Clinical trials: Brain Health Activities
Ebola Virus Disease, Marburg Virus Disease
Evaluation of Safety, Tolerability and Immune Responses of Ebola-S and Marburg Vaccines in Healthy Adults
Primary Objective: To evaluate the safety and tolerability of cAd3-EBO-S and cAd3 Marburg vaccines when administered Intramuscular (IM) at a dose of 1 x 10^11 particle units (PU) to healthy adults.
- Trial name
- NCT04723602
- Testing
- cAd3-Marburg, cAd3-EBO-S
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Albert B. Sabin Vaccine Institute
Cancer, Physical Activity
Mobile Weight Loss Intervention for Adolescent and Young Adult Cancer Survivors
The purpose of this study is to conduct a 6-month pilot randomized trial to determine the feasibility and acceptability of theory-based mobile weight loss interventions for survivors of adolescent and young adult cancer (AYAs).
- Conditions
- Cancer, Physical Activity, Cancer Survivorship, Mental Health
- Trial name
- AYAConnect (NCT06171945)
- Testing
- AYA Connect intervention, Positive Psychology (PP) intervention, Positive Psychology Plus (PP+) intervention
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Healthy, Cognitive Function 1, Social
Investigating Gains in Neurocognition in an Intervention Trial of Exercise
This randomized control trial will examine whether a 12 month monitored exercise intervention improves brain health in cognitively normal older adults.
- Trial name
- IGNITE (NCT02875301)
- Testing
- 150 Minutes Week, 225 Minutes Week, Stretch and Tone
- Where
- 5 sites in United States
- Volunteers
- 648 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Pelvic Girdle Pain, Chronic Pain
Exploring Central Sensitization in Pregnant Women
Pelvic Girdle Pain (PGP) is reported by 50% of pregnant women and up to 11 years after pregnancy, 10% of women have persistent and per definition chronic PGP.
- Trial name
- NCT05507853
- Where
- Sweden
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Caregivers
Life Enhancing Activities for Family Caregivers (LEAF 2.0)
The goal of the proposed intervention, called LEAF (Life Enhancing Activities for Family Caregivers) is to reduce burden and increase well-being in Alzheimer's Disease caregivers through the practice of positive emotion skills.
- Trial name
- NCT03610698
- Testing
- LEAF Positive Emotion Intervention, Emotion Reporting Control Condition
- Where
- United States
- Volunteers
- 386 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Caregiving Stress, Caregiver Burden
SAGE LEAF 2: An Online Program to Reduce Dementia Caregiver Burden
The goal of this clinical trial is to learn if the SAGE LEAF (Social Augmentation of self-Guided Electronic delivery of the Life Enhancing Activities for Family caregivers) online positive emotion skill-building program delivered…
- Trial name
- SAGE LEAF 2 (NCT06708182)
- Testing
- SAGE LEAF Positive Emotion Skills Course
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Stroke
Smart Trainer Arm Ergometry Exercise Training in Individuals Post-Stroke
The smart trainer ergometer is comprised of an ergometer with foot and hand pedals, and a visual display in front of the user that can show a variety of scenic pathways.
- Trial name
- NCT05410600
- Testing
- Arm ergometer smart trainer cycling program
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Alabama at Birmingham
Multiple Sclerosis
Exercise & Brain Health in MS
The purpose of this study is to learn more about multiple sclerosis (MS). The investigators are studying whether aerobic exercise is better than a stretching program at improving brain health in people with MS.
- Trial name
- NCT02263339
- Testing
- Aerobic Exercise, Stretching, Aerobic Exercise- Healthy Subjects
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Oregon Health and Science University
Healthy Aging
Virtual Reality Study - COVID-19 Protocol
The overarching goal of this pilot clinical trial is to use a novel virtual reality (VR)-based intervention that simultaneously engages physical and cognitive activity aimed at improving brain and cognitive outcomes in older…
- Trial name
- NRVR (NCT04678778)
- Testing
- Physical and Cognitive Activity
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Mild Dementia, Moderate Dementia
The Effects of a Park Visit Program on Individuals With Dementia and Their Caregivers
The overall goals of our project is to understand the effects of participating in park visits and nature-based activities for people living with dementia and their caregivers.
