Clinical trials: Brain Health Activities
Mild Cognitive Impairment, Alzheimer's Disease
Passport to Brain Wellness in Sedentary Adults
Numerous modifiable lifestyle factors have been identified that may affect the risk of older adults developing mild cognitive impairment (MCI) and Alzheimer's disease (AD).
- Trial name
- NCT00979446
- Testing
- Guided, Self-directed
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- HealthPartners Institute
Health Personnel, Stress
Cereset Research for Performance Improvement in a Hospital Nursing Unit
The purpose of this study is to explore whether an implementation process composed of offering CR to staff in a single hospital nursing unit has any potential impact on unit-level quality measures post-implementation.
- Conditions
- Health Personnel, Stress, Anxiety, Insomnia
- Trial name
- NCT06378554
- Testing
- Cereset Research
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Dementia, Physical Activity
Co-design and Pilot Study in VR-based Physical Activity and Cognitive Training
Physical activity and reminiscence therapy alone have been studied with no clear effectiveness in Alzheimer's disease, but their combined intervention remains unknown.
- Conditions
- Dementia, Physical Activity, Reminiscence Therapy, Co-design
- Trial name
- NCT06982170
- Testing
- A physical activity and reminiscence therapy
- Where
- Hong Kong
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hong Kong University of Science and Technology
Parkinson Disease (PD), Parkinson's Disease
Real-world Patient Experiences With Inbrija®
Parkinson's disease can cause OFF episodes, when medication effects wear off and symptoms return, affecting movement, daily activities, comfort, and wellbeing.
- Conditions
- Parkinson Disease (PD), Parkinson's Disease, Off Episodes of Parkinson Disease
- Trial name
- INHALE-PD (NCT07797790)
- Testing
- Levodopa inhalation powder
- Where
- 2 sites in Austria
- Volunteers
- 120 people
- Sponsor
- Merz Therapeutics GmbH
Parkinson Disease
Telerehabilitation for Dysautonomia in Parkinson's Disease
People diagnosed with Parkinson's Disease (PD) exhibit a combination of motor and non-motor symptoms, with the latter posing challenges in terms of identification and management.
- Trial name
- PKT (NCT06017232)
- Testing
- Hybrid telerehabilitation program
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- Université de Sherbrooke
Cognitive Impairment
The Effect of Exercise on Cognition in Older Adults At-risk for Diabetes: A Feasibility Pilot Study
Older adults with type 2 diabetes experience cognitive decline and are at higher risk for developing dementia. Consequently, older adults at-risk for developing type 2 diabetes (based on body mass, glucose levels) are at higher…
- Trial name
- NCT03254381
- Testing
- Resistance Training, Balance and Tone Training
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Western University, Canada
Stroke
The Effectiveness of Occupation-based Bilateral Arm Training on Motor Functions and Activity Participation Among Stroke Survivors During Inpatient Rehabilitation.
People with stroke often experience limitations in motor functions and activity participation. Occupation-based bilateral upper limb training (OBBT) using occupations as meaningful daily activities, and as part of the therapy.
- Trial name
- NCT07164612
- Testing
- Occupation-Based Bilateral Upper Limb Training (OBBT), Conventional therapy group
- Where
- Qatar
- Volunteers
- 150 people
- Sponsor
- Hamad Medical Corporation
Postpartum
Effectiveness of a Smartphone App (PRIMI) to Promote Healthy Diet and Physical Activity After Pregnancy in Migrant Women
The PRIMI trial (Promoting Reproductive health In MIgrant women) is a randomized controlled trial evaluating the effectiveness of a smartphone app designed to promote a healthy diet, physical activity, and health literacy among…
- Trial name
- NCT06881277
- Testing
- Mobile phone based intervention
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Linkoeping University
Parkinson Disease
KEEP Intervention for People Newly Diagnosed With Parkinson's
Parkinson's Disease (PD) is a progressive neurological condition that affects movement, balance and cognition, resulting in loss of independence and compromised quality of life over the course of the condition.
- Trial name
- KEEP (NCT05253040)
- Testing
- KEEP Intervention, control
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Cambridge
Hypertension (HTN), Vascular Diseases
The BASIC-S Feasibility Study for Vascular Risk Reduction
Vascular risk factors drive stroke, heart disease, and dementia, but translating lifestyle guidelines into routine clinical care remains challenging.
