Clinical trials: Brain Injuries
Brain Injuries
Acceptance and Commitment Therapy (ACT) and Carers
Background: Research has extensively documented the adverse impact that caring for an individual with an acquired brain injury can have including financial difficulties, social isolation, family tension and conflict, relationship…
- Trial name
- NCT02584101
- Testing
- ACT, Enhanced Treatment as Usual
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Traumatic Brain Injury, Concussion, Mild
Rapid Biochemical Diagnostics of Traumatic Brain Injury
The objective of the study is to confirm the clinical relevance of the novel biomarker for traumatic brain injury (TBI) detection.
- Conditions
- Traumatic Brain Injury, Concussion, Mild, Bone Fracture
- Trial name
- NCT03306563
- Testing
- Sample collection
- Where
- 3 sites in Finland
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Medicortex Finland Oy
Cerebral Palsy
Quantifying Energetic Demands of Walking for People With Cerebral Palsy
The purpose of this study is to examine the underlying mechanisms that contribute to high energy costs for people with cerebral palsy (CP) as they walk.
- Trial name
- NCT04303078
- Testing
- Varying levels of harness support during walking
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Washington
PTSD, Trauma
PPG Project 3 - PET/MRI of the Brain-hematopoiesis-atherosclerosis Axis in PTSD Patients
Project 3 of the PPG grant "Stress and Atherosclerotic Plaque Macrophages A Systems Biology Approach," funded by the NHLBI, examines the relationship between psychosocial stress and atherosclerotic inflammation, cell…
- Conditions
- PTSD, Trauma, Healthy
- Trial name
- NCT03279393
- Testing
- fluorodeoxyglucose (FDG)-PET/MRI
- Where
- 2 sites in United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Zahi Fayad
Skull Fractures, Stroke
Simulation Training in Emergency Department Imaging 2
Background and study aims: Computerised Tomography (CT) head scans are frequently requested by Emergency Department (ED) clinicians as one of the investigations for their patients.
- Conditions
- Skull Fractures, Stroke, Intracranial Bleed, Brain Tumor
- Trial name
- STEDI2 (NCT05427838)
- Testing
- Online training
- Where
- 6 sites in United Kingdom
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Oxford University Hospitals NHS Trust
Cerebral Palsy, Muscle Hypertonia
Hypertonia in Patients With Cerebral Palsy
This study will classify types of hypertonia in patients with cerebral palsy and determine if the classifications are reasonable in relation to the functional task of walking. Hypertonia is an abnormal increase in muscle tension.
- Trial name
- NCT00123708
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Stroke, Parkinson Disease
Wearable Airbag Technology to Mitigate Falls in Individuals With High Fall Risk
The purpose of this study is to evaluate the feasibility and efficacy of a smart airbag system that detects and mitigates fall-related impact in individuals with high fall risk.
- Conditions
- Stroke, Parkinson Disease, Lower Limb Amputation Knee, Fall Injury
- Trial name
- NCT05076565
- Testing
- Airbag Belt Fall Protection System
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Cerebral Palsy, Hemiparesis
Whole Body Vibration Versus Functional Strength Training On Balance In Children With Hemiparetic Cerebral Palsy
The study will be directed to compare which of whole body vibration (WBV) training and Functional strength training (FST) has better effect on balance in children with hemiparesis
- Trial name
- NCT05936554
- Testing
- whole body vibration, Functional strength training
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Amany Ibrahim AbdElhamed Sabra
Cerebral Palsy, Bilateral Cerebral Palsy
Stepping to Understand Lower Limb Impairments in Bilateral Cerebral Palsy
The purpose of this study is to investigate lower limb impairments in children with bilateral cerebral palsy during stepping tasks.
- Conditions
- Cerebral Palsy, Bilateral Cerebral Palsy, Diplegic Cerebral Palsy
- Trial name
- NCT04957277
- Testing
- load modulation
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Cerebral Palsy, Brachial Plexus; Injury, Newborn
Multi-modal Neuroimaging in Children With Cerebral Palsy or Brachial Plexus Birth Palsy
The main goal of this study is to identify abnormal functional and anatomical brain reorganization associated with hand, foot, and shoulder function in children (0-18 years old) with cerebral palsy (CP) due to periventricular…
- Trial name
- NCT03712072
- Testing
- Magnetoencephalography (MEG), Electroencephalography (EEG), Transcranial Magnetic Stimulation (TMS)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Infant, Newborn, Infant, Low Birth Weight
In Utero Magnesium Sulfate Exposure: Effects on Extremely-Low-Birth-Weight Infants
This study examined the effect of magnesium sulfate (MgSO4) exposure on adverse outcome in extremely low birth weight (ELBW) infants.
