Clinical trials: Brain Disorders
Stroke Patients
Comparison of Face-to-face, Synchronous and Asynchronous Use of Methods Tele-Assessment
The aim of the study is to examine the reliability and validity of the synchronous and asynchronous application of Berg Balance Scale and Tinetti Balance Test in stroke patients.
- Trial name
- NCT05263063
- Testing
- Comparison of Face-to-face, Synchronous and Asynchronous Use of Methods Used for Balance Assessment in Individuals With Chronic Stroke
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Alzheimer Disease
Tricaprilin Liquid Formulation PK Study
The purpose of this study is to evaluate the pharmacokinetics, safety, and tolerability of new liquid formulations of tricaprilin, with the aim of finding a suitable formulation to advance in development.
- Trial name
- NCT05028114
- Testing
- AC-1202, AC-OLE-01, AC-OLE-02
- Where
- Australia
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Cerecin
LBSL, Leukoencephalopathies
Quantifying Disease Progression in LBSL
Leukoencephalopathy with brain stem involvement and lactate elevation (LBSL) is a genetic disorder caused by biallelic mutations in the DARS2 gene that encodes mitochondrial aspartyl tRNA synthase.(1, 2) It is characterized by…
- Trial name
- LBSL (NCT05750979)
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- M. Engelen
Gaucher Disease, Type III
Eliglustat on Gaucher Disease Type IIIB
Evaluation of the safety in the combination usage of Cerdelga and Cerezyme in type III Gaucher disease patients and the efficacy on soft tissue diseases.
- Trial name
- NCT03519646
- Testing
- Eliglustat
- Where
- Taiwan
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Mastication Disorder
The Reliability and Validity of Family Report Chewing Evaluation
The family has a primary prescription in the identification of the chewing disorder in children to plan appropriate rehabilitation program and implementation of the training.
- Trial name
- NCT03116646
- Testing
- Chewing evaluation
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Epilepsy
A Double-blind, Randomised, Placebo-controlled, Rising Multiple Dose Study to Investigate the Safety, Tolerability, Steady State Pharmacokinetic Profile and CNS Effects of BIA 2-093
The purpose of this study is to investigate the safety and tolerability of multiple dose regimens of BIA 2-093 in healthy young male volunteers
- Trial name
- NCT02171234
- Testing
- BIA 2-093
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Healthy
Study Evaluating the Safety and Pharmacokinetics of a Single Dose of GSI-953
The purpose of the protocol is to assess the initial pharmacokinetic (PK) profile of a single oral dose of GSI-953 to healthy male Japanese subjects and healthy elderly male Japanese subjects.
- Trial name
- NCT00441987
- Testing
- GSI-953
- Where
- Japan
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Parkinson, Dystonia
Sensorimotor Integration in Monogenic Parkinson-dystonia Syndromes
Hereditary Parkinson and dystonia syndromes are rare, as are people who carry the predisposition for Parkinson or dystonia but do not have symptoms.
- Conditions
- Parkinson, Dystonia, DYT3, DYT5
- Trial name
- SensoMo-PD (NCT05713721)
- Testing
- Transcranial magnetic stimulation (TMS), Video-based clinical examination, 24 hours drug withdrawal of dopaminergic medication
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital Schleswig-Holstein
Cognitive Decline, Cognitive Dysfunction
Brain Vascular and Neurocognitive Health
The overall research objective of this proposal is to determine the acute and chronic impact of transcranial photobiomodulation on indices of cerebral vascular health and neurocognitive function.
- Conditions
- Cognitive Decline, Cognitive Dysfunction, Alzheimer Disease, Vascular Disease, Peripheral
- Trial name
- NCT06497413
- Testing
- Transcranial Photobiomodulation, Transcranial Photobiomodulation helmet (Neuradiant 1070 Plus) with no light administered
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Traumatic Brain Injury
Effects of Intravascular Administration of Mesenchymal Stromal Cells Derived from Wharton's Jelly of the Umbilical Cord on Systemic Immunomodulation and Neuroinflammation After Traumatic Brain Injury.
Traumatic brain injuries (TBI) are one of the leading causes of death and disability worldwide. These patients are burdened by physical, cognitive, and psychosocial deficits, leading to an important economic impact for society.
