Clinical trials: Brain Injuries
Brain Trauma
Plasma Neurofilament Light and Its Relationship With Omega-3 Status and Soccer Heading in Women Soccer Players
The purpose of this study is to (1) assess how a competitive season of purposeful gameplay soccer heading in collegiate women soccer players is related to a blood biomarker for sports-related brain injury, plasma neurofilament…
- Trial name
- NCT05457023
- Testing
- Plasma Neurofilament Light (NF-L), Omega-3 Index, HeadCount Questionnaire
- Where
- 2 sites in United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Brain Trauma
Magnetic Resonance (MR) Spectroscopy and Diffusion Tensor Imaging in Determining Brain Injury and Subsequent Clinical Outcome in Patients of Moderate Brain Trauma
The purpose of this study is to use magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI) to assess for traumatic brain injury and determine if there is any correlation of these findings to clinical outcome.
- Trial name
- NCT00760903
- Testing
- Conventional MRI of the brain, MR spectroscopy (MRS), MR Diffusion Tensor Imaging (DTI)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Michigan
Dementia, Traumatic Brain Injury
Improving Family Quality of Life Through Training to Reduce Care-Resistant Behaviors by People With AD and TBI
To reduce care resistant behaviors (CRB) among people with dementia residing in nursing homes, to a distance-learning education, training, and coaching program for family caregivers of people with dementia or TBI; assess the…
- Trial name
- NCT03734289
- Testing
- Caregiver Coaching
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Cerebral Palsy, Sensation Disorders
Upper Extremity Sensation and Function in Children With Cerebral Palsy
This cross-sectional study was designed to evaluate upper extremity sensation in children with spastic cerebral palsy and to investigate its effect on upper extremity use in activities of daily living.
- Conditions
- Cerebral Palsy, Sensation Disorders, Upper Extremity Dysfunction
- Trial name
- NCT07352735
- Testing
- Vibration Sense Assessment, Stereognosis, Tactile Sense
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Traumatic Brain Injury
Emotional Processing Intervention for Children With TBI
Investigating an emotional processing program, that is modified for use with children, is effective for children with a traumatic brain injury (TBI).
- Trial name
- NCT04826068
- Testing
- Emotional Processing
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Pediatric ALL, Concussion, Mild
Concussion Active Rehabilitation
In this study, the investigator plans a randomized trial of active rehabilitation and standard care for acute concussion management.
- Conditions
- Pediatric ALL, Concussion, Mild, Concussion, Brain, Concussion, Intermediate
- Trial name
- NCT04248218
- Testing
- Active Rehabilitation Group/Case
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Surgical Site Infection, Brain Tumor
Infection Prevention Bundle in Brain Tumor Surgery
This study aimed to evaluate the effectiveness of an infection prevention bundle on surgical site infections in patients undergone brain tumor surgery.
- Trial name
- NCT04285697
- Testing
- infection prevention bundle
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Traumatic Brain Injury, Penetrating Head Injury
Vietnam Head Injury Study - Phase III
The Vietnam Head Injury Study (VHIS)-Phase III is a prospective, long-term follow-up study of head-injured Vietnam veterans. The purpose of this research study is to determine the long-term consequences, if any, of head injury.
- Conditions
- Traumatic Brain Injury, Penetrating Head Injury, Closed Head Trauma
- Trial name
- NCT00132249
- Where
- United States
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Chorioamnionitis, Cerebral Palsy
Early Identification of Brain Insult in Chorioamnionitis
Premature breaking of the amniotic fluids during pregnancy caries high risk for infection of the amniotic fluid. One of the results of chorioamnionitis is brain injury of the fetus.
- Trial name
- NCT01778725
- Where
- Israel
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Cerebral Palsy, Neck Disorder
Improving Neck Control in Children With Cerebral Palsy Using Robotics
The goal of this study is to characterize the head-neck motion of children with cerebral palsy and investigate how robotics can be used to improve the head-neck coordination of these children. Aim 1 is a cross-sectional study.
