Clinical trials: Brain Connectivity
Epilepsies
Structural and Functional Connectivity in Partial Epilepsies Studied with MRI and MEG
Surgery may be an effective therapy for refractory focal epilepsies with a clear delineated focus but surgical benefits are less clear for patients with a poorly defined focus such as non lesional refractory partial epilepsies.
- Trial name
- NCT01313260
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Healthy
Physiology of Human Brain Connectivity
The purpose of this study is to investigate the effective connectivity between different regions of the human brain in healthy participants, and the mechanisms which influence and modulate its development.
- Trial name
- NCT06246942
- Testing
- Single-pulse transcranial magnetic stimulation (spTMS), Paired associative stimulation (PAS), Magnetic resonance imaging (MRI)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Preterm, Infant ALL
Effects of Touch on Brain Connectivity and Metabolic Biomarkers in Preterm Infants
Improving the quality of life of preterm children by 2035 is the top priority of worldwide health organisations, including the WHO.
- Conditions
- Preterm, Infant ALL, Premature, Disease
- Trial name
- NCT05853991
- Testing
- osteopathic manipulative treatment, Active comparator
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Come Collaboration
Chronic Insomnia
Impact of Insomnia Treatment on Brain Responses During Resting-state and Cognitive Tasks
Individuals with chronic insomnia have persistent difficulty falling and staying asleep, as well as complaints of altered daytime functioning that may be associated with cognitive impairments.
- Trial name
- NCT04024787
- Testing
- Cognitive-Behavioural therapy for insomnia (CBT-I)
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Concordia University, Montreal
Single Seizure, Epilepsy
Seizure Recurrence After Unprovoked First Seizure
One in 10 people have a seizure during their life. Usually no cause is identified. Seizures without an identified cause are called unprovoked first seizure (UFS). Most people with UFS do not have further seizures.
- Trial name
- NCT05724719
- Where
- 2 sites in Canada
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Dr. Gavin Winston
Parkinson Disease
Subthalamic Nucleus Connectivity in Parkinson's Disease With Ultra-high Field Magnetic Resonance Imaging
The purpose of this study is to investigate the segregation of the subthalamic nucleus into its motor and non-motor regions in patients with Parkinson's disease and healthy controls with the aid of ultra-high field magnetic…
- Trial name
- NCT01981577
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Substance Use Disorder
Functional Connectivity Changes During Early Recovery as a Marker for Relapse
The study purpose is to examine whether there are structural or functional differences in the brains of individuals who use cocaine or amphetamines as opposed to control participants who have never used cocaine or amphetamines.
- Trial name
- NCT02861820
- Testing
- MRI: Brain Imaging Data Collection
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Cluster Headache
Circadian Changes of the Hypothalamic Activity in Patients Suffering From Cluster Headache
Cluster headache attacks do not occur randomly throughout the day, but have a clear circadian rhythmicity. The aim of this study is to investigate circadian changes of the brain, the autonomic nervous system and pain processing…
- Trial name
- NCT04409977
- Testing
- MRI examination
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Migraine
BIOMIGA: Results From Magnetic Resonance Imaging
The projects comprising in the multicenter BIOMIGA project have been preregistered earlier with ID NTC04503083 at clinicaltrials.gov. Here the imaging subproject within the overall BIOMIGA aims is specified.
- Trial name
- NCT06633484
- Testing
- functional magnetic resonance imaging
- Where
- 3 sites in Germany, Italy and 1 more
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Stroke, Brain Disease
Brain Connections for Arm Movement After Stroke
The purpose of this study is to use Transcranial Magnetic Stimulation (TMS) while subjects are making reaching movements in a robotic arm device in order to discover how different brain areas control movement before and after…
- Conditions
- Stroke, Brain Disease, Central Nervous System Diseases, Nervous System Diseases
- Trial name
- CAM (NCT04286516)
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Brain Health, Longevity
L-serine and Strength Training in the Elderly
This study investigates whether taking the amino acid L-serine, either alone or in combination with targeted strength training, can have a positive effect on mental performance, brain function, and physical fitness in older…
- Conditions
- Brain Health, Longevity, Cognitive Performance, Strength Training Effects
- Trial name
- AAAging (NCT07466290)
- Testing
- Strength training, L-serine supplementation, Control (cornstarch)
- Where
- Austria
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Post-COVID Syndrome
Neurobehavior and Brain Connectivity in Post COVID-19 Patients
COVID-19 neurological effects can generate long-term neurobehavioral dysfunction. Our main objective is to examine the impact of COVID-19 on neurobehavior and its relationship with illness severity.
- Trial name
- NAUTILUS (NCT05307575)
- Where
- Spain
- Volunteers
- 630 people, healthy volunteers welcome
- Sponsor
- Consorci Sanitari de Terrassa
Emotion Regulation, Estradiol
Estradiol's Effect on Brain Volume and Connectivity
Ovarian hormones are not only modulators of cognitive function, emotion regulation and mental health, but also seem to affect brain plasticity and functional connectivity, During the menstrual cycle, women experience cyclic…
- Trial name
- NCT06312033
- Testing
- Estradiol Valerate
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- International Research Training Group 2804
Migraine
Longitudinal Changes of Brain Functional Connectivity in Migraine
The purpose of this study is to identify a core fMRI feature that determines migrainous brain and plastic fMRI features that changes with longitudinal courses of migraine.
- Trial name
- NCT03487978
- Testing
- resting-state functional MRI
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Epilepsy
Contribution of High Resolution EEG Functional Connectivity Measures to Presurgical Evaluation of Patients With Intractable Epilepsy
Electroencephalography (EEG) with very high spatial resolution (HR-EEG, 256 electrodes) allow for better analysis of local and global activity of the cerebral cortex, as compared with conventional EEG.
- Trial name
- conneXion (NCT01738516)
- Testing
- Electroencephalography, Electroencephalography and additional experimental tasks
- Where
- France
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Mild Cognitive Impairment, Traumatic Brain Injury
Neuromodulation and fMRI in Neurodegenerative Diseases Study
In addition to neuronal loss, dysfunction in brain network connectivity has been identified as a correlate of cognitive deficits in neurodegenerative and post-traumatic brain injury states.
- Conditions
- Mild Cognitive Impairment, Traumatic Brain Injury, Neurodegeneration
- Trial name
- NCT06873750
- Testing
- Transcranial Alternating Current Stimulation
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Healthy Volunteers, fMRI Research
Frequency Effects of Transcutaneous Trigeminal Nerve Stimulation (eTNS) on Brain and Autonomic Function
This study aims to investigate how different frequencies of transcutaneous Trigeminal Nerve Stimulation (eTNS) affect brain activity and the autonomic nervous system in healthy individuals.
- Trial name
- NCT07662291
- Testing
- 2Hz Transcutaneous Trigeminal Nerve Stimulation, 120Hz Transcutaneous Trigeminal Nerve Stimulation
- Where
- China
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Xidian University
Gender Identity Disorder
Effects of Sex Steroid Hormones on Human Brain Function, Structure and Connectivity
This ultrahigh-field MRI study gives us the unique opportunity to measure changes in brain function and structure induced by long-term opposite-sex steroid hormone administration in transsexual subjects. Our aim is 1.
- Trial name
- NCT01292785
- Testing
- Hormones
- Where
- Austria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Chronic Pain, Temporomandibular Joint Disorders
Brain Connectivity Patterns in Chronic Temporomandibular Joint Disorders
This study addresses the timely problem of painful temporomandibular disorders (TMD), the most common cause of orofacial pain second only to tooth pain.
- Conditions
- Chronic Pain, Temporomandibular Joint Disorders, Temporomandibular Joint Pain
- Trial name
- NCT05068908
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Healthy Older Adults
tDCS Effects on GABA Concentration and Brain Functional Connectivity in Older Adults of Retirement Age
The aim of this study is to investigate whether anodal tDCS over the left M1 leads to a decrease of GABA concentration and alterations of functional brain connectivity in older people, compared to sham tDCS.
- Trial name
- TRAINSTIM1 (NCT02794259)
- Testing
- tDCS
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany