Clinical trials: Brain Disorder
Attention Deficit Hyperactivity Disorder
Brain Training in Children With/At-risk for Attention-Deficit/Hyperactivity Disorder and Executive Function Impairment
The purpose of this study is to determine if different forms of child-friendly, computer-based puzzles and games ("brain training") targeting executive function (EF) skills (i.e., thinking, problem-solving) result in improvements…
- Trial name
- NCT02588365
- Testing
- Brain Training (Active), Brain Training (Passive), Brain Training (Active or Passive)
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Stanford University
Polypharmacy, Dementia
Adapting the Shed-MEDS Deprescribing Intervention to Dementia Care in Assisted Living
This single-arm pilot study will evaluate the effects of an intervention to reduce exposure to unnecessary or potentially harmful medications among residents with dementia living in an assisted living facility.
- Conditions
- Polypharmacy, Dementia, Quality of Life
- Trial name
- NCT05956665
- Testing
- Shed-MEDS deprescribing intervention
- Where
- 2 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Alzheimer Disease
Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SAM-315 in Healthy Japanese Males
To assess the safety and tolerability of ascending single oral doses of SAM-315, an investigational drug, in healthy Japanese male subjects.To obtain preliminary pharmacokinetic (PK) and pharmacodynamic (PD) profiles of SAM-315…
- Trial name
- NCT00480467
- Testing
- SAM-315
- Where
- Japan
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Spinal Cord Injuries, Stroke
Restorative Neuromodulation for Lower Extremity Functions
The overall objective of the proposed study is to restore lower-extremity functions of paraplegic individuals. Paralysis following Stroke or spinal cord injury (SCI) result harsh sufferings including lifelong dependence on…
- Conditions
- Spinal Cord Injuries, Stroke, Paralysis
- Trial name
- NCT04171375
- Testing
- trans-spinal Electrical Stimulation (tsES)
- Where
- Hong Kong
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Aging, Mild Cognitive Impairment
Modulating Cortical Dynamics of Dual-task Standing in MCI
The investigators have designed a brain stimulation study to understand its effect on an individual's standing, walking, and thinking abilities in older adults with and without mild cognitive impairments (MCI).
- Trial name
- NCT05680701
- Testing
- real tACS
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hebrew SeniorLife
Alcoholism, Alcohol Amnestic Disorder
From Uncomplicated Alcoholism to Korsakoff's Syndrome
This research project aims to identify factors that contribute to the heterogeneity observed in neuroradiological and neuropsychological signs of chronic alcoholism.
- Trial name
- ALCOBRAIN (NCT01455207)
- Testing
- Neuropsychological testing, blood draw, genetic testing
- Where
- France
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Parkinson Disease
DAT SPECT and Procedural Motor Skills in Parkinson's Disease
Patients with Parkinson's disease (PD) are known to be affected by subtle cognitive impairment early in the disease course, mostly in the executive field.
- Trial name
- NCT03076307
- Testing
- Procedural Motor Skills with mirror-drawing of figures
- Where
- Switzerland
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Stroke Sequelae, Gait, Hemiplegic
ACTive Exoskeleton for Unilaterally-Assisted Locomotion (ACTUAL)
Walking difficulties are common symptoms after stroke, significantly reducing quality of life. Walking recovery is therefore one of the main priorities of rehabilitation.
- Trial name
- ACTUAL (NCT06061601)
- Testing
- Exoskeleton stroke group
- Where
- Italy
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Glucose Metabolism Disorders (Including Diabetes Mellitus), Cognitive Decline
Glucose Variability and Cognition in Prediabetes
This study examines the association of variability in glucose values over a 10-day period with cognitive function and AD risk markers among individuals with prediabetes, aged 50 or older.
- Conditions
- Glucose Metabolism Disorders (Including Diabetes Mellitus), Cognitive Decline, PreDiabetes, Aging
- Trial name
- NCT04201600
- Testing
- Continuous Glucose Monitoring System (CGMS)
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Equine Encephalitis
Vaccination Trial of a Recombinant MVA-BN-WEV Vaccine in Healthy Adult Subjects
To assess safety and tolerability as well as immune responses to the MVA-BN-WEV vaccine in the 3 treatment groups receiving different doses.
