Clinical trials: Brain Infarction
Cerebral Small Vessel Diseases, CADASIL (Diagnosis)
Establishment of a CSF Bank for the Development of Biomarkers of Smooth Muscle Cell (SMC) Damage in Monogenic Cerebral Small Vessel Disease
The main objective of this research is to obtain biological markers of smooth muscle cells dysfunction or degeneration in cerebral small vessel diseases.
- Trial name
- CSF-cSVD (NCT05793424)
- Testing
- Cerebrospinal fluid (CSF) sample and additional blood samples
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiovascular Disease, Dementia
Recombinant Herpes Zoster Vaccine for Prevention of Cardiovascular Events and Dementia
DAN-ZOSTER is a nationwide randomized study investigating whether vaccination against herpes zoster (shingles) can reduce the risk of cardiovascular disease and dementia in older adults.
- Trial name
- DAN-ZOSTER (NCT07485283)
- Testing
- Recombinant Herpes Zoster Vaccine (Shingrix)
- Where
- 2 sites in Denmark
- Volunteers
- 168,460 people, healthy volunteers welcome
- Sponsor
- Tor Biering-Sørensen
Stroke With Hemiparesis
Transfer of Grasp Control Across Hands After Stroke
The purpose of this study is to examine if the strong hand can assist in the recovery of muscle function in the weak hand after a stroke.
- Trial name
- NCT00589368
- Testing
- Transfer of grasp control across hands
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Atherosclerotic Cardiovascular Disease, Cardiovascular Diseases
Immunomodulatory Effects of PCSK9 Inhibition
Cardiovascular disease (CVD) represents the leading cause of death worldwide. While medications, such as statins, significantly reduce atherosclerotic CVD (ASCVD) risk by lowering low density lipoprotein levels, they may also…
- Conditions
- Atherosclerotic Cardiovascular Disease, Cardiovascular Diseases, Atherosclerosis, Arterial Inflammation
- Trial name
- INSPIRAR (NCT05720156)
- Testing
- 99mTc-tilmanocept SPECT/CT scanning
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Abdominal Aortic Aneurysm, Acute Myocardial Infarction
Body Mass Index and Initial Presentations of Cardiovascular Diseases
The association between obesity and cardiovascular disease (CVD) has mostly been studied using broad endpoints or have focused on cause-specific mortality.
- Conditions
- Abdominal Aortic Aneurysm, Acute Myocardial Infarction, Stroke, Heart Failure
- Trial name
- CALIBER (NCT01704300)
- Where
- United Kingdom
- Volunteers
- 2,240,000 people, healthy volunteers welcome
- Sponsor
- University College, London
Cardiovascular Disease
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of AZD3366 in Healthy Subjects, Japanese and Chinese Subjects
Part A of this study is a Phase 1, First-in-human (FiH), randomized, single-blind, placebo controlled study to assess the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of AZD3366 following single…
- Trial name
- NCT04588727
- Testing
- AZD3366, Ticagrelor, acetylsalicylic acid (ASA)
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Stroke, Atrial Fibrillation
Atrial Fibrillation and Premature Atrial Complexes in Patients With Ischemic Stroke.
The purpose of this study is to improve secondary prevention of ischemic stroke patients by 1. Estimating prevalence and the prognostic significance of frequent premature atrial complexes in ischemic stroke patients in relation…
- Conditions
- Stroke, Atrial Fibrillation, Premature Atrial Complexes
- Trial name
- Pacific (NCT02180542)
- Where
- Denmark
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
CADASIL
Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) Study
This is an observational study to better understand the risk factors and progression of CADASIL, a leading cause of vascular cognitive impairment and dementia (VCID).
- Trial name
- NCT05677880
- Testing
- Study Procedures
- Where
- 12 sites in United States
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Cadasil
CADASIL Registry Study
The aim of this study is to determine the clinical spectrum and natural progression of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) and related disorders in a prospective…
- Trial name
- NCT04310098
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Bin Cai
Traumatic Brain Injury, Cerebral Infarction
Characteristics of Blood- Brain Barrier Permeability in Neurological Patients
The main goal of the present study is to challenge the hypothesis that blood- brain barrier disruption following brain injury increases the risk for long-term disability, development of brain dysfunction, epileptic seizures and…
- Conditions
- Traumatic Brain Injury, Cerebral Infarction, Cerebral Hemorrhage
- Trial name
- NCT00419874
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
Thrombosis, Acute Coronary Syndrome
Safety, Pharmacokinetic and -Dynamic Study of PR-15, an Inhibitor of Platelet Adhesion
Primary objective: To evaluate safety and tolerability, adverse events (AEs), vital signs, ECG, bleeding time, evaluation of antibody titer and safety laboratory tests Secondary objectives: To evaluate the pharmacokinetics and…
- Conditions
- Thrombosis, Acute Coronary Syndrome, Myocardial Infarction, Stroke
- Trial name
- PR-15/01 (NCT01042964)
- Testing
- revacept (PR-15)
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- AdvanceCor GmbH
Death, Stroke
Postoperative Atrial Fibrillation and Long-term Survival
The aim of the investigators trial was to evaluate association between new onset postoperative atrial fibrillation (POAF) and late cardiovascular morbidity and mortality.
- Conditions
- Death, Stroke, Myocardial Infarction
- Trial name
- POAF (NCT02349269)
- Volunteers
- 519 people, healthy volunteers welcome
- Sponsor
- Kuopio University Hospital
Coronary Artery Disease
Eliminate Coronary Artery Disease
The purpose of this study is to determine whether pharmacologic lowering of low density lipoprotein cholesterol (LDL), initiated in healthy young to middle aged adults can eliminate or markedly reduce the composite endpoint of…
- Trial name
- ECAD (NCT02245087)
- Testing
- Atorvastatin
- Where
- 3 sites in Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Stroke, Not Specified as Hemorrhage or Infarction, Angina Pectoris
Clinical Study of Medicinal Product Cardionat® Using in Health Athlete Volunteers
The objective of this study is to evaluate the long-term plasma and urine pharmacokinetic parameters of Cardionat®, capsules 250 mg, when used in healthy athlete volunteers. The study consists of four steps: Step 1.
- Trial name
- NCT02758912
- Testing
- оral intake of study drug capsules; study drug - Cardionat ® (trimethylhydrazinium propionate dihydrate), oral capsules 250 mg
- Where
- Russia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Burnasyan Federal Medical Biophysical Center
Rehabilitation of Upper Limb Motor Function in Hemiplegia Due to Supratentorial Cerebral Infarction Using Armeo Power Robot
Effects of Armeo Power Robot Therapy on Upper Limb Recovery in Hemiplegic Stroke Patients
This study investigates the effectiveness of combining Armeo Power robotic therapy with conventional rehabilitation techniques to improve upper limb motor function in patients with hemiplegia caused by supratentorial cerebral…
- Trial name
- BV108/RAPPHCN (NCT06708065)
- Testing
- Armeo Power robot restores upper limb motor function., A Home Exercise Program, Occupational therapy activities
- Where
- Vietnam
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Hanoi Medical University
Silent Cerebral Infarct, Biomarkers / Blood
Biomarkers as Prognostic Factors of Silent, Cerebral Infarctions in Patients Undergoing High-thromboembolic-risk Transcatheter Interventions
Background: The transcatheter interventions with high thromboembolic risk, as transcatheter carotid angioplasty or transcatheter ablation of cardiac arrhythmias are associated with asymptomatic strokes- silent strokes.
- Conditions
- Silent Cerebral Infarct, Biomarkers / Blood, Cardiac Ablation, Cognitive Impairment
- Trial name
- PRINCESS (NCT07844850)
- Testing
- High-thromboembolic-risk transcatheter interventions
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Heart Diseases, Cardiovascular Diseases
Risk Factors in the Initial Presentation of Specific Cardiovascular Disease Syndromes
Cardiovascular disease (CVD) is an important public health problem that affects millions of people worldwide. Associations between risk factors, such as smoking, dyslipidaemia or hypertension, and prevalent CVD are well…
- Conditions
- Heart Diseases, Cardiovascular Diseases, Acute Myocardial Infarction, Unstable Angina
- Trial name
- NCT01804439
- Volunteers
- 2,240,000 people, healthy volunteers welcome
- Sponsor
- University College, London
CADASIL
Imaging Study of Neurovascular Coupling in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL)
The aim of this study is to investigate using fMRI methods, EEG and dedicated mathematical models, the potential alterations of neurovascular coupling in CADASIL.
- Trial name
- MACOUPLING-CAD (NCT02071784)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Dementia, Dementia Alzheimers
Acrylamide and Health Outcomes
Acrylamide, a widespread food-processing contaminant, poses a major public health concern due to its high exposure level in the general population and its toxicity.
- Conditions
- Dementia, Dementia Alzheimers, Parkinson Disease, Myocardial Infarction
- Trial name
- NCT06224725
- Testing
- dietary acrylamide exposure measured via biomarkers in blood (hemoglobin adducts of acrylamide and glycidamide)
- Where
- Sweden
- Volunteers
- 1,700 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Spatial Neglect, Stroke
Transcranial Stimulation (tDCS) and Prism Adaptation in Spatial Neglect Rehabilitation
The present study aims to compare the relative therapeutic efficacy of prism adaptation therapy combined with real versus sham tDCS.
- Conditions
- Spatial Neglect, Stroke, Cerebrovascular Disorders, Cerebral Infarction
- Trial name
- NCT02080286
- Testing
- Prism Adaptation, Anodal tDCS
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Oxford