Clinical trials: Brain Developmental Diseases
Asperger's Syndrome, Dyslexia
My Scrivener® - Measuring Effectiveness and Dose Response in Children
This study will assess whether a computer haptic peripheral device programmed to provide repetitive motion training is as effective as the same repetitive motion training provided by a human being.
- Conditions
- Asperger's Syndrome, Dyslexia, Cerebral Palsy, Attention Deficit Disorder
- Trial name
- NCT00919906
- Testing
- My Scrivener(R)
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- Obslap Research LLC
Stroke, Acute
Development of Dysphagia Protocol in Ankara City Hospital Stroke Patients
Stroke, also called cerebrovascular disease, is a sudden-onset neurological disorder that causes a regional or general dysfunction in the brain due to vascular causes.
- Trial name
- NCT04739514
- Testing
- Exercises for dysphagia rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Nazife Kapan
Intracranial Hemorrhages, Head Trauma
PREhospital Prediction of the Risk of Intracranial Hemorrhagic Injury in the Elderly Patient With a Fall
Monocentric study at Toulouse University Hospital. A questionnaire collecting the elements of the study is made available to regulating physicians.
- Trial name
- PRELHIC (NCT06784284)
- Testing
- Glasgow Outcome Scale -Extended (GOSE)
- Where
- France
- Volunteers
- 1,100 people
- Sponsor
- University Hospital, Toulouse
Autism Spectrum Disorder, Anxiety
Brain Activity Changes After Cognitive Behavioral Therapy for Anxiety in Autistic Youth From High-Need Communities
The goal of this clinical trial is to investigate neural constructs related to anxiety symptoms in response to Facing Your Fears (FYF) treatment in autistic participants with co-occurring anxiety.
- Trial name
- IAA (NCT06904508)
- Testing
- Facing Your Fears (FYF) Intervention: A CBT Focused Group Treatment for Autistic Youth with Anxiety
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Montclair State University
Hemiplegic Stroke, Hemiplegic Cerebral Palsy
Evaluating Human-Machine Interfaces in a Robotic Thumb Orthosis
We plan to investigate whether the Isolated Orthosis for Thumb Actuation (IOTA) can effectively facilitate the ability of participants to perform a specific set of clinically relevant tasks conducted in a clinic setting.
- Trial name
- IOTA (NCT01973426)
- Testing
- Isolated Orthosis for Thumb Actuation (IOTA)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Wyss Institute at Harvard University
Brain Disease, Ischemic Attack, Transient
Natural History of Stroke: Cause and Development
The purpose of this study is to learn more about stroke and obtain information that may serve as the basis for future investigations.
- Conditions
- Brain Disease, Ischemic Attack, Transient, Cerebrovascular Accident, Cerebrovascular Disorder
- Trial name
- NCT00009243
- Where
- 3 sites in United States
- Volunteers
- 4,000 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Child Development Disorders, Pregnancy
The Effect of Thyroid Hormone Levels in Pregnant Women on the Intelligence Quotient (IQ) of Their Children
This study is designed to test the hypothesis that the level of the thyroid hormone thyroxine (specifically, free thyroxine, FT4) circulating in the blood of pregnant women is the key thyroid-related factor to influence early…
- Conditions
- Child Development Disorders, Pregnancy, Subclinical Hypothyroidism
- Trial name
- NCT00147433
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Growth Disorders
Long-Acting Growth Hormone in Children Compared to Daily rhGH
The trial will compare a twice-monthly somavaratan dosing regimen for non-inferiority of treatment effect against daily injections of rhGH.
- Trial name
- VELOCITY (NCT02339090)
- Testing
- Somavaratan, rhGH
- Volunteers
- 138 people
- Sponsor
- Versartis Inc.
Parkinson's Disease
Development and Validation of a Scale Measuring Preoperative Expectations in Parkinson's Disease
Subthalamic nucleus deep brain stimulation (STN-DBS) has become a choice treatment for fluctuating Parkinson's disease (PD) patients, inducing remarkable improvement in motor symptoms.
- Trial name
- NCT04933513
- Testing
- pre DBS patients responding to the DBS-PS scale
- Where
- France
- Volunteers
- 22 people
- Sponsor
- Central Hospital, Nancy, France
Growth Hormone Deficiency, Septo-Optic Dysplasia
Endocrine Dysfunction and Growth Hormone Deficiency in Children With Optic Nerve Hypoplasia
Hypotheses: 1. The prevalence of endocrinopathies, and growth hormone (GH) deficiency in particular, among young children diagnosed with optic nerve hypoplasia (ONH) is higher than is commonly thought. 2.
