Clinical trials: Brain Disorders
Cerebral Infarction
The Effect of Erigeron Injection on Acute Cerebral Infarction Serum VEGF, MMP-9 and EPC Levels
To study the effects of Erigeron Injection on human serum VEGF, MMP-9 and EPC levels after acute cerebral infarction,test is made by random double-blind controlled.patients with acute cerebral infarction were divided randomly…
- Trial name
- NCT01926834
- Testing
- Erigeron Injection
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Guangzhou University of Traditional Chinese Medicine
Parkinson's Disease
Clinical, Molecular and Metabolic Characteristics of Parkinson's Disease (PD) Patients With Parkin Mutation
Parkinson's disease is a frequent neurodegenerative disorder. Genetic forms of the disease have been recently identified. The monogenic form due to parkin mutation is responsible for many familial cases and sporadic forms.
- Trial name
- NCT00169364
- Testing
- positron emission tomography
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Dementia
Construction and Validation of Dementia Care Management Competency
This study will use the concept of competency-based education to develop an innovative integrated curriculum with EPAs to guide learning and assessment of competency performance to equip students with dementia care management…
- Trial name
- NCT06032351
- Testing
- Innovation-integrated curriculum for dementia care and care management, Traditional classroom teaching course programs
- Where
- Taiwan
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Hypopituitarism, Central Diabetes Insipidus
Identification and Clinical Relevance of an Oxytocin Deficient State (GLP1 Study)
Oxytocin (OT) is a hypothalamic peptide that enters the peripheral circulation via the posterior pituitary gland. OT plays a key role in regulating appetite, psychopathology, prosocial behavior and sexual function.
- Conditions
- Hypopituitarism, Central Diabetes Insipidus, Panhypopituitarism, Psychological Disorder
- Trial name
- NCT04897802
- Testing
- Experimental: GLP1-RA (exenatide) administration
- Where
- Spain
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Mild Cognitive Impairment, Dementia, Mild
The Brain Health Champion Study
6-month, randomized, controlled investigation measuring the effect of increased clinical contact and personalization compared to standard physician counseling on adherence to consensus-based, brain health recommendations for…
- Conditions
- Mild Cognitive Impairment, Dementia, Mild, Subjective Cognitive Decline, At Risk for Cognitive Decline
- Trial name
- BHC (NCT03772977)
- Testing
- Brain Health Champion
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Dementia, Mild Cognitive Impairment
HOme-based Brain Monitoring With a GARment-EEG to Study Cognitive Decline in the Aging Population
This study will investigate the validity of the HOGAR EEG/PSG monitoring kit designed by Bitbrain as a tool for characterizing and assessing cognitive function in older adults, as well as for detecting and predicting cognitive…
- Conditions
- Dementia, Mild Cognitive Impairment, Dementia Alzheimers, Dementia, Mixed
- Trial name
- Hogar (NCT06993207)
- Testing
- Home Lab
- Where
- Spain
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Bitbrain
Alzheimer Disease
Motor Slowing and Its Lesion-related Correlates in Alzheimer's Disease
In AD (Alzheimer disease), the anatomic correlates of attention disorders (as evaluated by motor slowing) have not been thoroughly characterized.
- Trial name
- TAMA (NCT02811653)
- Testing
- Brain MRI, neuropsychological evaluation, Blood
- Where
- France
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Partial Epilepsy
Study to Evaluate Pharmacokinetics and Tolerability of Multiple Doses of Eslicarbazepine Acetate and Oxcarbazepine
This purpose of this study is to measure the concentrations of two anti-epileptic drugs (Eslicarbazepine acetate and oxcarbazepine) and their metabolites in the cerebrospinal fluid and blood plasma of healthy subjects and also to…
- Trial name
- NCT00900237
- Testing
- Eslicarbazepine acetate, Oxcarbazepine
- Where
- Belgium
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Emotion Regulation, Anxiety
Prebiotics and Mental Health: Behavioural
A behavioural study of the microbiota-gut-brain axis in brain development and mental health
- Trial name
- NCT04616937
- Testing
- GOS
- Where
- United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Surrey
Phenylketonuria
SNAP: Study Nutrients in Adult PKU
Phenylketonuria (PKU) is a rare inherited metabolic disorder, where subjects are born with a genetic deficiency in the phenylalanine hydroxylase enzyme (PAH), which leaves them unable to convert Phenylalanine (Phe) into Tyrosine…
- Trial name
- SNAP (NCT03858101)
- Where
- 4 sites in Belgium, Denmark and 1 more
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Nutricia Research
Alzheimer's Disease, Dementia
A Study to Evaluate the Effects of MK-0249 and an Alzheimer's Disease Medication on Cognitive Function in Adults With Alzheimer's Disease (MK-0249-023)
This study will evaluate acute symptomatic improvements in cognitive performance in healthy elderly participants with mild-to-moderate Alzheimer's disease.
