Clinical trials: Brain Disorder
Vestibular Disorder
Vestibular Treatment in Adolescents Following Sport Related Concussion
Each year, nearly 2 million children and adolescents have a sport-related concussion (SRC) in the U.S., but 57% of them do not receive appropriate clinical care following their injury.
- Trial name
- NCT03555370
- Testing
- Vestibular Exercise Intervention, Standard of Care
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Diabetes Mellitus, Type 1, Epilepsy
Impact of Parental Perfectionistic Cognitions Self-compassion Intervention Effects on Shame in Child Health Context
Parents of children with long-term health conditions (LTCs) can experience shame related to parenting. Whilst self-compassion interventions (SCIs) can reduce parental shame, this has not been studied with parents of children with…
- Conditions
- Diabetes Mellitus, Type 1, Epilepsy, Asthma, Shame
- Trial name
- NCT03504605
- Testing
- Online self-compassion intervention
- Where
- United Kingdom
- Volunteers
- 344 people, healthy volunteers welcome
- Sponsor
- University of Sheffield
Epilepsy
Embrace: Seizure Characterization
The study is intended to characterize sleep, stress, and seizures in daily life with the Empatica Embrace watch and smartphone-based diary-alert system.
- Trial name
- NCT03206502
- Testing
- Embrace + Alert App
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Empatica, Inc.
Glioma Tumor Recurrence, Radiation Necrosis
Diffusion Tensor MRI to Distinguish Brain Tumor Recurrence From Radiation Necrosis
This study will examine the use of a variation of standard magnetic resonance imaging (MRI) called diffusion tensor MRI (DT-MRI) for distinguishing injured brain tissue due to radiation therapy (radiation necrosis) from the…
- Conditions
- Glioma Tumor Recurrence, Radiation Necrosis, Primary Brain Tumor
- Trial name
- NCT00285324
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Alzheimer's Disease
Relative Bioavailability Study in Healthy Subjects to Evaluate the Pharmacokinetics of HTL0009936 After One Dose of Prototype Formulation
The purpose of this study is to find a modified release oral tablet formulation for this drug, which will be safe and well tolerated.
- Trial name
- NCT02710188
- Testing
- HTL0009936 modified release, HTL0009936 immediate release
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Nxera Pharma UK Limited
Dementia, Brain Injuries
Building Better Caregivers Online: An Online Workshop for Caregivers of Those With Traumatic Brain Injury, Post Traumatic Stress Disorder, or Alzheimer's or Other Dementia
The workshop is a 6-week online workshop for caregivers of people with traumatic brain injury, post traumatic stress disorder, or dementia.
- Conditions
- Dementia, Brain Injuries, Stress Disorders, Traumatic
- Trial name
- NCT00799786
- Testing
- Building Better Caregivers Online Workshop
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Stanford University
Dementia, Alzheimer Dementia (AD)
Fuzhou Aging Brain Health Initiative
The goal of this observational study is to learn about the pathophysiological characterization and evolutionary patterns of Alzheimer's disease (AD) in older adults in Fujian Province, China.
- Conditions
- Dementia, Alzheimer Dementia (AD), Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD)
- Trial name
- FAITH (NCT07891429)
- Testing
- Fluids biomarker and neuroimaging of AD diagnosis
- Where
- 4 sites in China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University Union Hospital
Hydrocephalus, Alzheimer Disease
MR Evaluation of Cerebrospinal Fluid (CSF) Dynamics
The Researchers are trying to test a MR imaging method for detection of Cerebral Spinal Fluid (CSF) flow in the brain to help diagnosis and better understand diseases that affect brain function.
- Trial name
- NCT04099823
- Testing
- MRI screening form, Urine pregnancy test, MR brain
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Moyamoya Disease, Intracranial Hemorrhages
5T MRI and Metabolomics-Based Hemorrhage Risk Prediction in Moyamoya Disease
Intracranial hemorrhage is a leading cause of death and disability in patients with moyamoya disease (MMD), yet clinically available tools for predicting long-term hemorrhage risk are lacking.