- Conditions
- Growth Hormone Deficiency, Septo-Optic Dysplasia, Hypopituitarism
- Trial name
- NCT00140413
- Testing
- Nutropin AQ
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's Hospital Los Angeles
Glioma, Coagulopathy
Hemostasis Alterations in Neurosurgical Patients
Prospective, observational study aimed to investigate the specific hemostatic alterations in patients undergoing glial tumor resection.
- Conditions
- Glioma, Coagulopathy, Acquired Platelet Function Disorder, Thromboelastometry
- Trial name
- ABCD (NCT02652897)
- Testing
- Exposure to glioma resection surgery, Exposure to colon resection surgery
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Santiago R. Leal-Noval
Heart Failure, Growth Hormone Deficiency
Treatment of GHD Associated With CHF
Aim of the current study is to assess the cardiovascular effects of GH replacement therapy in patients with coexisting GHD and CHF
- Trial name
- NCT03775993
- Testing
- Human growth hormone
- Volunteers
- 64 people
- Sponsor
- Federico II University
Autism Spectrum Disorder, Healthy
Differences in Prosocial Behaviors and Related Brain Networks in Children With Autism and Typical Development
The goal of this observational study is to compare the brain functional network between children with autism and typical development, using magnetic resonance imaging (MRI), electroencephalogram/event-related potentials(EEG/ERPs)…
- Trial name
- NCT06908174
- Testing
- ADOS-2
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Fudan University
Brain Injury, Brain Tumor Adult
Development and Implementation of an Intervention Enhancing Involvement of Relatives to Patients With Acquired Brain Injury or Malignant Brain Tumour
Caring for a loved one with a serious illness like acquired brain injury (ABI) or primary malignant brain tumors (PMBT) can be a challenging and burdensome experience, often affecting the well-being and quality of life of…
- Conditions
- Brain Injury, Brain Tumor Adult, Traumatic Brain Injury, Glioblastoma
- Trial name
- NCT06796335
- Testing
- RIGht
- Where
- Denmark
- Volunteers
- 35 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cerebral Palsy, Developmental Delay
Efficacy of the START-Play Program for Infants With Neuromotor Disorders
The purpose of this project is to evaluate the efficacy of Sitting Together And Reaching To Play (START-Play), an intervention designed to target sitting, reaching, and motor-based problem solving to improve development and…
- Conditions
- Cerebral Palsy, Developmental Delay, Infant Development
- Trial name
- START-Play (NCT02593825)
- Testing
- START-Play intervention, Business as usual
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- Duquesne University
Developmental Delay
Mirror Neuron Network Dysfunction as an Early Biomarker of Neurodevelopmental Disorder
Background: People show changes in brain activity when they watch other people do actions. This may be part of early social and communication skills.
- Trial name
- NCT03307317
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Alzheimer's Disease
A Retrospective Database Study for the Development and Validation of Algorithms for Intracerebral Hemorrhage and Seizures in Alzheimer's Disease
The primary objective of this study is to develop and validate claims-based algorithms to identify intracerebral hemorrhage >1 cm in diameter, ensuring differentiation from amyloid-related imaging abnormality-microhemorrhage and…
- Trial name
- NCT07723950
- Testing
- No intervention
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Eisai Inc.
Alzheimer Disease
Health Behavior Change in Midlife Adults at Risk for Alzheimer's Disease
Modifying health behaviors like physical activity level, diet, stress, and mental activity level can lower risk for Alzheimer's disease, but many middle-aged and older adults find it difficult to sustain health behavior changes…
- Trial name
- NCT05599425
- Testing
- Enhanced Healthy Living Education, Basic Healthy Living Education
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
Huntington Disease
Gene Therapy Development and Validation for Huntington's Disease Fibro TG-HD
Huntington's disease is a rare and fatal monogenic neurodegenerative disorder whose molecular origin is an expansion of CAG triplets within the first exon of the Huntingtin gene.
- Trial name
- FibroTG-HD (NCT06444217)
- Testing
- skin biopsy
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Angers
Healthy Volunteers, Growth Hormone Deficiency
A Study to Compare the Uptake Into the Blood of Two Strengths of Somapacitan After Injection Under the Skin in Healthy Subjects
This study will compare two strengths of the new long-acting growth hormone somapacitan. The aim of this study is to test if both strengths are taken up in the blood in the same way.
- Trial name
- NCT03905850
- Testing
- somapacitan
- Where
- Germany
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
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