Clinical trials: Brain Disorder
Cerebral Palsy
"Comparing the Plaque Removal Ability of Two Different Toothbrushes Among School Going CP Children
It was an intervention utilizing two toothbrushes on school going cerebral palsy children age (6 -18 yrs). The triple head tooth brush and single head brush was provided to parents along with dental health education to their…
- Trial name
- NCT05536648
- Testing
- Comparing the plaque removal ability of triple head tooth brush versus single head tooth brush among school based cerebral palsy children: A Randomized Control Trial
- Where
- Pakistan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Multiple Sclerosis, Relapsing-Remitting
Cognition and MRI Markers in MS Patients With Aubagio® Treatment
Cognitive impairment is nowadays more and more recognized as an important feature of the multiple sclerosis (MS) disease which contributes largely to disability.
- Trial name
- AUBACOG (NCT03768648)
- Testing
- Clinical assessment, Ecological evaluation, Neuropsychological evaluation
- Where
- France
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Alzheimer Disease
A Phase 1 Trial to Assess Safety, Tolerability and Pharmacokinetics of ALIA-1758 in Healthy Participants
This is a Phase 1, first in human (FIH), double-blind, placebo-controlled, single ascending dose (SAD) trial to assess the safety, tolerability, and pharmacokinetics (PK) of intravenously (IV) or subcutaneously (SC) injected…
- Trial name
- NCT06406348
- Testing
- ALIA-1758
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- AbbVie
Nicotine Dependence
NeuroControl of Nicotine Dependence
The purpose of the study is to examine the effects of continuous theta burst stimulation (cTBS) on different forms of cognitive control in adults who smoke cigarettes, and to determine if the location where cTBS is delivered may…
- Trial name
- NCT06347055
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Posttraumatic Stress Disorder (PTSD)
Non Invasive Brain Stimulation for PTSD
This study is designed to identify changes in the brain that underlie symptoms of combat-related PTSD using brain imaging (fMRI).
- Trial name
- NCT02442843
- Testing
- Active tDCS
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Major Depression, Sleep
Sleep TMS for Depression
The goal of this study is to establish the feasibility, tolerability, and preliminary efficacy of sleep-state transcranial magnetic stimulation (TMS) for enhancing plasticity in depression treatment.
- Trial name
- NCT06824415
- Testing
- TMS
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Stanford University
Huntington's Disease (HD)
Biology-Driven Cognitive Profiling in Huntington's Disease
Huntington's disease (HD) is a genetic, progressive neurodegenerative disorder characterized by early and widespread brain changes that can begin more than a decade before the onset of unequivocal motor signs.
- Trial name
- NCT07503743
- Where
- Spain
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Anorexia Nervosa, Healthy Volunteer
Food Intake and IgA Microbiota in Anorexia Nervosa
Anorexia nervosa is characterized by intestinal dysbiosis, related to the feeding behavior impairment presented by these patients.
- Trial name
- AAMIAM (NCT05842343)
- Testing
- Stool sample, Food intake evaluation
- Where
- France
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Obstructive Sleep Apnea
Effects of Exercise Training on Cognitive Performance and Sympathetic Activity in Obstructive Sleep Apnea
Abstract Obstructive sleep apnea syndrome (OSA) is characterized by complete or partial collapse of a narrowed pharynx and it's associated with reduction in cerebral blood flow, cardiovascular disease, and neuropsychological…
- Trial name
- NCT02289625
- Testing
- Exercise Training
- Where
- Brazil
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Epilepsy
The Value of EEG in Stroke Units
Τhe aim of the study is to investigate the role of EEG both in predicting epileptogenesis in patients with acute stroke and in detecting and clarifying the clinical significance of subclinical epileptic seizures in a stroke unit.
