Clinical trials: Brain Disorders
Concussion, Traumatic Brain Injury
Advanced MRI Applications for Mild Traumatic Brain Injury-Phase 2
This is an open-label, non-randomized, prospective, multi-site, parallel group (segment), hypothesis-generating study designed to collect data that will aid in future scientific and engineering exploration of correlations between…
- Trial name
- mTBI-phase2 (NCT02556177)
- Testing
- MRI
- Where
- 7 sites in United States
- Volunteers
- 477 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Dementia, Nursing Caries
The Effect of Simulation in Gaining Skills to Nursing Students
This research is a randomized controlled study conducted to examine the effect of standard patient simulation training in providing nursing students with the ability to care for individuals with dementia.
- Trial name
- NCT05246501
- Testing
- Simulation, No simulation
- Where
- Turkey (Türkiye)
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Alzheimer Disease, Dementia
Utilizing Senior Companions to Enhance Dementia Care
The inability of healthcare systems to effectively manage Alzheimer's disease and related dementias (ADRD) often results in families remaining unaware of important community-based, long-term services and supports (LTSS) that…
- Trial name
- NCT03667924
- Testing
- PorchLight Project
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Growth Hormone Deficiency
304-C03/L3301n: Effects of Growth Hormone on Glucose and Protein Metabolism in Children With Growth Hormone Deficiency
The purpose of the proposed study is to investigate the effects of rhGH treatment on glucose, protein and fat metabolism in GHD children.
- Trial name
- NCT00362063
- Testing
- growth hormone (Nutropin)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Maple Syrup Urine Disease
Neurocognitive Outcomes and Quality of Life in Adults With Maple Syrup Urine Disease (MSUD)
Maple Syrup Urine Disease (MSUD) is a disorder of protein metabolism that leads to neurological differences. It is an exciting time where people diagnosed with MSUD are living longer.
- Trial name
- NCT04828863
- Testing
- Neurocognitive testing
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Reading Disorder
A Multisensory Music Intervention for Children With Reading Disorders (RitMoZ)
With this study, we wish to test how effective/ beneficial music activities can be for children with dyslexia.
- Trial name
- NCT05137353
- Testing
- Music Training (RitMoZ Training), Spelling Training
- Where
- Hungary
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Research Centre for Natural Sciences
Parkinson's Disease (PD)
Pharmacokinetic-pharmacodynamic Interaction Between Each of Three Different Single Doses of BIA 9-1067 and a Single-dose of Controlled-release 100/25 mg Levodopa/Carbidopa
To investigate the effect of three single oral doses of BIA 9-1067 (25 mg, 50 mg and 100 mg) on the levodopa pharmacokinetics when administered in combination with a single-dose of controlled-release levodopa/carbidopa 100/25 mg…
- Trial name
- NCT02169453
- Testing
- BIA 9-1067, Sinemet® CR 100/25
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Parkinson's Disease, Apathy
Role of Mesocorticolimbic Pathway in Apathy of Patients With Parkinson's Disease. - Study Using Diffusion Tensor Imaging and Fibres Tracking
Use lay language. Apathy is one of the most under recognised, underdiagnosed and poorly managed aspects of Parkinson's disease. Depending on methodological approach of the study, its prevalence is estimated to be between 16 and…
- Trial name
- NCT01794195
- Testing
- Diffusion tensor imaging and fibres tracking
- Where
- France
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Healthy, Cognition
Reliability of Standardized IQ Testing Under Modafinil, Racetam-Class Compounds, Sleep Restriction and Daily Activity
This study examined whether standardized IQ test scores in healthy adults aged 18-35 are stable measures of cognitive ability and evaluated whether standardized cognitive-test performance and response-initiation measures vary…
- Conditions
- Healthy, Cognition, Sleep Deprivation
- Trial name
- NCT07852130
- Testing
- Modafinil, Oxiracetam, Pramiracetam
- Where
- United Kingdom
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Abdulraheem Mohamed Gouda
Alzheimer Disease, Dementia
Supporting Caregivers of Persons With Dementia: A Pilot Study
The purpose of this study is to pilot the home Environmental Skill-Building Program (ESP) and an educational control intervention with persons with dementia and their caregivers (n=40) in preparation for a larger double-blind…
- Trial name
- NCT00908492
- Testing
- Education Control, Environmental Skill Building
- Where
- Canada
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- McMaster University
Parkinson Disease, Multiple System Atrophy
Augmenting Effects of L-DOPS With Carbidopa and Entacapone
An experimental drug called L-DOPS increases production in the body of a messenger chemical called norepinephrine. Cells in the brain that make norepinephrine are often gone in Parkinson disease.
