Clinical trials: Brain Injured Patients
Traumatic Brain Injury
Is Sensory Stimulation Effective in Reducing Time Spent in a Coma or Vegetative State
A randomised control trial of patients who have a severe brain injury to determine if patients who receive a standardised sensory stimulation program emerge earlier from a vegetative state.
- Trial name
- NCT00163878
- Testing
- Sensory Stimulation, Sesnory Modality Assessment and Rehabilitation Technique
- Where
- 2 sites in Australia
- Sponsor
- Bayside Health
Brain Injury, Consciousness Disorders
Early Stepping Verticalization in ICU for ABI Patients
Verticalization was reported to improve the level of arousal and awareness in patients with severe acquired brain injury (ABI) and to be safe in ICU.
- Trial name
- NCT02828371
- Testing
- stepping verticalization, conventional mobilization
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Ospedale Generale Di Zona Moriggia-Pelascini
Brain Injuries
The NIPA Study Naloxegol Administration to Prevent Opioids Induced Gastrointestinal Motility Disturbance in Brain Injured PAtients
Impaired gastrointestinal transit (IGT) especially constipation, is common among patients under mechanical ventilation, occurring in up to 80 % of the patients during the first week, and has been associated with worse outcome in…
- Trial name
- NIPA (NCT05008926)
- Testing
- Naloxegol
- Where
- 10 sites in France
- Volunteers
- 370 people
- Sponsor
- University Hospital, Brest
Brain Injuries, Mechanical Ventilation
Patient-ventilator Asynchrony in Patients With Brain Injury
Mechanical ventilation is an important support strategy for critically ill patients. It could improve gas exchange, reduce the work of breathing, and improve patient comfort.
- Trial name
- NCT03212482
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Jian-Xin Zhou
Brain Injured Patients
Comparison of a New Automated Ventilatory Mode Named Intellivent to Standard Controlled Ventilation in Brain Injured Patients
Comparison of the ability of a new automated ventilatory mode named Intellibrain to maintain capnia and oxgen partial pressure within predefined ranges in comparison to the control of capnia and oxgen partial pressure obtained by…
- Trial name
- NCT01695603
- Testing
- Intellivent
- Where
- Switzerland
- Volunteers
- 23 people
- Sponsor
- Prof. Philippe Jolliet
Disorders of Consciousness, Severe Brain Injury
Transcranial Temporal Interference Stimulation In Severely Brain Injured Patients With Disorders of Consciousness
The purpose of this academic lead study is to explore the effect of noninvasive neuromodulation of the CM-pf via tTIS for patients with disorders of consciousness.
- Conditions
- Disorders of Consciousness, Severe Brain Injury, Unresponsive Wakefulness Syndrome, Minimally Conscious State
- Trial name
- NCT06851156
- Testing
- tTIS
- Where
- 2 sites in China
- Volunteers
- 10 people
- Sponsor
- Xijing Hospital
Moderate to Severe Traumatic Brain Injury
Continuous Hyperosomolar Therapy for Traumatic Brain-injured Patients
Traumatic brain injury (TBI) is a major cause of death and severe prolonged disability. Intracranial hypertension (ICH) is a critical risk factor of bad outcomes after TBI.
- Trial name
- COBI (NCT03143751)
- Testing
- NaCl20% (Continuous hyperosmolar therapy)
- Where
- 10 sites in France
- Volunteers
- 370 people
- Sponsor
- Nantes University Hospital
Traumatic Brain Injury, Coma
Optimized Therapy in Severe Traumatic Brain Injured Patients
Severe traumatic brain injury is associated with life-threatening and incapacitating secondary injury. Contemporary therapeutic interventions are aimed at preventing and treating secondary damage.
- Trial name
- NCT02130674
- Testing
- Dipeptiven
- Where
- Switzerland
- Volunteers
- 12 people
- Sponsor
- University of Zurich
Brain Injury, Vascular, Hemorrhagic Stroke
Development and Validation of a Structured Tele-rehabilitation Programme of Brain Injured Patients
The goal of this research project is to develop a tele-rehabilitation programme, which will constitute an original care pathway for brain damaged patients.
- Conditions
- Brain Injury, Vascular, Hemorrhagic Stroke, Ischemic Stroke
- Trial name
- TELERE (NCT06016374)
- Testing
- telerehabilitation
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Brain Injury Traumatic Severe, Disorder of Consciousness
Five-day 20-minute 10-Hz tACS in Patients With a Disorder of Consciousness
This study first aims to validate the feasibility of a multimodal 5-day 20-minute tACS protocol in subacute brain-injured patients with a disorder of consciousness during their ICU stay, and conduct a clinical pilot study…
- Conditions
- Brain Injury Traumatic Severe, Disorder of Consciousness, Brain Injuries
- Trial name
- NCT05833568
- Testing
- Active Transcranial alternative current stimulation
- Volunteers
- 138 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Brain Lesion, Head Trauma
Feasibility Study of Cortical Recording Depolarizations in Brain-injured Patients, and Their Use as Biomarkers of New Lesions.
