Clinical trials: Brain Derived Neurotrophic Factor Level
Stroke
Effect of Lifestyle Changes on BDNF Level After Stroke
This is a pilot study to determine whether a lifestyle medicine intervention following stroke may increase levels of Brain-Derived Neurotrophic Factor (BDNF).
- Trial name
- NCT03701815
- Testing
- Wellness in Rehabilitation program
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- VA Palo Alto Health Care System
Phenylketonuria
Effect of L-carnitine Supplementation on Phenylalanine and Brain-derived Neurotrophic Factor Levels in Infants and Children With Phenylketonuria
Effect of L-carnitine supplementation on phenylalanine and brain-derived neurotrophic factor levels in infants and children with phenylketonuria L-carnitine is mainly obtained from foods such as red meat and milk that are limited…
- Trial name
- NCT06901323
- Testing
- L-carnitine
- Where
- Egypt
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Overactive Bladder
Urinary Neurotrophin Levels in Healthy Children
The aim of this study is to analyse urinary neurotrophin levels in healthy children. Urine samples will be collected at 3 different times of day (morning, noon, and evening) at urge sensation from all age groups of children who…
- Trial name
- NCT02389270
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Zagreb
Carpal Tunnel Syndrome (CTS)
Photobiomodulation for Median Nerve Neuroplasticity in Carpal Tunnel Syndrome: A Randomized Controlled Trial
Carpal Tunnel Syndrome (CTS) is the most common peripheral entrapment neuropathy, causing pain, paresthesia, and hand dysfunction due to median nerve compression at the wrist.
- Trial name
- PBM-CTS-RCT (NCT07714720)
- Testing
- Photobiomodulation (Low-Level Laser Therapy), Routine Physiotherapy Programme
- Where
- Pakistan
- Volunteers
- 70 people
- Sponsor
- University of Lahore
Cervicogenic Headache, Sleep Disturbance
Effect of Isometric Neck Exercises on Cervicogenic Headache Symptoms, Cortisol and BDNF Levels Among Smart Phone Users
Cervicogenic headache (CGH) is a secondary headache type caused due to refereed pain arising from the cervical spine in the forehead, sometimes in temporal region.
- Conditions
- Cervicogenic Headache, Sleep Disturbance, Stress
- Trial name
- NCT07354776
- Testing
- Isometric Neck Exercise Program, Usual Care
- Where
- Pakistan
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Khyber Medical University Peshawar
Schizophrenia
Cognitive Behavioral Therapy Added to Risperidone for Schizophrenia
This study evaluated whether cognitive behavioral therapy (CBT), when added to risperidone treatment, improves cognitive function and serum brain-derived neurotrophic factor (BDNF) levels in patients with schizophrenia.
- Trial name
- CBT-BDNF-SCZ (NCT07609953)
- Testing
- Risperidone 4 to 6 mg/day, Cognitive Behavioral Therapy
- Where
- Indonesia
- Volunteers
- 42 people
- Sponsor
- Hasanuddin University
Sleep, Sleep Restriction
Effects of Sleep Restriction on Female Soccer Players: Physical Performance, Muscle Damage, Inflammation, and BDNF Levels.
This research aims to investigate the interplay between menstrual cycles, sleep patterns, and athletic performance. Before experimental sessions, participants will maintain menstrual diaries for three months and complete…
- Trial name
- NCT06251362
- Testing
- Sleep restriction
- Where
- 2 sites in Poland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University School of Physical Education, Krakow, Poland
Cognitive Impairment, Aging
Influence of Overground Walking on Biomarkers, Cognitive Function, and Quality of Life in Elderly With Mild Cognitive Impairment
The purpose of this research is to investigate the impact of overground walking as a part of a rehabilitation program on the increase in Brain-derived neurotrophic factor (BDNF) levels, decrease in IL-6 levels, decrease in hs-CRP…
- Trial name
- NCT06029920
- Testing
- Overground Walking
- Where
- Indonesia
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Universitas Padjadjaran
Osteoarthritis of Knee
Whole-body Vibration Training on Functional Performance of the Elderly With Knee Osteoarthritis
The present study evaluated the effects of adding whole body vibration to squat training on the isometric quadriceps muscle strength, the plasma concentration of brain-derived neurotrophic factor at rest in elderly woman with…
- Trial name
- NCT03918291
- Testing
- Addition of whole-body vibration to squat training, Squat training
- Volunteers
- 15 people
- Sponsor
- Federal University of the Valleys of Jequitinhonha and Mucuri
Chronic Low Back Pain, Brain Derived Neurotrophic Factor Level
The Prediction of Clinical Outcome Using the Serum BDNF Level
Low back pain (LBP) is one of the most commonly observed conditions in patients over the age of 50 and imposes a substantial socioeconomic burden.
- Trial name
- NCT07776379
- Testing
- Erector Spinae Plane Block, Blood sampling for ELISA
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Keimyung University Dongsan Medical Center
Anesthesia, Neuroinflammation
Neuroinflammatory Biomarkers After General Anesthesia: A Comparison Study
This prospective, observational study investigates the impact of repeated general anesthesia exposure on neuroinflammatory biomarkers and neurotrophic factors.
