Clinical trials: Brain Aging
Aging, MCI
Accelerating Cognitive Gains From Digital Inverventions With Noninvasive Brain Stimulation
The overall goal of this project is to collect pilot feasibility and early efficacy data showing improvements in cognition and wellbeing in adults with mild cognitive impairment (MCI) through a combination treatment of…
- Trial name
- NCT06633952
- Testing
- MediTrain, Worder, noninvasive neurostimulation device
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cardiovascular, Diabetic
Exercise and Cardiovascular Control During Upright Tilt in Older Adults With Type 2 Diabetes
Older persons with diabetes have a harder time maintaining blood pressure when standing up. When blood pressure drops when standing up, fainting may occur.
- Trial name
- NCT00387452
- Testing
- Aerobic Exercise and Strength Exercise, Strength training
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Multiple Sclerosis, Sclerosis
Power Training in Older Multiple Sclerosis Patients
The study seeks to investigate whether 24 weeks of power training has neuroprotective effects in older PwMS. Additional purposes are to examine the effects of 24 weeks power training on physical function, cognitive function and…
- Conditions
- Multiple Sclerosis, Sclerosis, Demyelinating Autoimmune Diseases, CNS, Autoimmune Diseases of the Nervous System
- Trial name
- POTOMS (NCT04762342)
- Testing
- Power training
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Parkinson Disease, Aging
Role of Sleep on Motor Learning in Parkinson's Disease and Healthy Older Adults
People with Parkinson's disease (pwPD) often present difficulty consolidating newly learned skills into long-term memory. Sleep facilitates motor memory consolidation in healthy adults, especially in combination with targeted…
- Trial name
- TARGET-SLEEP (NCT04144283)
- Testing
- NAP, WAKE
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Cognitive Deterioration, Disorder of Aging
Exercise, Age-Related Memory Decline, And Hippocampal Function
The purpose of this study is to test the hypothesis that aerobic exercise leads increased cerebral blood volume in the dentate gyrus of the hippocampus in a sample of young and older adults.
- Trial name
- NCT01329653
- Testing
- aerobic training, Wait list
- Where
- United States
- Volunteers
- 233 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Brain Aging
AvoCog - the Effect of Daily Avocado Intake on Cognitive Function in Older Adults
The goal of this clinical trial is to determine if adding avocados to the diet of impacts cognition in 70 older adults, age 65-85, without dementia.
- Trial name
- AvoCog (NCT06137339)
- Testing
- Avocado Group
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Aging, Mild Cognitive Impairment
Implication of Cognitive Reserve in Non-pharmacological Intervention Outcomes
Cognitive reserve (CR) is defined as the gradual accumulation of neural resources and their adaptability (i.e., efficiency, capacity, flexibility) due to genetic and/or lifelong environmental factors that mitigate the cognitive…
- Conditions
- Aging, Mild Cognitive Impairment, Dementia With Lewy Bodies
- Trial name
- NCT06563453
- Testing
- transcranial alternating current stimulation
- Where
- Czechia
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Masaryk University
Healthy
REMINDer - A Digital Environmental Enrichment Intervention
The primary goal of this pilot study is to assess the feasibility and effectiveness for improving overall mental and physical well-being of a multimodal intervention program in older adults carried out in a digital telehealth…
- Trial name
- REMINDer (NCT06530277)
- Testing
- REMINDer (A digital environmental enrichment intervention)
- Where
- Germany
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- German Center for Neurodegenerative Diseases (DZNE)
Aging, Mild Cognitive Impairment
China Longitudinal Aging and Cognitive Impairment Study
This is a multi-center longitudinal study that consists of five cohorts: cognitive normal aging (CN), Subjective cognitive impairment (SCI), mild cognitive impairment (MCI), Alzheimer's disease (AD) and vascular cognitive…
- Conditions
- Aging, Mild Cognitive Impairment, Alzheimer Disease, Neurodegeneration
- Trial name
- CLACIS (NCT05468905)
- Testing
- None of intervention
- Where
- 2 sites in China
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Alzheimer Disease, Dementia
Predictors of Cognitive Decline in Normal Aging
The goal of this project is to develop an early diagnostic test for Alzheimer's disease (AD) by monitoring loss of neurons and brain size reductions over a period of five years.
