Clinical trials: Brain Injuries, Traumatic
Stress Disorders, Post-Traumatic
Brain Structure and Function Before and After Treatment for Post-Traumatic Stress Disorder
This study, conducted at the University of Pennsylvania and at the National Institutes of Health in Bethesda, Maryland, will examine deficits in brain structure and function in people exposed to trauma who developed…
- Trial name
- NCT00069225
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Mild Traumatic Brain Injury (mTBI), Brain Injury
A Feasibility Study in Combat Athletes With Mild Traumatic Brain Injury
The use of Hyberbaric Oxygen Therapy (HBOT) would be a new treatment plan rather than conventional rest. If effective, this new use technology would add to the clinical treatment among mild traumatic brain injury (mTBI) patients.
- Conditions
- Mild Traumatic Brain Injury (mTBI), Brain Injury, Concussion
- Trial name
- NCT06901310
- Testing
- Hyberbaric Oxygen Therapy
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Michael Harl
Traumatic Brain Injury
Amyloid Accumulation After Mild Traumatic Brain Injury
There will be 200 participants, who aged 30 years or older with TBI in 1,5,10,15 years ago and GCS=13-15 will be recruited. Another group of 200 participants with the same age and gender and without TBI will be recruited as the…
- Trial name
- NCT01871610
- Testing
- [18F]AV-45 PET amyloid binding imaging
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
REM Sleep Behavior Disorder, Concussion, Brain
The COSP-RBD Study: Concussions and Contact Sports in RBD vs Controls
The goal of this observational study is to investigate concussions and contact sports practices in REM sleep behaviour disorder (RBD).
- Trial name
- COSP-RBD (NCT06270290)
- Testing
- Exposure to contact sports or history of concussions
- Where
- United Kingdom
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Concussion, Mild, Post-Concussion Symptoms
Bright Light Therapy for Treatment of Sleep Problems Following Mild Traumatic Brain Injury
The purpose of the research study is to understand the effectiveness of a six-week course of light exposure on cognitive functioning, mood, activity, and sleep in people that have suffered a head injury leading to a concussion.
- Conditions
- Concussion, Mild, Post-Concussion Symptoms, Sleep Problems
- Trial name
- NCT02374918
- Testing
- mTBI wavelength-1 bright light, mTBI wavelength-2 bright light, HC wavelength-1 bright light
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Brain Injuries, Traumatic
Safety Study of NNZ-2566 in Healthy Female Subjects
The purpose of this study is to obtain evidence of the safety of NNZ-2566 in healthy female volunteers and to determine the pharmacokinetics (PK) of NNZ-2566 in healthy female volunteers.
- Trial name
- NCT00961779
- Testing
- NNZ-2566
- Where
- Australia
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Neuren Pharmaceuticals Limited
Mild Traumatic Brain Injury
The Use of the VOMS Tool With Military Personnel to Track mTBI Recovery and RTD Status
The purpose of the proposed project is to determine if the VOMS is an effective screening tool to identify and track recovery of vestibular and ocular motor impairment and symptoms following mTBI, that corpsman-level medical…
- Trial name
- NCT02634944
- Testing
- Vestibular Ocular Motor Screening Tool (VOMS)
- Where
- United States
- Volunteers
- 452 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Traumatic Brain Injury, Brain Injury
The Effects of Mindfulness Based Stress Reduction on Patients With Traumatic Brain Injury
This study is studying the effects of Mindfulness Based Stress Reduction (MBSR), a standard protocol of gentle yoga and breath meditation, on patients with Traumatic Brain Injury (TBI).
- Conditions
- Traumatic Brain Injury, Brain Injury, Stress
- Trial name
- NCT01613872
- Testing
- Mindfulness Based Stress Reduction
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
Brain Injuries, Brain Diseases
Influence of Physical Exercise on Cognitive Functioning of Traumatic Brain Injury Patients
The aim of this study is to determine the effects of an acute session of physical exercise on cognitive functioning and humor of traumatic brain injury patients and to investigate whether different cognitive responses can be…
- Conditions
- Brain Injuries, Brain Diseases, Central Nervous System Diseases, Craniocerebral Trauma
- Trial name
- NCT01395472
- Testing
- Acute Physical Exercise, Stretching protocol
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Mild Concussion, Post Concussion Syndrome
Clinical Evaluation of a Novel Balance, Vestibular and Oculomotor Assessment Tool
The iDETECT (Integrated Display Enhanced Testing for Concussion and mild traumatic brain injury) system is a novel portable, open access platform that enables immediate and rapid assessment of multimodal neurologic function.