- Conditions
- Parkinson Disease, Multiple System Atrophy, Autonomic Nervous System Diseases
- Trial name
- NCT00547911
- Testing
- Droxidopa, Carbidopa, Entacapone
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Alzheimer's Disease (AD), Time Perception
Evaluation of a Neuropsychological Tool to Assess Temporal Processing Abilities in Alzheimer's Disease
Perceiving and representing the passage of time allows us to temporally organize perceptions and memories for the coordination of actions, planning, and the mobilization of cognitive processes toward a goal.
- Trial name
- CHRONOS (NCT07341009)
- Testing
- Chronos battery
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Healthy Individuals, Diabetes
Heidelberg In Vivo Confocal Microscopy to Evaluate the Ocular Surface Disorders of Healthy and Diseased Individuals
In vivo confocal microscopy (IVCM) has been used in clinical settings for more than 25 years, and is noninvasive, rapid and easily repeatable technique to investigate ocular surface disorders.
- Conditions
- Healthy Individuals, Diabetes, Hypertension, Fabry Disease
- Trial name
- NCT04025801
- Where
- Taiwan
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Migraine, Migraine Disease
A Prospective, Open-Label Study Evaluating the Effectiveness of Gepants for Acute Treatment of Migraine in the Emergency Department
Prospective, single-site, open-label, non-controlled pilot study consisting of two parallel trials. Participants will receive rimegepant or zavegepant for acute migraine treatment during a single Emergency Department visit, with…
- Conditions
- Migraine, Migraine Disease, Migraine in Adults, Migraine Headache
- Trial name
- NCT07667621
- Testing
- Rimegepant, Zavegepant
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Risk of Dementia, Dementia
Development and Empirical Evaluation of a Brief Lifestyle Intervention for Older Adults at Risk of Dementia Within an Integrated Medical-Preventive Grid-Based Service Model
Lifestyle factors are among the most important modifiable risk factors for dementia, and primary prevention through lifestyle interventions is considered the most cost-effective approach to reducing the incidence of dementia.
- Trial name
- NCT07831616
- Testing
- Brief lifestyle intervention
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University
Parkinson's Disease
Predictors of Motor Progression in Parkinson's Disease
Treatment resistant motor features, such as postural instability and freezing of gait are common in people with Parkinson's disease and major contributors to morbidity and mortality.
- Trial name
- NCT02769039
- Testing
- No intervention. Observational studies of sleep, movement and brain imaging
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Cognitive Dysfunction, Cognitive Dysfunction, Cognitive Disorder
China-NINE Cohort：Neuroimmune Network in Elderly / Neurodegeneration
This is an observational study aimed at understanding the cognitive, functional, and behavioral characteristics of Chinese patients with cognitive impairment, exploring the underlying mechanisms, and providing evidence for early…
- Conditions
- Cognitive Dysfunction, Cognitive Dysfunction, Cognitive Disorder, Parkinson's Disease (PD)
- Trial name
- NCT07586501
- Where
- 2 sites in China
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Yantai Yuhuangding Hospital
Carer Stress Syndrome, Dementia
Effects of a Modified Mindfulness-based Cognitive Therapy for Family Caregivers of People With Dementia
Caring for people with dementia (PWD) poses many challenges which may cause high levels of caregiver stress. This study aims to investigate the effects of a modified Mindfulness-based Cognitive Therapy for stress reduction in the…
- Trial name
- NCT03354819
- Testing
- Modified MBCT, SIRE on dementia
- Where
- Hong Kong
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Breast Cancer
Magnetic Resonance Imaging (MRI) of Tumor Response and Cognitive Impairment in Breast Cancer Patients Undergoing Chemotherapy
We will use magnetic resonance imaging (MRI) to investigate tumor changes in women with breast cancer who are receiving anthracycline-based systemic chemotherapy.
- Trial name
- NCT01045044
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Kettering Health Network
Dementia, Frontotemporal
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of VES001 in Healthy Participants
This is a Phase 1, randomized, placebo-controlled, double-blind study to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of single and multiple doses of VES001 in a two part followed by a…
- Trial name
- SORT-IN-1 (NCT06226064)
- Testing
- VES001
- Where
- Netherlands
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Vesper Biotechnologies ApS
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