Clinical trials: Brain Disorders
Parents, Epilepsy in Children
The Effect of the Training Programme Based on the Health Promotion Model Given to Parents
This randomised controlled study evaluates the effect of a training programme based on the Health Promotion Model developed for parents of children diagnosed with epilepsy on parents' level of knowledge about epilepsy, parents'…
- Conditions
- Parents, Epilepsy in Children, Disease Management
- Trial name
- NCT06388577
- Testing
- Education
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Mersin University
Stroke, Sarcopenia
Evaluating and Monitoring Physical Fatigue While Performing Functional Activities
Fatigue is a critical health parameter in older adults and stroke patients and is associated with negative health outcomes. Current assessment tools predominantly focus on walking related fatigue, neglecting other activities of…
- Conditions
- Stroke, Sarcopenia, Fatigue
- Trial name
- NCT06513377
- Testing
- Performance test
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Epilepsy
Ketogenic Diet Program for Epilepsy
This study will assess the effectiveness of the ketogenic diet (high-fat, low-carbohydrate, and moderate protein) in treating epilepsy.
- Trial name
- NCT02497105
- Testing
- Ketogenic Diet
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Shriners Hospitals for Children
Epilepsy, Tumor
Diffusion MRI-1 Imaging Database
The purpose of the dMRI-1 data collection study is to establish a database of clinical images and limited medical history information from patients that have previously received a dMRI scan.
- Conditions
- Epilepsy, Tumor, Healthy, Other
- Trial name
- dMRI-1 (NCT03775694)
- Testing
- dMRI Scan
- Where
- 6 sites in United States, Canada
- Volunteers
- 299 people, healthy volunteers welcome
- Sponsor
- Medtronic Spinal and Biologics
Traumatic Brain Injury, Post-traumatic Epilepsy
Transforming Research and Clinical Knowledge in Traumatic Brain Injury Epileptogenesis Project (TRACK-TBI EPI)
The overarching goal of this study is to improve understanding of the long-range natural history of TBI and post-traumatic epilepsy (PTE) by extending follow-up of a previously enrolled cohort (TRACK-TBI) beyond the first 12…
- Trial name
- NCT05823766
- Testing
- In-Person Outcome Assessment, 3T Magnetic Resonance Imaging (MRI), Clinical Visit
- Where
- 9 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Parkinson Disease
A Randomized, Open-Label, Crossover Study to Evaluate the Pharmacokinetic Profiles of Rotigotine After a Single Dose of LY03003 (28 mg) Versus After a Week of Daily NEUPRO® Transdermal Patch (4 mg Every 24 Hours) in Healthy Volunteers
This is a randomized, open-label, 2-sequence, 2-treatment cross-over study in healthy adult subjects. Rotigotine PK profiles will be obtained from all subjects after both a single dose of 28 mg LY03003 and 1 week of 4 mg q24h…
- Trial name
- NCT04384666
- Testing
- LY03003 (rotigotine extended release microspheres for intramuscular [IM] injection), Neupro 4 mg / 24 Hr. Transdermal Patch
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Luye Pharma Group Ltd.
Stroke
Motor Learning of a Planning Task in Stroke Patients: the Maze Paradigm Measured Through Time and Error as Variables
The purpose of this study is to investigate the process of acquiring a motor skill subject in post-stroke, comparing them with healthy subjects.
- Trial name
- NCT00740402
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Faculdades Metropolitanas Unidas
Concussion, Mild
Sex and Age Ultrasound Response to Differential Jugular Vein Pressure
Clinical trials have suggested that this device is effective in mitigating changes in brain structure and function in athlete populations.
- Trial name
- NCT03017937
- Testing
- Q-collar
- Where
- United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Intracranial Aneurysm, Stent Complication
Stent-Assisted Coiling Followed by Ticagrelor Monotherapy Instead of Dual Antiplatelet Therapy in Unruptured Intracranial Aneurysm
The primary goal of the trial is to investigate whether the experimental arms (receiving the P2Y12 inhibitor Ticagrelor) compared with the control arm (taking dual antiplatelet therapy) could reduce bleeding complications in…
- Trial name
- SAC-TIDE (NCT06015477)
- Testing
- Ticagrelor monotherapy, Dual Antiplatelet Therapy
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Spinal Cord Injuries, Stroke
Wheelchair Cushion Comparison Study: SAFETY
Purpose: To examine the safety of the use of two wheelchair cushions for healthy individuals with intact sensation and individuals post stroke and spinal cord injury with impaired sensation.
