Clinical trials: Brain Disorders
Post-traumatic Stress Disorder (PTSD), Trauma
Functional Brain Imaging in PTSD
Patients with post-traumatic stress disorder (PTSD) have abnormalities in the function of the amygdala and medial prefrontal cortex (particularly anterior cingulate), in addition to abnormalities of hippocampal volume.
- Trial name
- NCT02053532
- Testing
- Positron emission tomography/magnetic resonance imaging
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Alzheimer Disease, Early Onset, Posterior Cortical Atrophy
MECHANISMS OF NEURONAL RESILIENCE IN ALZHEIMER'S DISEASE AND ITS FOCAL VARIANTS: A PET/MR STUDY
Patients with Alzheimer's disease and with early onset of symptoms (<65 years) (AD-Y) have a multi-domain cognitive deficit, whereas memory disorders (typical of the elderly patient's AD) are less often in the foreground.
- Trial name
- PET-AL (NCT04150198)
- Testing
- TEP/IRM
- Where
- 2 sites in France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Obesity
MIND Diet Intervention and Cognitive Performance
This single-center, randomized trial examined the effect of MIND diet intervention on cognition and brain structure changes of healthy obese women over three months.
- Trial name
- MIND (NCT04383704)
- Testing
- New Dietary pattern ( Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND))
- Where
- Iran
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Shiraz University of Medical Sciences
Parkinson's Disease (PD)
Effect of BIA 9-1067 on the Pharmacokinetics and Pharmacodynamics of Warfarin
The purpose of this study is to investigate CYP2C9 inhibition by BIA 9-1067 through the assessment of its effect on the pharmacokinetics of S-warfarin, a substrate of CYP2C9.
- Trial name
- NCT02169440
- Testing
- BIA 9-1067, Warfarin
- Where
- Portugal
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Parkinson Disease
Investigation of Exercise Capacity, Muscle Oxygenation and Physical Activity Level in Parkinson's Patients
The primary aim of this study is to compare maximum and functional exercise capacity and muscle oxygenation during exercise test in patients with Parkinson's disease.
- Trial name
- NCT05816889
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Gazi University
Dementia With Lewy Bodies, Alzheimer Disease
Self and Autobiographical Memory in Dementia With Lewy Bodies and Alzheimer Disease: a Behavioral and Multimodal Neuroimaging Study
The present project aims at exploring different components of Self-consciousness or 'the Self', such as autobiographical memory, self-concept and subjective sense of Self, in dementia with Lewy Bodies (DLB) compared to…
- Conditions
- Dementia With Lewy Bodies, Alzheimer Disease, Self, Autobiographical Memory
- Trial name
- SELF-MCL (NCT04616287)
- Testing
- Neuropsychological assessment and Multimodal brain MRI
- Where
- France
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Alzheimer Disease, Mild Cognitive Impairment
Ultralow Dose PET Imaging of 18F-Florbetapir, 18F-Flutemetamol
The goal of this clinical trial is to evaluate an investigational ultralow dose Positron Emission Tomography (PET) imaging technique for Alzheimer's disease, mild cognitive impairment, other forms of dementia detection and…
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Dementia, Healthy Volunteers
- Trial name
- NCT07012993
- Testing
- 18F-Florbetapir or 18F-Flutemetamol
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Akiva Mintz
Cognition, Affect (Mental Function)
ETASCAN Project: ETAS Project 2
This study aims to investigate the chronic effects of ETAS® on cognitive, affective and neural outcomes in healthy adults aged 60-80 years with mild to moderate subjective cognitive complaints.
- Conditions
- Cognition, Affect (Mental Function), Sleep, MRI
- Trial name
- ETASCAN (NCT07550140)
- Testing
- ETAS®
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Reading
Stroke
Evaluation of Sensorimotor Ankle Impairments in Chronic Stroke
The purpose of this study is to capture sensorimotor ankle function in a chronic stroke population through validation of novel, experimental metrics and their comparison with established, clinical measures of function.
