Clinical trials: Brain Injuries
Traumatic Brain Injury
Neural Basis of Decision-Making Deficits in Traumatic Brain Injury
Background: People with a traumatic brain injury (TBI) can have trouble making the best possible decisions. Researchers want to learn more about the parts of the brain that control decision making.
- Trial name
- NCT02169310
- Testing
- tDCS, [11C] Raclopride
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Vascular Cognitive Impairment
Study on Early Brain Injury Mechanism and Comprehensive Intervention of VCI
Alzheimer's disease (AD) and vascular dementia (VaD) are the most common forms of senile dementia. Although the animal research of dementia has made remarkable progress, clinical trials of drugs for AD pathology have failed in…
- Trial name
- NCT04999813
- Testing
- Comprehensive intensive intervention
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Zhongnan Hospital
Spinal Cord Injuries, Stroke
Muscle-tendon Interaction in the Spastic Sural Triceps During Gait
This project aims to study the mechanical behavior of the muscle-tendon unit (MTU) of the gastrocnemius medialis (GM) and the Achilles tendon (AT) in post-stroke and spinal cord injured (SCI) patients compared to a healthy…
- Trial name
- GEcho (NCT06474117)
- Testing
- Gait analysis coupled with ultrasound, Isokinetic dynamometer with simultaneous ultrasound
- Where
- France
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Brain Injury, Chronic
Investigating the Role of the Premotor Cortex in Higher Cognitive Functions
This project aims at understanding better the role of the frontal lobe of the brain in our capacity to perceive visual information consciously, and also, in our capacity to perceive others' actions.
- Trial name
- NCT00842413
- Where
- France
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
OCD, Major Depressive Disorder (MDD)
Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics
This is an observational study which does NOT directly administer a psychedelic substance but rather recruits participants who are already participating in another clinical trial in which they may receive a serotonergic…
- Conditions
- OCD, Major Depressive Disorder (MDD), Alcohol Use Disorder (AUD), Healthy Volunteer
- Trial name
- NCT06624137
- Testing
- Serotonergic Psychedelic
- Where
- 2 sites in United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Yale University
Mild Traumatic Brain Injury
Treatment Optimization of Brain-injured Warfighters
Prescribed sub-symptomatic adaptable exercise treatment (SAET) is a potential solution that promotes recovery needs following a TBI.
- Trial name
- (TOBI-SET) (NCT06561100)
- Testing
- Sub-symptomatic Adaptable Exercise Treatment (SAET), Stretching Control Group (SCG)
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Psychological Outcomes, Quality of Life
Acceptance and Commitment Therapy for Parenting Children With Cerebral Palsy
The goal of this randomized controlled trial is to evaluate whether a group-based acceptance and commitment therapy (ACT) can improve the psychological outcomes and quality of life (QOL) of children with cerebral palsy.
- Trial name
- NCT07814911
- Testing
- ACT intervention, Usual/standard control
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Cerebral Palsy
Igniting Mobility in Adolescents and Young Adults With Cerebral Palsy
The study design will consist of a cohort of adolescents and young adults with cerebral palsy (CP) that will undergo a gait training protocol.
- Trial name
- NCT04360395
- Testing
- Gait Therapy
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Father Flanagan's Boys' Home
Knowledge, Attitudes, Practice
Nighttime Postural Care: Caregiver Training Program and Outcome Measure Feasibility
This experimental study investigated the feasibility of a sleep care positioning training protocol by comparing two educational interventions using a randomized control design.
- Trial name
- NCT04787081
- Testing
- Sleep Care Positioning Training Program GRP1, Sleep Care Positioning Training Program GRP2
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- St. Catherine University
Convergence Insufficiency, Traumatic Brain Injury
Eye Recovery Automation for Post Injury Dysfunction (iRAPID)
This study will test a portable virtual reality (VR) system with integrated eye tracking called Virtual Eye Rotation Vision Exercises (VERVE). The proposed VERVE platform will deliver vergence therapy in an automated manner.