- Conditions
- Mild Dementia, Moderate Dementia, Alzheimer Disease
- Trial name
- NCT05527587
- Testing
- Nature Connections Intervention
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Stroke
ICF Activity and Participation Needs in Post-stroke Patients
Stroke is regarded as one of the leading causes of adult mortality and disability. Conventional rehabilitation programs for post-stroke patients focus on the augmentation of body functions.
- Trial name
- NCT05941078
- Testing
- ICF-based post-stroke rehabilitation program
- Where
- Hong Kong
- Volunteers
- 55 people
- Sponsor
- The Hong Kong Polytechnic University
Sedentary Lifestyle
Effects of a Bicycling Intervention on Cognitive Skills and Cardiovascular Health
Although exercise is known to delay cognitive decline and decrease our risk of Alzheimer's Disease, there is a lack of understanding of how exercise protects the aging brain.
- Trial name
- BIKE (NCT02453178)
- Testing
- Cycling
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Stroke
Exercise Intensity Matters in Stroke Rehabilitation
The main objective of this multi-site project is to compare the effects of 12 weeks of HIIT vs. MICT on brain plasticity. The effects of HIIT vs.
- Trial name
- NCT03614585
- Testing
- 12 weeks of High-intensity Interval Training, 12 weeks of Moderate-Intensity Continuous Training
- Where
- 2 sites in Canada
- Volunteers
- 80 people
- Sponsor
- McGill University
Dementia, Alzheimer Disease
Assessing a Novel Virtual Environment That Assists With Activities of Daily Living
This Phase 1 study looks at how a new videogame-based program can help residents and care partners prepare for ADLs in a fun way with minimal risk, potentially reducing escalating problems associated with ADL completions.
- Conditions
- Dementia, Alzheimer Disease, Neurodegenerative Diseases
- Trial name
- NCT05418296
- Testing
- A novel digital health device
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- mandy
Healthy Aging
Effect of Mindfulness on EEG Brain Activity for Cognitive and Psychological Well-being in the Elderly
As the worldwide population of older adults rapidly increases over the coming years, effective strategies are needed to help this population to maintain and enhance physical, cognitive, and psychological well-being.
- Trial name
- NCT05941143
- Testing
- mindfulness-based intervention
- Where
- Italy
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- IRCCS Centro San Giovanni di Dio Fatebenefratelli
Parkinson Disease
Randomized Trial to Test the "Coordinated Care for Health Promotion and Activities in Parkinson's Disease" Intervention in the VA
Health care benefits and services are received through the Veterans Health Administration (VHA), a component of the United States Department of Veterans Affairs.
- Trial name
- CHAPS (NCT01532986)
- Testing
- Coordinated care management for Parkinson's disease, Educational handout
- Where
- 5 sites in United States
- Volunteers
- 345 people
- Sponsor
- VA Office of Research and Development
Aging, Alzheimer Disease
Lifestyle for the BRAin Health - Nutrition and Exercise Training Intervention
Due to the increasing incidence of dementia and the lack of causal treatment, non-pharmacological interventions represent an attractive and effective therapeutic strategy of neurodegenerative diseases, such as Alzheimer's…
- Conditions
- Aging, Alzheimer Disease, Life Style, Healthy, Exercise
- Trial name
- LIBRA-NET (NCT06986096)
- Testing
- Aerobic-strength training and nutritional counseling, Cognitive training and stretching.
- Where
- Slovakia
- Volunteers
- 40 people
- Sponsor
- Slovak Academy of Sciences
Leukemia, Brain Tumor
Children and Adolescents With Leukemia, Brain Tumors, and Sarcomas
Aim of this study is to investigate the influence of social factors on participation and activity among children and adolescents aged 10-18 years with leukemia, brain tumors, and sarcomas.
- Conditions
- Leukemia, Brain Tumor, Sarcoma, Childhood Cancer
- Trial name
- SUPATEEN (NCT04101123)
- Testing
- Non-Interventional
- Where
- Germany
- Volunteers
- 68 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg