Clinical trials: Brain Imaging
Healthy Volunteer, Magnetic Resonance Imaging
Study of New Magnetic Resonance Imaging Methods of the Brain
The purpose of this investigation is to develop improved magnetic resonance imaging (MRI) techniques and hardware for studying brain function.
- Conditions
- Healthy Volunteer, Magnetic Resonance Imaging, Healthy, fMRI
- Trial name
- NCT00004577
- Where
- United States
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Traumatic Brain Injury, Aging Disorder
Carbon Dioxide Administration and Brain Waste Clearance
The current study tests whether different exposures to carbon dioxide (CO2) can safely result in the increased movement of proteins from the brain into the blood.
- Conditions
- Traumatic Brain Injury, Aging Disorder, Magnetic Resonance Imaging (MRI)
- Trial name
- COPETBI (NCT07357090)
- Testing
- Hypercapnia task performed during fMRI
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Andrew Mayer
Brain Imaging
A Pilot Study of a Portable Head-Only MRI Scanner
This is a pilot study to demonstrate human brain imaging with a new portable 0.7 Tesla (T) MRI brain scanner recently developed at the CMRR.
- Trial name
- NCT07444034
- Testing
- 0.7 T MRI
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Cleft Lip and/or Palate, Speech Disorder
Neural Changes After Speech Therapy in Patients With Cleft Palate: A Brain Imaging Study
Cleft palate is one of the most common maxillofacial congenital malformations, which results in severe speech disorders. Compensatory articulation disorder, also known as non-oral articulation disorder (NOA), is considered as the…
- Conditions
- Cleft Lip and/or Palate, Speech Disorder, Speech Therapy, Brain
- Trial name
- fMRI-Speech-CP (NCT07330687)
- Testing
- Structured Speech Training for Decompensation
- Where
- China
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Shufan Zhao
Cerebral Small Vessel Diseases, Cadasil
Taiwan Associated Genetic and Nongenetic Small Vessel Disease
The TAG-SVD enrolled patients with clinical and neuroimaging features of cerebral small vessel disease (CSVD). All enrolled patients will receive next-generation sequence (NGS) with probes designed to target five candidate CSVD…
- Conditions
- Cerebral Small Vessel Diseases, Cadasil, HTRA1-Related Autosomal Dominant Cerebral Angiopathy, COL4A1-Related Brain Small Vessel Disease With Haemorrhage
- Trial name
- TAG-SVD (NCT05473637)
- Testing
- MRI
- Where
- Taiwan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Healthy Volunteer, Traumatic Brain Injury
Estimating Brain Biomechanics Using MRI
Objective: In this study we will develop and apply imaging techniques to perform the first three-dimensional (3-D) measurements of brain biomechanics during mild head movement in healthy human subjects.
- Conditions
- Healthy Volunteer, Traumatic Brain Injury, Brain Mapping, Craniocerebral Trauma
- Trial name
- NCT01633268
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Brain Imaging
tFUS Imaging & LIFU
This study is investigating a new method of brain imaging - transcranial functional ultrasound (tFUS). We are comparing the imaging capabilities with functional magnetic resonance imaging (fMRI).
- Trial name
- NCT07222865
- Testing
- Feasibility of imaging using tFUS
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Chronic Non-Specific Low Back Pain, Cognitive Decline
The Impacts of Chronic Non-specific Low Back Pain on Cognitive Functions of Older Adults: A Longitudinal Study
Chronic non-specific low back pain (CNSLBP) is a common condition among older adults and has been associated with an increased risk of executive function impairment.
- Conditions
- Chronic Non-Specific Low Back Pain, Cognitive Decline, Longitudinal Study, Older Adults
- Trial name
- NCT07134699
- Testing
- Participants are not assigned an intervention
- Where
- Hong Kong
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Cortical Development Malformation, Multiparametric Magnetic Resonnance Imaging
Normative Brain Volume Profiles From Multicenter Fetal MRI
Fetal brain MRI is an essential diagnostic tool to inform parents about the prognosis of abnormalities detected on routine ultrasound.
- Conditions
- Cortical Development Malformation, Multiparametric Magnetic Resonnance Imaging, Brain Cortical Thickness, Prenatal Diagnosis
- Trial name
- MULTINORMFET (NCT06081036)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 1,423 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Alzheimer's Disease, Hippocampus
Using Neuroimaging to Early Diagnose Alzheimer's Disease Through Hippocampal Atrophy Assessment
This study aims to better understand Alzheimer's disease by looking at brain scans, specifically MRI images, to detect early signs of brain changes linked to the disease.
