Clinical trials: Brain Disorders
Heart Arrest, Brain Injuries
A Comprehensive Evaluation of Hyperbaric Oxygen Therapy in Resuscitation Medicine - a Pilot Study (HOT-RESUS 1 Trial)
In this prospective pilot study, the effects of hyperbaric oxygen therapy (HBOT) in post-cardiac arrest syndrome will be evaluated. However, the primary outcome of this pilot study will be the feasibility of this approach.
- Trial name
- HOT-RESUS 1 (NCT05646875)
- Testing
- hyperbaric oxygen therapy
- Where
- Belgium
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Alcoholism, Healthy
The Effect of Positive and Negative Emotions on Brain Activity in Alcoholics and Nonalcoholics
This study was designed to learn more about the areas of the brain involved in the experience of positive and negative emotions.
- Trial name
- NCT00001675
- Where
- United States
- Volunteers
- 1,194 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Venezuelan Equine Encephalitis, Venezuelan Equine Encephalitis Virus Infection
A Phase 1 Study Evaluating the Safety, Tolerability, and Immunogenicity of V4020 Vaccine in Healthy Volunteers
The purpose of the study is to evaluate the safety and immunogenicity of a novel Venezuelan Equine Encephalitis virus (VEEV) vaccine (V4020) for the first time in humans compared to placebo when administered by subcutaneous or…
- Trial name
- VEEV (NCT07088822)
- Testing
- V4020
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Medigen, Inc.
Parkinson Disease
Pathways Mediating Impaired Postural Control in Parkinson's Disease
The purpose of this project is to use transcranial magnetic stimulation (TMS) to explore the state of excitability of corticocortical and corticofugal (cortex to spinal cord, cortex to brainstem to spinal cord) pathways that…
- Trial name
- NCT06464029
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Mild Cognitive Impairment
Treatment of Mild Cognitive Impairment With Transcutaneous Vagal Nerve Stimulation
Patients with amnestic mild cognitive impairment (MCI) often have compromised quality of life (QOL). Cognitive impairment is a major contributor to decrements in QOL and progression of MCI often leads to loss of independence and…
- Trial name
- TVNS MCI (NCT03359902)
- Testing
- Transcutaneous vagal nerve stimulation
- Where
- 3 sites in United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of Florida
Stroke
Effects of Mobile Application-Based Cognitive Training Along With Aerobic Training
This randomized controlled trial will determine the effects of combining mobile application-based cognitive training with aerobic exercise on cognitive function and the effects of combining mobile application-based cognitive…
- Trial name
- NCT07148453
- Testing
- Experimental Group, Control Group
- Where
- Pakistan
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Acute Mountain Sickness, High Altitude Pulmonary Edema
Hemodynamic Changes in Altitude Adaptation
We use a new technology (Nexfin from BMEYE-Inventive Hemodynamics) to monitor Cardiac Output, Blood Pressure, Fluid Responsiveness, Pulse Oximetry, Hemoglobin Concentration, Oxygen Delivery in Climbers during their process of…
- Conditions
- Acute Mountain Sickness, High Altitude Pulmonary Edema, High Altitude Cerebral Edema
- Trial name
- NCT01698619
- Where
- Germany
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Goethe University
Stroke Sequelae, Gait, Hemiplegic
ACTive Exoskeleton for Unilaterally-Assisted Locomotion (ACTUAL)
Walking difficulties are common symptoms after stroke, significantly reducing quality of life. Walking recovery is therefore one of the main priorities of rehabilitation.
- Trial name
- ACTUAL (NCT06061601)
- Testing
- Exoskeleton stroke group
- Where
- Italy
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Alcoholism
Imaging Cannabinoid CB1 Receptors in Alcohol Dependence
The cannabinoid type 1 (CB1) receptor is a protein found in the brain that is involved with the effects of marijuana; it may also play a role in the effects of alcohol dependence and withdrawal.
- Trial name
- NCT00816439
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Trauma, Brain
(POCUS) As an Early Screening Tool for Diagnosing Skull Fractures in Children
This study aims to evaluate the accuracy of POCUS as a screening tool for early diagnosis of skull fractures in children with mild closed head injuries admitted to the emergency department.
- Trial name
- NCT05726201
- Testing
- ultrasound
- Where
- Egypt
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Assiut University
Parkinson Disease(PD)
AR Stimulation Effects on Gait, Anxiety, and Brain Connectivity in Parkinson's Disease
A project aims at addressing gait impairments and non-motor symptoms such as anxiety and stress in Parkinson's disease (PD) patients through a novel approach involving heart rate variability (HRV) feedback and Augmented Reality…
- Trial name
- NCT06367101
- Testing
- AR training with gait and HRV feedback
- Where
- Taiwan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Chang Gung University
Huntington Disease, Irritability
Evaluating the Efficacy of Dextromethorphan/Quinidine in Treating Irritability in Huntington's Disease
The purpose of this study is to assess efficacy and safety of dextromethorphan/quinidine 20mg/10mg (DM/Q 20mg/10mg) in patients with irritability due to Huntington's disease.
- Trial name
- NCT03854019
- Testing
- Dextromethorphan/quinidine 20mg/10mg (DM/Q 20mg/10mg)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Concussion, Mild
Return to Learn Implementation Bundle for Schools (RISE) After Youth Concussion
Using the Consolidated Framework for Implementation Research, as our overarching conceptual framework, this translational 2 ½ year pragmatic RCT uses a clustered, stepped wedge design to test the effectiveness of a school-based…
- Trial name
- NCT04635475
- Testing
- RISE Bundle
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Washington
Parkinson's Disease, Somatosensory Disorders
Somatosensory Dysfunction as the Underlying Mechanism of Upper Limbs Motor Blocks in People With Parkinson's Disease
Motor blocks during gait and upper limb movements (FOULs) are a disabling and common motor impairment in mild to severe stages of Parkinson's disease (PD).
- Trial name
- NCT02610257
- Testing
- Mechanical stimulus (vibration) applied on the forearm
- Where
- Belgium
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Healthy Controls, Parkinson's Disease
Development of Digital Services for Parkinson's Disease
In this project, ocular motor, pupil and gait data in people with Parkinson's disease (PD) will be collected in order to develop machine learning models for the diagnosis and monitoring of PD.
- Trial name
- NCT06733077
- Testing
- gait with cueing wearable device and neuro-ocular performance
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Cerebral Ischemia
A Prospective Study of a New Device for Monitoring Cerebral Oxygenation on Healthy Volunteers
The purpose of this study is to determine whether a new cerebral oxygen monitoring device is effective and comparatively similar to the current approved devices.
- Trial name
- NCT00598819
- Testing
- CDI 1000 COM
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Anosognosia, Brain Damage
Cognitive-functional Evaluation of Anosognosia
Acquired brain damage patients usually show severe cognitive deficit that alter their performance on every day life activities. Some of them suffer anosognosia and they are not aware of their own limitations.
- Trial name
- NCT03712839
- Testing
- Cognitive-functional evaluation
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- María Rodríguez Bailón
Stroke
Upper Limb Movement Quality Following Stroke
The aim of this study is to monitor the daily upper limb movement of persons with stroke, and to relate these quantities to measures of recovery and impairment.
- Trial name
- NCT06497881
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Adi Negev-Nahalat Eran
Surgery, Cardiac Death
Endothelial Dysfunction and Non-cardiac Surgery
Endothelial dysfunction is a cardiovascular disease hallmark. After non-cardiac surgery, cardiovascular events correlate with surgical outcomes. Understanding the role of endothelial function in these events is crucial.
- Conditions
- Surgery, Cardiac Death, Stroke, Myocardial Injury
- Trial name
- NCT05778981
- Testing
- FMD - Troponin measurement
- Where
- Chile
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Chile
Nicotine Dependence, Drug Abuse
Effects of Nicotine on Cognitive Task Performance and Brain Activity as Measured by fMRI
Background: Many cigarette smokers claim that smoking improves their ability to think and concentrate, and have reported problems in thinking and concentration after quitting smoking.
- Trial name
- NCT01036711
- Where
- United States
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
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