- Trial name
- TRAUMACELL (NCT06146062)
- Testing
- Mesenchymal Stromal Cells (MSC)
- Where
- 3 sites in France
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Myalgia, Muscle Pain
Concentration of Receptors With Affinity for Cannabidiol and Cannabinol and the Effect on Chronic Orofacial Pain of Muscle Origin
The main aim of the presented project will be to examine the concentration of selected receptors (CB1, CB2, TRPV-1) showing affinity for binding to cannabidol (CBD) and cannabinol (CBN) in blood samples collected from people with…
- Conditions
- Myalgia, Muscle Pain, Orofacial Pain, Headache, Tension
- Trial name
- NCT06405646
- Testing
- Blood CB1, CB2, TRPV-1 concentration measurement
- Where
- Poland
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Major Depressive Disorder, Bipolar Affective Disorder, Currently Depressed, Moderate
The Role of Negr1 In Modulating Neuroplasticity in Major Depression (RONIN)
Patients belonging to Group 1 (Major Depression) and 2 (Bipolar Disorder) will be tested with psychometric and functional scales at baseline (T0) and after 4 weeks of pharmacological therapy (T1), to evaluate clinical and…
- Trial name
- RONIN (NCT06131268)
- Testing
- Venlafaxine
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Alzheimer's Disease
Alzheimer's Disease: Clinical Investigation and Neuroimage Studies Including 18F-PM-PBB3 and 18F-florbetapir (AV-45) PET Examination
Dementia is a common neurodegenerative syndrome in aged population. Alzheimer's disease (AD) is the most common disease. The main pathological findings in AD include senile plaques (SP) and neurofibrillary tangles (NFT).
- Trial name
- PMPBB3/AV45 (NCT04305210)
- Testing
- F-18 PMPBB3, 18F-florbetapir
- Where
- Taiwan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Parkinson Disease
Connect.Parkinson: Connecting Individuals With Parkinson Disease to Specialists in Their Homes
Connect.Parkinson is a randomized comparative effectiveness study, comparing usual care enhanced with educational materials to usual care, educational materials, and the delivery of specialty care via telemedicine into patient's…
- Trial name
- NCT02038959
- Testing
- Virtual Visits
- Where
- 20 sites in United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Alzheimer Disease, Mild Cognitive Impairment
Biodistribution of [11C]PIB in Patients With Risk Factors for Alzheimer's Disease
Participants enrolled at the Alzheimer's Disease Research Center (ADRC) at Wake Forest School of Medicine will be invited to take part in this study.
- Trial name
- NCT03089827
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Major Depressive Disorder, Perinatal Depression
The Role of Sex Steroids and Serotonin Brain Dynamics in Perinatal Mental Health
Hormonal transitions such as across pregnancy and postpartum may trigger depressive episodes in some women. It is not known why, but estrogen sensitivity may play a critical role.
- Trial name
- NCT03795688
- Testing
- Pregnancy
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vibe G Frøkjær, MD, PhD
Accidental Falls, Muscle Weakness
The Effects of a Walking Program on Balance, Falls and Well Being in Individuals Residing in Long-term Care
The purpose of this study is to assess the effectiveness of a regular walking program (which inevitably involves human interaction) compared to a usual care condition and to a human interaction condition (without the extra…
- Conditions
- Accidental Falls, Muscle Weakness, Gait, Unsteady, Depression
- Trial name
- NCT01277809
- Testing
- Interpersonal Interaction, Walking Program
- Where
- Canada
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Infant Development, Sensory Disorder
The Prechtl's General Movement Assessment, Hammersmith Infant Neurological Examination and Sensory Profile-2
In the Neonatal Intensive Care Unit (NICU), infants encounter many sensory stimuli (excessive noise, bright lights, painful medical applications, etc.) that are not present in the uterus.
- Conditions
- Infant Development, Sensory Disorder, Sensory Processing Disorder, Motor Delay
- Trial name
- highrisk (NCT05217199)
- Testing
- Measurements
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Mild Cognitive Impairment, Subjective Memory Impairment
The Cognitive Ageing Nutrition and Neurogenesis (CANN) Trial
There is a dearth of research which takes a multi-compound approach to dietary interventions, in humans, aimed at improving outcome measures of cognition.
- Trial name
- CANN (NCT02525198)
- Testing
- fatty acid/flavonoid blend
- Where
- 3 sites in United States, Australia and 1 more
- Volunteers
- 259 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Traumatic Brain Injury
Imaging of Traumatic Brain Injury
This project aims to study the prognostic ability of various MRI imaging markers in the evaluation of TBI patients. Cognitive, social, and occupational recovery will be measured at each time point, and compared to MRI findings.
- Trial name
- Imaging of TBI (NCT01196299)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
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