- Conditions
- Alzheimer's Disease, Hippocampus, Brain Atrophy, Magnetic Resonance Imaging
- Trial name
- NCT06965816
- Where
- France
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier de Saint-Denis
Brain Imaging, Whole Body Imaging
Improving PET Image Quality and Quantification by Using Motion Correction, Parametric Imaging and MAP Reconstruction
The purpose of this study is to assess the effectiveness of new software available on a new PET/CT scanner in the Molecular Imaging Research PET/CT Facility.
- Trial name
- NCT04417998
- Testing
- 18F-FDG, 18F-AV1451, Siemens E7 Reconstruction Tool
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Chronic Non-Specific Low Back Pain, Cognitive Decline
The Impacts of Chronic Non-specific Low Back Pain on Cognitive Functions of Older Adults
Chronic non-specific low back pain (CNSLBP) is a prevalent condition among older adult and has been associated with an increased risk of executive function impairment.
- Conditions
- Chronic Non-Specific Low Back Pain, Cognitive Decline, Cross-Sectional Study, Older Adults
- Trial name
- NCT06704425
- Testing
- For observational studies, participants are not assigned an intervention as part of the study.
- Where
- 3 sites in Hong Kong
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Development, Child, Executive Functions
Orchestra in Class, a Novel Booster for Executive Functions and Brain Development in Young Primary School Children
How to optimally stimulate the developing brain is still unclear. Executive functions (EF) exhibited substantially stronger far transfer effects in children who learned to play a musical instrument than in children who acquired…
- Conditions
- Development, Child, Executive Functions, Interventions, Music
- Trial name
- ORBIT (NCT05912270)
- Testing
- Orchestra in Class
- Where
- Switzerland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- School of Health Sciences Geneva
Brain Injuries, Traumatic, Biomarkers
Detecting Traumatic Intracranial Hemorrhage With Microwaves and Biomarkers
This study will evaluate if traumatic intracranial hemorrhage can be safely ruled out by using a microwave scanner (MD100) in conjunction with a combination of different brain biomarkers analyzed in serum.
- Conditions
- Brain Injuries, Traumatic, Biomarkers, Microwave Imaging
- Trial name
- MBI01 (NCT04666766)
- Testing
- Microwave scanning of the head
- Where
- Sweden
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Region Skane
Social Media, Mental Health Disorder
The Impact of Shallow Reading in Social Media
Social media is pervasively used in our life. There is a research hypothesis that the information in social media is "shallow" and the long-term use of it will cause readers' addiction, insomnia, and inability to pay attention…
- Conditions
- Social Media, Mental Health Disorder, Brain Imaging
- Trial name
- NCT05097807
- Testing
- smartphone related behaviors
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Seizure Disorder, Seizure Disorder, Post Traumatic
Neuroimaging Biomarker for Seizures
This multi-site study will examine patients with epilepsy (ES) following head injury [i.e., posttraumatic epilepsy (PTE)] and posttraumatic psychogenic Non-epileptic seizures (PNES) and will compare them to patients with…
- Conditions
- Seizure Disorder, Seizure Disorder, Post Traumatic, Traumatic Brain Injury, Non-Epileptic Seizure
- Trial name
- NIBMSZS (NCT03441867)
- Testing
- Cognitive Behavioral Therapy for Seizures, Standard Medical Care
- Where
- 3 sites in United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Providence VA Medical Center
Brain Injuries, Brain Edema
Non-contact DCS-Speckle Multi-parameter Imaging for Neurological Diseases
This study aims to evaluate brain injuries and brain edema with non-contact DCS-Speckle multi-parameter imager.
- Conditions
- Brain Injuries, Brain Edema, Optical Imaging
- Trial name
- NCT04623307
- Testing
- Non-contact DCS-Speckle multi-parameter imaging
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ting Li
Imaging of the Brain and Antipsychotics, Neuronal Network Changes
Acute D2 Receptor Blockade Induced Neuronal Network Changes in Human Volunteers
To detect the effect of second-generation antipsychotic drug on the neural activity.
- Trial name
- NCT01931059
- Testing
- Risperidone
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Northwell Health
CB1, Cannabinoid
PET Imaging of Cannabinoid CB1 Receptors Using [18F]FMPEP-d2
The purpose of this protocol is to measure brain CB1 receptors in the hope to better understand how they work, so that one day we can understand how the CB1 receptors are involved in psychiatric, neurological, and behavioral…
- Conditions
- CB1, Cannabinoid, PET, Brain Imaging
- Trial name
- NCT00598286
- Testing
- [18F]FMPEP-d2
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Cognition Disorder, Functional Brain Imaging
fMRI and NIRS Imaging for Traumatic Brain Injury
Background: The amount of blood flowing in brain areas goes up when those areas are being used for activities, such as movement or seeing.
- Trial name
- NCT01668758
- Volunteers
- healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)