Clinical trials: Brain Injury, Acute
Brain Injuries, Acute, Respiration, Artificial
Brain Recovery With Automated VEntilation
Thus far, the closed-loop ventilation mode INTELLiVENT-ASV has been extensively tested in various groups of critically ill patients, and has been shown to be effective and safe in various groups of ventilated patients, including…
- Conditions
- Brain Injuries, Acute, Respiration, Artificial, Automation
- Trial name
- BRAVE (NCT06367816)
- Testing
- INTELLiVENT, Conventional ventilation
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Genova
Post-Cardiac Arrest Syndrome
The Effect of IABP Early Insertion on Mortality in Post Cardiac Arrest Patients With Acute Coronary Syndrome
The prevalence of cardiac arrests is still high worldwide. Despite the return of spontaneous circulation (ROSC), mortality and morbidity in post cardiac arrest patients is reported high.
- Trial name
- NCT03638609
- Testing
- Intra Aortic Balloon Pump
- Where
- Indonesia
- Volunteers
- 102 people
- Sponsor
- Universitas Indonesia
Chronic Pain, Chronic Pain Syndrome
Outcomes Mandate National Integration With Cannabis as Medicine
This will be a multistate, multicenter clinical study to determine the efficacy and safety of medical cannabis for a wide variety of chronic medical conditions.
- Conditions
- Chronic Pain, Chronic Pain Syndrome, Chronic Pain Due to Injury, Chronic Pain Due to Trauma
- Trial name
- OMNI-Can (NCT03944447)
- Testing
- Cannabis, Medical, RYAH-Medtech Inhaler
- Where
- 17 sites in United States
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- OMNI Medical Services, LLC
Traumatic Brain Injury
Acute Intermittent Hypoxia to Improve Airway Protection in Chronic Traumatic Brain Injury
Acute intermittent hypoxia (AIH) involves 1-2min of breathing low oxygen air to stimulate neuroplasticity. Animal and human studies show that AIH improves motor function after neural injury, particularly when paired with…
- Trial name
- NCT06520358
- Testing
- Acute Intermittent Hypoxia (AIH), Task specific Airway Protection Training
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Florida
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative
Traumatic Brain Injuries
Therapeutic Benefits of Pareidolia in Acute Traumatic Brain Injury Patients
This study will investigate whether viewing and identifying meaningful shapes or images hidden within nature pictures (pareidolia) can improve motivation and engagement in rehabilitation therapy for adults with mild to moderate…
- Trial name
- NCT07867119
- Testing
- Therapeutic Benefits of Pareidolia, Active Comparator #1
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Shirley Ryan AbilityLab
Brain Injuries, Acute
Severe Acquired Brain Injuries: Prognostic Factors and Quality of Care
The main purpose of this project is to identify the medium-term prognostic factors for patients with Severe Acquired Brain Injuries and evaluate their impact.
- Trial name
- NCT04905264
- Where
- 27 sites in Italy
- Volunteers
- 2,500 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Delirium - Postoperative, Postoperative Cognitive Dysfunction (POCD)
Value of the Time-Weighted Average (TWA) of Mean Arterial Pressure (MAP) and Cerebral Oximetry (rSO₂) as Predictors of Postoperative Tissue Perfusion Impairment in Patients Undergoing Cardiac Surgery
Neurological problems after heart surgery are common and include confusion, memory loss, and difficulty thinking clearly. These issues may appear hours or days after surgery and can negatively affect recovery.
- Conditions
- Delirium - Postoperative, Postoperative Cognitive Dysfunction (POCD), Postoperative Acute Kidney Injury, Postoperative Morbidity
- Trial name
- NCT07510711
- Testing
- Continuous intraoperative monitoring of MAP and rSO₂; observational study with no therapeutic intervention.
