Clinical trials: Brain Edema, open to volunteers
Stroke
Effects of Task-Based Mirror Therapy for Post-stroke Shoulder-Hand Syndrome
The study aims to determine the effects of task-based mirror therapy on edema, pain and upper limb motor function with shoulder-hand syndrome in post stroke patients.
- Trial name
- NCT07428811
- Testing
- Task based mirror therapy, Conventional exercises
- Where
- 2 sites in Pakistan
- Volunteers
- 34 people
- Sponsor
- Riphah International University
Stroke, Intra Cerebral Hemorrhage
Influence of Cerebral Oedema in Intracerebral Haemorrhage
In 2020, IntraCerebral Haemorraghe (ICH) remains the most devastating type of stroke. Besides stroke unit care, no specific treatment has been proven effective yet.
- Trial name
- COPITCH (NCT04621357)
- Testing
- Brain MRI, Biological biomarkers
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Lille
Aneurysmal Subarachnoid Hemorrhage
Decompressive Craniectomy After Aneurysmal Subarachnoid Hemorrhage (DECIDE-SAH)
DECIDE-SAH is an international, multicenter, retrospective, observational, non-interventional secondary-use cohort study of adults with aneurysmal subarachnoid hemorrhage (aSAH).
- Trial name
- DECIDE-SAH (NCT07872774)
- Testing
- Decompressive craniectomy
- Where
- Germany
- Volunteers
- 10,000 people
- Sponsor
- University Hospital, Essen
Cardiovascular Diseases, Cardiovascular Diseases Risk
Cor360: Clinician-Facing Broad-Spectrum Cardiac Phenotyping and Risk Assessment Using COR® Wearable ECG to Inform Outcomes-Oriented Care Pathways
Cor360 is an observational study evaluating whether extended wearable electrocardiogram (ECG) data can support broad-spectrum cardiac phenotyping and risk assessment beyond conventional single-purpose ambulatory rhythm…
- Conditions
- Cardiovascular Diseases, Cardiovascular Diseases Risk, Cardiac Conduction System Disease, Bundle/Fascicular Abnormalities
- Trial name
- Cor360 (NCT07775976)
- Testing
- COR Wearable ECG Monitoring, Cor360 Clinician-Facing Decision-Aid Reporting
- Where
- 2 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Peerbridge Health, Inc
Traumatic Brain Injury
Modulating Inflammation in Neuro-Trauma
MINT is a single-site, prospective, randomized, double-blind, sham-controlled pilot trial evaluating the safety and feasibility of transcutaneous auricular vagus nerve stimulation (taVNS) in patients with moderate to severe…
- Trial name
- MINT (NCT07510074)
- Testing
- Nurosym taVNS
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Glioblastoma, Cerebral Metastases
Impact of Salovum® and SPC® Flakes on Brain Tumor Induced Edema
The objective of this clinical trial is to explore the effects of Salovum®, an egg yolk powder enriched with the endogenous protein antisecretory factor, and SPC® flakes , hydrothermically processed oats, on cerebral edema with…
- Conditions
- Glioblastoma, Cerebral Metastases, Meningioma
- Trial name
- AFBTEdema (NCT06710249)
- Testing
- Salovum/SPC flakes
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Peter Siesjö
Acute Liver Failure, Cerebral Edema
High-volume Versus Standard Volume Plasma Exchange in Patients With Acute Liver Failure With Cerebral Edema
In this prospective randomized controlled trial Investigator aim to evaluate the impact of high versus standard volume plasma-exchange in patients with acute liver failure with cerebral edema and clinical outcomes.
- Trial name
- NCT06515145
- Testing
- High Volume Therapeutic Plasma Exchange, Standard volume therapeutic plasma exchange
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Radiation Necrosis, Cerebral Edema
TENS of Auricular Vagal Nerve for Radiation Necrosis
This is a multi-center, randomized, blinded trial evaluating the effect of transcutaneous auricular vagal nerve stimulator (taVNS) on radiation necrosis-related cerebral edema.
- Trial name
- NCT07680127
- Testing
- Transcutaneous auricular vagal nerve stimulation (taVNS)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Virginia Commonwealth University
Traumatic Brain Injury, Head Injury
Setting Families on a Positive Path to Recovery After Pediatric TBI: Road-to-Recovery
This study has two main goals: 1) to refine and enhance the R2R-TBI intervention; and 2) to examine the efficacy of the R2R-TBI intervention in a randomized control trial.
- Conditions
- Traumatic Brain Injury, Head Injury, Head Injuries, Closed, Brain Hemorrhage, Traumatic
- Trial name
- NCT05622461
- Testing
- Road-to-recovery
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Traumatic Brain Injury, Rebound Intracranial Hypertension
ONSD Trajectory in Rebound ICH
The goal of this prospective observational study is to determine whether the trajectory of optic nerve sheath diameter (ONSD) after osmotherapy weaning can predict rebound intracranial hypertension in adult patients with…
- Conditions
- Traumatic Brain Injury, Rebound Intracranial Hypertension, Cerebral Edema
- Trial name
- ONSD/ INH (NCT07722702)
- Testing
- Optic Nerve Sheath Diameter Ultrasonography
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Benha University
Brain Edema
Haemodynamical Optimization During Brain Surgery
The decision to give fluids perioperatively could be based on methods used to identify preload responsiveness, either invasive or noninvasive estimates of stroke volume variation during mechanical ventilation.
