Clinical trials: Brain Disorder
Alzheimer Disease, Cognitive Decline
Computerized Tests of Cognitive Decline in Presymptomatic Alzheimer's Disease
The investigators will study performance on computerized cognitive tasks in healthy participants of different ages to gather normative data for newly developed computerized cognitive tests.
- Conditions
- Alzheimer Disease, Cognitive Decline, Aging
- Trial name
- NCT04800588
- Testing
- California Cognitive Assessment Battery
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Neurobehavioral Systems, Inc.
Parkinson Disease, Dysarthria, Hypokinetic
A Multidimensional Study on Articulation Deficits in Parkinsons Disease
Articulatory deficits are present in most speakers with dysarthria, which negatively impacts their speech intelligibility, yet little is known about the relationship between articulatory movement and speech intelligibility.
- Trial name
- NCT05754086
- Testing
- Clear Speech, Less Clear Speech
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Florida State University
Migraine
BIOmarkers of MIGraine: a Proof of Concept Study Based on the Stratification of Responders to CGRP Monoclonal Antibodies
Migraine is the 2nd most disabling neurological disease. It affects 14.7% of the population (children and adults) of whom 80% are female. In the European Union, the total annual cost of migraine is of 111 billion euros.
- Trial name
- BIOMIGA (NCT04503083)
- Where
- 3 sites in Germany, Italy and 1 more
- Volunteers
- 243 people, healthy volunteers welcome
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Atrial Fibrillation
The Effect and Safety of Different Intensity Anticoagulation Therapy in Elderly Patients With Non-valvular Atrial Fibrillation
Current guidelines recommend standard warfarin anticoagulation international normalized ratio (INR) goal of 2.0-3.0 in adults with non valvular atrial fibrillation (NVAF).
- Trial name
- NCT01438580
- Testing
- Warfarin, aspirin
- Where
- China
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Nanjing Medical University
Post-Acute COVID-19, Post Acute COVID-19 Syndrome
Safety and Dosage of a Computerized Cognitive Training Program for Cognitive Dysfunction After COVID-19
The goal of this Phase I/II clinical trial is to assess the safety and maximum tolerated training time of a self-administered computerized cognitive training (CCT) in individuals with cognitive dysfunction as a consequence of…
- Conditions
- Post-Acute COVID-19, Post Acute COVID-19 Syndrome, Cognitive Dysfunction, Cognitive Impairment
- Trial name
- CCTLongCOVID (NCT05582603)
- Testing
- CCT Long COVID
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidad Antonio de Nebrija
Cognitive Decline, Mild
Predict Early Cognitive Changes in a Healthy Elderly Population by Passively Recording Sensor Data From Mobile Devices
The study will recruit 100 participants aged 65+ residing in assisted living facilities. Eligible participants will undergo an initial cognitive assessment to document their baseline cognitive status using cognitive tests…
- Trial name
- 0150-24 SOR (NCT07596186)
- Where
- Israel
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
Stroke
Time Course of a Misperception of Verticality and Its Characteristics in Post-stroke Participants
Little is known about the time course of verticality perception after stroke. This study aims to assess: The time course of verticality perception (Subjective Visual, Haptic and Postural Vertical; resp., SVV, SHV, SPV); The…
- Trial name
- NCT05978596
- Where
- 2 sites in Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Equinus Deformity
Dynamic Evaluation of Ankle Joint and Muscle Mechanics in Children With Spastic Equinus Deformity Due to Cerebral Palsy
This research will lead to the first evaluation of intrinsic and dynamic joint and muscle mechanics of equinus in cerebral palsy. It would provide a direct cause and effect relationship between equinus and bone deformity.
