Clinical trials: Brain Disorder
Sleep Apnea, Obstructive
Prescision Medicine in Obstructive Sleep Apnea, Cardiovascular and Cerebrovascular Disease: AI Electrocardiogram Patch Does it All
Obstructive Sleep apnea(OSA) is a disease with multiple causes, and treatments are very diverse. Patients and doctors have a lot of choices.
- Trial name
- NCT05566860
- Testing
- Positional Therapy, Intraoral Negative Pressure Therapy, Oral Appliances
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Cardiovascular Diseases
Cardiac Rehab and Cerebral Blood Flow Study
This study is being done to better understand the influence of cardiovascular disease on brain blood flow regulation and cognitive function, determine whether exercise-based cardiac rehabilitation can lead to better regulation of…
- Trial name
- NCT05012878
- Testing
- Cardiac rehabilitation - high intensity interval training (HIIT), Cardiac rehabilitation - moderate intensity continuous training (MICT), Cardiac rehabilitation - control
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Cerebral Palsy Spastic Diplegia
Virtual Reality Training With Sensory Integration On The Gross Motor Functions Of Lower Limb
The objectives of this study are To determine the effect of virtual reality on balance and gross motor functions of the lower limb in spastic diplegic cerebral palsy.
- Trial name
- NCT04467385
- Testing
- VR training + Sensory Integration therapy + conventional therapy, VR training + conventional therapy
- Where
- Pakistan
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Cardiovascular Diseases, Heart Diseases
The Jackson Heart Study of Cardiovascular Disease Among African Americans
This is a prospective study of the environmental and genetic factors that influence the development of cardiovascular disease (CVD) in African American adults.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Atherosclerosis, Coronary Disease
- Trial name
- JHS (NCT00005485)
- Where
- United States
- Volunteers
- 5,306 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cerebral Palsy, Developmental Delay
SmarToyGym: Smart Detection of Atypical Toy-oriented Actions in At-risk Infants
The study aims to develop a SmarToyGym where sensitized, wireless toys are strategically hung and placed within reach of infants to elicit toy-oriented body and arm/hand movements.
- Conditions
- Cerebral Palsy, Developmental Delay, Stroke, Fine Motor Delay
- Trial name
- NCT02813889
- Testing
- SmarToyGym
- Where
- 2 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Type 1 Diabetes, Hypoglycemia
Investigation Into the Effects Upon Brain Response to Change in Circulating Glucose Levels in Diabetes Mellitus
This study is designed to investigate the effects of diabetes mellitus and its treatment upon the body's responses to low blood glucose (blood sugar) levels.
- Trial name
- NCT00580710
- Where
- United States
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Yale University
Lysosomal Storage Disorders
Molecular and Cellular Mechanisms of Lysosomal Storage Diseases
The lysosome is a specialized part of the cell that functions to degrade metabolic wastes in the cell. Defects in the functioning of the lysosome result in accumulation and subsequent storage of such metabolic wastes.
- Trial name
- NCT02000310
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- O & O Alpan LLC
Sleep, Gut Microbiome
Impact of Nutritional Supplementation on Sleep Quality and Gut Microbiome Composition in Older Adults
The aim of this study is to assess the impact of 5-hydroxytryptophan (5-HTP) supplementation on sleep quality and gut microbiome composition in older adults with normal cognition vs.
- Trial name
- NCT04078724
- Testing
- 5-HTP, Without 5-HTP
- Where
- 2 sites in Singapore
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
COPD, Non-invasive Ventilation
NIV Reduces CBF in COPD Patients Without Cognitive Function
Objectives: Investigate the acute NIV effects on CBF and cognitive functions in COPD patients. Methods: Nine non-hypercapnic stable COPD subjects (FEV1/FVC < lower limit of normal) and twelve healthy controls were enrolled.
- Conditions
- COPD, Non-invasive Ventilation, Cognitive Impairment, Cerebral Blood Flow
- Trial name
- NCT03149835
- Testing
- Non-invasive ventilation
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Ceara
Stroke
Mobile Service Robot for Task-Oriented Stroke Therapy: User Evaluations
By developing an affordable mobile service robot for therapeutic activities in a health center environment, this project addresses the issue of both the high cost and man-power required to provide rehabilitation for stroke…
- Trial name
- NCT02779517
- Testing
- Mobile Service Robot Survey, Mobile Service Robot Survey for Patients
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Parkinson's Disease, Movement Disorders
Farming and Movement Evaluation Study (FAME)
The long term goal of this research is to elucidate the cause(s) of Parkinson's disease, with a focus on environmental determinants.
