Clinical trials: Brain Disorder
Nicotine Dependence, Nicotine Withdrawal
Progesterone and Brain Imaging Study
Male and female smokers were recruited to undergo 2 phases of smoking cessation. Each phase was 4 days long and involved 3 brain-imaging scans, blood draws and an intervention involving progesterone or a matched placebo.
- Trial name
- NCT01954966
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Concussion, Brain
A Pragmatic Rehabilitation Intervention: The Active Rehab Study
The strategic objective of this research line is to examine improving short- and long-term outcomes for soldiers following mild traumatic brain injury (mTBI).
- Trial name
- ARM (NCT05320822)
- Testing
- Active Rehab (Group 2), Progressive Return to Activity (Group 1)
- Where
- 2 sites in United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Amnesia, Transient Global
Assessment of Emotional Memory During Transient Global Amnesia
There are few studies on the role played by emotions in transient global amnesia (TGA), in particular with regard to their impact on the functioning of memory.
- Trial name
- EMOTICTUS (NCT04548037)
- Testing
- PET-CT examination
- Where
- France
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Social Perception in Parkinson's Disease
Brain Mechanisms of Social Perception in Parkinson's Disease
Social cognition is a complex process that enables humans to interpret social information and behave appropriately in a social environment.
- Trial name
- Park Social (NCT06884722)
- Testing
- Behavioral task of social perception (stage 1), Functional magnetic resonance imaging: 3 Tesla magnetic resonance imaging (stage 2), Neurological and neuropsychological assessments
- Where
- France
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Intracranial Hypertension, Brain Edema
Optical Nerve Sheath Changes During Head Down Laparoscopy
Patient undergoing laparoscopic radical prostatectomy in steep trendelenburg position are at risk to develop complication from brain edema.
- Conditions
- Intracranial Hypertension, Brain Edema, Pneumoperitoneum, Surgery, Laparoscopic
- Trial name
- NCT03957837
- Testing
- Optical nerve sheath diameter ultrasound measurement
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- ASST Fatebenefratelli Sacco
Alzheimer Disease, Battery
Prediction of Cognitive Properties of New Drug Candidates for Neurodegenerative Diseases in Early Clinical Development
The early assessment of new drugs for Alzheimer's disease remains difficult because of the lack of predictive end-point. The use of a battery including different parameters could improve this early development of new drugs.
- Trial name
- PharmacogWP3 (NCT01487395)
- Testing
- Donepezil .
- Where
- 3 sites in France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Acromegaly
Prospective Study on Changes in Acromegaly
Rationale: Acromegaly is the clinical syndrome that results from an excess of growth hormone (GH). Craniofacial and hand disproportions due to soft tissue swelling and new bone formation are highly prevalent in patients with…
- Trial name
- NCT01612624
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Schizophrenia
Cognitive Enhancement Therapy for Early-Stage Schizophrenia
This study will determine the effectiveness of cognitive enhancement therapy (CET) in treating cognitive abnormalities in people experiencing the early stages of schizophrenia.
- Trial name
- NCT00167362
- Testing
- Cognitive enhancement therapy (CET), Enriched supportive therapy (EST)
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Parkinson's Disease (PD)
An Open-label Study in Healthy Male Subjects to Assess the Absorption, Distribution, Metabolism and Excretion of [14C]-Labelled BIA 9-1067 and Metabolites
The purpose of this study is to determine the rate and routes of excretion of OPC and the mass balance in urine, faeces and expired air.
- Trial name
- NCT02169427
- Testing
- OPC
- Where
- Netherlands
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Cerebral Palsy
The Effects of Electrical Stimulation Gait Training on Walking and Posture for Children With Cerebral Palsy
This proposal is designed to achieve the following specific aims and will test the associated hypotheses: AIM 1: To compare walking ability, standing posture, gait initiation and functional standing and stepping of twenty…
- Trial name
- NCT00292786
- Testing
- Walking Practice with Functional Electrical Stimulation, Walking Practice
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shriners Hospitals for Children
Stroke
Deficit Fields for Stroke Recovery
This study investigates the potential of customized robotic and visual feedback interaction to improve recovery of movements in stroke survivors.