- Conditions
- Mild Concussion, Post Concussion Syndrome, Vestibular Neuritis
- Trial name
- NCT02171312
- Testing
- iDETECT Assessment, Routine Balance and Vestibular Testing
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Emory University
Head Trauma, Cognitive Manifestations
Prevention of Head Impacts in Football: The HuTT Technique
The purpose of the study is to determine the effectiveness of the helmet-less tackling training (the HuTT Technique) intervention to reduce head impacts in high school football players and to gain an understanding of the…
- Trial name
- HuTT (NCT02519478)
- Testing
- Helmetless Tackling Training (HuTT)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of New Hampshire
Military Family, Brain Injuries, Traumatic
Effects of PSTon Mental Health Outcomes in Caregivers of Post-9/11 Combat Veterans With a Traumatic Brain Injury
The primary aim of this study is to assess the efficacy of PST for positively impacting distressed military family caregiver's depression and burden levels (secondary outcomes), ultimately enhancing their mental health quality of…
- Trial name
- NCT03211884
- Testing
- Problem-Solving Thearpy
- Where
- United States
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Duquesne University
Traumatic Brain Injury
Predicting Cognitive and Emotional Health From Neurocircuitry Following TBI
Abnormalities in structural and functional connectivity between brain regions have been suggested as putative biomarkers of mild traumatic brain injury (TBI) and significant contributors to neuropsychological functioning and…
- Trial name
- NCT01803048
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Traumatic Brain Injury
Application of Circulating Extracellular Vesicles in Early Disease Assessment and Prognosis After Traumatic Brain Injury
The purpose of this study was to observe the relationship between the changes of circulating extracellular vesicles and disease development and outcome in patients with traumatic brain injury, and to find early serum markers and…
- Trial name
- NCT05279599
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Pediatric Traumatic Brain Injury
Extradural Hematoma in Pediatrics After Acute Head Injury: Surgical and Clinical Outcome
Acute extradural hematoma (EDH) is a potentially life-threatening neurosurgical emergency in children, commonly resulting from traumatic head injury.
- Trial name
- NCT07696598
- Testing
- evacuation of hematoma
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sohag University
Traumatic Brain Injury
Evaluation of Mild TBI in Collegiate Athletes
The purpose of this study is to evaluate blood-based biomarkers before and after sports-induced concussion using neuroimaging and head impact sensor technology.
- Trial name
- AWARE (NCT02189525)
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Banyan Biomarkers, Inc
Healthy, Traumatic Brain Injury
Investigating Event-Related Potentials and Eye-Tracking Measures in Hockey Players
Traumatic brain injury (TBI) is a health issue impacting athletes and no clinical treatment protocol, other than rest, is yet established.
- Trial name
- NCT03975023
- Testing
- NeuroCatch Platform (NCP)
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Frederick Carrick, PhD, FACCN
Pressure Injuries, Spinal Cord Injuries (SCI)
Electrical Stimulation for Clinical and Psychosocial Outcomes in Chronic Pressure Injuries
Pressure injuries are chronic wounds that frequently occur in immobilized patients and are associated with delayed healing, reduced quality of life, and significant psychological burden.
- Conditions
- Pressure Injuries, Spinal Cord Injuries (SCI), Traumatic Brain Injury
- Trial name
- NCT07493889
- Testing
- High-Voltage Monophasic Pulsed Current Electrical Stimulation, Standard Wound Care
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Concussion, Brain
Neurocognitive Dysfunction After Anesthesia in Patients With Recent Concussion
Researchers are trying to determine if the impact of a concussion on the brain is affected by anesthesia and surgery.
- Trial name
- NCT03952208
- Testing
- Neurocognitive Testing
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Post Traumatic Stress Disorder, Traumatic Brain Injury
Non-invasive Nerve Stimulation for PTSD and Sleep
In this study, our objective is to determine the effect of two different nerve stimulation types in changing sleep architecture.
- Trial name
- NCT03170440
- Testing
- Transcutaneous nerve stimulation location 1
- Where
- 3 sites in United States
- Volunteers
- 221 people, healthy volunteers welcome
- Sponsor
- University of Florida