Clinical trials: Brain Injury
Traumatic Brain Injury, Depression
Feasibility Study of Duloxetine in the Treatment of Depression in Patients With Traumatic Brain Injury
The primary objective of the study is to compare the efficacy of duloxetine 60 mg by mouth daily with placebo in the prevention of depression associated with mild/moderate traumatic brain injury and to enhance cognitive function.
- Trial name
- Duloxetine (NCT01223001)
- Testing
- Duloxetine, Sugar pill
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Rehabilitation Hospital of Indiana
Traumatic Brain Injury, Alexithymia
The Emotion Builder: An Intervention for Emotional Deficits After Brain Injury
The purpose of this study is to examine a web-based training program for treating emotional problems in people who have suffered a traumatic brain injury (TBI).
- Trial name
- NCT02432300
- Testing
- Emotion Builder
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- EmotEd
Amblyopia
Increasing Patching for Amblyopia in Children 3 to < 8 Years Old
This study is designed to evaluate the effectiveness of increasing prescribed patching treatment from 2 to 6 daily hours after visual acuity has stabilized with initial treatment and amblyopia is still present.
- Trial name
- ATS15 (NCT00945100)
- Testing
- Eye Patch
- Where
- 2 sites in United States
- Volunteers
- 169 people
- Sponsor
- Jaeb Center for Health Research
Muscle Spasticity
Intrathecal (IT) Baclofen Drug Distribution
The goal of this pilot study to determine whether there is a significant therapeutic advantage to place the ITB catheter within the cervical, thoracic or lumbar region of the spine.
- Trial name
- ITB (NCT02903823)
- Testing
- Baclofen bolus injection
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Vanderbilt University
Traumatic Brain Injury
Non-invasive Clinical Imaging of Cerebral Metabolism Following Brain Injury Using 13C Magnetic Resonance Spectroscopy.
Despite the decline in fatal traumatic brain injury (TBI) incidence in recent years, TBI morbidity remains a public health challenge and is the leading cause of disability in the United States.
- Trial name
- NCT02745210
- Testing
- 13C magnetic resonance spectroscopy
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Cerebral Palsy (CP)
Safety and Tolerability of Dalfampridine in Subjects With Cerebral Palsy
A double-blind, placebo-controlled, crossover study in subjects with cerebral palsy (CP) to evaluate the safety and tolerability and the effect of dalfampridine extended release (ER) tablets on sensorimotor function
- Trial name
- NCT01468350
- Testing
- dalfampridine-ER 10mg
- Where
- 11 sites in United States
- Volunteers
- 35 people
- Sponsor
- Acorda Therapeutics
Cerebral Palsy
Testing an Adjustable Ankle Orthosis During Walking in Cerebral Palsy
This study seeks to determine how an adjustable stiffness ankle braces affects walking performance and biomechanics in cerebral palsy.
- Trial name
- NCT06262191
- Testing
- Differential and adjustable stiffness AFO (DAS-AFO)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Northern Arizona University
Self-Injurious Behavior, Self Harm
Treating Self Injurious Behavior: A Novel Brain Stimulation Approach
The purpose of this study is to explore the tolerability and effectiveness of transcranial direct current stimulation (tDCS) as a potential treatment for non-suicidal self-injury (NSSI).
- Conditions
- Self-Injurious Behavior, Self Harm, Self-injury, Self-inflicted Injury
- Trial name
- NCT04244786
- Testing
- Transcranial direct current stimulation, No intervention
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- New York State Psychiatric Institute
Obesity, Shoulder Impingement
Compression Stocking Use in Shoulder Arthroscopy in Beach Chair
Shoulder arthroscopy is one of the most commonly performed orthopaedic procedures and it is often done with the patient in the upright, or beach chair position (BCP).
- Trial name
- NCT01996813
- Testing
- Thigh-high compression stockings
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Loyola University
Head Injury, Intracranial Pathology
Effect of Intrathoracic Pressure Regulation on Decreased Cerebral Perfusion (4hour)
The purpose of the study is to evaluate the physiological response to application of the Intrathoracic Pressure Regulator (ITPR) in patients with compromised cerebral circulation.
- Conditions
- Head Injury, Intracranial Pathology, Compromised Cerebral Perfusion
- Trial name
- NCT02388880
- Testing
- ITPR
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Advanced Circulatory Systems
Mild Traumatic Brain Injury, Traumatic Brain Injury
Advanced MRI Applications for Mild Traumatic Brain Injury
This feasibility study is being conducted to determine potential associations between a broad range of clinical neurological symptoms and magnetic resonance images (MRI), data, and clinical findings involved in mild traumatic…
- Trial name
- TBI (NCT02070588)
- Testing
- MRI
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Shoulder Pain Chronic
An Implantable Microneuromodulator for the Treatment of Chronic Shoulder Pain in Chronic Post-Stroke Subjects
The goal of this research study is to investigate safety and gather initial effectiveness data for a new implanted device designed to treat chronic shoulder pain in chronic post-stroke subjects.
