Clinical trials: Brain Disorder
Migraine, Epilepsy
High-field MR Imaging in Migraine, Visual Snow and Epilepsy
In this project, the aim is to recruit patients with drug resistant epilepsy and those suffering from migraine. Interestingly, patients suffering from epilepsy are also more often reporting to suffer from migraine.
- Conditions
- Migraine, Epilepsy, Visual Snow Syndrome
- Trial name
- NCT05524493
- Testing
- Structural MRI, Quantitative MRI, Diffusion MRI
- Where
- 2 sites in Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Stroke, Post-Stroke Hemiparesis
Evaluation of a Wearable Exoskeleton for Functional Arm Training
The purpose of this study is to investigate how the cable-driven arm exoskeleton (CAREX) can assist task performance during 3D arm movement tasks under various experimental conditions in healthy individuals and patients with…
- Trial name
- NCT02726204
- Testing
- Gravity Elimination Alone, Path Assistance Alone, Path Assistance and Gravity Elimination
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Inflammatory Bowel Diseases
Association Between Functional Changes in the Brain and the Perception of Pain in Patients With Inflammatory Bowel Diseases (IBD) - Measured With Functional Magnetic Resonance Imaging.
In the study the investigators aim to test whether transcranial direct current stimulation (tDCS)-induced pain reduction is in association with functional changes in the brain measured with functional magnetic resonance imaging…
- Trial name
- NCT03348852
- Testing
- Transcranial direct current stimulation
- Where
- Germany
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Parkinson Disease
The Effect and Mechanism of Transcutaneous Auricular Vagus Nerve Stimulation on Gait Impairments in PD
This study is a double blind comparative study examining the effectiveness of the transcutaneous auricular vagus nerve stimulation treatment on Parkinson's disease patients .
- Trial name
- NCT05561348
- Testing
- Transcutaneous auricular vagus nerve stimulation
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Disorders of Consciousness, Acquired Brain Injury
Spontaneous Eye Blinking Evaluation for Cognitive Assessment of Individuals With Severe Acquired Brain Injury
Assessment of consciousness and attention in individuals with severe Acquired Brain Injury (sABI) is crucial for planning rehabilitation, but it is often hindered by coexisting sensory-motor and/or cognitive-behavioural…
- Trial name
- SEE-ABI (NCT06464549)
- Testing
- EEG-EOG recording at rest and during an auditory oddball paradigm
- Where
- 2 sites in Italy
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Alfonso Magliacano
Head Injury Trauma, Cognition Disorder
Assessment and Rehabilitation of Social Cognition in People With Traumatic Brain Injury
Patients who have suffered moderate to severe traumatic brain injury (TBI) frequently develop behavioural changes, which can have deleterious consequences on interpersonal relationships, social, family and professional…
- Trial name
- CogniSo-TC (NCT04562844)
- Testing
- sociale cognition
- Where
- 4 sites in France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
Parkinson Disease
DB RCT for Specialized Phototherapy in Parkinson's Disease.
This is a pivotal study to determine whether light therapy can improve non-motor and motor function in Parkinson's disease, on top of current best medical treatment.
- Trial name
- LIGHT-PD (NCT04453033)
- Testing
- Celeste Specialized Phototherapy Device
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- PhotoPharmics, Inc.
Parkinson Disease, Medication
Behavioural Profiling of Disease-related Cognitive and Motor Impairment in PD
In this project, patients with Parkinson's Disease (PD) will be characterized by measuring cognitive and motor function and relation to effect of Levodopa.
- Conditions
- Parkinson Disease, Medication, UPDRS, Motor Function
- Trial name
- NCT06275633
- Testing
- Levodopa
- Where
- Denmark
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Stroke
Use of Repetitive Facilitative Exercise Program in Established Stroke
The purpose of this study is to assess whether a novel therapy approach (repetitive facilitative exercise (RFE)) is more effective than conventional rehabilitation in facilitating the recovery of upper extremity function…
- Trial name
- NCT01574599
- Testing
- Occupational therapy- Repetitive Facilitative Exercise
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Shaken Baby Syndrome, Mothers
The Effect of a Shaken Baby Syndrome Prevention Program
Objective: This randomized controlled study aims to examine whether the education program prepared to prevent shaken baby syndrome has an effect on mothers' knowledge and attitudes.