- Trial name
- NCT07190976
- Testing
- Routine EEG
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Attikon Hospital
Alzheimer Disease, Late Onset
Synaptic Injury and Functional Connectivity in Alzheimer's Disease
The purpose of this study is to examine cross-sectional associations between CSF markers of synaptic injury (Ng and SNAP-25) and functional connectivity in default and semantic memory networks using 3T- fMRI in individuals with…
- Trial name
- NCT03300726
- Testing
- CSF analysis, Functional MRI
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Schizophrenia, Schizoaffective Disorder
Brain Health and Exercise in Schizophrenia
To determine the effects of aerobic exercise on hippocampal volumes and severity of psychotic symptoms in a population of psychosis patients compared to healthy age/gender matched volunteers.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Poor Memory
- Trial name
- PEHP (NCT01392885)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- BC Mental Health and Addictions Research Institute
Parkinson's Disease
Subthalamic Nucleus, Akinesia and Parkinson's Disease
This program aims to understand the role of the subthalamic nucleus in the control of the movement in healthy humans and patients with Parkinson's disease, how the STN dysfunction contributes to akinesia and how the STN…
- Trial name
- GB-MOV (NCT01682668)
- Testing
- Bilateral subthalamic stimulation
- Where
- 2 sites in France
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Parkinson Disease, Cognitive Deficit in Attention
The Effect of Different Types of Focus Instructions in Parkinson's Rehabilitation
Parkinson's disease is the most common progressive neurodegenerative movement disorder. Common movement impairments in Parkinson's include balance and walking difficulties.
- Conditions
- Parkinson Disease, Cognitive Deficit in Attention, Feedback, Psychological, Gait, Festinating
- Trial name
- NCT06615115
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Alzheimer Disease, Physical Activity
Inspiring Seniors Towards Exercise Promotion to Protect Cognition
The goal of this clinical trial is to test the benefits of beat-accented music stimulation (BMS) for behavioral changes of physical activity (PA) in older adults with subjective memory complaints.
- Trial name
- iSTEP+ (NCT06496425)
- Testing
- Beat-accentuated, personalized music stimulation (BMS), Strength Training (ST), Aerobic exercise (AE)
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Emory University
Dementia, Elder Abuse
Primary Care Screening and Intervention for Patients With Dementia and Caregivers
The goal of this clinical trial is to evaluate the impact of screening for elder neglect in older adults with dementia in primary care settings and the impact of an intervention for caregivers of older adults with dementia.
- Conditions
- Dementia, Elder Abuse, Elder Mistreatment
- Trial name
- SIRENS (NCT07758738)
- Testing
- SIRENS application, SIRENS screening
- Where
- United States
- Volunteers
- 774 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Ataxia Telangiectasia
Oxidative Stress, Low Grade Inflammation, Tissue Breakdown and Biomarkers in Cerebrospinal Fluid of A-T
Ataxia telangiectasia (A-T) is a rare devastating human recessive disorder characterized by progressive cerebellar ataxia, immunodeficiency, chromosomal instability, and cancer susceptibility.
- Trial name
- NCT02285348
- Testing
- Lumbar puncture
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Diabetes Mellitus, Type 2, Diabetes Complications
Arterial Stiffness and Complication Risk in Type 2 Diabetes
Background The prevalence and incidence of type 2 diabetes is increasing globally. A common complication of diabetes is the disease of the blood vessels, vascular diseases, which can cause disorders like myocardial infarction…
- Conditions
- Diabetes Mellitus, Type 2, Diabetes Complications, Diabetic Angiopathies, Diabetic Nephropathies
- Trial name
- NCT02001532
- Where
- Denmark
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Amyotrophic Lateral Sclerosis, Frontotemporal Dementia
TRIAL READY (Clinical Trial Readiness)
This study, being conducted under the auspice of the CReATe Consortium, will enroll patients with ALS and related disorders as well as healthy controls, with the goal of facilitating clinical validation of leading…
- Conditions
- Amyotrophic Lateral Sclerosis, Frontotemporal Dementia, ALS-Frontotemporal Dementia, Primary Lateral Sclerosis
- Trial name
- NCT03912987
- Where
- 3 sites in United States
- Volunteers
- 610 people, healthy volunteers welcome
- Sponsor
- University of Miami
Parkinson Disease
Efficacy of Pattern Respiratory PNF Associated Aerobic Training on Lung Volumes and 6MWT Test in Parkinson Individuals
INTRODUCTION: Parkinson's disease (PD) is a neurodegenerative disorder that causes motor disorders such as bradykinesia, rigidity and tremor.
- Trial name
- NCT02600052
- Testing
- PNF, treadmill
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
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