Clinical trials: Brain Injuries
Traumatic Brain Injury, Multiple Sclerosis
Measuring Cerebral Blood Flow Using Pseudo-continuous Arterial Spin Labeling Perfusion Magnetic Resonance Imaging
This study will test a new MRI sequence that measures cerebral blood flow (CBF). Because this technique for measuring CBF is new, there is little information on what the normal values for different regions of the brain should be.
- Conditions
- Traumatic Brain Injury, Multiple Sclerosis, Alzheimer's Disease, Tumor
- Trial name
- NCT02767609
- Testing
- Magnetic Resonance Imaging
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Eye-tracking
EYE-TRAC Advance: Technology Verification (ETA-TV) Cohort 2
This is a prospective multi-center cohort feasibility and exploratory study.
- Trial name
- ETA-TV (NCT02877732)
- Testing
- EYE-SYNC eye-tracking, SCAT-3 subtests, DEM
- Where
- 4 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Stanford University
Coma
Beneficial Effects of Music on Cognition and Consciousness Level
Exposure to music improves cognitive function in 'healthy' participants and in brain-damaged patients. However, it is still difficult to understand what precisely in music causes a positive effect : are they emotional components…
- Trial name
- MUSICOREVEIL (NCT02742506)
- Testing
- Electroencephalography (EEG)
- Where
- France
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Neurologic Diseases, Hemiparesis
NuroSleeve Powered Brace & Stimulation System to Restore Arm Function
The purpose of this study is to investigate if a person with weakness or paralysis in one or both arms, can use the NuroSleeve combined powered arm brace (orthosis) and muscle stimulation system to help restore movement in one…
- Conditions
- Neurologic Diseases, Hemiparesis, Quadriplegia, Muscular Dystrophies
- Trial name
- NCT04798378
- Testing
- Neurosleeve
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Orthostatic Hypotension, Spinal Cord Injuries
A Study of Blood Pressure and Blood Supply to the Brain in Persons With a Spinal Cord Injury.
The purpose of this study is to determine how blood pressure and blood flow are controlled during head-up tilt in a semi-upright position.
- Trial name
- NCT00248807
- Testing
- 1.25 mg enalaprilat IV, Head up tilt (HUT)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Cerebral Palsy
The Follow Study of Speech Functions in Preschool Children With Cerebral Palsy: Clinical Measures and Acoustic Analysis
The aims of this study: 1. to investigate the difference in motor speech functions among children with cerebral palsy (CP) of different motor severities. 2.
- Trial name
- NCT02378987
- Where
- Taiwan
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Infant, Premature, Brain Injuries
Structural Brain Abnormalities in Children Born Prematurely: New Detection Methods and Clinical-Pathological Correlates
The purpose of the study is to detect structural brain changes using MRI and to correlate these findings with neurodevelopmental assessments in two-year old children previously enrolled in the NIH sponsored trial of inhaled…
- Trial name
- NCT00153855
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Wheelchair Users, Caregivers
New Rear Anti-tip Device for Manual Wheelchairs: Subjective Input (RAD-SI)
The objective of this study is to obtain subjective input from wheelchair service providers and end-users about their experiences with conventional rear anti-tip devices (C-RADs) of manual wheelchairs and the potential usefulness…
- Conditions
- Wheelchair Users, Caregivers, Wheelchair Service Providers, Amputation
- Trial name
- RAD-SI (NCT06831240)
- Testing
- Local wheelchair service provider questionnaires, Global wheelchair service provider questionnaires, End-users questionnaires
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Spinal Cord Injuries
Patient Self-managed BCI-FES
This study aims to assess the feasibility of therapist-caregiver-patient training to use BCI and FES technology with a view to the inexpensive equipment eventually being used for home use by tetraplegic patients as a continuing…
- Trial name
- NCT03257982
- Testing
- BCI-FES hand therapy
- Where
- United Kingdom
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- NHS Greater Glasgow and Clyde
Lower Limb Amputation Below Knee (Injury)
Human-Prosthetic Interaction: Brain & Technology After Lower-Limb Loss
This study evaluates brain neuroplasticity and functional performance in people with unilateral lower limb amputation.