- Trial name
- BBPM (NCT00567541)
- Testing
- Battery Powered Microneuromodulator (BBPM)
- Where
- 3 sites in United States
- Volunteers
- 16 people
- Sponsor
- Bioness Inc
Concussion, Headache
Use of Ibuprofen and Acetaminophen for Treatment of Acute Headache Post Concussion in Children
Concussions and headache are a significant problem for children and athletes. While headache generally resolves within 7-10 days; a significant proportion of children, 72-93% experience prolonged headache as a symptom of Post…
- Trial name
- NCT02268058
- Testing
- Acetaminophen, Ibuprofen
- Volunteers
- 80 people
- Sponsor
- McMaster Children's Hospital
Hemorrhagic Shock, Traumatic Brain Injury
Shock, Whole Blood, and Assessment of TBI S.W.A.T. (LITES TO 2)
The LITES Network is an operational trauma center consortium which has the expertise, track record and confirmed capabilities to conduct prospective, multicenter, injury care and outcomes research of relevance to the Department…
- Trial name
- SWAT (NCT03402035)
- Where
- United States
- Volunteers
- 1,051 people
- Sponsor
- University of Pittsburgh
Epilepsy, Dravet Syndrome
A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of TAK-935 (OV935) as an Adjunctive Therapy in Pediatric Participants With Developmental and/or Epileptic Encephalopathies
The purpose of this study is to investigate the effect on the frequency of all seizures (convulsive and drop) in participants treated with TAK-935 compared to placebo.
- Conditions
- Epilepsy, Dravet Syndrome, Lennox-Gastaut Syndrome
- Trial name
- ELEKTRA (NCT03650452)
- Testing
- TAK-935
- Where
- 44 sites in United States, Australia and 6 more
- Volunteers
- 141 people
- Sponsor
- Takeda
Cerebral Palsy, Developmental Delay
Efficacy of the START-Play Program for Infants With Neuromotor Disorders
The purpose of this project is to evaluate the efficacy of Sitting Together And Reaching To Play (START-Play), an intervention designed to target sitting, reaching, and motor-based problem solving to improve development and…
- Conditions
- Cerebral Palsy, Developmental Delay, Infant Development
- Trial name
- START-Play (NCT02593825)
- Testing
- START-Play intervention, Business as usual
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- Duquesne University
Vertebral Artery Dissection, Cerebrovascular Accident
Vertebral Artery and Cerebral Hemodynamics After Various Head Positions & Manipulation in Patients With Neck Pain
The Investigators are performing a study to determine, in patients with chronic/recurrent neck pain, the cerebrovascular hemodynamic consequences of cervical spine movements, including manipulation, in vivo using fMRI technology…
- Conditions
- Vertebral Artery Dissection, Cerebrovascular Accident, Stroke
- Trial name
- NCT02667821
- Testing
- Head positions and spinal manipulation
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Canadian Memorial Chiropractic College
Mild Traumatic Brain Injury, Concussion
Neurocognitive Evaluation of Mild Traumatic Brain Injury in the Hospitalized Pediatric Population
Brain injuries from trauma are common in children, often resulting in death and disability. Most brain injuries are minor, yet their treatment can be challenging.
- Trial name
- NCT00715949
- Testing
- Immediate Post-concussion Assessment and Cognitive Testing
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Children's Hospital of Philadelphia
Cerebral Palsy, Hip Dysplasia
Peri-operative Use of a Pain Injection in Pediatric Patients With Cerebral Palsy
Pain management in pediatric patients presents a difficult challenge. Unlike adults, pediatric patients often cannot communicate their pain management needs clearly.
- Conditions
- Cerebral Palsy, Hip Dysplasia, Pain, Postoperative
- Trial name
- NCT04074265
- Testing
- Ropivacaine injection, normal saline
- Where
- 4 sites in United States
- Volunteers
- 34 people
- Sponsor
- University of California, Los Angeles
Cerebral Palsy, Prematurity
NEO Rehab Program for Premature Infants at Risk for Cerebral Palsy
The goal of this project is to investigate the acceptability, feasibility and fidelity of an innovative NICU rehabilitation program that will include six multimodal, gestational age (GA) appropriate, parent-administered…
- Conditions
- Cerebral Palsy, Prematurity, Early Intervention, Family Centered Care
- Trial name
- NCT04330859
- Testing
- NeoRehab Bundle, Routine care
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Virginia