- Volunteers
- 120 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Pediatric Acute Neurologic Disease, Traumatic and Non-traumatic
RCT: Early Rehabilitation Protocol vs. Usual Care in the Pediatric ICU for Children With Acute Brain Injury
Background. Early rehabilitation programs (ERP) that include physical, occupational, and speech therapies lessens debilitation and promotes return to previous physical and cognitive functioning and have been successfully applied…
- Trial name
- NCT02209935
- Testing
- Early Rehabilitation Protocol, Usual care
- Where
- 3 sites in United States
- Volunteers
- 58 people
- Sponsor
- University of Pittsburgh
TBI (Traumatic Brain Injury), Stroke Acute
The Multicenter Italian INCEPT (INfarto CErebrale Post-Traumatico) Study
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide (Ghajar, 2000). With an estimated annual incidence of up to 500 per 100,000 population and more than 200 hospital admissions per 100,000 admissions…
- Trial name
- NCT02430324
- Testing
- posttraumatic cerebral infarction
- Where
- Italy
- Volunteers
- 143 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Acute Brain Injuries
Effect of Increased Positive End-expiratory Pressure on Intracranial Pressure in Different Respiratory Mechanic in Acute Respiratory Distress Syndrome
There are concerns that the use of positive end-expiratory pressure (PEEP) for the treatment of pulmonary complications in patients with brain injury may potentially elevate intracranial pressure (ICP), and deteriorate…
- Trial name
- NCT02670733
- Testing
- Positive end-expiratory pressure
- Volunteers
- 30 people
- Sponsor
- Capital Medical University
Pediatric Traumatic Brain Injury
Validating a Blood Test for the Detection of Traumatic Brain Injury in Children
The primary objective of this study is to establish if Glial Fibrillary Acidic Protein (GFAP) and Ubiquitin C-terminal Hydrolase L1 (UCH-L1) are predictive of computed tomography (CT) findings in pediatric traumatic brain…
- Trial name
- NCT06940232
- Testing
- Blood Test for Glial Fibrillary Acidic Protein (GFAP) and Ubiquitin C-terminal Hydrolase L1 (UCH-L1) Acute Biomarkers
- Where
- United States
- Volunteers
- 330 people
- Sponsor
- University of Nebraska
Neurologic Decompensation, Acute, Traumatic Brain Injury
Ventilatory Parameters in Acute Neurological Injury
The goal of this observational study is to test the association between baseline ventilatory parameters (in particular mechanical power (MP), mechanical power normalized to predicted body weight (MP/PBW) and driving pressure (DP)…
- Conditions
- Neurologic Decompensation, Acute, Traumatic Brain Injury, Stroke, Subarachnoid Hemorrhage
- Trial name
- NCT06192342
- Where
- Argentina
- Volunteers
- 19 people
- Sponsor
- Ramos Mejía Hospital
Acquired Brain Injuries, Delirium
DANish DELIrium Study On Neurointensive Care Patients
Abstract Background Studies have shown that delirium in medical and surgical intensive care units (ICUs) increases mortality, length of stay (LOS) as well as the risk of dementia symptoms and cerebral atrophy after discharge.
- Conditions
- Acquired Brain Injuries, Delirium, Acute Brain Injury
- Trial name
- DANDELION (NCT02594982)
- Testing
- intervention bundle (sedation, pain, mobilization and sleep)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Kirsten Moller
Acute Brain Injury
Rate of Postpyloric Migration of Spiral Nasojejunal Tubes in Brain Injured Patients
The success rate of unguided nasojejunal feeding tube insertion will be determined in acute brain injured patients. Factors influencing tube self-progression will be evaluated.
- Trial name
- NCT00562146
- Testing
- placement of spiral nasojejunal tube
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Capital Medical University
Intraoperative Arterial Hypotension
Association of Intraoperative Blood Pressure Excursions Below Cerebral Autoregulatory Boundaries With Organ Injury Following Major Noncardiac Surgery
The aim of study is to investigate the clinical relevance of blood pressure (BP) excursions below cerebral autoregulatory boundaries in major noncardiac surgery.
- Trial name
- AR-NONCARDIAC (NCT05336864)
- Testing
- Non-invasive cerebral oximetry monitoring, additional perioperative blood sampling, clinical & telephone assessments
- Where
- 3 sites in Switzerland
- Volunteers
- 650 people
- Sponsor
- University Hospital, Basel, Switzerland
Hypertension
The Effect of Clevidipine on Intracranial Pressure and Cerebral Perfusion Pressure (CCP) in Brain Injured Patients
Patients with acute brain injury are at risk for complications such as increased pressure in the brain (intracranial pressure (ICP)), decreased blood flow, bleeding, and brain swelling (cerebral edema).
- Trial name
- NCT01526876
- Testing
- clevidipine butyrate
- Sponsor
- Columbia University
Brain Injuries, Acute, Brain Trauma
BRIDGE-US: Bridging Readiness in Deployed Neurotrauma Gaps for Excellence
The purpose of this research study is to prospectively collect biospecimens, imaging, and clinical data from patients with penetrating brain injuries across high-volume PBI sites in the US (including UChicago).
- Conditions
- Brain Injuries, Acute, Brain Trauma, Penetrating Head Injury, Traumatic Brain Injury
- Trial name
- BRIDGE-US (NCT07636213)
- Testing
- Blood Sample Collection
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- University of Chicago
Extracorporeal Membrane Oxygenation Complication, Acute Brain Injury
Assessing Brain Injury Using Portable Magnetic Resonance Imaging (MRI)
This study aims to assess the feasibility of assessing acute brain injury using a portable low field MRI in patients on ECMO.
- Trial name
- SAFE MRI (NCT05469139)
- Testing
- Portable MRI acquisition
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Johns Hopkins University
Acute Brain Injury
Chest Physiotherapy Effects on Intracranial Pressure
The investigators will study the effects of a chest physiotherapy technique (rapid thoracic compression) on the intracranial pressure of individuals with acute cerebral injury and with need of intubated mechanical ventilation
- Trial name
- NCT03609866
- Testing
- rapid thoracic compression technique, inferior limb passive mobilization
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- University of Santiago de Compostela