Clinical trials: Brain Disorder
Short Stature, Growth Hormone Deficiency
The IGFBP-3 Stimulation Test: A New Tool for the Diagnosis of Growth Hormone Deficiency in Children.
This project is designed to answer the question: Is there an acute IGFBP-3 response in normal children? Our specific hypothesis states that under the influence of growth hormone secretagogues, intact IGFBP-3 molecule will undergo…
- Trial name
- NCT00235599
- Testing
- IGFBP-3 Stimulation Test
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Premature Ejaculation
Investigation of the Changes of Brain Structure and Function in Premature Ejaculation Patients and the Effects of Dapoxetine on Central Neural Activity in Premature Ejaculation Patients
Lifelong premature ejaculation (LPE) is a common male sexual dysfunction with a high prevalence in global. Up to now, the etiology of LPE remains unclear.
- Trial name
- NCT03583112
- Testing
- Dapoxetine Hydrochloride Tablet
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Xidian University
Epilepsy, Drug-resistant Focal Epilepsy
Impact of Epilepsy on the Brainstem Adenosine Pathway and Its Relation With Arousal and Respiratory Reactivity
Despite the continuous development of new antiseizure medications over the past 25 years, 30% of patients with epilepsy suffer from drug-resistant seizures and are at risk of epilepsy-related complications, like cognitive…
- Conditions
- Epilepsy, Drug-resistant Focal Epilepsy, Healthy Controls
- Trial name
- BRAVE (NCT07249034)
- Testing
- 1 Hypercapnic challenge while participant is awake, PET/MRI acquisition
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Alzheimer's Disease(AD), Mild Cognitive Impairment (MCI)
A Study of QLH2405 in Healthy Participants and Participants With Mild Cognitive Impairment Due to Alzheimer's Disease and Mild Alzheimer's Disease
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of QLH2405 injection in healthy participants and participants with mild cognitive impairment (MCI) due to…
- Trial name
- NCT07489599
- Testing
- QLH2405
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Alzheimer Disease, Oxidative Stress
Isolated Erythrocyte Membrane Susceptibility to Photo-oxidative Stress in Alzheimer's Disease
High lipid peroxidation and altered antioxidant defenses have been frequently reported in Alzheimer's disease patients. The purpose of this study is to investigate susceptibility to photo-oxidation of isolated erythrocyte…
- Conditions
- Alzheimer Disease, Oxidative Stress, Adrenocortical Hyperfunction
- Trial name
- NCT01707719
- Where
- Italy
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Raffaele Antonelli Incalzi
Healthy Volunteers
A Study to Assess the Safety, Tolerability and PK of NPT520-34 in Healthy Subjects
To evaluate the PK, safety and tolerability of orally administered NPT520-34 in healthy subjects at single and multiple doses that may be therapeutically relevant.
- Trial name
- NCT03954600
- Testing
- NPT520-34 (125 mg)
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Neuropore Therapies Inc.
Alzheimer Disease
Beta Amyloid PET Imaging for Alzheimer Disease With [18F]-Fluselenamyl
The purpose of this research study is to determine the safety of a radiotracer 18F-Fluselenamyl using positron emission tomography (PET) imaging.
- Trial name
- NCT06439992
- Testing
- 18F-Fluselenamyl
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Lewy Body Disease, Alzheimer Disease
A Study of Neurodegeneration and Neuronal Fluctuations in Lewy Body Disease and Alzheimer's Disease
The purpose of this research study is to investigate how the brain, memory, thinking, and motor behavior change both in individuals with movement and/or cognitive disorders, as well as healthy individuals.
- Conditions
- Lewy Body Disease, Alzheimer Disease, Healthy
- Trial name
- NCT06057909
- Testing
- Magnetic Resonance Imaging, Electroencephalography, Electromyography
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Brain Concussion
Tissue Repository and Master Database for Concussion Biomarker and Risk Calculator Development
The purpose of this study is to prospectively collect a comprehensive, multi-modality set of diagnostics on patients who have had a concussion, repeating some of these tests serially over time, so that the investigators may then…
- Trial name
- NCT02519998
- Testing
- Concussion
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Dementia
GamePlan4Care: Online Support for Family Caregivers
As the population of older adults grows, almost doubling in size from 2012 to 2040, so too will the need for family caregiving. Caregiving can lead to negative psychosocial outcomes such as depression, anxiety, and burden; social…
- Trial name
- GP4C (NCT04540198)
- Testing
- GamePlan4Care, Resources4Care
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Tourette Syndrome
Impulsivity in Tourette Syndrome : Behavioral and Neuroimaging Study
Tourette syndrome (TS) is characterized by the presence of multiple vocal and motor tics. Behavioral disorders associated with TS are common, particularly impulsivity, anti-sociality and socially inappropriate behavior.