- Conditions
- Spinal Cord Injuries, Stroke, Healthy Adults
- Trial name
- NCT03430375
- Testing
- Alternating air wheelchair cushion, Static air cushion
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Idiopathic Pulmonary Fibrosis (IPF), Idiopathic Pulmonary Fibrosis
PET Study of PIPE-791 in Healthy Volunteers and Volunteers With PrMS and IPF
This is a study of PIPE-791, an investigational study drug to treat progressive multiple sclerosis (MS) and idiopathic pulmonary fibrosis (IPF).
- Conditions
- Idiopathic Pulmonary Fibrosis (IPF), Idiopathic Pulmonary Fibrosis, Multiple Sclerosis, Multiple Sclerosis, MS
- Trial name
- NCT06683612
- Testing
- PIPE-791
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Contineum Therapeutics
Alzheimer's Disease
Brain Imaging Study in Subjects With Alzheimer Disease in Comparison to Healthy Subjects
The underlying goal of this study is to assess 123-I MNI-168 SPECT imaging as a tool to detect ß-amyloid deposition in the brain of Alzheimer's Disease (AD) research participants and similarly aged and gender matched healthy…
- Trial name
- NCT00870519
- Testing
- I-123-MNI-168, 123-I MNI-168
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Institute for Neurodegenerative Disorders
Stroke, Chronic Stroke
Neural Operant Conditioning
The goal of this clinical trial is to learn if operant conditioning can reduce spasticity in order to improve walking in stroke patient.
- Conditions
- Stroke, Chronic Stroke, Gait, Hemiplegic, Gait, Spastic
- Trial name
- NCT06113965
- Testing
- Peripheral Nerve Stimulation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- MetroHealth Medical Center
Alzheimer Disease
UAB Alzheimer's Disease Center Core Cohort - Tau Imaging Substudy
The primary objective of this study is to measure the concentration and the regional brain distribution of pathologic tau deposition using the PET tracer AV-1451 in participants in the UAB-ADC cohort.
- Trial name
- AV1451 ADC (NCT03809351)
- Testing
- [F-18]AV-1451-PET
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Healthy, Overweight and Obesity
Westlake Precision Nutrition Study
This is a dietary intervention study, which aims to explore different diet challenges for glucose metabolism, including carbohydrates and intermittent fasting (IF) dietary pattern.
- Trial name
- NCT05054153
- Testing
- refined carbohydrate breakfast, whole grain breakfast, intermittent fasting
- Where
- China
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Westlake University
Huntington Disease
Clinicopathological MRI and CSF Correlates in Huntington's Disease.
In this study the investigators will link brain iron levels obtained from quantitative susceptibility maps of HD patients with specific and well-known clinical CSF markers for iron accumulation, neurodegeneration and…
- Trial name
- NCT05534139
- Testing
- 7T MRI-scan, CSF collection via lumbar puncture, Blood withdrawal
- Where
- Netherlands
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Sleep Disorders, Intrinsic
Cerebral Hemodynamics in Sleep Disorders
The purpose of this study is to determine the relationship between sleep disorders and cerebral hemodynamics.
- Trial name
- NCT02752139
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Yi Yang
Dystonic Disorders
Brain Inhibition of Muscle Movement in Normal Volunteers
This study will use transcranial magnetic stimulation, or TMS (described below), to examine how the brain controls muscle movement to prevent unwanted movements in surrounding muscles.
- Trial name
- NCT00047957
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cerebral Palsy (CP), Unilateral Cerebral Palsy
Neural Correlates of Goal-directed Action Observation and Execution in Children With Unilateral Cerebral Palsy
Cerebral palsy (CP) is the most common childhood-onset motor disorder, with Unilateral Cerebral Palsy (UCP)- motor impairment predominantly impacting one side of the body-representing the most frequent form of CP.
- Conditions
- Cerebral Palsy (CP), Unilateral Cerebral Palsy, EEG, Action Observation
- Trial name
- EEG_AINCP (NCT07369167)
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- IRCCS Fondazione Stella Maris
Late Onset Pompe Disease, Pompe Disease
Search for Serum/Plasma Biomarkers in Pompe's Disease
This study aims to analyze serum and plasma samples from patients with late onset Pompe disease treated and not treated with enzyme replacement therapy (ERT) to identify microRNA that could be specific of the disease.
- Trial name
- BIOPOMPE (NCT03045042)
- Testing
- Enzyme Replacement Agent
- Where
- Spain
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
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