- Conditions
- Convergence Insufficiency, Traumatic Brain Injury, Concussion, Mild
- Trial name
- iRAPID (NCT06105892)
- Testing
- Virtual Eye Rotation Vision Exercise (VERVE)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- New Jersey Institute of Technology
Cerebral Palsy
Biomechanical Properties and Their Association With Balance and Functional Mobility in Children With Cerebral Palsy
This study aimed to investigate the differences in the biomechanical properties of the dorsal trunk and lower extremity muscles of children with unilateral spastic cerebral palsy compared with their typically developing peers…
- Trial name
- NCT05818839
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ilke KARA
Cerebral Palsy, Hemiplegia
Immersive Virtual Reality for Visuo-motor Integration Skill Assessment
A significant deficit affecting nearly half of children with hemiplegia is visual-motor integration, or eye-hand coordination. Children have difficulties integrating visual and motor information to effectively plan and execute…
- Trial name
- NCT04612049
- Testing
- Immersive virtual reality visuo-motor skill assessment
- Where
- 3 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Northeastern University
Shaken Baby Syndrome, Crying
Effects of PURPLE Cry Intervention
The proposed study is designed to investigate whether the PURPLE Crying program attains efficacy by optimizing the neural response in the anterior insula, and augmenting activity in regions of the brain known to be important for…
- Conditions
- Shaken Baby Syndrome, Crying, Trauma
- Trial name
- NCT02227979
- Testing
- The Purple Cry Intervention, Control Intervention
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Emory University
Brain Concussion, Knowledge, Attitudes, Practice
Comparing Concussion Education Types
The purpose of this study is to determine if there are differences in knowledge, self-efficacy, and empathy surrounding concussions, as well as intent to report a concussion, after viewing concussion education (CrashCourse and…
- Trial name
- NCT05836662
- Testing
- CrashCourse Concussion Education in Virtual Reality
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Piya Sorcar
Cerebral Palsy Infantile
BIOchemical, DEnsitometric, TEChnological and Imaging Tools to Evaluate the Bone/muscle in Children with Cerebral Palsy
Cerebral palsy (CP) is the most common chronic disability in childhood, burden by motor, sensation, cognition, feeding and communication impairment.
- Trial name
- BIODETECT_CP (NCT06672731)
- Testing
- REMS: Radiofrequency Echographic Multi Spectrometry
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- IRCCS Fondazione Stella Maris
Brain Damage, Chronic
The Effect of tDCS on Subcortical Brain Functioning
This research is being done to determine whether transcranial direct current stimulation (tDCS) can improve certain abilities related to cognition, emotion and/or physical functioning in individuals with subcortical brain damage.
- Trial name
- NCT01602276
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cerebral Palsy, Spasticity
Spinal Cord Stimulation for Children With Cerebral Palsy
The goal of this clinical trial is to help understand spinal cord excitability in children with cerebral palsy compared to neurologically typical children.
- Trial name
- NCT07516067
- Testing
- Transcutaneous Spinal Cord Stimulation (tSCS)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Martin Piazza
Mother of a Child With Cerebral Palsy
Effect of Vagus Nerve Stimulation and Breathing Exercise on the Autonomic Nervous System
This project will compare the effects of intraaural vagus nerve stimulation and deep breathing exercises on the autonomic nervous system in mothers of children with cerebral palsy.
- Trial name
- NCT06970769
- Testing
- Vagus nerve stimulation, Deep Breathing Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Atlas University
Cerebral Palsy, Dental Diseases
Salivary Cytokine Profile as a Biomarker for Dental Pain
always reliable.Pain is an important diagnostic tool in dentistry. The type of treatment, extent of treatment and, sometimes, even the decision on whether to treat or not is dependent on the pain history obtained from the…
- Trial name
- NCT03471195
- Testing
- Total Salivary Cytokine profile
- Where
- Saudi Arabia
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Riyadh Colleges of Dentistry and Pharmacy
Cerebral Palsy (CP), Typically Developing Children
Interaction Between Spasticity and the Initial Response After Balance Perturbations in Children With Spastic Cerebral Palsy
The aim of this study was to investigate the link between spasticity and the initial response after standing balance perturbations in children with spastic cerebral palsy.
- Trial name
- NCT07616193
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
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