- Trial name
- NCT00094939
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Alzheimer Disease, Cognitive Impairment
Biomarker Exploration in Aging, Cognition and Neurodegeneration
The purpose of this research study is to understand the factors that underlie changes in thinking and memory with increasing age.
- Conditions
- Alzheimer Disease, Cognitive Impairment, Cognitive Decline
- Trial name
- BEACoN (NCT03860857)
- Testing
- Amyloid PET scan, Tau PET scan using MK-6240, Neurocognitive testing
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Cognitive Decline, Healthy Aging
Non-invasive Brain Stimulation and Strategic Memory Training
Physiological aging is often associated with memory function decline. Recently, the use of transcranial direct current stimulation (tDCS), a type of non-invasive brain stimulation, has been combined with adaptive working memory…
- Trial name
- StMe-tDCS (NCT05929872)
- Testing
- Non-invasive brain stimulation
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Down Syndrome (Trisomy 21), Neuropsychology
Neuropsychological Evaluation in Intellectual Disability (ENDI)
The goal of this observational study is to evaluate the acceptability ofpatients with trisomy 21 (T21) to perform the full battery of ENDI neurospychological tests and each of the subsets.
- Conditions
- Down Syndrome (Trisomy 21), Neuropsychology, Cognitive Aging, Alzheimer Disease
- Trial name
- ENDI (NCT07047963)
- Testing
- ENDI (Neuropsychological Evaluation in Intellectual Disability)
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Epilepsy
Healthy Aging in People With Epilepsy Program
The goal of this clinical trial is to develop and test an educational program about dementia in older adults living with epilepsy. The main questions it aims to answer are: 1.
- Trial name
- HAP-E (NCT06052605)
- Testing
- Healthy Aging in People with Epilepsy Program, Patient Survey, Provider Survey
- Where
- United States
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Anny Reyes
Alzheimer Disease, Cognitive Decline
Computerized Tests of Cognitive Decline in Presymptomatic Alzheimer's Disease
The investigators will study performance on computerized cognitive tasks in healthy participants of different ages to gather normative data for newly developed computerized cognitive tests.
- Conditions
- Alzheimer Disease, Cognitive Decline, Aging
- Trial name
- NCT04800588
- Testing
- California Cognitive Assessment Battery
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Neurobehavioral Systems, Inc.
Mild Cognitive Impairment (MCI), Cognition
LpD3.5 Intervention Study in Older Adults- LISA-I Trial
This randomized placebo-controlled clinical study, called the LpD3.5 Intervention Study in Older Adults (LISA), aims to evaluate whether a heat-inactivated postbiotic of human origin (LpD3.5) can serve as a non-pharmacological…
- Conditions
- Mild Cognitive Impairment (MCI), Cognition, Brain Aging, Microbiome Dysbiosis
- Trial name
- Postbiotics (NCT07794956)
- Testing
- LpD3.5
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Dementia
Cardiovascular Risk Factors, Aging and Dementia
The global challenges caused by dementia affect society from both the public health and economic perspective, and are exacerbated by the rapid growth of the population in the oldest age groups.
- Trial name
- CAIDE (NCT03938727)
- Where
- Finland
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Aging Disorder, Parkinson Disease
Contribution of Virtual Reality and Modelling in Falling Risk Assessment in Elderly and Parkinson's Disease Patients
The process of ageing affects at the same time the sensory, cognitive and driving functions. Furthermore, ageing is often accompanied by pathologies increasing the effects of the senescence.
- Trial name
- PrévSim (NCT03848897)
- Testing
- Metrology of motor behavior
- Where
- France
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Alzheimer's Disease, Mild Cognitive Impairment
Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer's Disease
This is a prospective cohort study for cognitively normal (young and old), mild cognitive impairment, and Alzheimer's disease people
- Trial name
- KBASE (NCT02137460)
- Where
- South Korea
- Volunteers
- 721 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital