Clinical trials: Brain Damage, Chronic
Chronic Pain, Traumatic Brain Injury
Establishing Efficacy of a Functional-Restoration Based CAM Pain Management Program in Post-9/11 Veterans
This is a research study of an interdisciplinary pain management program for U.S. military veterans who served during the post-9/11 combat eras (e.g., Operations Iraqi Freedom [OIF], Enduring Freedom [OEF], New Dawn [OND])…
- Conditions
- Chronic Pain, Traumatic Brain Injury, Posttraumatic Stress Disorder, Depression
- Trial name
- NCT02657317
- Testing
- FORT-A, VA Treatment as Usual
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Brain Injuries, Acute, Brain Injuries, Traumatic
Antiseizure Medication in Seizure Networks at Early Acute Brain Injury
The goal of this clinical trial is to explore the effect of FDA-approved antiseizure drugs in the brain connectivity patterns of severe and moderate acute brain injury patients with suppression of consciousness.
- Conditions
- Brain Injuries, Acute, Brain Injuries, Traumatic, Brain Ischemia, Brain Hypoxia
- Trial name
- NCT06081283
- Testing
- Phenobarbital Sodium Injection, Levetiracetam, Lacosamide Injectable Product
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of North Carolina, Chapel Hill
Blepharoptosis, Ptosis, Eyelid
Clinical Trial Comparing Two Non-Surgical Treatments for Severe Blepharoptosis
This clinical trial will evaluate two non-surgical devices designed to improve eye lid opening for patients with severe Blepharoptosis (incomplete opening of the eyelids).
- Conditions
- Blepharoptosis, Ptosis, Eyelid, Myasthenia Gravis, Stroke
- Trial name
- NCT04678115
- Testing
- Magnetic Levator Prosthesis (MLP), Kinesiotape Frontalis Sling (KTFS)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Cerebral Palsy, Children
Does Increasing Auditory Cueing Affect Gait Parameters in Children With Cerebral Palsy During a Functional Task?
To determine the clinical efficacy of auditory cueing using a cross over design to investigate whether increasing auditory cueing frequency by 20% above self paced cadence affects gait parameters in children with Cerebral Palsy…
- Trial name
- NCT02666560
- Testing
- Auditory Cueing
- Volunteers
- 19 people
- Sponsor
- Institute of Child Health
Cerebral Palsy
Cerebral Palsy Early Mobility Training
The purpose of this study is to determine the optimal treatment duration of a novel early mobility training program (dynamic supported mobility, DSM) between 6 to 24 weeks of treatment; and to evaluate the clinical futility of…
- Trial name
- iMOVE (NCT02340026)
- Testing
- Dynamic Supported Mobility, Conventional Therapy
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Children's Hospital of Philadelphia
Chronic Pain, Brain Injuries, Traumatic
Telehealth Pain Self-Management for Employed Adults
The E-TIPS trial will evaluate an evidence-based, telehealth pain self-management intervention compared to standard care (a waitlist) for chronic pain in adults with physical disabilities who are employed.
- Conditions
- Chronic Pain, Brain Injuries, Traumatic, Multiple Sclerosis, Spinal Cord Injuries
- Trial name
- E-TIPS (NCT04248725)
- Testing
- E-TIPS
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- University of Washington
Cerebral Palsy, Hypoxic-Ischemic Encephalopathy
Therapeutic Intervention Supporting Development From NICU to 6 Months for Infants Post Hypoxic-Ischemic Encephalopathy
The purpose of this study is to evaluate the feasibility and begin to evaluate the effect of a sensorimotor intervention (SMI) provided in the first 6 months of life for infants with hypoxic-ischemic encephalopathy.
- Trial name
- NCT05130528
- Testing
- Sensorimotor Intervention
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- University of Southern California
Cerebral Palsy
Piloting Movement-to-Music With Arm-based Sprint-Intensity Interval Training Among Children With Physical Disabilities
This study is investigating the potential effects of a high-intensity home-exercise program among children with cerebral palsy. The program includes rhythmic movements to music that are adapted for wheelchair uses and…
- Trial name
- NCT05619211
- Testing
- Sprint-Intensity Interval Training with Telecoaching
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Traumatic Brain Injury, Word Finding Difficulty
Treating Civilian Traumatic Brain Injury With High Definition Transcranial Direct Current Stimulation (ciTBI-HDtDCS)
The purpose of the study is to test whether low level electric stimulation, called transcranial Direct Current Stimulation (tDCS), on the part of the brain (i.e., pre-supplementary motor area) thought to aid in memory will…
- Conditions
- Traumatic Brain Injury, Word Finding Difficulty, Acquired Brain Injury, Cognitive Change
- Trial name
- NCT05408975
- Testing
- Active Transcranial direct current stimulation
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- The University of Texas at Dallas
Cerebral Palsy Spastic Diplegia
Cerebral Palsy: Short-burst Interval Training
This study examines the effect of short burst interval treadmill training in ambulatory children with cerebral palsy. Half the sample will receive 20 sessions of training over 4 weeks, while half will receive the training over 10…
- Trial name
- NCT03373890
- Testing
- Short Burst Interval Locomotor Treadmill Training (SBLTT)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Seattle Children's Hospital
Cerebral Palsy
Development of a Robotic Ankle Assist Device
The overall objectives of this work is to establish feasibility of a robotic ankle assist device (RAAD) to improve mobility in free-living settings and to establish the RAAD as an effective tool to provide increased dose and…
- Trial name
- NCT04516343
- Testing
- Robotic Ankle Assist Device (RAAD)
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- BiOMOTUM, Inc.
Cerebral Palsy
Safety and Effectiveness of Banked Cord Blood or Bone Marrow Stem Cells in Children With Cerebral Palsy (CP).
The purpose of this study is to compare the safety and effectiveness of two types of stem cells,(either banked cord blood or bone marrow), in children between the ages of 2 to 10 years with CP.
- Trial name
- ACT for CP (NCT01988584)
- Testing
- umbilical cord blood (hUCB) cells, bone marrow derived mononuclear cells (BMMNCs)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas Health Science Center, Houston
Chronic Post Traumatic Headache
Treatment of Chronic Post-Traumatic Headache With OnabotulinumtoxinA
This study will provide evidence on whether the use of an FDA-approved drug therapy for the treatment of chronic migraine (OnabotulinumtoxinA) shows similar efficacy for treatment of chronic headaches caused by traumatic injury…
- Trial name
- NCT02160535
- Testing
- OnabotulinumtoxinA
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Washington
Cerebral Palsy
Robotic-assisted Therapy to Improve Manual Dexterity in Children With Cerebral Palsy
This is an intervention study including a baseline data collection, 6 weeks of robot-assisted training targeting hand dexterity, and a post-intervention data collection.
- Trial name
- NCT02923167
- Testing
- Robotic-assisted training of the hand
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Spaulding Rehabilitation Hospital
Cerebral Palsy
Study Assessing High-Frequency Chest Wall Oscillation (HFCWO) in Preventing Pulmonary Exacerbations
To asssess efficacy of airway clearance provided by Vest therapy (HFCWO) in the reduction of respiratory exacerbations requiring hospitalization or antibiotic utilization in patients with muscle weakness and restrictive lung…
- Trial name
- NCT00739310
- Testing
- Vest Treatment (high frequency chest wall oscillation)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Hill-Rom
Brain Concussion
LED Therapy for the Treatment of Concussive Brain Injury
A double blind randomized trial of light-emitting diode (LED) therapy for patients suffering from mild traumatic brain injury (mTBI).
- Trial name
- NCT02383472
- Testing
- MedX Health Console model 1100
- Where
- 2 sites in United States
- Volunteers
- 53 people
- Sponsor
- Boston Children's Hospital
Cerebral Palsy, Developmental Delay
Endermotherapy for Children With Developmental Disabilities
Children with developmental disabilities often sustain decreased range of motion in their extremities. The decrease in flexibility may be due to neuromuscular disorders such as spasticity or dystonia.
- Trial name
- NCT01207570
- Testing
- Endermotherapy, Passive manual stretching
- Where
- Hong Kong
- Volunteers
- 54 people
- Sponsor
- The Hong Kong Polytechnic University
Small/Large Bowel
PillCam SB3 Capsule- Feasibility Study
Study hypothesis: PillCam SB3 is a new capsule designed to provide an improved image quality, and improved SB and duodenum tissue coverage due to Adaptive Frame Rate (AFR) of 2-6 fps, which will create more images for evaluation…
- Trial name
- NCT01433042
- Testing
- capsule endoscopy
- Where
- 4 sites in Israel, Romania and 2 more
- Volunteers
- 225 people
- Sponsor
- Medtronic - MITG
Cerebral Palsy
Early Powered Mobility for Toddlers With Cerebral Palsy Using the Permobil® Explorer Mini and a Modified Ride-On Car
The use of powered mobility devices for young children with cerebral palsy (CP) has been gaining traction, with evidence that the use of powered mobility at young ages complements (rather than detracts from) other interventions…
- Trial name
- NCT04684576
- Testing
- Permobil Explorer Mini, Modified Ride-On Car
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- University of Washington
Cerebral Palsy
Sensory Stimulation During CIMT
The long-term goal of this project is to assess the impact of the novel sensory stimulation technique in enhancing outcomes of constraint-induced movement therapy (CIMT) in children with cerebral palsy. This is a pilot project.
- Trial name
- NCT03558230
- Testing
- Standardized Constraint-Induced Movement Therapy, Vibration
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Medical University of South Carolina