Clinical trials: Brain Disease
Alzheimer Disease
Effect on the Electrocardiographic QT Interval Corrected for Heart Rate (QTc) in Healthy Subjects
The purpose of this study is to determine the effect of BMS-708163 on the QTc interval (QT interval corrected for heart rate).
- Trial name
- NCT00979316
- Testing
- BMS-708163, Moxifloxacin
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Mild Traumatic Brain Injury, Posttraumatic Stress Disorder
Imaging Biomarkers of Mild Traumatic Brain Injury: a Longitudinal Cohort Study
This longitudinal cohort study aims to detect the topographical nature of the white matter microstructure and resting state functional connectivity patterns across the whole brain in the evolution of pathology as a function of…
- Conditions
- Mild Traumatic Brain Injury, Posttraumatic Stress Disorder, Affective and Somatic Complaints, Cognitive Impairments
- Trial name
- NCT02868684
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Carotid Artery Disease, Carotid Stenosis
Carotid Angioplasty and Stenting Versus Endarterectomy in Asymptomatic Subjects Who Are at Standard Risk for Carotid Endarterectomy With Significant Extracranial Carotid Stenotic Disease (ACT I)
The study is being conducted to demonstrate the non-inferiority of carotid artery stenting (CAS) using the Emboshield® Embolic Protection System with the Xact® Carotid Stent System to carotid endarterectomy (CEA) for the…
- Conditions
- Carotid Artery Disease, Carotid Stenosis, Stroke, Atherosclerosis
- Trial name
- ACT I (NCT00106938)
- Testing
- Carotid artery stenting with filter (interventional), Carotid artery endarterectomy (surgical)
- Where
- 62 sites in United States
- Volunteers
- 1,663 people
- Sponsor
- Abbott Medical Devices
Parkinson Disease, Movement Disorders
Characterizing Biomarkers of Early Parkinson's Disease Progression (TREG)
The purpose of this study is to look at a blood marker of inflammation in early untreated Parkinson's disease.
- Trial name
- TREG (NCT03716258)
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Oregon Health and Science University
Workplace Migraine Treatment
Does Treximet Improve Productivity and Patient Satisfaction Due to Sustained Response and Consistency of Response?
Researchers want to learn about work productivity after treatment of a migraine headache with your usual migraine medication as compared to your work productivity after treatment with Treximet.
- Trial name
- NCT01086358
- Testing
- Triptan, Treximet 85Mg-500Mg Tablet
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The Cleveland Clinic
Cerebral Ischemia
Reversing Cerebral Oxygen Desaturations Greater That 10% of Baseline Values Using NIRS in the ICU
Study objectives: The main objective of this study is to determine the feasibility of implementing measures in the intensive care unit (ICU), based on a physiological algorithm, to reverse decreases in cerebral oxygen saturation…
- Trial name
- NIRS-ICU (NCT01875055)
- Testing
- NIRS and Algorithm, NIRS derived cerebral oximetry
- Where
- Canada
- Volunteers
- 49 people
- Sponsor
- University of Manitoba
Cerebral Palsy
Robot-assisted Training in Children With CP
Cerebral palsy (CP) is the most common physical disability in early childhood causing serious motor and sensory impairments. Effective interventions for the recovery of motor functions are of profound significance to children…
- Trial name
- NCT06450158
- Testing
- Robot (Amadeo)-assisted Training
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cook Children's Health Care System
Intracranial Pressure Increase
Non-invasive Diagnostic for Assessing Elevated Intracranial Pressure
The study is a prospective, multi-center, non-randomized, open label observational study. The objective of this study is to compare the accuracy of the EyeBOX to a clinical diagnosis of abnormal ICP as determined by an external…
- Trial name
- NCT03418753
- Testing
- EyeBOX for ICP
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Oculogica, Inc.
Ménière
Treatment of Meniere's Disease With Migraine Medications
Meniere's disease (MD) is a chronic disease with a variety of fluctuating signs and symptoms, which include vertigo, hearing loss, tinnitus (ringing noise in the ear), aural pressure (feeling of ear fullness), and disequilibrium…
- Trial name
- NCT05582837
- Testing
- nortriptyline + topiramate
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, Irvine
Posterior Fossa Lesion
Comparison of Surgical Outcomes of Craniotomy and Craniectomy in Posterior Fossa Lesions
The purpose of this randomized controlled trial is to compare the surgical outcomes of craniotomy and craniectomy among patients with posterior fossa lesions.
- Trial name
- NCT06831695
- Testing
- Craniotomy, Craniectomy
- Volunteers
- 80 people
- Sponsor
- University of Health Sciences Lahore
Concussion (Diagnosis), MTBI - Mild Traumatic Brain Injury
BCAAs in Concussion 3.0
This study is a randomized, placebo-controlled, double-blinded, therapeutic exploratory clinical trial of branched chain amino acids (BCAAs) in the treatment of concussion.