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- MgSO4 (NCT01203501)
- Where
- 15 sites in United States
- Volunteers
- 1,339 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Acquired Brain Injury (Including Stroke)
Stimulus Equivalence Learning in Acquired Brain Injury.
Stimulus Equivalence Learning (SEL) is a form of learning in which stimuli (such as words, pictures, or sounds) become linked to one another in memory, even though this specific connection has not been directly taught.
- Trial name
- NCT07345481
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Klimmendaal Revalidatiespecialisten
Unilateral Cerebral Palsy
Multi Sensory Stimulation And Priming (MuSSAP) in Infants at Risk of Unilateral Cerebral Palsy
A pilot randomized clinical trial exploring the effect of a Multi Sensory Stimulation And Priming (MuSSAP) training on improving manual ability in infants at risk of developing unilateral Cerebral Palsy.
- Trial name
- MuSSAP (NCT05533476)
- Testing
- Multi Sensory Stimulation and Priming, Intensive Usual Care (Upper Limb)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Sint Maartenskliniek
Vascular System Injuries, Concussion, Brain
Sildenafil Treatment for Mild TBI
About 300,000 people are hospitalized for traumatic brain injury (TBI) each year. After TBI, secondary brain injury escalates due in part to heightened levels of oxidant injury, inflammation, and vascular injury.
- Conditions
- Vascular System Injuries, Concussion, Brain, Post-Concussion Syndrome
- Trial name
- NCT03598140
- Testing
- Sildenafil Citrate
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Fatigue Symptom, Fatigue Intensity
Monitoring Fatigue In Daily Life In Adults With Cerebral Palsy or Acquired Brain Injury
The goal of this observational study is to learn about levels and patterns of fatigue in adults with cerebral palsy (CP) and acquired brain injury (ABI) in daily life.
- Conditions
- Fatigue Symptom, Fatigue Intensity, Cerebral Palsy (CP), Acquired Brain Injury Including Stroke
- Trial name
- NCT07135791
- Testing
- Real-time monitoring
- Where
- Denmark
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Spinal Cord Injury
Magnetic Resonance Imaging of Cognitive Deficits in the Brain of Individuals With Spinal Cord Injury
In the case of spinal cord injury, rehabilitation is particularly focused on motor skills. Non-motor impairments such as thinking difficulties did not receive a lot of attention to date.
- Trial name
- SCI_Cog (NCT06309888)
- Where
- Switzerland
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Swiss Paraplegic Research, Nottwil
Spastic Paresis, Stroke
GOAT (Gait Observation of Achilles Tendon)
The purpose of this study is to evaluate the mechanical properties of the Achilles tendon (stiffness, length, volume) and the force production capacities of the gastrocnemius medialis muscle in patients with spastic paresis…
- Conditions
- Spastic Paresis, Stroke, Spinal Cord Injury
- Trial name
- GOAT (NCT07467382)
- Testing
- 3D Gait Analysis, Ultrasound, Dynamometry
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Heart Arrest, Hypothermia
Histones and Free-plasma DNA After Cardiac Arrest
To evaluate the significance of free-plasma deoxyribonucleic acid (DNA) and plasma histones in cardiac arrest patients.
- Conditions
- Heart Arrest, Hypothermia, Post Cardiac Arrest Syndrome
- Trial name
- NCT02733146
- Testing
- cardiac arrest
- Where
- Denmark
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Carpal Tunnel Syndrome
Effects of Cerebral & Peripheral Electrical Stimulation on Pain and Function in CTS
This is a randomized, double-blind, multi-center, factorial clinical trial to study the effectiveness of cerebral and peripheral electrical stimulation on pain and functional limitations associated with carpal tunnel syndrome…
- Trial name
- DCS-ENS-CTS (NCT04092088)
- Testing
- tDCS-r, TENS-r, tDCS-s
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Suez Canal University
Concussion, Mild, Neurocognitive Dysfunction
Biomarker Levels as A Predictor of Concussion Severity OUTcomes (BlacOut)
The overall research aim of this pilot study is to determine if the structural brain protein calpain-cleaved αII-spectrin N-terminal fragment (SNTF) can be used as a blood biomarker to accurately identify patients who will have…
- Trial name
- BlacOut (NCT02992327)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- HealthPartners Institute
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