Clinical trials: Brain Cancer
Malignant Brain Neoplasm, Malignant Solid Neoplasm
Breathing Practice for Brain and Mental Health in Cancer and Neurodegenerative Diseases
This clinical trial studies the effect of respiratory training for enhancing brain and mental health among patients with multiple sclerosis (MS) and cancer (along with their caregivers).
- Conditions
- Malignant Brain Neoplasm, Malignant Solid Neoplasm, Multiple Sclerosis, Neuroendocrine Tumor
- Trial name
- NCT06788886
- Testing
- Biospecimen Collection, Exercise Intervention, Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Adult Brain Tumor
Induction of Cortical Plasticity
The study aims to induce plastic reorganization by a therapeutic protocol to increase the rate of gross total resection (GTR) and to optimize the oncological result.
- Trial name
- NCT04553341
- Testing
- Navigated repetitive transcranial magnetic stimulation
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Brain Tumors
Working Memory Performance Among Childhood Brain Tumor Survivors
Children treated with radiation therapy for brain tumors are at risk for cognitive problems. These problems have typically been demonstrated on global cognitive measures including measures of intellectual functioning (IQ).
- Trial name
- NCT00693914
- Testing
- Series of tests/questionnaires
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
Chemotherapy-Related Cognitive Impairment, Chemotherapeutic Toxicity
Investigating Cognitive Impairment in Young Patients With Cancer Prospectively
The MyBrain study investigates the brain function of children, adolescents and young adults during and after chemo treatment for cancer.
- Conditions
- Chemotherapy-Related Cognitive Impairment, Chemotherapeutic Toxicity, Chemo-brain, Cancer
- Trial name
- MyBrain (NCT05840575)
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Childhood Acute Lymphoblastic Leukemia in Remission, Childhood Brain Tumor
Creating a Decision Support System for the Corporate Management of Physical Therapy
The purpose of this study is to create a software product on the basis of the support technologies for making decisions for the collaboration of the different specialists, the family and the patient himself in the process of…
- Conditions
- Childhood Acute Lymphoblastic Leukemia in Remission, Childhood Brain Tumor, Physical Activity, Physical Disability
- Trial name
- NCT03586401
- Where
- Russia
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Glioma
Magnetic Resonance Elastography in Glioma: Exploring Tumor Stiffness and Adhesion
this study will investigate the relationship between tumor stiffness and adhesion in gliomas using MRE. By utilizing preoperative MRE and Intraoperative neuronavigation, followed by comprehensive molecular pathology analysis, we…
- Trial name
- NCT05990244
- Testing
- Magnetic Resonance Elastography, Assessment and Recording
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shengjing Hospital
Brain Tumors
Integrated Pulmonary Index and Opioid Based Patient Controlled Analgesia
An optimal analgesic therapy is very important for postoperative recovery. In recent years, several studies showed that the prevalence of the moderate to severe pain after craniotomy ranged from 69 to 87% of patients.
- Trial name
- NCT04313374
- Testing
- Morphine PCA 1 mg, Morphine PCA 0,5 mg
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Pituitary Neoplasms, Prolactinoma
Interdisciplinary Pituitary Disorders Centre of Excellence: Assessment of Patient Education Tools
The purpose of this research study is to determine the utility of educational materials designed to inform patients of their pituitary condition, in an effort to assist the patients, families, and staff deal with pituitary…
- Conditions
- Pituitary Neoplasms, Prolactinoma, ACTH-Secreting Pituitary Adenoma, Gigantism
- Trial name
- NCT01775332
- Testing
- Educational Intervention
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Posterior Fossa Brain Tumor Group, Healthy Control Group
Physical Performance and Quality of Life in Children With Brain Tumors
This study is designed to assess physical performance and quality of life in children with posterior fossa brain tumors compared to healthy children.
- Trial name
- NCT07810673
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sarah Mohammed El-Abasiri
Parkinson's Disease (PD), Mild to Moderate Parkinson's Disease
A Phase I Study in Healthy Volunteers and Parkinson's Disease (PD) Patients.
The goal of this trial is to learn if MTX325 can be developed as a potential disease-modifying treatment for Parkinson's Disease. Parts 1-4 complete, Part 5 (multiple doses in patients with Parkinson's Disease) in progress.
