Clinical trials: Brain Developmental Diseases
Growth Hormone Deficiency
A US Non-interventional, Effectiveness and Safety Study of Patients Treated With SKYTROFA
The goal of this study is to genrate evidence on long-term effectiveness and safety of SKYTROFA (lonapegsomatropin) in patients with growth hormone deficiency under routine clinical care
- Trial name
- SkybriGHt (NCT05820672)
- Testing
- No intervention
- Where
- 27 sites in United States
- Volunteers
- 900 people
- Sponsor
- Ascendis Pharma Endocrinology Division A/S
Brain Concussion
Tissue Repository and Master Database for Concussion Biomarker and Risk Calculator Development
The purpose of this study is to prospectively collect a comprehensive, multi-modality set of diagnostics on patients who have had a concussion, repeating some of these tests serially over time, so that the investigators may then…
- Trial name
- NCT02519998
- Testing
- Concussion
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Attention Deficit Hyperactivity Disorder, Schizophrenia
Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Volunteers
Magnetic Resonance Imaging (MRI) unlike X-rays and CT-scans does not use radiation to create a picture. MRI use as the name implies, magnetism to create pictures with excellent anatomical resolution.
- Conditions
- Attention Deficit Hyperactivity Disorder, Schizophrenia, Attention Deficit Disorder With Hyperactivity
- Trial name
- NCT00001246
- Where
- United States
- Volunteers
- 4,276 people
- Sponsor
- National Institute of Mental Health (NIMH)
Dementia
Development and Evaluation of E-training and Mentoring Support Program on Dementia Care for Home-care Workers
This study evaluate the effects of three-month dementia care e-training and mentoring support program on home-care workers using a two-group randomized controlled trial.
- Trial name
- NCT03822286
- Testing
- e-training course, Support group, traditional classroom teaching course programs
- Where
- Taiwan
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Tzu Chi University
Menopausal, Dementia
Development of a Personalized, Psychosocial Intervention for Menopausal Individuals With Elevated Dementia Risk
By age 45, women's lifetime risk of dementia is estimated to be 1 in 5. Two-thirds of people currently living with a dementia diagnosis are women, and-women make up the majority of carers for people with dementia.
- Trial name
- PERI-MIND (NCT06965686)
- Testing
- PERI-MIND
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Chicago
Immature Infant, Essential Fatty Acid Deficiency
Nutrition Therapy in the Immature Infant (ImNuT)
The primary objective of this double-blind randomized study is to assess the effects of an early, enhanced supply of the essential fatty acids (FAs) arachidonic acid (ARA) and docosahexaenoic acid (DHA) on brain maturation…
- Trial name
- ImNuT (NCT03555019)
- Testing
- Formulaid, MCT-oil
- Where
- Norway
- Volunteers
- 121 people
- Sponsor
- Oslo University Hospital
Parkinson Disease
Cognitive Testing Online in Parkinson's Disease
This is a feasibility and pilot study. Though large-scale online neurocognitive testing is increasingly being done in psychiatry, there are no such efforts in Parkinson's research.
- Trial name
- NCT05025254
- Testing
- Neurocognitive testing
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- McGill University
Growth Hormone Deficiency
PK and PD Study of LUM-201 in Children With Idiopathic Growth Hormone Deficiency: (OraGrowtH212)
The goals of this single site trial are to study the pharmacokinetics (PK) and pharmacodynamics of LUM-201 and effects of LUM-201 administration on growth hormone release over time in children with idiopathic pediatric growth…
- Trial name
- OraGrowtH212 (NCT04806854)
- Testing
- LUM-201
- Where
- Chile
- Volunteers
- 24 people
- Sponsor
- Lumos Pharma
Epilepsy, Cerebral Palsy
A Pilot Study of Dexmedetomidine-Propofol in Children Undergoing Magnetic Resonance Imaging
This is a pilot study to determine if a standard bolus dose and infusion of dexmedetomidine can significantly decrease the dose of propofol (infusion) required for accomplishing an MRI.
- Conditions
- Epilepsy, Cerebral Palsy, Developmental Delay
- Trial name
- NCT02633241
- Testing
- Dexmedetomidine bolus and high infusion-Propofol, Dexmedetomidine bolus and low infusion-Propofol, Dexmedetomidine bolus only - Propofol
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Joseph Cravero
Epilepsy, Hippocampal Sclerosis
Gene Expression Changes of Brain Tissue in Human Temporal Lobe Epilepsy With Hippocampal Sclerosis
Epilepsy is a common neurological disease, manifested in the sudden abnormal discharge of neurons leading to short-term brain dysfunction, has become the neurology after headache the second most common disease.