- Trial name
- NCT06410989
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Muscle Spasticity, Paralysis; Cerebral
The Decline in Walking Performance in Adults With Cerebral Palsy - Influence of Performance Fatigability
Due to an early brain injury occurring in antenatal or postnatal, cerebral palsy (CP) causes alteration in motor function with posture and gait disorders.
- Trial name
- FAT-GAIT (NCT06163950)
- Testing
- Fatigability assessment
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Movement Disorder, Focal Dystonia
Movement-Related Brain Networks Involved in Hand Dystonia
This study will use various methods to measure the activity of the motor cortex (the part of the brain that controls movements) in order to learn more about focal hand dystonia.
- Trial name
- NCT00137384
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Localization-related Epilepsy, Partial Epilepsy
Improving Lesion Detection in Children With Magnetic Resonance Imaging (MRI)-Negative Partial Epilepsy Using Diffusion Tensor Imaging
Focal cortical dysplasia is one of the most common lesions responsible for medically refractory epilepsy in the pediatric population.
- Trial name
- NCT00894478
- Testing
- Diffusion Tensor Imaging (DTI), Magnetoencephalography
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Migraine
Longitudinal Changes of Brain Functional Connectivity in Migraine
The purpose of this study is to identify a core fMRI feature that determines migrainous brain and plastic fMRI features that changes with longitudinal courses of migraine.
- Trial name
- NCT03487978
- Testing
- resting-state functional MRI
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Anemia During Pregnancy, Anemia Complicating Pregnancy
Middle Cerebral Artery Doppler( MCA-PSV) & Perinatal Outcome
can we predict neonatal outcome by the results of 3rd trimester MCA Doppler Indices In pregnant women with anemia?? --- the aim of this study is to evaluate values of MCA Doppler indices in determining fetal outcome in pregnant…
- Conditions
- Anemia During Pregnancy, Anemia Complicating Pregnancy, Anemia
- Trial name
- NCT07135635
- Testing
- Middle Cerebral Artery doppler
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Ischemic Stroke
Study to Test Sensitivity and Specificity of Passive Wave Pressure Device in Determining Ischemic Stroke
That the Jan Medical Nautilus NeuroWaveTM system provides significantly higher sensitivity to hyper acute ischemic stroke than does CT.
- Trial name
- NCT01643525
- Testing
- Nautilus NeuroWaveTM System
- Where
- 3 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Jan Medical, Inc.
Dementia Prevention
Dementia Prevention Internet-Based Intervention: Randomized Controlled Trial and Knowledge Translation
In this proposal, the investigators plan to study the effectiveness of a web-based intervention on dementia prevention knowledge, intentions, and behaviour change related to dementia risk.
- Trial name
- NCT06911047
- Testing
- Education Intervention, Education Control
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- McMaster University
Traumatic Brain Injury
Emotional Processing Intervention for Children With TBI
Investigating an emotional processing program, that is modified for use with children, is effective for children with a traumatic brain injury (TBI).
- Trial name
- NCT04826068
- Testing
- Emotional Processing
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Internalizing Psychopathologies (IPs) Depression and Anxiety
Negative Valence Brain Targets and Predictors of Anxiety and Depression Treatment
Internalizing psychopathologies (IPs) involving depression and anxiety are among the most prevalent, costly and disabling illnesses.
- Trial name
- NCT01903447
- Testing
- SSRI, CBT
- Where
- United States
- Volunteers
- 271 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Sleep Disorder, Parkinson Disease
Sleep Disorder in Parkinson Disease and rTMS
The crude prevalence rate of Parkinson's disease in Upper Egypt governorates ranging from 557-436/100,000 (Assiut and Qena governorates respectively) which was one of the highest prevalence of PD around the world .Parkinson's…
- Trial name
- NCT05599035
- Testing
- repititive transcranial magnetic stimulation
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Assiut University
Epilepsy, Depression
fMRI Investigation of Depression in Patients With Epilepsy
Depression is very common in epilepsy. Depression is the strongest predictor of poor quality of life in patients with epilepsy. The biological basis for depression in epilepsy remains poorly understood.
- Trial name
- NCT00532376
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
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