- Trial name
- NCT04131595
- Testing
- MVA-BN-WEV Dose 1, MVA-BN-WEV Dose 2, MVA-BN-WEV Dose 3
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Bavarian Nordic
Migraine
Migraine is Associated With Altered Mechanical Pain Sensitivity. This Study Investigates Mechanical Pain Sensitivity, Headache Burden, and Quality of Life in Episodic and Chronic Migraine, Comparing Pressure Algometry and Algopeg® and Assessing Mechanosensitivity of Peripheral Nerves.
Migraine is one of the most prevalent neurological disorders and is associated with a substantial individual and societal burden.
- Trial name
- MechSens_Migra (NCT07559565)
- Testing
- pressure pain algometry
- Where
- Austria
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Bernhard Taxer
Cerebral Palsy
Urdu Translation of Bimanaual Fine Motor Functional Classification System 2
In 2002, Beckung and Hagberg introduced the Bimanual Fine Motor Function (BFMF) classification system. However, the initial version struggled to clearly distinguish between its five defined levels.
- Trial name
- NCT06484465
- Where
- Pakistan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Dysphagia, Oropharyngeal, Stroke
Screening of Dysphagia Via Ultrasonography in Patients With Stroke
Oropharyngeal dysphagia is commonly seen in patients with stroke. Clinical assessment may be used to evaluate dysphagia in patients with stroke however reliability of this method is controversial and videofluoroscopic study is…
- Trial name
- NCT04344392
- Testing
- Ultrasonographic study, Videofluoroscopic study temporal parameters, Videofluoroscopic study distance parameters
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Traumatic Brain Injury
Blended Reality Immersion for Geriatric Head Trauma: The BRIGHT Study
Traumatic brain injury (TBI) is a major public health concern, particularly among older adults (OAs) ≥ 65 years of age. Each year in the United States, TBI results in over 600,000 emergency department visits and hospitalizations…
- Trial name
- BRIGHT (NCT06074328)
- Testing
- Virtual Reality Neurocognitive Exercises administered through an Oculus Headset
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Parkinson Disease(PD)
Central and Peripheral Fatigue in Individuals With Parkinson's Disease - Evaluation and Training
Fatigue is one of the most common symptoms in individuals with Parkinson's Disease (PD). Past research indicated that more than half of the individuals with PD demonstrated fatigue symptom.
- Trial name
- NCT01971528
- Testing
- Electronic muscle stimulator, Muscle strength training
- Where
- Taiwan
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Chang Gung University
Cognitive Aging, Alzheimer Disease, Protection Against
The Revitalize Study in Older Adults at Risk for Alzheimer's Disease
The goal of this multi-site double blinded randomized sham-controlled Phase II clinical trial is to test a novel, relatively low cost, low risk, and potentially high impact therapeutic intervention in older adults who are at…
- Trial name
- NCT04018092
- Testing
- Active NIR-PBM
- Where
- 2 sites in United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- University of Florida
Cerebral Hemorrhage
Prognostic Value of Plasma Thrombospondin-1 Levels After Acute Intracerebral Hemorrhage
The current study was designed to investigate the change of plasma thrombospondin-1 levels and assess the prognostic predictive effect of plasma thrombospondin-1 levels in the patients with acute intracerebral hemorrhage.
- Trial name
- NCT02465671
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Jinhua People's Hospital
Stroke
Navigation Repetitive Transcranial Magnetic Stimulation in Stroke Rehabilitation
The aim of research to study therapeutic possibilities of navigation transcranial magnetic stimulation in stroke rehabilitation, finding optimal protocol.
- Trial name
- NTMSR (NCT01652677)
- Testing
- Transcranial magnetic stimulation
- Where
- 2 sites in Russia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Russian Academy of Medical Sciences
Stroke, Hemiplegia
Use of Tendon Vibration and Mirror for the Improvement of Upper Limb Function and Pain Reduction
Upper limb paralysis following stroke is a very common problem. Only 30% of stroke patients who suffer from upper limb paresis experience a full recovery of function.
- Trial name
- VibMirror (NCT01010607)
- Testing
- Vibration and Mirror, Mirror therapy
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Alzheimer Disease, Dementia
Caregiver Study Dr. Phillips
This study will examine whether a performing arts class will improve the well-being of primary unpaid caregivers of people with dementia
- Trial name
- NCT03653871
- Testing
- Performing Arts Instruction
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- AdventHealth
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