- AMD-PARK (NCT03415984)
- Testing
- Color retinography, Optical coherence tomography, Fundus autofluorescence imaging
- Where
- France
- Volunteers
- 133 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Cognitive Decline, Aging
Zinde Zihin Program to Reduce Alzheimer's Disease Risk in Adults Aged 65 and Older
This study aims to evaluate the feasibility and implementation of the Zinde Zihin ("Fit Mind") multidomain lifestyle program for older adults aged 65 years and older living in public nursing homes.
- Conditions
- Cognitive Decline, Aging, Alzheimer Disease
- Trial name
- ZZ-MIND (NCT07244848)
- Testing
- Zinde Zihin (Fit Mind) Multidomain Lifestyle Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Burdur Mehmet Akif Ersoy University
Stroke, Stroke (6 Months or More After Onset)
Co-Designed Digital Education and Peer Support for Young and Middle-Aged Stroke Survivors
Stroke survivors often experience persistent unmet needs during long-term recovery. Young and middle-aged stroke survivors may face additional challenges in balancing rehabilitation with work and family responsibilities.
- Trial name
- NCT07725666
- Testing
- Patient-Centered Digital Education and Peer Support Program, Usual Post-Stroke Care
- Volunteers
- 148 people
- Sponsor
- Chang Gung Memorial Hospital
Neurocognitive Disorders, Dementia
The Impact of Dementia and Neurocognitive Disorders on Hypertension Treatment in the Elderly
Neurocognitive disorders and hypertension occur commonly with aging. While, by definition, older adults are at high cardiovascular risk, there is no guideline exist currently on blood pressure management of elderly hypertension.
- Conditions
- Neurocognitive Disorders, Dementia, Hypertension, Aged, 80 and Over
- Trial name
- TAHOC (NCT05845736)
- Testing
- Antihypertensive Agents
- Where
- France
- Volunteers
- 353 people
- Sponsor
- Central Hospital, Nancy, France
Premature
Gut Bacteria and Brain of the Baby
The project is a prospective French population based cohort. A hundred moderate preterms born at GA30-326/7 will be enrolled for a longitudinal follow-up up to 2 years of corrected age.
- Trial name
- BaBBa (NCT04432636)
- Testing
- Data collection of environmental factors, Collection of maternal feces, Collection of infant feces
- Where
- France
- Volunteers
- 94 people
- Sponsor
- Rennes University Hospital
Epilepsy
Study to Investigate Lacosamide as Add-on Therapy in Subjects ≥4 Years to <17 Years of Age With Partial Onset Seizures
Study to evaluate the efficacy of Lacosamide (LCM) administered in addition to 1 to ≤3 other Anti-Epileptic Drugs in subjects with epilepsy ≥4 years to <17 years of age who currently have uncontrolled partial onset seizures.
- Trial name
- NCT01921205
- Testing
- Lacosamide
- Where
- 118 sites in United States, Argentina and 26 more
- Volunteers
- 404 people
- Sponsor
- UCB Pharma
Epilepsy
Double-blind Study in Paediatric Epileptic to Compare the Subject Preference for ESL Suspension Formulation With Alternative Flavours
The purpose of this study is to investigate the taste preference in children of 3 different flavours of the ESL oral suspension.
- Trial name
- NCT02021461
- Testing
- ESL Banana taste, ESL Grape taste, ESL Tutti-Frutti taste
- Where
- 3 sites in Romania, Slovakia
- Volunteers
- 38 people
- Sponsor
- Bial - Portela C S.A.
Dementia, Alzheimer's Disease
Collaboration Between Department of Old Age Psychiatry and Nursing Homes
Dementia is a serious health problem showing an increasing prevalence rate with increasing age. In Norway, about 80% of nursing home patients have dementia. The mean age of nursing home residents in Norway is around 84 years.
