Clinical trials: Brain Function, open to volunteers
Irritable Bowel Syndrome (IBS), Anxiety
Anxiety and Depression in IBS: A Brain-Gut Axis Study
This study aims to understand how the gut and the brain communicate in people with Irritable Bowel Syndrome (IBS) who also experience anxiety and depression.
- Conditions
- Irritable Bowel Syndrome (IBS), Anxiety, Depression
- Trial name
- NCT07646834
- Testing
- Observational Study (No Intervention)
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
PARKINSON DISEASE (Disorder)
taVNS on Functional Mobility in People With DP
Parkinson's disease (PD) is characterized by motor impairments such as bradykinesia accompanied by resting tremor and/or rigidity.
- Trial name
- NCT07366411
- Testing
- Active taVNS
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Universidade Federal de Pernambuco
Stroke, Hemiplegia
Task-Oriented Training Versus High-Intensity Gait Training in People With Chronic Stroke
The purpose of this study is to compare the effects of high-repetition task-oriented training and high-intensity gait training on walking capacity and functional mobility in individuals with chronic stroke.
- Conditions
- Stroke, Hemiplegia, Chronic Stroke
- Trial name
- NCT07725211
- Testing
- Neurodevelopmental Treatment, High-Repetition Task-Oriented Training, High-Intensity Gait Training
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Istanbul University - Cerrahpasa
Functional Neurological Disorder, Conversion Disorder
Brain-computer Interface Rehabilitation And Virtual Environments in Functional Neurological Disorder (BRAVE-FND)
The purpose of this study is to determine whether a course of rehabilitation using a device called a brain-computer interface can change the level of control people feel over bodily movements, in functional neurological disorder.
- Conditions
- Functional Neurological Disorder, Conversion Disorder, Functional Neurological Disorders, Conversion Disorder With Weakness/Paralysis
- Trial name
- BRAVE-FND (NCT07006415)
- Testing
- Brain-computer interface rehabilitation
- Volunteers
- 24 people
- Sponsor
- King's College London
Stroke, Dysphagia
Effects of CTAR and a Swallowing Pressure Ball in Older Stroke Adults
This study aims to investigate the effectiveness of resistance swallowing rehabilitation using Chin Tuck Against Resistance (CTAR) exercises combined with an innovative swallowing pressure ball in improving swallowing function…
- Conditions
- Stroke, Dysphagia, Post-Stroke Dysphagia
- Trial name
- NCT07620210
- Testing
- Innovative Swallowing Pressure Measurement Ball Combined With CTAR Training, Conventional Swallowing Rehabilitation
- Where
- Taiwan
- Volunteers
- 132 people
- Sponsor
- Chimei Medical Center
Anderson-Fabry Disease
Functional Capacity in Anderson-Fabry Disease Patients
The goal of this observational study is to observe the relation between excercise parameters - assessed by CPET - and rest/stress hemodynamic parameters - assessed by echocardiogram and CMR - in patients with a genetic diagnosis…
- Trial name
- OPTIMA-FD (NCT06884358)
- Where
- 5 sites in Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Policlinico S. Donato
Mild Cognitive Impairment, Alzheimer Disease
Music Therapy for Patients With Alzheimer's Disease
This study is designed to assess the feasibility that individualized reminiscence-based virtual music therapy sessions can enhance autobiographical memory, mood, and cognition in patients with mild cognitive impairment (MCI) or…
- Trial name
- NCT05151562
- Testing
- Virtual Music Therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Johns Hopkins University
Parkinson Disease (PD)
Synthetic Vasomotion for Glymphatic Enhancement
The goal of this pilot clinical trial is to learn whether a week-long study combining controlled breathing procedures, intermittent exposure to a low-concentration carbon dioxide gas mixture, and noninvasive vagus nerve…
- Trial name
- NCT07814534
- Testing
- Active noninvasive vagus nerve stimulation, Active intermittent hypercapnia, Guided breathing
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Florida Institute for Human and Machine Cognition
Psychosis
Investigating the Effect of a Single-dose of Levetiracetam on Brain Function, Chemistry and Cognitive Performance in Psychosis Risk
Background Psychosis is a mental health condition that affects around 3 in 100 people in their lifetime. Most treatments for psychosis target a brain chemical called dopamine but they don't work for everyone and don't address…
- Trial name
- LEVHIPPRO (NCT06224530)
- Testing
- Levetiracetam
- Where
- United Kingdom
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- King's College London
CP
LIFT & PEDALS on Balance and Mobility in Children With CP
Children with cerebral palsy (CP) have impaired balance due to poor postural control and coordination, increasing fall risk and limiting daily activities.