- Conditions
- Moyamoya Disease, Intracranial Hemorrhages, Stroke
- Trial name
- NCT07781579
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Beijing Hospital
Parkinson Disease
Effects of Telerehabilitation-Based Motor and Cognitive Dual-Task Exercise in Patients With Parkinson's Disease
The ability to respond to multiple stimuli is impaired in Parkinson's patients. Traditional rehabilitation approaches focus only on balance and gait training, but individuals with Parkinson's disease need to perform multiple…
- Trial name
- NCT05894473
- Testing
- Motor-Motor Dual Task Physical Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Yeditepe University
Alzheimer Disease, Aging
Spatial and Ocular Trajectories for the Early Diagnosis of Alzheimer's Disease.
Spatial navigation is a high-level cognitive function that enables humans to orientate themselves and move around in space by constructing a mental representation of the environment.
- Trial name
- ACTSOMA (NCT06213766)
- Testing
- Cognitive assessment, Questionnaires, Spatial navigation task with eye-tracking.
- Where
- 3 sites in France
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Attention Deficit Hyperactivity Disorder, Autism Spectrum Disorder
Clinical, Environmental, Neurocognitive, Brain Imaging, and Genetic Validity of Autism and ADHD
The behavioral patterns, neurocognitive and social impairments, and high heritability are the common characteristics of autism spectrum disorders (ASD) and attention-deficit hyperactivity disorder (ADHD), the two most common…
- Trial name
- NCT00916851
- Where
- Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Cerebral Palsy, Chronic Pain
Anatomical and Functional Imaging Correlates of Chronic Pain in Cerebral Palsy
The investigators hope to use MRI biomarkers to identify and characterize sensorimotor network disruption patterns associated with chronic pain and sensory deficits in CP.
- Trial name
- NCT05197946
- Testing
- MRI
- Where
- 4 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Morbid Obesity
Effects of Morbid Obesity and Bariatric Surgery on Brain Inflammation, and Activation of Central Reward System
Background: The investigators have found that obesity and insulin resistance result in significantly increased brain insulin-stimulated glucose uptake, whereas in every other tissue glucose uptake is lower in the obese compared…
- Trial name
- BARIBRAIN (NCT04343469)
- Testing
- Bariatric Surgery (RYGB or LSG)
- Where
- 2 sites in Finland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Cognitive Impairment, Mild Cognitive Impairment
ArtontheBrain: An Inclusive Evidence-based Cognitive Health App for Older Adults to Promote Aging at Home
The research proposed here will evaluate whether a web-based recreation intervention, called ArtontheBrain, has positive health benefits to older adult users.
- Conditions
- Cognitive Impairment, Mild Cognitive Impairment, Dementia, Age-related Cognitive Decline
- Trial name
- NCT03551483
- Testing
- ArtontheBrain, Seniors Online Victoria
- Where
- Canada
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Baycrest
Encephalitis, Tick-Borne
Study of the Safety, Tolerability and Immune Response of TBE Vaccines Administered to Healthy Children
The purpose of this study is to evaluate the safety, immunogenicity and tolerability of TBE vaccines administered to children.
- Trial name
- NCT00311441
- Testing
- Tick-Borne Encephalitis vaccine
- Where
- Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Novartis
Overweight and Obesity
Train Your Brain - Executive Function
The purpose of this research is to test if playing games designed to improve an individual's executive function can change their views about the types of foods they eat.
- Trial name
- NCT05938894
- Testing
- online games with various food images, online games with images of flowers and songbirds
- Where
- United States
- Volunteers
- 630 people, healthy volunteers welcome
- Sponsor
- USDA Grand Forks Human Nutrition Research Center
Malaria, Malaria, Cerebral
Study of the Safety of Intravenous Artesunate
The purpose of this study is to establish the safety, tolerability and pharmacokinetics of a single dose of the antimalarial drug artesunate.
- Trial name
- NCT00292929
- Testing
- Intravenous artesunate
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse)
Brain Imaging in Early Psychosis
This study assesses brain connectivity and function of individuals ages 13-25 at a prodromal or early stage of a psychotic disorder.
- Trial name
- NCT03932188
- Testing
- Mental Health Assessments and Computerized Cognitive Test, MRI scan
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Dementia, Physical Activity
Co-design and Pilot Study in VR-based Physical Activity and Cognitive Training
Physical activity and reminiscence therapy alone have been studied with no clear effectiveness in Alzheimer's disease, but their combined intervention remains unknown.
- Conditions
- Dementia, Physical Activity, Reminiscence Therapy, Co-design
- Trial name
- NCT06982170
- Testing
- A physical activity and reminiscence therapy
- Where
- Hong Kong
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hong Kong University of Science and Technology
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