- Trial name
- NCT04568538
- Testing
- Training program
- Where
- Turkey (Türkiye)
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Spastic Cerebral Palsy (sCP)
Stop Tip-toeing Around Toe-walking
The purpose of this study is to explore the interplay among nervous-, musculoskeletal-, and psychological systems and how they impact toe-walking behavior, and vice versa.
- Trial name
- NCT04879199
- Testing
- Static stability measurement, Dynamic stability measurement
- Where
- Switzerland
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital Basel
SCI - Spinal Cord Injury, PD - Parkinson's Disease
Differential Assessment of Hypertonia
Spasticity and rigidity are common symptoms of central nervous system injuries, such as spinal cord injury and Parkinson's disease, and result in distinct patterns of increased resistance during passive joint movements.
- Trial name
- NCT06596187
- Testing
- Continuous passive motion device (CPM) of ankle - fast, Continuous passive motion device (CPM) of ankle - slow
- Where
- Taiwan
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Chang Gung University
Gait Disorders, Neurologic
Biomechanical Parameters of Gait in Patients With Parkinson's Disease and Parkinsonian Syndromes
Gait disorders and falls are frequent in patients with parkinsonian syndromes. In patients with Parkinson's disease (PD), these signs occurred later during the course of the disease in comparison to patients with other…
- Trial name
- NCT00139321
- Testing
- Force platform and electromyography
- Where
- France
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Dementia
Brief Behavioural Treatment for Insomnia in Dementia Carers
Background: between 50-74% of dementia carers report some sleep disturbance. However, relatively few studies have looked at psychological treatment for insomnia in this group.
- Trial name
- NCT02983032
- Testing
- BBTI
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- NHS Greater Glasgow and Clyde
Phenylketonurias
Remote Neurocognitive and Psychological Assessment in PKU
PKU is a rare autosomal recessive condition associated with disruption in dopamine synthesis. Although early diagnosis and treatment prevent the severe impairments associated with untreated PKU, individuals with early-treated PKU…
- Trial name
- NCT04943393
- Testing
- nointervention
- Where
- 2 sites in United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Parkinson's Disease
Role of Dopamine on Loss Aversion Behaviour: Study on Parkinsonian Patients
Use lay language. Many decisions involve the possibility of gaining or losing relative to the status quo. The loss aversion behaviour is a cognitive concept explaining that people are more sensitive to the possibility of losing…
- Trial name
- NCT01780467
- Testing
- Role of dopamine
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Alzheimer's Disease
Pathological and Non-pathological Aging, Physical Activity, Genotype and Cognition
Alzheimer's disease (AD) is an irreversible, progressive brain disease. It is the most common form of dementia and the major cause of functional dependence in the elderly.
- Trial name
- VIAGECO (NCT02520232)
- Testing
- Combination of aerobic and strength exercises, Stretching and balance exercise program
- Where
- 2 sites in France
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Mild Cognitive Impairment, Alzheimer's Disease
Home-Based Assessment for Alzheimer Disease Prevention
The purpose of this study is to evaluate three methods of performing home-based assessments in Alzheimer's Disease (AD) prevention trials. The initial in-person assessment will be done in the clinic or at home.
- Trial name
- HBA (NCT00546767)
- Testing
- Mail and Live Phone, Interactive Voice Response (IVR), Home-based Computer Kiosk
- Where
- 28 sites in United States
- Volunteers
- 640 people, healthy volunteers welcome
- Sponsor
- Alzheimer's Disease Cooperative Study (ADCS)
Dementia
Constructing and Evaluating the Effectiveness of a Community-based Older Adults Dementia Prevention Education Program
This study adopted a mixed-methods approach and was conducted in two exploratory phases. The first phase focused on development and involved three focus group interviews with community-dwelling older adults.
- Trial name
- NCT06998836
- Testing
- Dementia prevention education, General Health Education Leaflet
- Where
- Taiwan
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Chang Gung University of Science and Technology
Alzheimer Disease
Ecological Assessment of Apathy in Alzheimer's Disease and in Control Subjects: Video Recognition and Actigraphy
Cognitive and memory disorders are characterized of Alzheimer disease. In addition, psychologic and behavioural symptoms, called speak neuropsychiatric symptoms, are frequents and play an important role in prognostic and…
- Trial name
- NCT01384344
- Testing
- observational
- Where
- France
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
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