Clinical trials: Brain Injuries
Healthy, Traumatic Brain Injury
Investigating Event-Related Potentials and Eye-Tracking Measures in Hockey Players
Traumatic brain injury (TBI) is a health issue impacting athletes and no clinical treatment protocol, other than rest, is yet established.
- Trial name
- NCT03975023
- Testing
- NeuroCatch Platform (NCP)
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Frederick Carrick, PhD, FACCN
Cerebral Palsy, Chronic Pain
Anatomical and Functional Imaging Correlates of Chronic Pain in Cerebral Palsy
The investigators hope to use MRI biomarkers to identify and characterize sensorimotor network disruption patterns associated with chronic pain and sensory deficits in CP.
- Trial name
- NCT05197946
- Testing
- MRI
- Where
- 4 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Traumatic Brain Injury
Evaluation of VA's Traumatic Brain Injury (TBI) Clinical Reminder and Comprehensive TBI Evaluation (CTBIE)
The purpose of the proposed study is to determine the clinical validity and reliability of the VA's Traumatic Brain Injury (TBI) Clinical Reminder Screen and the Comprehensive TBI Evaluation used to screen for mild traumatic…
- Trial name
- TBI (NCT00852527)
- Where
- 3 sites in United States
- Volunteers
- 456 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Brain Injury
Neural Bases of Cognitive Rehabilitation for Brain Injury
Some of the most common and disabling consequences of brain injury are deficits in cognition, such as difficulty with sustained attention, memory, organization, and goal management.
- Trial name
- NCT01120756
- Testing
- Goal-oriented attentional self-regulation, Brain Health Education
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Brain Injuries, Traumatic, Traumatic Brain Injury
Proteomics of Brain Trauma-associated Elevated Intracranial Pressure (ICP)
The specific aim of this research is to determine if the blood from brain-injured patients contains reproducible protein markers that appear prior to elevations in intracranial pressure (ICP).
- Trial name
- Proteomics (NCT00178659)
- Testing
- Blood/saliva samples for protein/molecular analysis
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Brain Injury
MIND (Management of Traumatic Brain Injury Diagnosis)
Procure blood specimens from individuals presenting to the emergency department with suspected brain injury.
- Trial name
- MIND (NCT02262286)
- Where
- Germany
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- Abbott Diagnostics Division
Mild Traumatic Brain Injury
SSVEP Evaluation of Brain Function (PRO)
The investigational device used in this clinical investigation, the Nurochek PRO System (NCPRO), is a portable electroencephalogram (EEG) headset which delivers a visual stimulus and measures a VEP.
- Trial name
- NCT06013566
- Testing
- SSVEP
- Where
- Australia
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Headsafe MFG
Cerebral Palsy
Development of Kinect-assisted Home-based Bilateral Arm Training Program for Cerebral Palsy
The purpose of the present study is to develop a long term cost-effectiveness (efficient protocol, playful context, and practical strategy) training program for school-age children with Cerebral Palsy.
- Trial name
- NCT02801279
- Testing
- Conventional bilateral arm training, Kinect-based bilateral arm training
- Where
- Taiwan
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Traumatic Brain Injury
Treatment of Citalopram for Anxiety Disorders Following a Traumatic Brain Injury
The proposal will assess the effectiveness of SRI treatment of anxiety following TBI. We hypothesize that participants will report significantly fewer and less severe anxiety symptoms after a 12-week course of citalopram than…
- Trial name
- NCT00208572
- Testing
- Citalopram
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Medical Center
Rehabilitation, Working Memory
The Neural Substrates for Working Memory Training
This study aims to conduct a contrast study on the characteristics of functional and structural connectivity of neural networks of working memory in patients with acquired brain injury versus normal controls, using resting-state…
- Trial name
- WMT (NCT03012269)
- Testing
- Working memory training
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- China Rehabilitation Research Center
Brain Injury, Chronic
Investigating the Role of the Premotor Cortex in Higher Cognitive Functions
This project aims at understanding better the role of the frontal lobe of the brain in our capacity to perceive visual information consciously, and also, in our capacity to perceive others' actions.
- Trial name
- NCT00842413
- Where
- France
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Traumatic Brain Injury
Assessment of Noninvasive Neuromodulation in a Group of Traumatic Brain Injured Patients and Healthy Volunteers
Background: Severe traumatic brain injury, particularly diffuse axonal injury (DAI), often leads to lasting neurological issues.