- Trial name
- NCT02570256
- Testing
- Deficit-fields to reduce error, Deficit-fields to expand range of motion, Deficit-fields to improve function
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Hypopituitarism, Central Diabetes Insipidus
Identification and Clinical Relevance of an Oxytocin Deficient State (GLP1 Study)
Oxytocin (OT) is a hypothalamic peptide that enters the peripheral circulation via the posterior pituitary gland. OT plays a key role in regulating appetite, psychopathology, prosocial behavior and sexual function.
- Conditions
- Hypopituitarism, Central Diabetes Insipidus, Panhypopituitarism, Psychological Disorder
- Trial name
- NCT04897802
- Testing
- Experimental: GLP1-RA (exenatide) administration
- Where
- Spain
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Dementia
Producing a Fully Asynchronous Online Savvy Program
This is a pilot/feasibility study to develop and test a fully online, self-administered psychoeducation program to enhance the caregiving mastery of family and friends who provide unpaid care for persons living with Alzheimer's…
- Trial name
- NCT04951037
- Testing
- Fully Asynchronous Online Savvy Program
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Emory University
Progressive Supranuclear Palsy
Quality of Life of the Patient and the Burden of the Caregiver in Progressive Supranuclear Palsy
Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease from the parkinsonian syndrome group. PSP is characterised by the association of a non-doparesponsive parkinsonian syndrome with axial signs.
- Trial name
- Qual-PSP (NCT03638505)
- Testing
- PSP-QoL
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Parkinson Disease
Prospective Study for Neuromelanin Image Analysis
In order to develop an image analysis system that automatically detects and quantifies neuromelanin, this study aims to construct a database of a wide sample by collecting brain MRI neuromelanin images prospectively.
- Trial name
- NCT05513794
- Testing
- MRI Imaging
- Where
- 3 sites in South Korea
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Heuron Inc.
Stroke, Upper Extremity Paresis
Cortical Enhancement of Posture, Movement Planning, and Execution of Upright Reaching Following Stroke
Stroke is the leading cause of disability and diminished quality of living that frequently includes impairments of postural control and upper extremity (UE) function.
- Trial name
- NCT04308629
- Testing
- Transcranial direct current stimulation
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Parkinson's Disease
Cholinergic Mechanisms of Gait Dysfunction in Parkinson's Disease Experiments 1 & 2 - Proj #3
Varying oral doses of Varenicline (VCN), starting with very low doses, will be administered to participants with Parkinson's Disease (PD) or healthy controls without PD for several days.
- Trial name
- UdallP3 (NCT02933372)
- Testing
- Varenicline
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Brain Tumor
Evaluation of Changes in Brain Connectivity After Tumor Resection
This study is being done to see the changes in structural and functional connectivity that happen in the brain of patients undergoing brain tumor surgery.
- Trial name
- NCT04536142
- Testing
- MRI, neuropsychological tests and qualitative assessment
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Cerebral Palsy
Do Core Stability Exercise Classes Help Children With Cerebral Palsy Improve Their Balance
This study aims to determine if participation in a core stability physiotherapy group programme can improve the balance of children with cerebral palsy.
- Trial name
- NCT02351596
- Testing
- Physiotherapy Core Stability Group Programme, Control Group
- Where
- Ireland
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Royal College of Surgeons, Ireland
Mild Cognitive Impairment, Dementia
Dementia Patient's Behavior Evaluation Using Noninvasive Ambient Sensor
This study is an observational study that uses daily activity and environmental sensing techniques to establish behavioral models of early dementia patients and cognitive healthy function to assess their daily behavior and…
- Trial name
- NCT03120741
- Where
- Taiwan
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
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