Clinical trials: Brain Insulin-sensitivity
Brain Vascular Function, Cerebral Blood Flow
Effects of Peanut Consumption on Brain Function
Impaired brain vascular function precedes the development of reduced cognitive performance, while brain insulin-resistance is also associated with cognitive decline.
- Conditions
- Brain Vascular Function, Cerebral Blood Flow, Brain Insulin Sensitivity, Cognitive Performance
- Trial name
- NCT05724654
- Testing
- Skin roasted peanuts
- Where
- Netherlands
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Diabetes Mellitus, Type 2, Hypertension
Study of the Relationship Between Blood Vessels and Insulin Response in Adolescents
This study is designed to determine whether there is a relationship between the way insulin and blood vessels work. The difference in the interaction between Caucasian and African American adolescents will also be examined.
- Conditions
- Diabetes Mellitus, Type 2, Hypertension, Heart Disease, Stroke
- Trial name
- NCT00374361
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Healthy, Brain Insulin Sensitivity
Long-Term Effects of Walnut Consumption on Brain Function
Rationale: Healthy foods, including mixed nuts, may improve brain function, which is essential for cognitive and metabolic health, and may contribute to improved food intake regulation.
- Conditions
- Healthy, Brain Insulin Sensitivity, Cerebral Blood Flow, Brain Vascular Function
- Trial name
- WalBrain (NCT07422220)
- Testing
- Walnuts
- Where
- Netherlands
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Brain Vascular Function, Cognitive Function
Effects of Protein Supplementation on Brain Function
Protein-rich foods may improve brain insulin-sensitivity, which is important for cognitive and metabolic health, and may also translate into an improved food intake regulation.
- Conditions
- Brain Vascular Function, Cognitive Function, Satiety, Cerebral Blood Flow
- Trial name
- NCT07057245
- Testing
- Protein supplementation with an animal-based protein isolate, Protein supplementation with a plant-based protein isolate, Control arm - cornstarch
- Where
- Netherlands
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Insulin Sensitivity
The Importance of Insulin Action in the Brain for the Immune System During Physical Activity
The goal of this clinical trial is to clarify the interaction of central insulin action and physical activity with the immune system. Therefore, participants will undergo bicycle spiroergometer tests.
- Trial name
- NCT06552130
- Testing
- Spiroergometer test with intranasal insulin spray
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Acromegaly
Growth Hormone, IGF-1 and Medical Treatment in Acromegaly: Are There Effects on Gut Hormone Physiology and Postprandial Substrate Metabolism?
Acromegaly is a rare hormonal disorder leading to increased morbidity and mortality. In the vast majority of cases, a pituitary somatotroph cell adenoma causes excess growth hormone (GH) secretion, leading to hepatic…
- Trial name
- NCT02152124
- Where
- Belgium
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Obesity, Diabetes Mellitus, Type 2
Effect of High Caloric Diet on Brain Insulin Sensitivity and Inflammation
Obesity if known to be associated with brain insulin resistance in humans and evidence is rapidly accumulating that brain insulin resistance influences peripheral metabolism, eating behavior and cognition.
- Trial name
- NCT03590561
- Testing
- High caloric diet
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Obesity, Diabetes Mellitus Type 2
Diet, Insulin Sensitivity And the Brain
Obesity and insulin resistance may be in part explained by an altered reward system with changes in the serotonin/dopamine system.
- Trial name
- DISAB (NCT01297738)
- Testing
- Meal size increase with HFHS, Meal size increase with HS, Meal frequency increase with HFHS
- Where
- Netherlands
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Insulin Resistance, Obesity
The Effect of Artificial Sweeteners (AFS) on Sweetness Sensitivity, Preference and Brain Response in Adolescents
The purpose of this study is to investigate the effects of dietary exposure to artificial sweeteners on taste sensitivity, preference and brain response in adolescents using fMRI, psychophysical measures, and questionnaires.
- Trial name
- NCT02499705
- Testing
- Sucralose, Sucrose, Sucralose + maltodextrin
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Yale University
Insulin Sensitivity
Influence of Brain Insulin Sensitivity on Peripheral Insulin Sensitivity
The researchers will investigate if brain insulin action influences peripheral insulin sensitivity in healthy humans.