- Conditions
- Dementia, Alzheimer's Disease, Behavioral Symptoms, Agitation
- Trial name
- SAM-AKS (NCT01217541)
- Testing
- Education and Supervision, Control
- Where
- Norway
- Volunteers
- 700 people
- Sponsor
- Sykehuset Innlandet HF
Preterm, Sensory Disorders
Evaluation of The Effectiveness of The SAFE Early Intervention Program
In this study, it was aimed to examine the effect of SAFE, which is a sensory-based, activity-oriented early intervention approach applied in an enriched environment with family cooperation, on cognitive, language, motor and…
- Conditions
- Preterm, Sensory Disorders, Cerebral Palsy
- Trial name
- NCT06930482
- Testing
- Safe early intervention, early intervention approach based on neurodevelopmental treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Gazi University
Phenylketonuria
Phase 3 Open-label Study to Evaluate the Response and Safety of Kuvan® in Subjects With Phenylketonuria
This is an open-label, non-comparative, Phase 3 study to evaluate the degree, frequency of response and safety of Kuvan® (sapropterin dihydrochloride) in subjects aged 4 to 18 years who have phenylketonuria and with elevated…
- Trial name
- NCT01732471
- Testing
- Kuvan®
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Substance Use Disorder
Substance Use in Elderly Individuals: Brain and Cognitive Correlates and the Effect of Psychotherapy
The prevalence of addictive disorders in old age is increasing. Age specific and appropriate therapeutic concepts tailored to in-patients thus represent a promising approach for the future.
- Trial name
- NCT02835144
- Testing
- TIQAAM_therapy, Psychoeducation
- Where
- Switzerland
- Volunteers
- 12 people
- Sponsor
- Prof. Dr. med. Egemen Savaskan
Intermittent Fasting, Aging
The Effect of Intermittent Fasting on Brain Health
The central hypothesis of this study is that closer adherence to time restricted eating (TRE) will improve endothelial function, neurovascular (NVC) responses, resulting in improved cognitive performance, potentially through…
- Trial name
- NCT06019195
- Testing
- Time restricted eating
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Physical Conditioning, Human, Cognition
Effects of Aerobic Exercise on Cognitive Function and Brain-derived Neurotrophic Factor in Young Adults
The present study will investigate the effects of aerobic exercise on cognition and growth factors including brain-derived neurotrophic factor (BDNF) in young adults aged 15-21 years.
- Trial name
- NCT02075944
- Testing
- High intensity aerobic exercise, Low intensity aerobic exercise
- Where
- Denmark
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Cerebral Palsy, Infant, Premature, Diseases
Associations Between Early Neonatal Neuroimaging, Hammersmith Infant Neurological Examination and General Movements
High risk infant is defined as infant with a negative history of environmental and biological factors, which can lead to neuromotor development problems.
- Conditions
- Cerebral Palsy, Infant, Premature, Diseases, Infant Development, Neurologic Disorder
- Trial name
- highrisk (NCT05217186)
- Testing
- Measurements
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Partial Seizures With or Without Secondary Generalization, Epilepsy
A Study to Test the Safety/ Efficacy of Brivaracetam (BRV) Used as Adjunctive Treatment in Subjects >=16 Years of Age With Partial Seizures With or Without Secondary Generalization
The purpose of the study is to evaluate the long-term safety and tolerability of Brivaracetam (BRV) in focal epilepsy subjects with partial seizures and to evaluate the maintenance of efficacy of BRV over time.
- Trial name
- NCT03250377
- Testing
- Brivaracetam
- Where
- 59 sites in China, Japan
- Volunteers
- 207 people
- Sponsor
- UCB Biopharma SRL
Epilepsy
Counseling on the Interaction of Hormonal Contraceptives and Antiepileptics
Previous studies have shown that women on anti-seizure medications are not informed about the pharmaceutical drug interactions between anti-seizure medications (antiepileptic drugs, AEDs) and certain hormonal contraceptive.
- Trial name
- NCT02485756
- Testing
- Educational handout
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of California, San Diego
Oral Health, Old Age; Dementia
Evaluation of the Use of a Novel Oral Health Screening Instrument by Caregivers in Nursing Homes
BACKGROUND: Oral health of nursing home residents is often poor. Oral health is related to general health, quality of life and well-being.
- Conditions
- Oral Health, Old Age; Dementia, Long-Term Care, Nursing Homes
- Trial name
- OHS-interRAI (NCT06536322)
- Testing
- OHS-interRAI
- Where
- Belgium
- Volunteers
- 462 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Bardet-Biedl Syndrome, POMC Deficiency Obesity
Setmelanotide in Pediatric Participants With Rare Genetic Diseases of Obesity
This is a phase 3 open-label, clinical study to evaluate the efficacy, safety and tolerability of setmelanotide over 1 year of treatment, in pediatric participants aged 2 to <6 years with obesity due to either biallelic variants…
- Conditions
- Bardet-Biedl Syndrome, POMC Deficiency Obesity, PCSK1 Deficiency Obesity, LEPR Deficiency Obesity
- Trial name
- NCT04966741
- Testing
- Setmelanotide
- Where
- 6 sites in United States, Australia and 2 more
- Volunteers
- 12 people
- Sponsor
- Rhythm Pharmaceuticals, Inc.