Clinical trials: Brain Disorder
Dementia, Dementia, Mixed
Uppsala-Dalarna Dementia and Gait Project
UDDGait™ is a multidisciplinary research project with the overreaching goal of providing an aid for early identification of cognitive impairment and risk of dementia development, thereby providing a basis for adequate symptom…
- Conditions
- Dementia, Dementia, Mixed, Dementia Senile, Dementia of Alzheimer Type
- Trial name
- UDDGait™ (NCT05893524)
- Testing
- Timed Up-and-Go (TUG single-task), Timed Up-and-Go dual-task (TUGdt), Clinical functional assessment
- Where
- 2 sites in Sweden
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Dalarna University
Caregivers, Caregiver Burden
Feasibility Study of Project Carer Matters for Family Caregivers of Persons With Dementia
The study uses the Reach, Effectiveness, Adoption, Implementation and Maintenance (RE-AIM) framework to assess the Carer Matters programme for dementia caregivers in Singapore.
- Conditions
- Caregivers, Caregiver Burden, Caregiver Burnout, Dementia
- Trial name
- NCT05205135
- Testing
- SHARE Programme
- Where
- Singapore
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Tan Tock Seng Hospital
Alzheimer Disease
Alzheimer's Disease Anti-Inflammatory Prevention Trial (ADAPT)
The purpose of this trial is to test the ability of the non-steroidal anti-inflammatory medications naproxen and celecoxib to delay or prevent the onset of AD and age-related cognitive decline.
- Trial name
- NCT00007189
- Testing
- Naproxen Sodium (Aleve), Celecoxib (Celebrex)
- Where
- 6 sites in United States
- Volunteers
- 2,625 people, healthy volunteers welcome
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Refractory Epilepsy
Effect of Blue Light on Vagus Nerve Stimulation in Patients With Refractory Epilepsy
Vagus nerve stimulation (VNS) is an adjunctive treatment for refractory epilepsy. Although widely used, there is still a substantial number of patients with insufficient response.
- Trial name
- BLUELIGHTVNS (NCT06304389)
- Testing
- electroencephalography, electrocardiogram, pupillometry, evoked potentials, light administration, transcutaneous vagus nerve stimulation, electroencephalography, pupillometry, electrocardiogram, light administration
- Where
- Belgium
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Epilepsy
Role of Antibodies Against Glutamate Receptors and Double Stranded DNA in Epilepsy Patients
The investigators will check the serum of epilepsy patients for antibodies against glutamate receptors and double stranded DNA. They will characterise the patients (by the kind of epilepsy, autoimmune disease comorbidity, and…
- Trial name
- NCT00317668
- Where
- Israel
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Phantom Limb Pain
Examining Brain Changes Using Functional Magnetic Resonance Imaging (fMRI) in Amputees With Phantom Limb Pain Following Mirror Therapy
Almost everyone who has a traumatic limb amputated will experience a phantom limb - the vivid impression that the limb not only still is present, but also in many cases, painful.
- Trial name
- NCT00662415
- Testing
- mirror-box treatment, observation
- Where
- 2 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- United States Department of Defense
Alzheimer's Disease and Related Dementia, Fall Injury
Fall Detection and Prevention for Memory Care Through Real-time Artificial Intelligence Applied to Video
The purpose of the research is to study a new safety monitoring system developed by SafelyYou to help care for a loved one with dementia. The goal is to provide better support for unwitnessed falls.
- Trial name
- NCT03685240
- Testing
- SafelyYou Fall Prevention System
- Where
- United States
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- SafelyYou
Parkinson's Disease
Effect on Parkinson's Disease After Therapeutic Induction of CranioSacral Integrated Therapy
We are studying \& researching the effect of CranioSacral Integrative therapy on Parkinson's Diseased Patients for 3 months. With a therapeutic induction via manual CranioSacral integrative therapy for 90 minutes per session with…
- Trial name
- NCT01989013
- Testing
- biweekly intervention
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Zia, Al Raza
All Cause Mortality, Cardiovascular Diseases
Advice of Moderate Drinking Pattern Versus Advice on Abstention on Major Disease and Mortality
The goal of this clinical trial is to test two advices on alcohol drinking in more than 10.000 Spanish adult drinkers (men of 50 or more years and women of 55 or more years).
- Conditions
- All Cause Mortality, Cardiovascular Diseases, Invasive Cancer, Liver Cirrhosis
- Trial name
- UNATI (NCT06338215)
- Testing
- Moderate Alcohol Drinking Pattern, Abstention
- Where
- Spain
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Eating Disorders
Evaluating the Brain's Response to Natural Versus Artificial Sweetener in Women Who Have Had an Eating Disorder
This study will compare the brain's ability to distinguish between natural and artificial sweeteners in women with and without a history of eating disorders.
