Clinical trials: Brain Lesions
Stroke
Correlation Analysis Between Brain Lesions and Sensorimotor Impairments in Individuals With Stroke (Preliminary Study)
The objective of the preliminary study is: 1. To identify correlations between brain lesions and sensorimotor impairments in stroke. 2.
- Trial name
- NCT02465281
- Testing
- Device: 3T scanner with MRI-compatible robot
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Perinatal Brain Injury
Feasibility of Action Observation Training [AOT] in Infants After Unilateral Brain Lesion
The study examines whether infants with a perinatal unilateral brain lesion can perform an "Action Observation Training" [AOT] at the age of 9-12 months .
- Trial name
- NCT04194281
- Testing
- Action Observation Training [AOT]
- Where
- Switzerland
- Volunteers
- 8 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Unruptured Intracranial Aneurysms
Brain Lesions Following Endovascular and Surgical Treatment of Unruptured Intracranial Aneurysms
The purpose of this study is to determine the incidence and impact of brain lesions in MRI after coiling and clipping of unruptured intracranial aneurysms on clinical and neurological outcome of patients.
- Trial name
- LESUIA (NCT01490463)
- Where
- Germany
- Sponsor
- Johann Wolfgang Goethe University Hospital
Stroke, Bruises
Prevention and Treatment for Bruises in Patients With Ischemic Stroke
Background Over the past few decades, significant advances have been made in the diagnosis and treatment of strokes. Most studies focus on functional recovery in stroke patients.
- Conditions
- Stroke, Bruises, Skin Lesions
- Trial name
- NCT06823999
- Testing
- Ascorbic acid (Vitamin C)
- Volunteers
- 400 people
- Sponsor
- Chiayi Christian Hospital
Multiple Sclerosis, Clinically Isolated Syndrome
AT RISK FOR MS - Clinical Conversion of Female Monozygotic Twins Discordant for CIS/MS
The definition of the most 'at-risk' population within highly susceptible groups would provide an opportunity for preemptive therapeutics.
- Trial name
- ARMS (NCT00617383)
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Fetal Alcohol Syndrome
In Utero Alcoholic Exposure: PlGF, Biomarker of Fetal Brain Lesions
This study aims to validate that PLGF is a biomarker of cerebral lesions and therefore of secondary developmental disorders and disabilities that will be best diagnosed at 2 and 6 years of age.
- Trial name
- ALCOBRAIN (NCT03371641)
- Testing
- ASQ parental questionnaire, Development scales, Scale of Conners
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Multiple Sclerosis (MS), Multiple Sclerosis, Relapsing-Remitting
Assessing Changes in Multi-parametric MRI in MS Patients Taking Clemastine Fumarate as a Myelin Repair Therapy
The clinical trial is intended to assess for clinical evidence of Clemastine Fumarate as a myelin repair therapy in patients with chronic inflammatory injury-causing demyelination as measured by multi-parametric MRI assessments.
- Conditions
- Multiple Sclerosis (MS), Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Primary Progressive, Multiple Sclerosis, Chronic Progressive
- Trial name
- ReVIVE (NCT05359653)
- Testing
- Clemastine Fumarate
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of California, San Francisco
Acute Ischemic Stroke
ATILA Project: Aspirin Versus Tirofiban in Endovascular Treatment for Patients With Acute Ischemic Stroke Due to Tandem Lesion
Patients with tandem lesions (TL) are defined as patients with an acute ischemic stroke (AIS) with occlusion of an intracranial vessel of the anterior circulation and an occlusion or severe stenosis (70-99%) of the origin of the…
- Trial name
- ATILA (NCT05225961)
- Testing
- Tirofiban, Acetylsalicylic acid
- Where
- 13 sites in Spain
- Volunteers
- 240 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Focal Epilepsy
Arterial Spin Labeling MRI Focal Abnormalities in Refractory Epilepsy
This study will evaluate a type of Magnetic Resonance Imaging (MRI) sequence called arterial spin labeling (ASL). The investigators hope that ASL can better localize areas of the brain (lesions) that cause epilepsy.
- Trial name
- NCT01772654
- Testing
- Arterial Spin Labeled (ASL) MRI sequence
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Mayo Clinic
Glioblastoma
Safety and Feasibility of MR-guided Laser Thermal Ablation of Brain Lesions
This will be an open-label, pilot, exploratory, single centre clinical investigation. This is an early feasibility single arm study. No formal hypothesis is proposed.
- Trial name
- NCT05296122
- Testing
- TRANBERG® laser applicators when used in MR-guided laser thermal ablation of brain lesions using the TRANBERG® Thermal Therapy System and TRANBERG® Thermoguide Workstation.
