Clinical trials: Brain Disorder
Epilepsy
Cognitive Effects of Vinpocetine in Healthy Adults and Patients With Epilepsy
Pilot studies in healthy volunteers and in patients with epilepsy to assess the potential efficacy and safety of different dosages of vinpocetine in improving cognition.
- Trial name
- NCT02011971
- Testing
- Vinpocetine
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Stanford University
Caregiver Burden, Lewy Body Disease
VOCALE LBD+ for Caregivers of Persons With Lewy Body Dementia
The goal of this clinical trial is to evaluate the feasibility, acceptability, and initial efficacy of the VOCALE LBD+ intervention in caregivers of persons living with Lewy Body Dementia.
- Conditions
- Caregiver Burden, Lewy Body Disease, Stress, Skill, Coping
- Trial name
- NCT05622734
- Testing
- VOCALE LBD+
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Washington
Hemorrhagic Stroke, Intracerebral, Cerebral Cavernous Malformation
CCM Blood Biomarker Validation Study
Cerebral cavernous malformations (CCMs), one of the most common microvascular malformations in the capillary beds of the brain, are susceptible to hemorrhagic stroke.
- Trial name
- NCT05148663
- Testing
- CCM Hemorrhagic Panel
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center, El Paso
Concussion, Mild, Post-Concussion Symptoms
Effects of Bright Light Therapy in Mild Traumatic Brain Injury
Mild traumatic brain injuries (mTBI) or "concussions" are an increasingly prevalent injury in our society. Patients with post-concussion syndrome have been shown to have deficits on tests of short term memory, divided attention…
- Conditions
- Concussion, Mild, Post-Concussion Symptoms, Sleep Problems
- Trial name
- NCT01747811
- Testing
- wavelength-1 bright light, wavelength-2 bright light
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Arizona
MTBI - Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury
Rapid Diagnosis and Prognosis Recognition of Imaging and Biomarkers in Mild to Moderate Traumatic Brain Injury
The investigators will carry out multi-center and large sample research based on the Chinese population, screen the optimal diagnostic and prognosis recognition biomarkers and analyze the diagnostic critical cutoff values in…
- Trial name
- NCT05108909
- Testing
- MRI, CT, and serum biomarkers
- Where
- China
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Stroke
Prognostic Value for Predicting Outcome Using Functional Near-infrared Spectroscopy in Stroke Rehabilitation
To investigate the prognostic value of Functional Near-Infrared Spectroscopy (fNIRS) in stroke rehabilitation with serial measurements.
- Trial name
- NCT04288414
- Testing
- functional near-infrared spectroscopy
- Where
- South Korea
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Growth Hormone Deficiency
Growth Hormone's Effect on the Cardiovascular System
To evaluate specific markers of cardiovascular risk before and after growth hormone replacement therapy in a population of growth hormone deficient adults, as compared to an age, gender, and BMI-matched healthy population.
- Trial name
- NCT00397319
- Testing
- Growth Hormone
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Carotid Stenosis, Optical Coherence Tomography (OCT)
Endovascular Treatment of Cerebrovascular Diseases Guided by Optical Coherence Tomography (OCT) Technology（CVD-OCT）
OCT techniques have been used in the assessment of both intracranial and extracranial lesions.(1) Preprocedural evaluation: The morphologic characteristics of carotid atherosclerotic plaques can be evaluated by OCT before surgery…
- Conditions
- Carotid Stenosis, Optical Coherence Tomography (OCT), Endovascular Treatment
- Trial name
- （CVD-OCT) (NCT06986330)
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Wannan Medical College
AIDS Dementia Complex
Ferumoxytol-enhanced Imaging and Mapping in neuroAIDS
This project will investigate the ability of a novel MRI contrast agent to identify and quantitate ongoing monocyte/macrophage (M/MΦ)-mediated inflammation in the brains of HIV-infected individuals.
- Trial name
- NCT02678767
- Testing
- Ferumoxytol
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Beau Nakamoto
Stroke, Healthy Participants
Prefrontal Brain Activity and ECG Patterns in Stroke and Healthy Adults
This observational study will evaluate brain activity and heart rhythm patterns in people with and without stroke. Brain activity will be measured using functional near-infrared spectroscopy (fNIRS) and electroencephalography…
- Trial name
- NCT07322107
- Where
- South Korea
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Pusan National University Yangsan Hospital
Celiac Disease, Cerebellar Ataxia
Gluten-Free Diet in Patients With Gluten Sensitivity and Cerebellar Ataxia
This study will screen patients with cerebellar ataxia to check for antibodies that indicate allergy to gluten (wheat protein) and will study the effect of a gluten-free diet in patients with these antibodies.