- Trial name
- NCT01847456
- Testing
- human insulin as nasal spray
- Where
- Germany
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Insulin Resistance
Effect of Weight Loss on Brain Insulin Sensitivity in Humans
Obesity if known to be associated with brain insulin resistance in humans. This condition has not only implication for the brain but also for whole-body energy homeostasis.
- Trial name
- NCT02991365
- Testing
- nasal insulin
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Growth Hormone Deficiency
Insulin Sensitivity and Substrate Metabolism Before and After Treatment in Patients With Growth Hormone Deficiency
The purpose of this study is to further characterize the treatment related changes in insulin sensitivity, substrate metabolism and intrahepatic-intramyocellular lipids in patients with growth hormone deficiency (GHD).
- Trial name
- NCT00646815
- Testing
- growth hormone (genotropin)
- Where
- 2 sites in Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Impairment of Oral Perception, Insulin Resistance
The Effect of Artificial Sweeteners (AFS) on Sweetness Sensitivity, Preference and Brain Response in Adults
The purpose of this study is to investigate the effects of dietary exposure to artificial sweeteners on taste sensitivity, preference and brain response in adults.
- Trial name
- AFS-adult (NCT02335021)
- Testing
- Sucralose, Sucrose, Sucralose + maltodextrin
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Yale University
Insulin Resistance, Obesity
Effects of Age and Obesity on Brain Insulin Sensitivity
Obesity and especially type 2 diabetes (T2D) increases the risk of neurocognitive dysfunctions including adverse effects on brain structure and function.
- Trial name
- Aging (NCT04372849)
- Testing
- Human nasal insulin
- Where
- Germany
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Brain Insulin-sensitivity, Brain Vascular Function
Effects of Wild Blueberry Consumption on Brain Function in Elderly
Impaired brain vascular function precedes the development of reduced cognitive performance, while brain insulin-resistance is associated with cognitive decline.
- Conditions
- Brain Insulin-sensitivity, Brain Vascular Function, Cerebral Blood Flow
- Trial name
- NCT07177781
- Testing
- Wild blueberry powder
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Autonomic Function
Understanding Individual Variability in Neuronal Signal Transmission to Target Organs in Health and Disease
The goal of this clinical trial is to evaluate the influence of parasympathetic transmission from the brain to different metabolic organs. This transmission can be blocked with the muscarinic antagonist atropine.
- Trial name
- CPB_Atropine (NCT06912048)
- Testing
- Oral glucose tolerance test with double-tracer dilution and atropine infusion
- Where
- Germany
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Brain Insulin Sensitivity, Brain Vascular Function
High-Dairy Food Patterns and Gut-Brain Axis
Disturbances in brain insulin sensitivity are associated not only with obesity and type 2 diabetes, but also with brain aging and cognitive decline.
- Conditions
- Brain Insulin Sensitivity, Brain Vascular Function, Cerebral Blood Flow, Cognitive Performance
- Trial name
- NCT07355309
- Testing
- High-dairy food pattern, Low-dairy food pattern
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Brain Vascular Function, Cognition
Aronia and Cognitive Fitness
Previously, beneficial effects of Aronia Melanocarpa extract (AME) supplementation on cognitive performance has been observed in healthy middle-aged adults. However, underlying mechanisms have not yet been addressed.
- Trial name
- NCT05268133
- Testing
- Aronia, Control
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Brain Insulin Sensitivity, Brain Vascular Function
Effects of Ketone Monoesters on Brain Function
Disturbances in brain insulin-sensitivity are not only observed in obesity and type 2 diabetes (T2D), but also during brain aging and in dementia.
- Conditions
- Brain Insulin Sensitivity, Brain Vascular Function, Cerebral Blood Flow, Cognitive Performance
- Trial name
- NCT06395051
- Testing
- Ketone Monoester
- Where
- Netherlands
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Nitrate, Brain Insulin-sensitivity
Nitrate and Brain Insulin-Sensitivity
Disturbances in brain insulin-sensitivity are not only observed in abdominal obesity and type 2 diabetes mellitus (T2D), but also during brain aging and in dementia.
- Conditions
- Nitrate, Brain Insulin-sensitivity, Vascular Function
- Trial name
- NO-BRAINS (NCT04700241)
- Testing
- Potassium nitrate
- Where
- Netherlands
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center