- Trial name
- NCT07373366
- Testing
- Subjects in the intervention group receive low-frequency radioelectric therapy
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Traumas, Brain, Alzheimer Disease
The COACH Project: Combined Online Assistance for Caregiver Health
This study evaluates the effect of a physical exercise + caregiver skills training on feelings of burden, mood, and biological markers of inflammation in persons who provide care for Veterans with a TBI or dementia.
- Conditions
- Traumas, Brain, Alzheimer Disease, Dementia, Head Injury
- Trial name
- COACH (NCT03123224)
- Testing
- Combined Aerobic and Resistance Exercise + Caregiver Skills Training, Stretching Balance and Flexibility + Caregiver Skills Training
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Palo Alto Veterans Institute for Research
Multiple Sclerosis, Stroke
An Assistive Powered Wheelchair: Stage 2 Trial
Preliminary evaluation of an obstacle alerting system to enhance the user's independent mobility by improving their confidence to drive and their safety in driving a powered wheelchair.
- Conditions
- Multiple Sclerosis, Stroke, Cystic Fibrosis, Motor Neurone Disease
- Trial name
- EDUCAT (NCT05292690)
- Testing
- Powered Wheelchair Obstacle Alerting System
- Where
- United Kingdom
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- East Kent Hospitals University NHS Foundation Trust
Spastic Diplegic Cerebral Palsy, Hemiplegic Cerebral Palsy
Strength Training in Children With Spastic Diplegic and Hemiplegic Cerebral Palsy Receiving Botulinum Toxin
To estimate the effectiveness of strength training after administration of botulinum toxin in children with spastic diplegic cerebral palsy and hemiplegic cerebral palsy on muscle volume and gross motor function.
- Trial name
- NCT04177186
- Testing
- Strength training, Strength training with botulinum toxin
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Asir John Samuel
Injury Brain, Eye Abnormalities
Reading Problems Associated With Central Nervous System (CNS) Pathologies.
This project aims to analyse eye movements, their alterations and influence in reading performance in patients with acquired CNS diseases and compare them with people of the same age, without neurological or ocular pathology and…
- Conditions
- Injury Brain, Eye Abnormalities, Multiple Sclerosis, Parkinson Disease
- Trial name
- NCT04937725
- Testing
- eye tracking
- Where
- Spain
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA
Head Trauma, Cognitive Manifestations
Prevention of Head Impacts in Football: The HuTT Technique
The purpose of the study is to determine the effectiveness of the helmet-less tackling training (the HuTT Technique) intervention to reduce head impacts in high school football players and to gain an understanding of the…
- Trial name
- HuTT (NCT02519478)
- Testing
- Helmetless Tackling Training (HuTT)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of New Hampshire
Child Development, Upper Motor Neurone Lesion
Validity and Reliability of the PROprioception Measurement Tool (PROMT)
This project assesses the feasibility, reliability, and validity of the PROMT in children with a UMN lesion. The study questions are: is the newly developed PROMT a feasible, reliable, and valid tool to assess lower limb…
- Conditions
- Child Development, Upper Motor Neurone Lesion, Cerebral Palsy, Proprioceptive Disorders
- Trial name
- PROMT (NCT05405881)
- Testing
- Proprioception measurement tool
- Where
- Switzerland
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital, Zurich
Spinal Cord Injury, Stroke
Investigating Techniques to Enhance the Sense of Embodiment in Immersive Virtual Reality
Embodiment is an important aspect of virtual reality because it affects how natural and engaging the experience feels and can influence performance and learning in VR-based applications, including rehabilitation [McAnally \&…
- Conditions
- Spinal Cord Injury, Stroke, Healthy
- Trial name
- NCT07870044
- Testing
- Immersive Virtual Reality Embodiment Manipulations
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Transient Hypothyroxinemia of Prematurity (THOP)
Study of Thyroid Hormones in Prematures
The investigators hypothesize that continuous infusion of 4 µg/Kg/day T4 with 30 µg/Kg/day oral potassium iodide (KI) for 42 days from birth will reduce by 30% or more (from an estimated 30% to 21%) the proportion of extremely…
- Trial name
- THOP2 (NCT02103998)
- Testing
- thryoid hormone T4 + oral potassium iodide (KI) for 42 days, D5W - 5% dextrose water
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- New York Medical College
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