Clinical trials: Brain Injury, Coma
Coma, Emotional Distress
The COMA Family Program: A Skills-Based Resiliency Program for Caregivers of Patients With Severe Acute Brain Injuries
The purpose of this study is to pilot a psychosocial skills-based intervention for caregivers of patients with severe acute brain injuries.
- Trial name
- COMA-F (NCT05761925)
- Testing
- COMA-F
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Disorders of Consciousness, Vegetative State
Effectiveness of tTIs for Improving Consciousness in Patients With DoC
The goal of this clinical trial is to learn if a new type of brain stimulation called theta-burst patterned temporal interference stimulation (tTIs) works to improve awareness in people with disorders of consciousness (DoC).
- Conditions
- Disorders of Consciousness, Vegetative State, Minimally Conscious State
- Trial name
- NCT07539740
- Testing
- Theta-burst Patterned Temporal Interference Stimulation (tTIs)
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Zhujiang Hospital
Chronic Consciousness Disorders, Vegetative State
Vagal Nerve Stimulation in Coma Patients
Minimally Conscious (MCS) or Vegetative State (VS) are disorders of consciousness which often occur following traumatic brain injury or ischemia.
- Conditions
- Chronic Consciousness Disorders, Vegetative State, Minimally Conscious State, Akinetic Mutism
- Trial name
- SNV (NCT02591069)
- Testing
- stimulation device
- Where
- France
- Volunteers
- 4 people
- Sponsor
- Hospices Civils de Lyon
Cardiac Arrest (CA), Anoxic Brain Injury
Early WAKE-up Predictors After Out-of-Hospital Cardiac Arrest
WAKE-OHCA is a prospective observational substudy of the Danish Out-of-Hospital Cardiac Arrest (DANOHCA) trial, identifier NCT05895838.
- Conditions
- Cardiac Arrest (CA), Anoxic Brain Injury, Comatose Survivors of Cardiac Arrest, EEG
- Trial name
- WAKE-OHCA (NCT06979700)
- Testing
- Automated Pupillometry, Transcranial Doppler Ultrasound, Optic Nerve Sheath Diameter
- Where
- 2 sites in Denmark
- Volunteers
- 250 people
- Sponsor
- University of Aarhus
Out-Of-Hospital Cardiac Arrest, Postcardiac Arrest Syndrome
Steroid, Thiamine and Ascorbic Acid for Comatose Out-of-hospital Cardiac Arrest Survivors
The mortality and neurological outcomes among out-of-hospital cardiac arrest survivors have not improved despite the medical advances. The whole body ischemia/reperfusion injuries after cardiac arrest mainly damaged the brain.
- Trial name
- NCT04921189
- Testing
- The combined supplement of Ascorbic acid, Thiamine, and Cortisol
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Asan Medical Center
Brain Injury, Coma
Brain Death and Organ Donation in Tunisian Intensive Care Units
The goal of this observational study was to identify factors associated with the progression to brain death in critically ill patients with severe brain injuries in Tunisian intensive care units (ICUs).
- Conditions
- Brain Injury, Coma, Organ Transplants
- Trial name
- BDOD-TN (NCT06948669)
- Where
- Tunisia
- Volunteers
- 104 people
- Sponsor
- Faculty of Medicine, Sousse
Stroke, Acute, TBI
Tracheostomy With Bedside Simultaneous Gastrostomy Vs Usual Care Tracheostomy And Delayed Gastrostomy Placement
There is currently no prospective study analyzing the effect of tracheostomy with bedside simultaneous gastrostomy versus tracheostomy with delayed gastrostomy placement (TSG versus TDG) on the outcomes of neurocritically-ill…
- Conditions
- Stroke, Acute, TBI, Neuromuscular Diseases, Status Epilepticus
- Trial name
- BEGASTON (NCT04758052)
- Testing
- Timing of placement
- Where
- United States
- Sponsor
- University of Mississippi Medical Center
Sepsis, Septic Shock
Central Venous Catheter Colonisation Among Critically Ill Patients in Intensive Care Units
Background: Central Venous catheter insertion technique and indwelling time are major risk factors for CVC colonisation. Colonisation occurs through microbial migration and biofilm formation along the catheter insertion tract.
- Conditions
- Sepsis, Septic Shock, Post-cardiac Surgery, Post-Cardiorespiratory Arrest Coma
- Trial name
- NCT03270774
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Makerere University
Consciousness Disorders
Validation of the Russian Version of Coma Recovery Scale-Revised (CRS-R)
The purpose of this study is to validate Russian version of Coma Recovery Scale - Revised and to assess its psychometric properties.
- Trial name
- NCT03060317
- Testing
- Examination with neurological scales.
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Research Center of Neurology, Russia
Disorder of Consciousness
Information of the Coma Recovery Scale-Revised for Neurobehavioral State and Recovery of Consciousness Prediction
Background: The Coma Recovery Scale-Revised (CRS-R) is the most recommended instrument to examine the neurobehavioral condition of individuals with disorders of consciousness (DOCs).
- Trial name
- CRS-R_Info (NCT05819177)
- Testing
- Rehabilitation program
- Where
- 2 sites in Spain
- Volunteers
- 171 people
- Sponsor
- Hospitales Nisa
Traumatic Brain Injury, Intracranial Injury
Usefulness of Biomarkers in the Management of Mild Traumatic Brain Injury in Adults (Biotraumap)
The indication of cranial computed tomography (CCT) is difficult to define for patients with mild traumatic brain injury (mTBI).
- Trial name
- Biotraumap (NCT04543162)
- Where
- France
- Volunteers
- 1,025 people
- Sponsor
- University Hospital, Clermont-Ferrand
Acquired Brain Injury, Coma
Amantadine and Functional Improvement Following ABI Measured by MRI Tractography; A Pilot Study
This is a pilot study. The objective is to further understand the mechanism by which amantadine improves function in patients with persistent vegetative state and minimally conscious state.
- Conditions
- Acquired Brain Injury, Coma, Persistent Vegetative State, Minimally Conscious State
- Trial name
- NCT02566720
- Testing
- Amantadine, MRI Tractography Study
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Hamilton Health Sciences Corporation
Traumatic Brain Injury
Evidence Based Diagnostics and Treatment Planning Solution for Traumatic Brain Injuries
Adult patients, age ≥ 18 years, with clinically diagnosed mild, moderate or severe brain trauma will be asked to participate in the study.
- Trial name
- NCT02021877
- Where
- 2 sites in Finland, United Kingdom
- Volunteers
- 396 people
- Sponsor
- Turku University Hospital
Consciousness Disorders, Persistent Vegetative State
Multimodal Assessment and Prognosis in Disorders of Consciousness After Severe Brain Injury (CyDoC-MAP)
After a severe brain injury some patients survive but cannot communicate, and deciding early which of them are likely to recover consciousness remains one of the hardest problems in neurocritical care.
- Conditions
- Consciousness Disorders, Persistent Vegetative State, Unresponsive Wakefulness Syndrome, Minimally Conscious State
- Trial name
- CyDoC-MAP (NCT07736820)
- Where
- Cyprus
- Volunteers
- 40 people
- Sponsor
- Nicosia General Hospital
Traumatic Brain Injury, Cerebral Anoxia
Intrathecal Baclofen Therapy and Paroxysmal Dysautonomia in Severe Brain-Injured Patients
Within the framework of a prospective double-blind and randomized study evaluating the efficacy of continuous intrathecal baclofen therapy (CIBT) on paroxysmal dysautonomia (main objective) and hypertonia, recovery and tolerance…
- Conditions
- Traumatic Brain Injury, Cerebral Anoxia, Coma, Hypertonia
- Trial name
- NCT00221689
- Testing
- baclofen (drug)
- Where
- France
- Volunteers
- 4 people
- Sponsor
- University Hospital, Bordeaux
Disorder of Consciousness, Traumatic Brain Injury
Sub-study of the NEURODOC Project : Neurophysiological Evaluation of a Routine Care Open Label tDCS Session
Limited treatments are available to improve consciousness in severely brain injured patients. Transcranial Direct Current stimulation (tDCS) is one of the few therapeutics that showed evidence of efficacy to increase level of…
- Conditions
- Disorder of Consciousness, Traumatic Brain Injury, Anoxic Brain Injury, Stroke
- Trial name
- Neurodoc (NCT04035655)
- Testing
- Coma Recovery Scale - revised, Electrophysiological recordings
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere