Clinical trials: Brain Developmental Diseases
Brain Tumor, Neurofibromatoses
Quality Improvement Project - "My Logbook! - I Know my Way Around!"; ("Mein Logbuch - Ich Kenne Mich Aus!")
In this study, the main goal is to implement and evaluate a novel, evidence-based psycho-educative program for children in oncological care. Patients are provided with booklets tailored to each specific stage of their treatment.
- Conditions
- Brain Tumor, Neurofibromatoses, Sarcoma, Leukemia
- Trial name
- NCT04474678
- Testing
- "My Logbook! - I know my way around!"
- Where
- 22 sites in Austria, Germany and 2 more
- Volunteers
- 240 people
- Sponsor
- Medical University of Vienna
Epilepsy, Focal Cortical Dysplasia
Use of a Tonometer to Identify Epileptogenic Lesions During Pediatric Epilepsy Surgery
Refractory epilepsy, meaning epilepsy that no longer responds to medication, is a common neurosurgical indication in children. In such cases, surgery is the treatment of choice.
- Conditions
- Epilepsy, Focal Cortical Dysplasia, Tuberous Sclerosis, Hemimegalencephaly
- Trial name
- NCT04344626
- Testing
- Intra-operative brain tonometry
- Where
- 2 sites in United States, Canada
- Sponsor
- University of California, Los Angeles
Amblyopia, Refractive Errors
The Effect of Early Glasses on the Development of Amblyopia
In a randomized controlled trial, we will establish whether early glasses for high refractive error at age one reduce the development of amblyopia between age one and four.
- Trial name
- EGS (NCT04740593)
- Testing
- Orthoptic care with the prescription of glasses from age 12-18 months onwards, Orthoptic care without the prescription of glasses from age 12-18 months onwards, First measurement only
- Where
- Netherlands
- Volunteers
- 601 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Child Development
Strengthening Bangladeshi Babies Brains (SBBB)
This study aims to establish a sustainable programme whereby early childhood development activities are integrated into the routine activities of community clinics in rural Bangladesh for undernourished children by developing a…
- Trial name
- BUDHI/SBBB (NCT04093934)
- Testing
- Psychosocial stimulation
- Where
- Bangladesh
- Volunteers
- 480 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Brain Tumors
Advanced MRI Applications Development
The goals of this study are to: 1. To improve upon and develop new innovative magnetic resonance imaging techniques that refine image quality and enhance performance.
- Trial name
- NCT01847833
- Testing
- MRI scan
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Autism Spectrum Disorder, Mitochondrial Pathology
Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders
The study involves up to 5 visits for a fasting blood draw, behavioral assessments, and/or questionnaires. Other samples may be collected when appropriate. This study is currently recruiting.
- Conditions
- Autism Spectrum Disorder, Mitochondrial Pathology, Epilepsy, Brain Tumor
- Trial name
- NCT04322734
- Where
- 2 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Southwest Autism Research & Resource Center
Congenital Portosystemic Shunt, CPSS (Congenital Portosystemic Shunt)
International Registry of Congenital Portosystemic Shunt (IRCPSS)
Congenital Portosystemic Shunt (CPSS) is a rare condition important by the multiplicity and severity of associated complications.
- Trial name
- IRCPSS (NCT06041906)
- Testing
- Shunt Closure
- Where
- 26 sites in United States, Australia and 14 more
- Volunteers
- 500 people
- Sponsor
- Prof. Valérie Mc Lin
Healthy, Growth Hormone Deficiency
Effects of GH and Lirglutide on AgRP
This is a randomized, placebo-controlled, cross-over study with 4 arms. Healthy and GH deficient adults ages 18-45 years will be studied. Arms will consist of 21-day treatment periods and be separated by 8-week washout periods.
- Trial name
- NCT05681299
- Testing
- growth hormone and lirglutide, growth hormone, liraglutide
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Columbia University
Growth Hormone Deficiency
Sexually Dimorphic Effects of GHRH in Adult Growth Hormone Testing
Specific Aim 1 Healthy male and female subjects and growth hormone (GH) deficient subjects display sexually dimorphic GH responses to GHRH administration Specific Aim 2 GH responses to GHRH in both healthy controls and in GH…
- Trial name
- NCT00324064
- Testing
- GHRH/arginine stimulation testing
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Growth Hormone Deficiency
Growth Hormone Administration and Its Effects on Cardiovascular Risk Factors in Growth Hormone Deficient Women
The purpose of the study is to evaluate the effects of growth hormone replacement on women with growth hormone deficiency. Growth hormone deficiency means the body no longer produces growth hormone due to a tumor or some kind of…
- Trial name
- NCT00136032
- Testing
- Somatropin
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Massachusetts General Hospital
PARKINSON DISEASE (Disorder), Upper Extremity
Upper Extremity Functional Skills in Patients With Parkinson Disease (pwPD)
Parkinson's disease (PD) is the second most common neurodegenerative disease, characterized pathologically by the progressive loss of dopaminergic neurons in the substantia nigra and clinically by the presence of motor symptoms…
- Conditions
- PARKINSON DISEASE (Disorder), Upper Extremity, Muscle Strength Development, Functional Skills
- Trial name
- pwPD (NCT07180004)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Epilepsy
The Role of Genetic Factors in the Development of Epilepsy in the Kazakh Population
This is a GWAS study that aims to identify possible candidate genes associate to epilepsy by exploring single nucleotide polymorphism (SNP) in a group of epilepsy, in the Kazakh population.
- Trial name
- NCT05088499
- Testing
- DNA analysis
- Where
- Kazakhstan
- Volunteers
- 600 people
- Sponsor
- Asfendiyarov Kazakh National Medical University
Parkinson Disease
A Study to Analyze Symptoms Prevalent in Early PD (Dysphonia, Tremor)
This is a web-based study that involves monitoring hallmark symptoms of Parkinson's Disease (PD), specifically dysphonia and tremor, using smartphone sensor data.
- Trial name
- NCT04288804
- Testing
- Smartphone microphone sensor, Smartphone accelerometer sensor
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Goalspal LLC
Short Stature, Constitutional Delay of Growth and Development
Role of Nutrition and Hormones in Boys With Disordered Growth
This study will determine whether adding more calories to the diet helps boys with growth problems grow better while being treated with Nutropin, a growth hormone that is used to help children grow taller.
- Conditions
- Short Stature, Constitutional Delay of Growth and Development, Dwarfism, Pituitary
- Trial name
- NCT00102258
- Testing
- Growth Hormone Therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Dyslexia, Developmental, Reading
Enhancing Letter-Speech Sound Learning and Reading Network Activation With Transcranial Electrical Stimulation
This study investigates the effects of transcranial electrical stimulation (tES) on the brain and its potential to enhance reading-related learning.
- Conditions
- Dyslexia, Developmental, Reading, Dyslexia, Learning
- Trial name
- LexiStim (NCT07546292)
- Testing
- Transcranial random noise stimulation
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Silvia Brem
Parkinson Disease
Non Invasive Neuromodulation for Patients With Motor Control Disorders
Movement disorders are neurological syndromes leading to excessive movements or to limited control of voluntary and automatic movements.
- Trial name
- NCT04017481
- Testing
- Repetitive transcranial magnetic stimulation (rTMS), EEG guided Neurofeedback (NFB)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidad Francisco de Vitoria
Attention Deficit Hyperactivity Disorder, Autism Spectrum Disorder
Internet-based Coaching for Young Adults With Neuropsychiatric Disorders
Purpose: To develop a model for internet-based support and coaching to young adults with neuropsychiatric disorders (NPD). To improve the individual's psychosocial functioning and his/her understanding of how he/she is…
- Conditions
- Attention Deficit Hyperactivity Disorder, Autism Spectrum Disorder, Tourette's Disorder
- Trial name
- NCT02316145
- Testing
- Habilitation (Internet-based support and coaching)
- Volunteers
- 12 people
- Sponsor
- Vardalinstitutet The Swedish Institute for Health Sciences
Congenital Heart Disease
Neurodevelopmental Outcomes in Hypoplastic Left Heart Syndrome
There have been many improvements in the care of children with hypoplastic left heart syndrome (HLHS). This has helped these children survive longer.
- Trial name
- NCT00399555
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Emory University
Mucopolysaccharidosis Disorders, Hurler Syndrome
MT2013-31: Allo HCT for Metabolic Disorders and Severe Osteopetrosis
This single-institution, phase II study is designed to test the ability to achieve donor hematopoietic engraftment while maintaining low rates of transplant-related mortality (TRM) using busulfan- and fludarabine-based…
- Conditions
- Mucopolysaccharidosis Disorders, Hurler Syndrome, Hunter Syndrome, Maroteaux Lamy Syndrome
- Trial name
- NCT02171104
- Testing
- Stem Cell Transplantation, IMD Preparative Regimen, Osteopetrosis Only Preparative Regimen
- Where
- United States
- Volunteers
- 149 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Alzheimer Disease
Socially Assistive Robots for Interaction With Older Adults With Dementia
A 12-month pilot study will be comprised of two groups of people diagnosed with mild Alzheimer's disease and related dementia for a total of 80 senior subjects.
- Trial name
- NCT04384978
- Testing
- Play Serious Games with a Social Robot (Ryan), Play Solitary Games Without a Social Robot
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- DreamFace Technologies, LLC
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