Clinical trials: Brain Developmental Diseases
Niemann-Pick Diseases
Induced Pluripotent Stem Cells for Niemann Pick Disease
Establishment of individualized human cellular disease models based on induced pluripotent stem cells that reflect the broad heterogeneous phenotypic spectrum of Niemann Pick disease
- Trial name
- IPSNPABC (NCT03883750)
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- CENTOGENE GmbH Rostock
Cerebral Palsy
Rhythm and Multisensoriality's Effects on the Motor Development in Children With Cerebral Palsy
Cerebral palsy (CP) affects the motor function but also the cognitive function of the child. Physical activity brings motor and cognitive benefits and appears as an important aspect of the therapy that is offered to them.
- Trial name
- APP-PaC (NCT03440749)
- Testing
- luminous stimuli
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Dementia
Animation-based Storytelling Education in Relation to Moral Development in 8-12 Year Olds With Dementia-affected Caregivers
This retrospective, single-blind, parallel group study investigates the impact of animation-based storytelling influence moral development in 8-12 year olds with dementia-affected caregivers.
- Trial name
- dementia care (NCT07004348)
- Testing
- Animation group will receive 4 sessions of animation as education media as intervention.
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Autism Spectrum Disorder
Brain Response to Serotonergic Medications in ASD
This study investigates brain response to single acute dose of citalopram, tianeptine, and placebo in males with and without autism spectrum disorder.
- Trial name
- NCT04145076
- Testing
- Citalopram, Tianeptine
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- King's College London
Mild Cognitive Impairment
Molecular Cerebral Imaging in Incipient Dementia (MCI-ID) II
A substantial portion of people covered by Medicare will develop Alzheimer's disease and other forms of dementia that together devastate the lives of millions of people in the United States, and cost us a total of over $200…
- Trial name
- NCT02317250
- Testing
- Amyloid imaging, FDG-PET
- Sponsor
- University of California, Los Angeles
Growth Hormone Deficiency, Idiopathic Short Stature
Long-term Safety and Effectiveness of Growtropin®-II Treatment in Children With Short Stature
This study evaluates long-term safety and effectiveness of Growtropin®-II treatment in children with short stature.
- Conditions
- Growth Hormone Deficiency, Idiopathic Short Stature, Turner Syndrome, Small for Gestational Age
- Trial name
- NCT04798690
- Where
- South Korea
- Volunteers
- 5,000 people
- Sponsor
- Dong-A ST Co., Ltd.
Brain Injury, Vascular, Hemorrhagic Stroke
Development and Validation of a Structured Tele-rehabilitation Programme of Brain Injured Patients
The goal of this research project is to develop a tele-rehabilitation programme, which will constitute an original care pathway for brain damaged patients.
- Conditions
- Brain Injury, Vascular, Hemorrhagic Stroke, Ischemic Stroke
- Trial name
- TELERE (NCT06016374)
- Testing
- telerehabilitation
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
OSA, Sleep Apnea
Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease?
Obstructive sleep apnea (OSA) is common in older adults and has recently been implicated in pathogenesis of Alzheimer's disease (AD). Research has shown that sleep disruptions have caused memory impairment.
- Conditions
- OSA, Sleep Apnea, Obstructive Sleep Apnea, Alzheimer Disease
- Trial name
- NCT05094271
- Testing
- Supplemental Oxygen, Continuous Positive Airway Pressure Machine, Room Air
- Where
- United States
- Volunteers
- 182 people
- Sponsor
- University of California, San Diego
Brain Injuries, Intracranial Hypertension
Development and Evaluation of the ICP Waveform Tracing Capabilities and Safety of HS-1000 Device
Invasive intracranial pressure (ICP) monitoring, using modalities such as parenchymal pressure transducer or external ventricular drain (EVD), provides an ICP waveform that encapsulates valuable diagnostic and monitoring clinical…
- Trial name
- NCT02772471
- Testing
- HS-1000
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- HeadSense Medical
CADASIL
Development and Validation of a Functional MRI Biomarker of Cerebral Small Vessel Dysfunction in CADASIL
Cerebral small vessel diseases (cSVD) are diseases of brain tissue involving vessels (arterioles or capillaries) with a diameter of less than 400 microns.
- Trial name
- fMRI BioSVD (NCT06859658)
- Testing
- Functional MRI at 3T
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pain, Traumatic Brain Injury
The NRC Dataset. Developing a Minimum Dataset for Multidisciplinary Rehabilitation: a Modified E-Delphi Study
Several rehabilitation datasets are presently in use for specific patient groups in England. The 'National Clinical Audit of Specialist Rehabilitation for patients with complex needs following major injury' (NCASRI) evaluated…
- Conditions
- Pain, Traumatic Brain Injury, Major Trauma, Multiple Sclerosis
- Trial name
- NCT06726135
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- ThomasCorbett
Stroke
Development of Upper Limb Motor Scale to Measure Quality of Movement and Body Awareness in Stroke
For the breathing intervention, participants completed two experimental sessions at least two weeks apart. The experimental sessions were randomized between the slow-breathing condition (6 breaths/min) or the control breathing…
- Trial name
- AFAS (NCT03328468)
- Testing
- Breathing Exercise
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Minnesota
Growth Hormone Deficiency
Phase 1 Safety Study of ALRN-5281 in Healthy Subjects
The primary objective of this study is to evaluate the safety and tolerability of a single dose of ALRN-5281 administered by subcutaneous injection to healthy adult volunteers.
- Trial name
- NCT01775358
- Testing
- ALRN-5281 0.015 mg/kg, ALRN-5281 0.05 mg/kg, ALRN-5281 0.15 mg/kg
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Aileron Therapeutics, Inc.
Autism Spectrum Disorders, Brain Disease
A Study of the Association Between Autism and Immune Changes in the Brain
Background: People with autism and autism spectrum disorders have problems with communication, behavior, and socializing, and many also have intellectual and developmental disabilities.
- Conditions
- Autism Spectrum Disorders, Brain Disease, Autism, Healthy Volunteers
- Trial name
- NCT01322555
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Institute of Mental Health (NIMH)
Motor Skills Disorders, Autism Spectrum Disorder
DCD & ASD Imaging Intervention Study
Developmental Coordination Disorder (DCD) is a neurodevelopmental disorder that affects a child's ability to learn motor skills, such as tying shoelaces, learning to print, or riding a bicycle (APA 2013).
- Trial name
- NCT04119492
- Testing
- CO-OP Treatment Group
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of British Columbia
Cerebrovascular Disorders, Brain Lesion
Neuropsychological and Brain Medical Imaging Study in Patients With Brain Damage 2
Two groups of subjects will be constitute: (i) patients with circumscribed brain injury (including stroke, vascular malformations, tumor or circumscribed infectious lesions) or degenerative/developmental disorders and selective…
- Conditions
- Cerebrovascular Disorders, Brain Lesion, Degenerative Disease, Developmental Disability
- Trial name
- CORAC2 (NCT03586258)
- Testing
- Neuropsychological testing, Brain Imaging, Galvanic Vestibular Stimulation (GVS)
- Where
- France
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Cerebral Palsy, Growth
Predictive Models of Weight and Height for the Evaluation of the Growth of Children and Adolescents With Cerebral Palsy
Cerebral palsy (CP) is the most frequent disability in children. The vast majority of these patients are malnourished. In this population, there are practical difficulties to perform a nutritional and growth assessment which…
- Conditions
- Cerebral Palsy, Growth, Child
- Trial name
- NCT03303755
- Where
- Argentina
- Volunteers
- 388 people, healthy volunteers welcome
- Sponsor
- National Council of Scientific and Technical Research, Argentina
Ischemic Stroke, Proprioception
Proprioceptive Error Correction for Post-Stroke Upper Limb Rehabilitation
The investigators aim to develop sensory transformation and augmentation technologies that minimize the impact of proprioceptive errors, thereby significantly enhancing motor learning and rehabilitation of the upper limbs.
- Trial name
- NCT07156955
- Testing
- Electrical stimulation cue, Visual stimulation cue, No cue
- Where
- South Korea
- Volunteers
- 3 people
- Sponsor
- Sungkyunkwan University
Stroke
Individualized rTMS Protocol for Stroke Recovery
This study aims to develop individualized therapeutic protocol to improve stroke recovery and fits the scheme of Mechanisms, biomarkers, and treatment strategies for stroke, aging, and Parkinson's disease by advanced EEG analysis…
- Trial name
- NCT03828435
- Testing
- rTMS
- Where
- Taiwan
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
IGHD - Isolated Growth Hormone Deficiency, Growth Retardation
Effect of Nutritional Formula Supplementation on Growth Rate of Growth Hormone (GH) Treated Children With Growth Hormone Deficiency (GHD) After the Second Year of Therapy
The Proposed study is a double blind, randomized, placebo controlled study The aim of the study is to evaluate the effect of combined Growth Hormone (GH) treatment \& nutritional formula supplementation versus GH \& placebo on…
- Trial name
- NCT03053687
- Testing
- Nutritional supplementation standardized formula
- Where
- Israel
- Volunteers
- 64 people
- Sponsor
- Rabin Medical Center
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