- Trial name
- NCT00517335
- Testing
- Functional magnetic resonance imaging (fMRI) scan
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Brain Tumor
Brain Tumor Patient-Caregiver Congruence, MD Anderson Symptom Inventory-Brain Tumor Module (MDASI-BT)
The goal of this study is to compare patient ratings of how severe their own symptoms may be, with their caregivers' ratings of how severe they think the patients' symptoms may be.
- Trial name
- NCT00748774
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Spinal Cord Injury, Spasticity, Muscle
Identification of Sodium Channel Fragments as Serum Biomarkers of a Traumatic Central Nervous System Injury
Following spinal cord injury (SCI), 75% of patients develop spasticity of the limbs characterized by an increase in muscle tone causing severe pain.
- Conditions
- Spinal Cord Injury, Spasticity, Muscle, Brain Injuries
- Trial name
- SpasT-SCI-T (NCT06532760)
- Testing
- Blood sampling
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Blast Injuries, Brain Injuries
Central Auditory Processing Deficits Associated With Blast Exposure
The current conflicts in Afghanistan and Iraq have resulted in unprecedented rates of exposure to high-intensity blasts and resulting brain injury.
- Conditions
- Blast Injuries, Brain Injuries, Age Factors
- Trial name
- NCT01567020
- Testing
- Diagnostic
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Alzheimer's Disease, Mild Cognitive Impairment
A Phase II Trial of Florbetapir (18F) Positron Emission Tomography (PET) Imaging in Japan of Healthy Volunteers, Patients With Mild Cognitive Impairment (MCI) and Patients With Alzheimer's Disease (AD)
Evaluate florbetapir (18F) positron emission tomography (PET) imaging for distinguishing Japanese healthy control subjects, from Japanese subjects with Alzheimer's disease (AD) or Mild cognitive impairment (MCI).
- Trial name
- NCT01662882
- Testing
- florbetapir (18F)
- Where
- 2 sites in Japan
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Avid Radiopharmaceuticals
Parkinson Disease
EEG Recordings and Analysis in Parkinson's Patients: Towards Adaptive Deep Brain Stimulation by Machine Learning
The objective of this protocol is to obtain on Parkinson's disease more accessible therapeutic targets than deep brain stimulation (HFS-STN), the neurosurgical treatment for this pathology.
- Trial name
- ElectroPARK (NCT05284526)
- Testing
- electroencephalogram (EEG) of control and parkinsonian subjects during the preparation and execution of movements
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Primary Brain Tumor, Radiation Toxicity
Cognitive Function After Radiation Therapy for Brain Tumours
This study will assess cognitive function in adult patients with a primary brain tumour treated with surgical resection with or without radiation therapy (RT). All types of brain tumours apart from glioblastoma will be included
- Trial name
- WP-12-pre (NCT04118426)
- Testing
- Cognitive testing
- Where
- Denmark
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Stroke
Transcranial Direct Current Stimulation and Functional Electrical Stimulation for Upper-limb Rehabilitation After Stroke
The aim of this study is to verify the effectiveness of tDCS combined with FES on upper limb rehabilitation of post-stroke subjects with moderate and severe compromise.
- Trial name
- NCT02818608
- Testing
- Functional Electrical Stimulation (FES), Combination of Transcranial direct brain stimulation (tDCS) and FES
- Where
- Brazil
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Federal University of Health Science of Porto Alegre
Parkinson Disease
Words Generation in Compulsives Gamblers and Parkinson's Disease Patients
The pathophysiology of compulsive disorders as gambling could be close to behavior problems encountered in Parkinson's disease associated with a hyperactivity of the motivational system.
- Trial name
- FLUENCE (NCT01888276)
- Testing
- evaluation of word generation and of motivation
- Where
- France
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Follow up, Parkinson Disease
Two-year Follow-up to High-intensity Multi-component Agility Intervention That Improves Clinical and Motor Symptoms of Parkinson's Disease
Individualization of exercise is recommended but rarely performed in patients with Parkinson's disease (PD). Unusually High Intensity and Individual Sensor Motor with Visuomotor Mobility Trainer The clinical symptoms, mobility…
- Conditions
- Follow up, Parkinson Disease, Rehabilitation
- Trial name
- NCT03193489
- Testing
- Follow-up, Post-treatment control, Control Parkinson group
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Somogy Megyei Kaposi Mór Teaching Hospital
PARKINSON DISEASE (Disorder), Rigidity
Spinal Mobility, Rigidity, and Kinesiophobia in PD and TMD
Axial rigidity and loss of spinal mobility commonly observed in Parkinson's disease (PD) lead to postural deformities and substantial reductions in trunk flexibility.
- Conditions
- PARKINSON DISEASE (Disorder), Rigidity, Temporomandibular Disorders (TMDs), Mobility
- Trial name
- NCT07850674
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
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