- Trial name
- FAME (NCT00042120)
- Where
- United States
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Brain Activity
Brain Activity by Magnetoencephalography for Children
Investigate the differences in activation of brain networks during performing functional tasks for children with attention deficit hyperactivity disorder with developmental delays and typical development
- Trial name
- NCT04629482
- Testing
- Brain networks activity
- Where
- Taiwan
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Loss of Chromosome 18q, Growth Hormone Deficiency
Growth Hormone and Chromosome 18q- and Abnormal Growth
We, the investigators at the University of Texas Health Science Center at San Antonio, want to learn if height and IQ (intelligence quotient) scores are improved by growth hormone (GH) treatment in children with chromosome 18…
- Trial name
- NCT00134420
- Testing
- Nutropin AQ, Arginine and Clonidine Stimulation Testing, Growth Factors Laboratory Testing
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Epilepsy, Alzheimer Disease
Study to Evaluate the Relative Bioavailability of a New Formulation of NPT 2042 Soft-Gelatin Capsules Compared to the Original Formulation of NPT 2042
A Single-center, Open-label, Single-dose, Three-period, Fixed Sequence Study to Evaluate the Relative Bioavailability of a New Formulation of NPT 2042 Soft-Gelatin Capsules
- Conditions
- Epilepsy, Alzheimer Disease, Epilepsy Intractable
- Trial name
- NCT07222878
- Testing
- NPT 2042 (Reference formula/Formulation 1), NPT 2042 (Test formula/Formulation 2)
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- NeuroPro Therapeutics, Inc.
Traumatic Brain Injury
Balance After Traumatic Brain Injury
A moderate traumatic brain injury (TBI) occurring in early or middle adulthood might have long-lasting effects on the brain that can accelerate the decline of physical and cognitive function in older age.
- Trial name
- NCT05714150
- Testing
- Complex Balance Tasks
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Dementia
Two Interventions for Early Stage Dementia: A Comparative Efficacy Trial
Alzheimer's disease (AD) is increasing exponentially, with a projected quadrupling of cases by the mid 21st century. Individuals with AD are at increased risk for a host of medical and psychiatric conditions, and evidence is…
- Trial name
- NCT01550718
- Testing
- ESML-EX (Physical Activity Program), ESML-Social (Social Activity Program)
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- University of Washington
Pseudotumor Cerebri
Optic Nerve Sheath Diameters in Idiopathic Intracranial Hypertension Patients
Idiopathic intracranial hypertensionis a type of increased intracranial pressure. Diagnosis is made by lumbar puncture, which is an invasive technique.
- Trial name
- NCT04603118
- Testing
- Optic ultrasonography, Lumbar puncture
- Where
- Turkey (Türkiye)
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Ege University
Parkinson Disease
Characteristics of Parkinson s Disease Associated With the LRRK-2 Gene Mutation
This study will identify symptoms and other characteristics of Parkinson s disease that may be associated with changes in a gene called leucine-rich repeat kinase 2 (LRRK2).
- Trial name
- NCT00467090
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Spinal Cord Injuries
Association of Quantitative and Functional Imaging With Clinical Outcome After Spinal Cord Injury
The overall study aim is to provide additional magnetic resonance imaging parameters of the cervical spinal cord, brainstem and brain and a better understanding of changes after spinal cord injury (SCI) and to define new magnetic…
- Trial name
- NCT03886610
- Testing
- Healthy controls, Subacute SCI patients, Chronic SCI patients
- Where
- Switzerland
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Swiss Paraplegic Research, Nottwil
Healthy, Neurologic Manifestations
Study of Brain Changes Shaped by Experience
This study will use magnetic resonance imaging (MRI) scans to explore how the brain changes (reorganizes itself) in response to learning and to brain lesions in healthy people and people with various physical disabilities.
- Trial name
- NCT00006424
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
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