- Where
- Sweden
- Volunteers
- 14 people
- Sponsor
- Clinical Laserthermia Systems AB
Epilepsy
A Wireless EEG Patch for Continuous Electrographic Monitoring
This proposal will evaluate an individual-use, patch-type telemetry device for simplified, single-channel EEG recording from human patients along-side the traditional in hospital wired EEG.
- Trial name
- NCT03583957
- Testing
- Observational only, Psychological and Behavioral interaction with a seizure forecasting mobile app, Seizure Alerting and Prediction System
- Where
- 3 sites in United States
- Volunteers
- 750 people
- Sponsor
- Epitel, Inc.
Mild Cognitive Impairment
Memory Improvement Through Nicotine Dosing (MIND) Study
The purpose of the study is to see if daily transdermal nicotine is able to produce a significant cognitive, clinical and functional improvement in participants with MCI.
- Trial name
- MIND (NCT02720445)
- Testing
- Nicotine Transdermal Patch
- Where
- 36 sites in United States
- Volunteers
- 348 people
- Sponsor
- University of Southern California
Brain Lesion
Neurofeedback in Patients With Frontal Brain Lesions
In this randomized double-blind controlled study we would like to test the benefit of neurofeedback for the recovery of patients with frontal brain injury during an early stage of neurorehabilitation.
- Trial name
- NCT02957695
- Testing
- Active-Neurofeedback
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- PD Dr. med. Margret Hund-Georgiadis
Cigarette Smoking
Brain Nicotine Receptor Density & Response to Nicotine Patch
Even though the health risks and societal costs of cigarette smoking are well-known, roughly 19.8% of American adults continue to smoke.
- Trial name
- NCT01526005
- Testing
- Transdermal Nicotine Patch
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Brentwood Biomedical Research Institute
Visual Field Defect Following Cerebrovascular Accident, Hemianopia
Multisensory Telerehabilitation for Visual Field Defects
Brain injuries may cause the loss of the ability to see portions of the visual field, the so-called visual field defects (VFDs).
- Conditions
- Visual Field Defect Following Cerebrovascular Accident, Hemianopia, Brain Injuries
- Trial name
- MUST (NCT06341777)
- Testing
- Audio-visual training (AVT) telerehabilitation
- Where
- Italy
- Volunteers
- 72 people
- Sponsor
- Istituto Auxologico Italiano
Child Development, Upper Motor Neurone Lesion
Validity and Reliability of the PROprioception Measurement Tool (PROMT)
This project assesses the feasibility, reliability, and validity of the PROMT in children with a UMN lesion. The study questions are: is the newly developed PROMT a feasible, reliable, and valid tool to assess lower limb…
- Conditions
- Child Development, Upper Motor Neurone Lesion, Cerebral Palsy, Proprioceptive Disorders
- Trial name
- PROMT (NCT05405881)
- Testing
- Proprioception measurement tool
- Where
- Switzerland
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital, Zurich
Alzheimer Disease
Motor Slowing and Its Lesion-related Correlates in Alzheimer's Disease
In AD (Alzheimer disease), the anatomic correlates of attention disorders (as evaluated by motor slowing) have not been thoroughly characterized.
- Trial name
- TAMA (NCT02811653)
- Testing
- Brain MRI, neuropsychological evaluation, Blood
- Where
- France
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Alzheimer's Disease
Efficacy, Safety and Tolerability of Rivastigmine Patch in Patients With Mild to Moderate Alzheimer's Disease Switched From Cholinesterase Inhibitors
This is a multicenter study to evaluate the efficacy, safety and tolerability of Rivastigmine patch in patients with mild to moderate Alzheimer's disease switched from Cholinesterase Inhibitors.
- Trial name
- NCT01529619
- Testing
- Rivastigmine transdermal patch
- Where
- 11 sites in Japan
- Volunteers
- 52 people
- Sponsor
- Novartis Pharmaceuticals
Focal Lesions, Focal Brain Lesion
Attention and Visual Perception
The NIMH is conducting studies aimed at gaining a better understanding of the areas of the brain that are involved in different types of mental processes.
- Trial name
- NCT00111293
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Brain and Central Nervous System Tumors, Lymphoma
Bortezomib and Temozolomide in Treating Patients With Brain Tumors or Other Solid Tumors That Have Not Responded to Treatment
RATIONALE: Bortezomib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
- Conditions
- Brain and Central Nervous System Tumors, Lymphoma, Metastatic Cancer, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00544284
- Testing
- bortezomib, temozolomide, pharmacological study
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- City of Hope Medical Center