- Trial name
- NCT06533293
- Testing
- Neck Brace Device
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Columbia University
Traumatic Brain Injury
Comparison of Brain Network Activation (BNA™) Analysis, Clinical Symptoms and Neuro-cognitive Performance in Concussed Children and Young Adults
The use of Event Related Potentials (ERP) and neurocognitive performance in patients following concussion has been examined previously in small cohorts and relatively long after concussion occurred.
- Trial name
- NCT01532271
- Where
- United States
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- ElMindA Ltd
Traumatic Brain Injury (TBI)
A First in Human Study of the Safety, Tolerability and Pharmacokinetics of PRV-002 in Healthy Volunteers
The purpose of this study is to assess the safety, tolerability, and pharmacokinetics of different dose levels of PRV-002 in Health Volunteers
- Trial name
- NCT05033444
- Testing
- PRV-002
- Where
- Australia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Odyssey Group International, Inc.
Stress Disorder, Post Traumatic
Benefits of Relaxation by Music Therapy on PTSD Symptoms
PTSD is a debilitating mental disorder that may develop after experiencing or witnessing a life-threatening event. With appropriate care, treatment efficiency is variable and around 20% of the patients do not respond to…
- Trial name
- TRACER (NCT03990064)
- Testing
- musicotherapy
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche Biomedicale des Armees
Brain Injury
Assessment and Rehabilitation of Central Sensory Impairments for Balance in mTBI
Our central hypothesis is that chronic balance deficits after mild traumatic brain injury (mTBI) result from impairments in central sensorimotor integration (CSMI) that may be helped by rehabilitation.
- Trial name
- NCT02748109
- Testing
- Vestibular Rehabilitation + audio biofeedback, Vestibular Rehabilitation
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Central Nervous System Disease, Cerebrovascular Accident
Brain Processing of Language Meanings
This research trial will study discourse processing-that is, how the brain processes the meaning of language. It will examine, for example, how words and sentences are interpreted in cases where more than one meaning is possible.
- Conditions
- Central Nervous System Disease, Cerebrovascular Accident, Craniocerebral Trauma, Head Injury
- Trial name
- NCT00005004
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Traumatic Chronic Encephalopathy
Cerebral and Cognitive Impact of Professional Soccer Practice
The objective of this study is to evaluate, using MRI, the microstructural consequences and the onset of any cognitive impairment in professional soccer players at the end of their career, who have experienced repeated minor head…
- Trial name
- TC-FOOT (NCT04903015)
- Testing
- MRI
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Brain Injuries, Traumatic
Brain Injury Biomarkers in the General Population
The purpose of this study is to use an investigational assay to assess levels of putative biomarkers of traumatic brain injury (TBI) in a general population.
- Trial name
- NCT01786460
- Testing
- Blood draw at Days 0, 7, 14, and 21
- Where
- 5 sites in United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Banyan Biomarkers, Inc
Hypoxic-Ischemic Encephalopathy
A Study of a Blood Marker in Newborns With Brain Injury Caused by Lack of Oxygen at Birth
Perinatal asphyxia is a significant health problem with an incidence of 1 to 8 per 1,000 live births and can lead to serious morbidity and mortality during the neonatal period.
- Trial name
- NCT07292220
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mustafa Gürkan
Psychoses
Brain Cell Injury in Patients With A First Episode of Psychosis
Patients experiencing a first episode of psychosis may have brain cell damage due to a chemical process called oxidation. This study will compare patients with psychosis to healthy volunteers to determine if there are differences…
- Trial name
- NCT00070889
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Concussion, Mild
Brain Dynamics in Response to Jugular Vein Compression
Clinical trials have suggested that this device is effective in mitigating changes in brain structure and function in athlete populations.
- Trial name
- NCT03236389
- Testing
- Q Collar
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
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