- Trial name
- NCT06996028
- Testing
- Strengthening domain, Balance domain, Coordination domain, Gait domain, Lower extremity strengthening, Cardiorespiratory endurance
- Where
- Pakistan
- Volunteers
- 20 people
- Sponsor
- Riphah International University
Brain Tumor, Brain Cancer
A Study to Measure the Effect of Brain Stimulation on Hand Strength and Function in Patients With Brain Tumors
The neurosurgical standard of care for treating a patient with a tumor invading hand primary motor cortex (M1) includes performing a craniotomy with intraoperative direct electrical stimulation (DES) mapping and to resect as much…
- Conditions
- Brain Tumor, Brain Cancer, Motor Cortex; Lesion
- Trial name
- NCT05023434
- Testing
- Intraoperative Brain Simulation - Alternate Stimulation Parameters
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Cerebral Infarction Recovery, Rehabilitation Treatment
The Application of Kinesio Taping Technique in the Early Upper Limb Functional Activities Induction of Hemiplegic Patients After Stroke
1. To observe the inducing and promoting effect of kinesio taping technique on the recovery of upper limb function in early-stage stroke patients. 2.
- Conditions
- Cerebral Infarction Recovery, Rehabilitation Treatment, Upper Extremity Motor Function, Emg Biofeedback
- Trial name
- NCT06834750
- Testing
- Experimental Group
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Stroke
High-definition Transcranial Electrical Stimulation for Upper Extremity Rehabilitation
Upper limb hemiparesis is the most common sequelae in patients, severely impacting their independence and quality of life. Transcranial electrical stimulation (tCES) is a non-invasive and safe treatment, which uses a low direct…
- Trial name
- NCT06409143
- Testing
- HD-tES, UE rehabilitation, HD-tES (Bilateral)
- Where
- 3 sites in Taiwan
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Pituitary Adenoma
Use of [18F] Fluoroethyl-L-tyrosine PET/MRI for Identifying Small Functional Pituitary Adenomas
The purpose of this research is to evaluate the diagnostic role and clinical efficacy of investigational FET-PET/MRI in detecting MRI-occult primary or residual/recurrent functional pituitary adenomas (PAs) and its influence on…
- Trial name
- NCT07456878
- Testing
- FET-PET/MRI
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Mayo Clinic
Chronic Pain, Opioid Use
Neuroimaging of Opioid Phase (OPAL)
The purpose of this study is to compare activity in the brains of female adults with chronic pain and/or opioid use, and healthy female adults that may help to develop new and targeted treatments for adults with chronic pain and…
- Trial name
- OPAL (NCT05905419)
- Testing
- Opioid Phase
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Duke University
Social Isolation, SCD
The Effects of Social Isolation and Social Interaction on the Risk of Dementia Progression and Brain Function in SCD (Subjective Cognitive Decline, SCD)
The goal of this clinical trial is to learn about the effects of social isolation and social interaction on the risk of dementia progression and brain function in SCD 1.
- Conditions
- Social Isolation, SCD, Subjective Cognitive Decline, MCI
- Trial name
- NCT06335836
- Testing
- social isolation
- Where
- China
- Volunteers
- 209 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Functional Heartburn (FH), Reflux Hypersensitivity
Volume-Oriented Incentive Spirometry-Assisted Diaphragmatic Breathing Exercise for Functional Heartburn or Reflux Hypersensitivity
The goal of this pilot randomized controlled trial is to determine whether volume-oriented incentive spirometry-assisted diaphragmatic breathing exercise (VIS-assisted DBE) can improve reflux-related symptoms and health-related…
- Trial name
- VISDBE (NCT07706101)
- Testing
- Volume-Oriented Incentive Spirometry-Assisted Diaphragmatic Breathing Exercise, standard pharmacological treatment with lifestyle modification education
- Volunteers
- 82 people
- Sponsor
- Changhua Christian Hospital
Suit Therapy, Dual Task Exercises
Effectiveness of Suit Therapy With Dual Task Exercises on Gross Motor Functions and Walking in Children With Diplegic Cerebral Palsy
This study aims to investigate the effect of suit therapy combined with dual-task training on gross motor performance and walking abilities in children with diplegic cerebral palsy.
- Conditions
- Suit Therapy, Dual Task Exercises, Gross Motor Functions, Walking
- Trial name
- NCT07096531
- Testing
- Suit therapy, Suit therapy + Dual-task exercises
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Kafrelsheikh University
Cerebral Palsy, Prematurity
Best Practices Fo Early Diagnosis of Cerebral Palsy
In this research, the investigators are using an implementation science approach to enhance the uptake of a clinical practice guideline for earlier diagnosis of cerebral palsy (i.e.
- Trial name
- CP (NCT06537622)
- Testing
- Implementation group, Standard of care
- Where
- Canada
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Healthy
Multifocal HD-tDCS and Motor Function
The purpose of this study is to understand how the brain controls movement and how Non-invasive Brain Stimulation (NIBS) with a technique called High-density transcranial direct current stimulation (HD-tDCS) can alter brain…
- Trial name
- NCT06561165
- Testing
- Standard HD-tDCS intervention, Multifocal network targeted HD-tDCS intervention, Functional Magnetic Resonance Imaging (fMRI)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Michigan
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