- Conditions
- Parkinson's Disease (PD), Mild to Moderate Parkinson's Disease, Early Stage Parkinson's Disease
- Trial name
- NCT07630545
- Testing
- MTX325
- Where
- 18 sites in Australia, France and 2 more
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Mission Therapeutics
Brain Neoplasms, Glioma
A Pediatric Phase I Trial of RMP-7 and Carboplatin in Brain Tumors
The presence of a highly selective blood-brain barrier (BBB) at the level of the brain capillary endothelium prevents chemotherapeutic agents from attaining therapeutic concentrations at the target site.
- Conditions
- Brain Neoplasms, Glioma, Medulloblastoma
- Trial name
- NCT00001502
- Testing
- RMP-7 and carboplatin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Pediatric Solid Tumor, Pediatric Brain Tumor
Effects of Music and Maternal Voice on Sedation Depth and Sedative Use During Pediatric Magnetic Resonance Imaging.
To evaluate the effects of music and maternal voice in children on sedation depth and sedative use during pediatric magnetic resonance imaging.
- Conditions
- Pediatric Solid Tumor, Pediatric Brain Tumor, Pediatric Cancer
- Trial name
- NCT04944875
- Testing
- Group headphone, Group music, Group maternal voice
- Where
- Turkey (Türkiye)
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Glioma, Glioma of Brain
Evaluation of Functional Magnetic Resonance Imaging (fMRI) in Patients Who Speak Two Languages Fluently
Functional magnetic resonance imaging (fMRI) is a non-invasive test used to detect changes in brain activity by taking picture of changes in blood flow. The imaging helps doctors better understand how the brain works.
- Conditions
- Glioma, Glioma of Brain, Glioma of Spinal Cord
- Trial name
- NCT03496181
- Testing
- Multilingual Aphasia Examination, Language paradigms + RS fMRI, Language paradigms + RS fMRI + one anatomical sequence
- Where
- 3 sites in United States, Italy
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Horton's Disease, Infectious Disease
Quantitative and Functional Study of TH17 Lymphocytes in Horton's Disease (HD)
The aim of this open, controlled, multicentre biomedical research study is to identify new markers specifically associated with Horton's disease.
- Conditions
- Horton's Disease, Infectious Disease, Neoplasia, Solid Tumor
- Trial name
- NCT02065297
- Testing
- 1 blood sample, 2 to 3 blood samples (at inclusion, at 3 months and at 6 months in cases of relapse)
- Where
- 3 sites in France
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Malignant Glioma
Mapping of Electrical Properties in the Brain
This study evaluates imaging methods for monitoring neural and electrical activity in the brain for improving clinical diagnosis.
- Trial name
- NCT06470711
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Sturge-Weber Syndrome
Innovative Approaches to Gauge Progression of Sturge-Weber Syndrome
This study has three aims that hope to expand the knowledge on the cause of Sturge-Weber Syndrome (SWS) and improve clinical care of Sturge-Weber Syndrome patients.
- Trial name
- NCT01425944
- Where
- 7 sites in United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Small-cell Lung Cancer
PCI for Patients With ES-SCLC After RCT:a Prospective Randomized Study
prophylactic cranial irradiation （PCI）was verified to decrease the brain metastases rates and improve the overall survival（OS）for patients with limited stage small cell lung cancer.We hypothesis that patients with extensive-stage…
- Trial name
- NCT04535739
- Testing
- prophylactic cranial irradiation
- Where
- China
- Volunteers
- 414 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences
Carcinoma, Non-Small-Cell Lung, Immunotherapy
Efficacy and Safety of PEMbrolizumab PD-L1-positive (>50% of Tumor Cells), Advanced NSCL Cancer(PEMBREIZH)
This study was a French multicentric cross-sectional study retrospectively of 108 consecutive advanced NSCLC patients with a PD-L1 TPS ≥50% and without EGFR/ALK aberrations treated by pembrolizumab in first line.
- Trial name
- PEMBREIZH (NCT05321212)
- Where
- 2 sites in France
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Near-Infrared Spectroscopy, Cancer Surgery
The Role of Near-infrared Spectroscopy Measurements in Determining İntraoperative Blood Loss in Cancer Surgery
Major cancer surgeries often involve significant intraoperative blood loss and require transfusion. Conventional markers, such as hemoglobin (Hb) and hematocrit (Hct), provide limited insight into tissue oxygenation and…
- Trial name
- NCT06773689
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Cancer, Brain Tumor, Primary
A Tailored Exercise Oncology Program for Neuro-Oncology Patients
Background: Exercise, or physical activity, is beneficial for all cancer survivors. Despite this knowledge, there is generally a gap between the evidence and practice.
- Trial name
- ACE-Neuro (NCT04831190)
- Testing
- Tailored Exercise Intervention
- Where
- 4 sites in Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Calgary