- Conditions
- Hypertension (HTN), Vascular Diseases, Stroke, Dementia
- Trial name
- BASIC-S (NCT07755631)
- Testing
- BASIC-S Intervention, Standard / Usual Care
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Andrew Appleton
Stroke, Physical Disability
A Trial of a Client-centered Intervention Aiming to Improve Functioning in Daily Life After Stroke
This is a cluster randomized controlled trial in which client-centered rehabilitation of activities of daily living (CADL) will be compared to usual rehabilitation of activities of daily living (UADL) regarding participation in…
- Conditions
- Stroke, Physical Disability, Multiple Disability
- Trial name
- LAS-2 (NCT01417585)
- Testing
- Client-centered ADL intervention, Usual ADL intervention
- Where
- Sweden
- Volunteers
- 280 people
- Sponsor
- Karolinska Institutet
Brain Injury, Craniocerebral Trauma
PariS -TBI Study: Paris Severe Traumatic Brain Injury Study - 8 Years
The objective of the protocol is to pursue the long-term follow-up of a large cohort of severe traumatic brain injury patients. This outcome is to be described in terms of activity, participation, quality of life…
- Conditions
- Brain Injury, Craniocerebral Trauma, Trauma, Nervous System
- Trial name
- TCS8 (NCT02050633)
- Where
- France
- Volunteers
- 130 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cognitive Ability, General, Brain Health
Investigating the Combined Effects of Intermittent Hypoxia and Exercise on Cognitive and Cerebral Function in Middle-Aged Adults
This study investigates whether intermittent hypoxia (IH) and physical activity (PA), either alone or in combination (simultaneously or sequentially), can improve cognitive function and brain health in middle-aged adults (50-65…
- Conditions
- Cognitive Ability, General, Brain Health, Cerebral Oxygenation
- Trial name
- HYPOX-AGE (NCT06874387)
- Testing
- Hypoxia, intermittent, physical exercise
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Ayoub Boulares
Stroke
Effects of Aerobic Training Post-stroke
Physical activity level is an important determinant of quality of life in persons post-stroke. There is a lack of knowledge regarding the effects of aerobic training on physical activity levels in subjects post-stroke.
- Trial name
- NCT02798237
- Testing
- Aerobic treadmill training, Control (overground walking)
- Where
- Brazil
- Volunteers
- 22 people
- Sponsor
- Federal University of Minas Gerais
COPD, Tetrahydrobiopterin Deficiency
O2 Transport and Utilization in Health and Lung Disease
Skeletal muscle dysfunction is a frequent and clinically relevant systemic manifestation of Chronic Pulmonary Obstructive Disease (COPD), which is still poorly understood.
- Conditions
- COPD, Tetrahydrobiopterin Deficiency, Oxidative Stress
- Trial name
- NCT04014712
- Testing
- Tetrahydrobiopterin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Massachusetts, Amherst
Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD)
LETHE-AT: a Personalized Multidomain Lifestyle Intervention for Individuals at Increased Risk of Memory Impairment.
The goal of this clinical trial is to learn whether a hybrid multidomain lifestyle program can prevent cognitive decline and reduce dementia risk in community-dwelling adults in mid- to late life who are at increased risk of…
- Trial name
- LETHE-AT (NCT07376135)
- Testing
- A tailored hybrid multidomain lifestyle intervention group, Self-guided multimodal lifestyle advice group
- Where
- 3 sites in Austria
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Aging, Cognitive Ability, General
Influence of Fitness on Brain and Cognition
The purpose of this study is to examine the effect of aerobic fitness training on human cognition, brain structure, and brain function of older adults.
- Trial name
- NCT00438347
- Testing
- Aerobic Exercise, Stretching and toning
- Where
- 2 sites in United States
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Children, Adolescents
Exercise and Endocannabinoids for Brain and Mental Health
This study will explore how exercise affects brain chemicals called endocannabinoids, which may improve thinking skills and reduce feelings of stress, anxiety, and low mood in children and teens aged 9 to 17.
- Trial name
- EMBH (NCT06808490)
- Testing
- Moderate Intensity Exercise, Light Intensity Stretching, Seated Meditation
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Exercise, Gait
Rhythmically Entrained Exercise in Community-Dwelling Older Adults
Researchers at the University of North Carolina at Greensboro conduct a single-arm intervention trial to investigate the efficacy of a music-based group exercise program for community-dwelling older adults.
- Conditions
- Exercise, Gait, Cognitive Decline, Caregiver Burden
- Trial name
- REECO (NCT05462977)
- Testing
- Group exercise program
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Greensboro
Mild Cognitive Impairment, Dementia
Exercise and Activities for Independent Living With Mild Cognitive Impairment (MCI)
The purpose of this project is to evaluate an exercise and health promotion program for older adults with mild memory loss. The study will investigate the efficacy of a memory-enhanced exercise and health promotion program to…
- Trial name
- NCT00446394
- Testing
- Resources and Activities for Life Long Independence (RALLI), Social Walking program (SW)
- Where
- United States
- Volunteers
- 181 people
- Sponsor
- University of Washington