- Trial name
- NCT04114799
- Testing
- Hemodynamic management based on invasive fluid responsiveness parameters, Hemodynamic management based on noninvasive cardiac output and SVV measurement
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- University Hospital Hradec Kralove
Cerebral Edema, Ischemic Stroke, Acute
A Trial of Adacolumn on Cerebral Edema After Anterior Circulation Ischemic Stroke
The primary objective is to investigate whether treatment with Adacolumn can ameliorate the progression of cerebral edema within 72 hours in patients with anterior circulation ischemic stroke.
- Conditions
- Cerebral Edema, Ischemic Stroke, Acute, Malignant Cerebral Edema, Anterior Circulation Brain Infarction
- Trial name
- NCT07386262
- Testing
- Adacolumn®, Standard Reperfusion Therapy, Standard Medical Management
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Intracerebral Hemorrhage
Auricular VNS Following Intracerebral Hemorrhage
This study will evaluate whether non-invasive auricular vagal nerve stimulation lowers inflammatory markers, and improves outcomes following intracerebral hemorrhage.
- Trial name
- NCT06799390
- Testing
- Auricular Vagus Nerve Stimulation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Washington University School of Medicine
Intracerebral Haemorrhage, ICH
Characterization of Peri-Hemorrhagic Cerebral Edema Using Synthetic Sodium Imaging With 7-Tesla and 3-Tesla MRI
Intracerebral haemorrhage is the type of stroke with the highest mortality rate, estimated at 40% in the acute phase. Among survivors, half will experience functional disability.
- Trial name
- TIPITCH-7T (NCT07789990)
- Testing
- Sodium tissue concentration will be measured in perihematomal oedema
- Volunteers
- 48 people
- Sponsor
- University Hospital, Lille
Intracerebral Hemorrhage
Reduction of Edema With a Specialized Cocktail for Ultra-early Management in Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is a severe stroke subtype with high mortality and disability rates, often worsened by perihematomal edema (PHE), which increases intracranial pressure and leads to poor outcomes.
- Trial name
- NCT06863558
- Testing
- PPA Intervention
- Volunteers
- 58 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hyponatremia Symptomatic, Osmotic Demyelination Syndrome
International Multi-center Retrospective Study of Patients With Serum Sodium ≤110 mmol/L to Determine the Relationship Between Osmotic Demyelination Syndrome (ODS) and Rapid Correction of Hyponatremia
Electronic medical records dating back as far as available for each center to identify patients admitted to the hospital with a serum sodium ≤110 mmol/l.
- Conditions
- Hyponatremia Symptomatic, Osmotic Demyelination Syndrome, Cerebral Edema
- Trial name
- PRONATREOUS (NCT07576036)
- Testing
- Hypertonic 3% saline
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Rochester General Hospital
Intracerebral Hemorrhage
Chinese Multicenter Cohort Study of Intracerebral Hemorrhage
Spontaneous intracerebral hemorrhage is a severe form of stroke associated with high mortality and long-term disability. The Chinese Multicenter Cohort Study of Intracerebral Hemorrhage (CASA) is a prospective observational…
- Trial name
- CMCS-ICH (NCT07833410)
- Where
- China
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Xiangya Hospital of Central South University
Carotid Stenosis, Coronary Artery Disease
Simultaneous Cardiac Surgery and Micronet-covered Stent Carotid Revascularization in High Perioperative Stroke Risk Patients
Prospective, single-center, clinical registry of patients with symptomatic/critical carotid artery stenosis at risk of stroke coexisting with unstable or multivessel severe coronary artery disease and/or severe valvular heart…
- Conditions
- Carotid Stenosis, Coronary Artery Disease, Valvular Heart Disease, Myocardial Infarction
- Trial name
- SIM-GUARD (NCT04973579)
- Testing
- Simutaneous (single anaesthesia) carotid artery stenting with MicroNet covered stent (CGuard) and cardiac surgery (CABG or surgical valve replacement / repair procedure)
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- John Paul II Hospital, Krakow
Idiopathic Intracranial Hypertension (IIH)
Intracranial Venous Stenting Evaluation in Patients With Idiopathic Intracranial Hypertension in the Early Phase
This study is aimed at patients suffering from recently discovered intracranial hypertension, caracterized by visual loss, chronic headache and/or tinnitus.
- Trial name
- DIVE IIN EARLY (NCT06919744)
- Testing
- Best medical care, Intervention (stenting)
- Where
- 3 sites in France
- Volunteers
- 114 people
- Sponsor
- University Hospital, Montpellier
Clinical Need for Craniotomy or Craniectomy, Clinical Need for Cranioplasty
A Multi-center, Early Feasibility Study of Using the Mechanical Tissue Resuscitation™ (MTR®) Therapy System for Removal of Excess Fluid in Subjects Who Have Had a Portion of Their Skull Removed to Expose the Dura/Brain and Require Drainage for Fluid Removal.
A multi-center, early feasibility study of using the Mechanical Tissue Resuscitation™ (MTR®) therapy system for removal of excess fluid in subjects who have had a portion of their skull removed to expose the dura/brain and…
- Trial name
- NCT06201429
- Testing
- Mechanical Tissue Resuscitation™ (MTR®)
- Where
- 3 sites in United States
- Volunteers
- 11 people
- Sponsor
- Renovo Concepts, Inc.