- Conditions
- Concussion (Diagnosis), MTBI - Mild Traumatic Brain Injury, Concussion, Brain, Concussion
- Trial name
- NCT07670195
- Testing
- BCAA
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Akiva Cohen
Migraine Disorders
Transcranial Direct Current Simulation in Chronic Migraine
This study is a pilot, double-blind, placebo-controlled, randomized trial aiming to compare the effects of transcranial direct current stimulation in Chronic Migraine.
- Trial name
- NCT02817139
- Testing
- TDCS
- Where
- Brazil
- Volunteers
- 15 people
- Sponsor
- Federal University of Paraíba
Dementia
The Hospice Advanced Dementia Symptom Management and Quality of Life Trial (HAS-QOL)
The Aliviado Dementia Care Program (formerly known as the Dementia Symptom Management at Home Program, or DSM-H) was developed to implement dementia friendly care for persons with Dementia and their caregivers living in the…
- Trial name
- NCT04175977
- Testing
- Aliviado Dementia Care-Hospice Edition QAPI program, Usual Care
- Where
- United States
- Volunteers
- 44,143 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Ischemic Stroke, Hypertension
Home Blood Pressure Study for Recent Stroke Survivors With High Blood Pressure *On Hold Due to Global Pandemic*
The purpose of this pilot study is to assess the feasibility of implementing a home blood pressure self-management program in a population of recent stroke survivors in the Washington, D.C. area.
- Trial name
- HBPS (NCT04226157)
- Testing
- Home Blood Pressure Monitoring Device (Qardio Arm), Primary Care Provider Blood Pressure Management
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- MedStar Georgetown University Hospital
Severe Traumatic Brain Injury, Intracranial Hypertension
Ketamine for Sedation in Severe Traumatic Brain Injury
This protocol is for an open-label randomized trial evaluating the safety of using ketamine in combination with propofol for sedation versus the standard of care analgosedation in patients admitted to the intensive care unit with…
- Conditions
- Severe Traumatic Brain Injury, Intracranial Hypertension, Intracranial Hemorrhage, Hypertensive
- Trial name
- Ketamine (NCT06429657)
- Testing
- Ketamine with propofol, Standard of Care propofol, fentanyl, dexmedetomidine, morphine, hydromorphone, midazolam, or lorazepam
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Leptomeningeal Metastasis, Breast Cancer
BRain-AVOidant Proton Craniospinal Irradiation for Leptomeningeal Metastases From Solid Tumor Malignancies
The purpose of this study is to determine the efficacy of BRain-AVOidant proton craniospinal irradiation (BRAVO pCSI) in adult participants with leptomeningeal metastases from solid tumors.
- Conditions
- Leptomeningeal Metastasis, Breast Cancer, Lung Cancer (NSCLC)
- Trial name
- BRAVO-LM (NCT07789912)
- Testing
- Radiation Treatments Using Brain- Avoidant Proton Craniospinal Irradiation (BRAVO- pCSI)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Miami
Complete or Incomplete Paraplegia/quadriplegia, Spinal Cord Injury
Research on Wireless Brain Implant System for General Control of External Devices
The clinical trial aims to evaluate the safety and efficacy of the minimally invasive, wireless brain-machine interface system (WRS) in enabling general brain control of external devices, such as a cursor and other assistive…
- Conditions
- Complete or Incomplete Paraplegia/quadriplegia, Spinal Cord Injury, Brainstem Stroke, Amyotrophic Lateral Sclerosis
- Trial name
- RISE (NCT06829212)
- Testing
- WRS
- Where
- China
- Volunteers
- 4 people
- Sponsor
- Shanghai StairMed Technology Co., Ltd.
Parkinson Disease, Multiple Sclerosis
Turkish Version of Mini-BESTest, Validity and Reliability for Adult Participants With Sensoriomotor Impairments
The aim of this study is to present the Turkish version of miniBESTest which evaluates the reasons of balance deficit and postural control.
- Conditions
- Parkinson Disease, Multiple Sclerosis, Trauma, Brain
- Trial name
- NCT03839381
- Volunteers
- 50 people
- Sponsor
- Ordu University
Functional Independence, Respiratory Insufficiency
More Air - Better Performance - Faster Recovery
The objective of this study is to investigate i) the effect of 3 weeks IMT to adults post-stroke to maximal inspiratory pressure (MIP) and ii) the effects of 3 weeks IMT to the degree of dependency in activities of daily living…
- Trial name
- IMT (NCT04686019)
- Testing
- Inspiratory muscle training (IMT)
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Central Jutland Regional Hospital
Friedreich Ataxia
Evaluation of the Effect of Artesunate in Friedreich Ataxia (FA)
This dose-escalation study is aimed at investigating a novel application for artesunate in the treatment of Friedreich ataxia. It will evaluate this novel application of oral artesunate using a surrogate biological marker as…
- Trial name
- ARTEMIS (NCT04921930)
- Testing
- Artesunate Oral Product
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France