- Trial name
- NCT04917939
- Testing
- RNA sequencing
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Stroke, Cerebrovascular
Clinical Development of a Tool for Optimized Self- and Hetero-diagnosis of Stroke Using Artificial Intelligence: Stage1- Collection of Video-clinical Data in a Pragmatic Situation.
The study authors aim to form a collection of video-clinical data in a pragmatic situation to enable the development of relevant AI algorithms (for both hetero- and self-diagnosis modes).
- Trial name
- PREDISTROKE (NCT05959746)
- Testing
- AI-STROKE application
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Alzheimer's Disease
A Retrospective Database Study for the Development and Validation of Algorithms for Intracerebral Hemorrhage and Seizures in Alzheimer's Disease
The primary objective of this study is to develop and validate claims-based algorithms to identify intracerebral hemorrhage >1 cm in diameter, ensuring differentiation from amyloid-related imaging abnormality-microhemorrhage and…
- Trial name
- NCT07723950
- Testing
- No intervention
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Eisai Inc.
Glioma, Coagulopathy
Hemostasis Alterations in Neurosurgical Patients
Prospective, observational study aimed to investigate the specific hemostatic alterations in patients undergoing glial tumor resection.
- Conditions
- Glioma, Coagulopathy, Acquired Platelet Function Disorder, Thromboelastometry
- Trial name
- ABCD (NCT02652897)
- Testing
- Exposure to glioma resection surgery, Exposure to colon resection surgery
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Santiago R. Leal-Noval
Adult Growth Hormone Deficiency
Extension Study on Safety of Long-Term Growth Hormone Replacement in Adult Patients With Growth Hormone Deficiency
To evaluate long-term safety of growth hormone replacement in adult patients with growth hormone deficiency
- Trial name
- NCT00191360
- Testing
- Somatropin
- Where
- 14 sites in Japan
- Volunteers
- 68 people
- Sponsor
- Eli Lilly and Company
Neonatal Seizure, Hypoxic-Ischemic Encephalopathy
Neonatal Seizure Registry - Developmental Functional EValuation
The NSR-DEV study is a longitudinal cohort study of around 280 Neonatal Seizure Registry participants that aims to evaluate childhood outcomes after acute symptomatic neonatal seizures, as well as examine risk factors for…
- Conditions
- Neonatal Seizure, Hypoxic-Ischemic Encephalopathy, Stroke, Intracranial Hemorrhages
- Trial name
- NSR-DEV (NCT04337697)
- Where
- 9 sites in United States
- Volunteers
- 188 people
- Sponsor
- University of California, San Francisco
Cerebral Palsy (CP), Infant ALL
Turkish Version of the Hammersmith Neonatal Neurological Examination (HNNE)
Infants at risk are defined as an infant with a history of adverse environmental and biological factors that may lead to neuromotor developmental problems.
- Conditions
- Cerebral Palsy (CP), Infant ALL, Neurological Development, Neonatal
- Trial name
- HNNE (NCT07182513)
- Where
- Turkey (Türkiye)
- Volunteers
- 126 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Migraine
The Effect of Sumatriptan and Placebo on Isosorbide-5-mononitrate Induced Headache
To develop a pragmatic migraine model the investigators will induce headache in healthy volunteers and in patients with migraine without aura with a long lasting Nitrogen Oxide (NO) donor.
- Trial name
- NCT02485340
- Testing
- 5-ISMN (isosorbide-5-mononitrate), Sumatriptan
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Developmental Articulation Disorder, Stuttering
Study of Brain Activity During Speech Production and Speech Perception
The purpose of this study is to gain a better understanding of the brain's activity and organization in the development of speech disorders.
- Trial name
- NCT00004991
- Where
- United States
- Volunteers
- 411 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Acromegaly, Growth Hormone Deficiency
Effects of Growth Hormone Administration on Cardiovascular Risk in Cured Acromegalics With Growth Hormone Deficiency
The purpose of the study is to evaluate the effects of growth hormone (GH) replacement in men and women with a history of acromegaly and who are now growth hormone deficient.
- Conditions
- Acromegaly, Growth Hormone Deficiency, Pituitary Disease
- Trial name
- NCT00182091
- Testing
- Recombinant human growth hormone, Saline
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Massachusetts General Hospital
SLC6A1
A Fully Remote Feasibility Trial of Phenylbutyrate for SLC6A1-Related Disorders
The purpose of this study is to evaluate the feasibility of a site-less (fully remote) clinical trial using phenylbutyrate for SLC6A1-related disorders.
- Trial name
- NCT07847918
- Testing
- Glycerol Phenylbutyrate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Scripps Translational Science Institute
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