- Conditions
- Anesthesia, Neuroinflammation, Cognitive Disorders
- Trial name
- NCT07388160
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Health Sciences Balikesir Hospital Eduation and Research
Depression
Effect of Electroconvulsive Therapy (ECT) and Transcranial Magnetic Stimulation(TMS) on Brain Derived Neurotrophic Factor (BDNF) in Depressed Patients.
To investigate the change in brain derived neurotrophic factor (BDNF) between pre and post treatment for patients with depression with either ECT or TMS.
- Trial name
- NCT00630123
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- Queen's University
Type2 Diabetes, Cognitive Impairment
The Effect of SGLT2 Inhibitors on Cognitive Functions and BDNF Levels in Patients With Type 2 Diabetes
Cognitive impairment is a common complication in diabetes for various reasons. Although glycemic control improves cognitive impairment, different antidiabetic medications' effects on cognitive functions are still being…
- Trial name
- NCT05341388
- Testing
- MOCA cognitive evaluation test, BDNF levels, SF-36 test
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Goztepe Training and Research Hospital
Alcohol Dependence
Brain Derived Neurotrophic Factor Serum Levels Evolution During the Six Months After Alcohol Withdrawal
Alcohol dependence is accompanied by several neurological mechanisms involving neuronal plasticity and neoneurogenesis, requiring Brain Derived Neurotrophic factor (BDNF) synthesis.
- Trial name
- NCT01491347
- Where
- 4 sites in France
- Volunteers
- 389 people
- Sponsor
- Centre Hospitalier Esquirol
Depression, Diabetes Mellitus
BDNF Level and val66met Polymorphism of Brain Derived Neurotropic Factor Gene in Patients With T2DM and Depression
This study aimed to evaluate the relation between the levels of (Brain Derived Neurotropic Factor) BDNF and val66met polymorphism of BDNF gene, and the presence of depression in type 2 diabetes.
- Trial name
- NCT05526131
- Testing
- Questionare
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Kasr El Aini Hospital
Investigation the Role of BDNF and S100B Serum Level as a Predictive of Outcome of Pulsed Radiofrequency in Treatment Lumbar Disc Prolapse Patients
The Potential Role of SI00B and Brain Derived Neurotrophic Factor in Predicting Outcome From Using Pulsed Radiofrequency in Treatment of Patients With Lumbar Disc Prolapsed
Chronic lumbar radicular (CLR) pain is a term used to describe neuropathic pain symptoms in the distribution of a particular lumbar nerve root due to disc protrusion, spinal stenosis, facet hypertrophy, or fibrosis after previous…
- Trial name
- NCT05193461
- Testing
- Pulsed mood radiofrequency on dorsal root ganglion
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Beni-Suef University
Gambling Disorder
The Effect of Theta-burst Stimulation on Serum BDNF
The goal of this clinical trial is to investigate the effect of theta burst stimulation for depression and serum brain-derived neurotrophic factor (BDNF) in individuals with major depression.
- Trial name
- NCT05854706
- Testing
- Theta Burst Stimulation
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taipei City Hospital
Type 2 Diabetes, Heart Rate Variability
The Effect of SGLT2 Inhibitors on Heart Rate Variability and BDNF Levels in Patients With Type 2 Diabetes
Cardiac autonomic neuropathy (CAN) in diabetic patients is an indicator of autonomic nervous system dysfunction and is an important marker for cardiovascular events.
- Trial name
- NCT05164523
- Testing
- 24-hour rhythm Holter, 36 item Short Form Survey (SF-36)
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Goztepe Training and Research Hospital
Elderly Individuals Aged 60 Years or Older, Mild Cognitive Impairment (MCI)
THE EFFECTS OF GAMBIR CATECHIN (UNCARIA GAMBIR ROXB) SUPPLEMENTATION ON COGNITIVE FUNCTION, EXPRESSION OF APP, MAPT, BDNF, IL-10, TGF-Β GENES, AND PLASMA MDA LEVELS IN THE ELDERLY.
Objective The primary objective of this clinical trial is to investigate the effects of gambir catechin administration on cognitive function, the expression of amyloid precursor protein (APP), microtubule-associated protein tau…
- Trial name
- NCT06604390
- Testing
- catechin extracts (health food), plasebo
- Where
- 2 sites in Fiji, Indonesia
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Rahmi Novita Yusuf
Depression - Major Depressive Disorder, Transcranial Magnetic Stimulation
Effects of Low-intensity Transcranial Magnetic Stimulation on Major Depressive Disorder, and on 5-hydroxyindoleacetic Acid and Brain-derived Neurotrophic Factor Levels
The goal of this randomised clinical trial is to evaluate the effects of transcranial magnetic stimulation (TMS) on major depressive disorder (MDD) and on the levels of 5-hydroxyindoleacetic acid (5-HIAA) and brain-derived…
- Conditions
- Depression - Major Depressive Disorder, Transcranial Magnetic Stimulation, Placebo
- Trial name
- NCT06667180
- Testing
- Low-intensity TMS
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Universidad de Guanajuato