- Trial name
- EQUINUS (NCT02814786)
- Testing
- MRI scanner, Gait analysis
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Age-related Cognitive Decline
ItaliaN Study With Tailored Multidomain Interventions to Prevent Functional and Cognitive Decline in Community-dwelling Older Adults
The goal of this interventional non-pharmacological study is to investigate the effects of a multi-domain intervention ( "active intervention"), compared to that followed by normal clinical practice ("self-guided intervention")…
- Trial name
- IN TeMPO (NCT06248723)
- Testing
- Nutritional intervention, Physical exercise, Cognitive training
- Where
- Italy
- Volunteers
- 1,340 people, healthy volunteers welcome
- Sponsor
- University of Milano Bicocca
Depressive Symptoms, Anxiety
Probiotics, Brain Structure and Psychological Variables
Theory and research on the gut-brain-axis emphasize complex interactions between the gut microbiota, immunological and hormonal responses, brain function, brain structure, as well as resulting behavioral manifestations, such as…
- Conditions
- Depressive Symptoms, Anxiety, Stress
- Trial name
- ProBrain01 (NCT03478527)
- Testing
- Vivomixx® powder
- Where
- Germany
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Mild Cognitive Impairment
Multimodal Investigation of Neural Plasticity
This study will evaluate the effects of a form of non-invasive brain stimulation on brain functioning and memory in cognitively intact older adults (healthy controls, HC) and in those with mild cognitive impairment (MCI).
- Trial name
- miniSTIM (NCT06453980)
- Testing
- active tDCS
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Overweight and Obesity
Translating Neuroscience to Population Health
The current study will examine the relationship between brain responses and a guided imagery exercise in overweight and obese individuals.
- Trial name
- NCT03976427
- Testing
- Guided Imagery
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Migraine, Chronic Headache
Does Topiramate Adjust the Excitability of the Brain in Migraine Sufferers?
The purpose of the study is to determine by the use of non-invasive magnetic stimulation if the medication Topiramate adjusts the excitability of the migraine sufferer's brain.
- Trial name
- NCT00286923
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Emerald City Headache Organization
Normal Physiology, Stroke
Effects of Prism Adaption and rTMS on Brain Connectivity and Visual Representation
Background: After a stroke, the balance between the two halves of the brain can be lost. This may cause people to lose the ability to perceive a side of space. This is called neglect.
- Trial name
- NCT02911129
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Multiple Sclerosis
BrainAgeMS - a Comparative Study of Brain Aging in Healthy and Patients With Multiple Sclerosis
The purpose of this study is to investigate new quantitative MRI-sequences for assessment of age-specific data for the prediction of brain aging.
- Trial name
- BrainAgeMS (NCT06221631)
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Stroke
Effect of a PBT Combined With FES on Reactive Balance Persons With in Stroke
The goal of this clinical trial is to evaluate the effect of a 4-week perturbation-based balance training with and without targeted Neuromuscular electrical stimulation on neuromechanic gait fall risk predictor and reactive…
- Trial name
- NCT06237972
- Testing
- 4-week Perturbation-based balance training, Neuromuscular electrical stimulation
- Where
- Chile
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Traumatic Brain Injury
Rapid Diagnostics for Traumatic Brain Injury (TBI)
Novel biomarkers of traumatic brain injury (TBI) have been discovered in laboratory animal models. The objective of this study is to find whether similar markers are detectable in the body fluids of human subjects that have…
- Trial name
- NCT02836951
- Testing
- Withdrawal of blood
- Where
- Finland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medicortex Finland Oy
Chronic Disease, Cancer
The Dampness Syndrome of Chinese Medicine Cohort Study
The researchers plain to build a large-scale, longitudinal, prospective cohort characterized by TCM dampness syndrome. With the biobank of this cohort the investigators want to find the causality between TCM dampness syndrome and…
- Conditions
- Chronic Disease, Cancer, Dementia Alzheimers, Metabolic Disease
- Trial name
- DACOS (NCT05315895)
- Testing
- natural aging process
- Where
- China
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Guangzhou University of Traditional Chinese Medicine
Parkinson's Disease, Essential Tremor
Sensory Gating Measured With Microelectrode Recording (MER) During Deep Brain Stimulation (DBS) Surgery
Deep brain stimulation (DBS) is an FDA approved, and widely used method for treating the motor symptoms of Parkinson's disease (PD), Essential Tremor (ET), Dystonia and Obsessive Compulsive disorder (OCD).
- Conditions
- Parkinson's Disease, Essential Tremor, Dystonia, Obsessive Compulsive Disorder
- Trial name
- NCT02320266
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Dementia
Northern Manhattan Caregiver Intervention Project
Elderly Hispanics have a higher burden of dementia compared to Non-Hispanic Whites. Furthermore, Hispanic caregivers tend to have a higher burden of care for their relatives with dementia.
- Trial name
- NOCIP (NCT01306695)
- Testing
- New York University Caregiver Intervention (NYUCI), Community Health Worker (CHW) Case Management
- Where
- United States
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Columbia University
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