- Trial name
- HumanIT (NCT05818410)
- Testing
- Prosthetic device (Lunaris), No prosthetic device, Prosthetic device (Sach foot)
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Heart Failure, Cardiomyopathies
Multimodal Physiologic State Intelligence Study
The OMNIPHYS study will investigate whether multimodal ultrasound and other routinely collected clinical and physiologic data can be combined with artificial intelligence to characterize changes in a person's physiologic state…
- Conditions
- Heart Failure, Cardiomyopathies, Pulmonary Hypertension, Myocarditis; Acute or Subacute
- Trial name
- OMNIPHYS (NCT07814118)
- Testing
- OMNIPHYS Multimodal Ultrasound Imaging System
- Where
- United States
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
Trauma, Brain
Caregiver Wellness After Traumatic Brain Injury (CG-WELL): An Intervention Designed to Promote Well-being in Caregivers of Acute Moderate to Severe Traumatic Brain Injuries
After injury, survivors of msTBI depend on informal family caregivers. Upwards of 77% of family caregivers experience poor outcomes, such as adverse life changes, poor health related quality of life, and increased depressive…
- Trial name
- CG-Well (NCT05307640)
- Testing
- CG-Well, Information Support & Referral (ISR)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Natalie Kreitzer
Post Concussion Syndrome, Head Injury
Evaluation of Two Treatments for Chronic Post Concussion Syndrome
This study is designed to investigate factors that are associated with prolonged recovery from mild head injury. The investigators are particularly interested in defining the impact of anxiety related variables, such as health…
- Trial name
- NCT00871884
- Testing
- Psychoeducation, Relaxation Training, Interoceptive Exposure
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Simon Fraser University
Chronic Stroke, Cerebral Palsy
Gondola Mechanism of Action
This study will investigate the clinical, functional and neurophysiological effects of automated mechanical peripheral stimulation (AMPS) via the Gondola device administered to patients with chronic stroke, cerebral palsy and…
- Conditions
- Chronic Stroke, Cerebral Palsy, Parkinson's Disease
- Trial name
- NCT05146648
- Testing
- Gondola AMPS
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Stroke, Spinal Cord Injuries
The Study of a Neural Interface and a Neurostimulation in the Rehabilitation of Upper Limb Movement Impairments.
The aim of the study is to investigate the effectiveness of a new rehabilitation technology for paralysis that occurs after stroke or spinal cord injury.
- Trial name
- NCT05115149
- Testing
- VIBRAINT RehUp robotic orthosis, tSCS during the exercise, tSCS prior to the exercise
- Where
- 6 sites in Russia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Skolkovo Institute of Science and Technology
Cerebral Palsy
Optimizing Assisted Communication Devices for Children With Motor Impairments Using a Model of Information Rate and Channel Capacity
For children who depend on devices to communicate, the rate of communication is a primary determinant of success. For children with motor impairments, the rate of communication may be limited by inability to contact buttons or…
- Trial name
- NCT00352326
- Testing
- reprogramming assisted communication device interface
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Cerebral Palsy (CP), Survey
A Survey of Turkish Pediatric Physical Therapists
CP encompasses a group of persistent disorders of movement and posture development resulting from injury to the developing brain.
- Conditions
- Cerebral Palsy (CP), Survey, Detection, Pediatric Physiotherapy
- Trial name
- NCT07180017
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Cerebral Palsy, Spastic Cerebral Palsy
Operant Conditioning of the Soleus Stretch Reflex in Adults With Cerebral Palsy
12 adults with spastic CP will complete 6 baseline sessions and 24 down conditioning sessions held 3 times/week. All clinical and physiological assessments collected at baseline will be reassessed after study completion, and…
- Trial name
- SRC-CP (NCT05571033)
- Testing
- Spinal reflex conditioning
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Burke Medical Research Institute
Spinal Cord Injury Cervical, Stroke
BoMI for Muscle Control
People with spinal cord injury (SCI), stroke and other neurodegenerative disorders can follow two pathways for regaining independence and quality of life. One is through clinical interventions, including therapeutic exercises.
- Trial name
- NCT04641793
- Testing
- Motion and Emg Control
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Gulf War Illness, Persian Gulf Syndrome
Exercise in Gulf War Illness (GWI)
The purpose of this study is to determine if submaximal exercise by bicycle stress tests with pulmonary measurement of VO2MAX plus maximal isometric hand grips on 2 consecutive days causes a higher level of "exertional…
- Trial name
- NCT01291758
- Testing
- Submaximal bicycle exercise stress tests performed 24 hr apart
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Georgetown University
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