- Trial name
- COGIT (NCT02960698)
- Testing
- IRM and comportemental tasks
- Where
- France
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Parkinson Disease
Upper Extremity Skills, Trunk Control, and Body Awareness in Parkinson's Disease
Parkinson's disease is associated with impairments in upper extremity function, postural control, and sensory-motor processing that may negatively affect daily activities and quality of life.
- Trial name
- NCT07639463
- Where
- Turkey (Türkiye)
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Baskent University
Huntington Disease, HD
iMagemHTT-009- FIH Evaluation of Novel Mutant Huntingtin PET Radioligand [11C]CHDI-00491009
This is a FIH (first-in-human) study to evaluate the clinical utility of the radioligand [11C]CHDI-00491009 as a PET tracer that binds specifically to mutant huntingtin (mHTT) aggregates in Huntington's disease (HD).
- Conditions
- Huntington Disease, HD, PET Tracer, Positron Emission Tomography
- Trial name
- iMagemHTT-009 (NCT06634628)
- Testing
- Radioligand [11C]CHDI-00491009
- Where
- Belgium
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- CHDI Foundation, Inc.
Phenylketonuria
The Effects of Kuvan on Functional Brain Connectivity in Individuals With Phenylketonuria (PKU)
The objective of the study is to determine whether Kuvan™ (sapropterin) improves the strength of the functional connectivity between brain regions in individuals with PKU.
- Trial name
- NCT00964236
- Testing
- Sapropterin
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Ductus Arteriosus, Patent
Analysis of the Impact of Patent Ductus Arteriosus on Brain Function in Preterm Neonates: Multimodal Approach Integrating EEG-NIRS, Ultrasound and Clinical Data
This project corresponds to the main field of research of the investigators's laboratory concerning analysis of cerebral electrometabolic and haemodynamic activity in neonates.
- Trial name
- NNP-MULTIMODAL (NCT02803671)
- Testing
- TFU-NIRS, NIRS, EEG
- Where
- France
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Alzheimer Disease, Cognitive Decline
40 Hz Transcranial Alternating Current Stimulation for Inducing Gamma Oscillations
This study aims to compare the efficacy of different 40 Hz tACS protocols in entraining gamma oscillations, which are linked to various cognitive functions and play a significant role in cognitive impairments like Alzheimer's…
- Trial name
- NCT06740864
- Testing
- Transcranial alternating current stimulation
- Where
- Iran
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The National Brain Mapping Laboratory (NBML)
Major Depressive Disorder
Study of Ibuprofen Effects on Brain Function
The aim of this project is to determine whether the acute oral administration of Ibuprofen changes the activation pattern in the amygdala and other brain structures during functional magnetic resonance imaging.
- Trial name
- NCT02507219
- Testing
- Ibuprofen
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Laureate Institute for Brain Research, Inc.
Parkinson Disease
Diagnostic Tools for Parkinson's Disease
The study aims to identify genetic variants associated to Parkinson's disease through the analysis of exome-sequencing data of familial cases and controls.
- Trial name
- NCT02403765
- Where
- Italy
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Stroke
Power Training Post-stroke
Hemiparesis, strictly defined as (muscular) weakness affecting one side of the body, is seen in three-quarters of individuals following stroke.
- Trial name
- NCT01970592
- Testing
- POWER training
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Atrial Fibrillation, Stroke
AFLETES-MRI: A Cardiac and Cerebral Magnetic Resonance Imaging Study in Athletes With Atrial Fibrillation
Participation in exercise improves cardiovascular health. However, long-term endurance exercise may increase the risk of an irregular heart rhythm called atrial fibrillation (AF).
- Trial name
- AFLETES-MRI (NCT06424171)
- Testing
- Cardiac and brain magnetic resonance imaging.
- Where
- United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Leicester
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