- Trial name
- NCT00874939
- Testing
- MK-0249 7.5 mg, MK-0249 25 mg, Donepezil 5mg
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Parkinson Disease
LRRK2 Activity and Markers of Parkinson's Disease in G2385R Carriers
The goals of this study are 1. To compare the functional effects of the LRRK2 G2385R variant among carriers with and without Parkinson's disease (PD) and non-carriers with and without PD 2.
- Trial name
- NCT04349865
- Where
- China
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Stroke, Acute
F.A.S.T.-BE FAST Stroke Warning Signs Study
The goal of this randomized controlled trial is to learn whether the BE FAST (Balance, Eyes, Face, Arm, Speech, and Time) acronym works at least as well or better than the F.A.S.T.
- Trial name
- NCT06483165
- Testing
- BE FAST Educational video, F.A.S.T. Educational Video
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- American Heart Association
Dementia, Senile, Family Members
Smart-Cloth Care System for Dementia
The purpose of this study is to develop and examine the preliminary effects of a smart cloth care system for facilitating family caregiving for persons with dementia in the home setting.
- Trial name
- NCT05063045
- Testing
- smart-cloth assisted home nursing care
- Where
- 2 sites in Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Mild Cognitive Impairment, Mild Dementia
Brain Health & the Microbiome
The GW SMHS supports research in complementary and integrative approaches to treatment of sickness and disease and for health promotion.
- Conditions
- Mild Cognitive Impairment, Mild Dementia, Alzheimer Disease 1
- Trial name
- bMicrobiome (NCT06039267)
- Testing
- Gut Microbiome Testing
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- George Washington University
Brain Diseases
Exploratory Study Using a New Head-only PET Scanner / ExploreNeuroLF
The "NeuroLF prototype" is a small aperture PET scanner. The NeuroLF prototype will be used with patients, which have just finished their regularly scheduled PET examination on a clinical whole body PET system.
- Trial name
- NCT06344871
- Testing
- NeuroLF, Conventional PET scan
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Positrigo AG
Brain Injuries
Acceptance and Commitment Therapy (ACT) and Carers
Background: Research has extensively documented the adverse impact that caring for an individual with an acquired brain injury can have including financial difficulties, social isolation, family tension and conflict, relationship…
- Trial name
- NCT02584101
- Testing
- ACT, Enhanced Treatment as Usual
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Parkinson Disease
Quantitative Imaging of Brain Glymphatic Function in Humans
Recent immunological and physiological studies have provided evidence in support of a central nervous system (CNS) lymphatic drainage system in vertebrate animals, and preliminary evidence has suggested that a similar system…
- Trial name
- NCT04768101
- Testing
- [11C]-PIB
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Alzheimer's Disease, Parkinson's Disease
Social Cognition and Personality Changes in Alzheimer's & Parkinson's Disease & Frontotemporal Lobar Degeneration
The aim of this study is to compare personality and social cognition changes, including emotion detection and self-awareness, and neuroanatomical correlates in patients, and how that affects the caregiver-patient relationship.
- Conditions
- Alzheimer's Disease, Parkinson's Disease, Frontotemporal Lobar Degeneration
- Trial name
- NCT02964611
- Testing
- Observational Study
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Alzheimers Disease
A Study of CNP520 Versus Placebo in Participants at Risk for the Onset of Clinical Symptoms of Alzheimer's Disease
The purpose of this study is to determine the effects of CNP520 on cognition, global clinical status, and underlying AD pathology, as well as the safety of CNP520, in people at risk for the onset of clinical symptoms of AD based…
- Trial name
- GS2 (NCT03131453)
- Testing
- CNP520 50mg, CNP520 15mg
- Where
- 194 sites in United States, Argentina and 23 more
- Volunteers
- 1,145 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.