The progression of brain lesions after severe head trauma or subarachnoid hemorrhage results from extra cranial aggression which is well controlled in intensive care and intracranial aggression which is less well known and…
- Conditions
- Brain Lesion, Head Trauma, Subarachnoid Hemorrhage
- Trial name
- SD-ICU (NCT04585503)
- Testing
- Electrode implantation
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Stress Disorder, Post-traumatic
Sensory Stimulation Program Delivered by Family Members of Brain-injured Patients in Critical Care: Effect on Relatives' Post-traumatic Stress
Severe traumatic brain injuries are common and can lead to major long-term disability. Patients with severe brain injury often require admission to critical care.
- Trial name
- StimulSensRea (NCT07456384)
- Testing
- Standardized family-delivered neurosensory stimulation protocol
- Where
- France
- Volunteers
- 200 people
- Sponsor
- CHU de Reims
Traumatic Brain Injury
Music Therapy for Comatose Brain Injured Patients
The goal of this single-arm observational study is to determine whether alpha music therapy, initiated early in the recovery period, can improve cognitive function for severe traumatic brain injury patients when compared to…
- Trial name
- NCT07544602
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- Mercy Health Ohio
Acute Brain Injury
Rate of Postpyloric Migration of Spiral Nasojejunal Tubes in Brain Injured Patients
The success rate of unguided nasojejunal feeding tube insertion will be determined in acute brain injured patients. Factors influencing tube self-progression will be evaluated.
- Trial name
- NCT00562146
- Testing
- placement of spiral nasojejunal tube
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Capital Medical University
Intensive Care, Brain Injuries
Use of Critical-Care Pain Observation Tool and Bispectral Index for Detection of Pain in Brain Injured Patients
Brain injured patients are at high risk of pain due to the illness itself and a variety of nociceptive procedures in intensive care unit.
- Trial name
- NCT03368326
- Testing
- Critical-Care Pain Observation Tool (CPOT)
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Capital Medical University
Traumatic Brain Injury
Exercise, Hypoxia and CPC in TBI Patients
Circulating progenitor cells (CPC) treatments may have great potential for the recovery of neurons and brain function. Our group has reported how exposure to intermittent hypobaric hypoxia with superficial muscle…
- Trial name
- TCECAM (NCT02083445)
- Testing
- cognitive activities, Exercise program, Muscle electro-stimulation
- Where
- Spain
- Volunteers
- 21 people
- Sponsor
- University of Barcelona
Disorder of Consciousness
Treating Severe Brain-injured Patients With Apomorphine
Background: Patients who survive severe brain injury may develop chronic disorders of consciousness. Treating these patients to improve recovery is extremely challenging because of scarce and inefficient therapeutical options.
- Trial name
- NCT03623828
- Testing
- Apomorphine Hydrochloride 50Mg/10mL Prefilled Syringe
- Where
- 2 sites in Belgium
- Volunteers
- 8 people
- Sponsor
- University of Liege
Brain Injured Patients
Validation of a Physiological Based Pharmacokinetic Model by the Study of Paracetamol Distribution in the Brain Compartments in Brain Injured Patients
Brain is composed of several anatomical compartments separated by physiological barriers allowing the maintenance of homeostasis.
- Trial name
- NCT03223506
- Testing
- Paracetamol
- Where
- France
- Volunteers
- 17 people
- Sponsor
- Poitiers University Hospital
Spinal Cord Injuries, Injury, Brain, Traumatic
Incidence of Neurogenic Paraosteoarthropathies in a Population of Brain Traumatized and Spinal Cord Injured Patients and Specific Markers of Early NPOA Development"
Neurogenic paraosteoarthropathies are peri-articular bone formations that may occur as a result of central neurological injury. Their occurrence limits reeducation and recovery capacities.
- Trial name
- BENTHOS (NCT04273347)
- Testing
- standard of care for patient with brain trauma and spinal cord injury
- Volunteers
- 118 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Traumatic Brain Injury
Becoming Traumatic Brain Injured Patients at Day 7 of Their Trauma
To study the future of traumatic brain injured patients at day 7 of their trauma Primary endpoint: Fate, classified as survival with or without sequelae, death.
- Trial name
- NCT04077268
- Testing
- GOS-E
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Poitiers University Hospital