- Conditions
- Celiac Disease, Cerebellar Ataxia, Healthy
- Trial name
- NCT00006492
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Severe Acquired Brain Injury, Cognitive Impairment
Feasibility and Acceptability of StimolIrpinia for Cognitive Rehabilitation After Severe Acquired Brain Injury
This single-center pilot study evaluates the feasibility, acceptability, usability, and preliminary stimulus validation of StimolIrpinia, a multimedia repository of culturally and territorially relevant autobiographical stimuli…
- Conditions
- Severe Acquired Brain Injury, Cognitive Impairment, Cognitive Rehabilitation, Neurorehabilitation
- Trial name
- StimolIrpinia (NCT07718321)
- Testing
- StimolIrpinia-supported cognitive rehabilitation activities
- Where
- Italy
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Alfonso Magliacano
Spinocerebellar Ataxia Type 1, Spinocerebellar Ataxia 3
Clinical Trial Readiness for SCA1 and SCA3
The investigators plan to fill the gap between the current state of clinical trial readiness and the optimal one for SCA1 and SCA3, which are fatal rare diseases with no treatments.
- Trial name
- READISCA (NCT03487367)
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The Methodist Hospital Research Institute
Epilepsy
A Sequential Multiple Ascending Dose Study of the Safety and Pharmacokinetics of Eslicarbazepine Acetate in Adult Healthy Volunteers
Randomized, double-blind, placebo-controlled, sequential multiple ascending dose study to determine a maximum tolerated dose
- Trial name
- NCT01879332
- Testing
- BIA 2-093 3000 mg once daily, BIA 2-093 3600 mg once daily
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Spinocerebellar Ataxia Type 6
Parkinsonism in Spinocerebellar Ataxia Type 6
The spinocerebellar ataxias (SCAs) are a genetically heterogeneous group of dominantly inherited progressive ataxia disorders. More than 30 different gene loci have been identified so far.
- Trial name
- NCT01934998
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Alzheimer Disease
Effect on the Electrocardiographic QT Interval Corrected for Heart Rate (QTc) in Healthy Subjects
The purpose of this study is to determine the effect of BMS-708163 on the QTc interval (QT interval corrected for heart rate).
- Trial name
- NCT00979316
- Testing
- BMS-708163, Moxifloxacin
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Cerebrovascular Disorders
Neuroprotective and Cardioprotective Effects Of Palm Vitamin E Tocotrienols
The purpose of the study is to assess the neuroprotective, anti atherogenic and hepatoprotective properties of tocotrienols (palm vitamin E) supplementation as determined by white matter lesion load on serial magnetic resonance…
- Trial name
- NCT00753532
- Where
- Malaysia
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Diabetes Mellitus, Type 2, Diabetes Mellitus Type 2 in Obese
From Skin Fibroblasts to Neural Stem Cells to Investigate in Vitro the Impact of Diabetes on Adult Neurogenesis
Obesity and glucose intolerance or overt diabetes are increasing at an alarming rate in the population, and are bound to become a public health issue and a major cause of disability, loss of independence and high social costs in…
- Conditions
- Diabetes Mellitus, Type 2, Diabetes Mellitus Type 2 in Obese, Diabetes Mellitus Type 2 in Nonobese, Obesity
- Trial name
- NCT05755321
- Testing
- Skin biopsy
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Alzheimer's Disease and Related Dementias
Reducing Behavioral and Psychological Symptoms of Dementia: Hospital Caregivers (Aim 2)
Persons with Alzheimer's Disease and Related Dementias (ADRD) account for 3.2 million hospital admissions per year and have over three times more hospitalizations than those without cognitive impairment, yet hospital caregivers…
- Trial name
- NCT04179721
- Testing
- PES-4-BPSD Model, The attention control condition
- Where
- 2 sites in United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Healthy
From FAST to FAST BEE - Video-Based Stroke Mnemonic Pilot
This online study evaluates immediate learning outcomes after viewing a short animated FAST BEE stroke-education video (1 minute 51 seconds).
- Trial name
- FAST BEE (NCT07440602)
- Testing
- FAST BEE Stroke Education Video (1 minute 51 seconds)
- Where
- India
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- Jubilee Mission Medical College and Research Institute
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