Clinical trials: Brain Modulation
Expectations, Motor Learning
Priming Expectations and Motor Learning With tDCS
The purpose of this study is to test if priming expectations of transcranial Direct Current Stimulation (tDCS) can improve the efficacy of tDCS in enhancing motor learning.
- Trial name
- NCT06039605
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Huntington's Disease
The Effect of Video Game Exercise on Dynamic Balance and Gait in Individuals With Huntington's Disease
To examine the benefits of using a video-game, Dance, Dance, Revolution, as an exercise modality to improve gait and balance in individuals with Huntington's disease.
- Trial name
- NCT01735981
- Testing
- Video game exercise using Dance Dance Revolution, hand-held video game
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Anne Kloos
Normal Physiology
Dopaminergic Modulation of Brain Activation Using Simultaneous PET/Pharmacological MRI
Background: Dopamine (DA) is a chemical signal in the brain linked to learning, memory, and habits. Stimulant drugs like methylphenidate can increase DA in the brain. Researchers want to measure DA with and without this drug.
- Trial name
- NCT03326245
- Testing
- Methylphenidate Pill, Intravenous methylphenidate
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Brain Cancer
Glioblastoma Multiforme (GBM) Proton vs. Intensity Modulated Radiotherapy (IMRT)
The goal of this clinical research study is to compare IMRT with IMPT in patients with glioblastoma. Researchers want to learn about cognitive side effects (mental status changes) that may occur, such as memory loss and impaired…
- Trial name
- NCT01854554
- Testing
- IMPT, IMRT, Cognitive Tests
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- M.D. Anderson Cancer Center
Depressive Disorder, Major
Modulating Repetitive Negative Thinking Related Brain Networks in Young Adults With Depression
In this project, the investigators use real-time fMRI neurofeedback (rtfMRI-nf) to causally relate dysfunction of right anterior insula (rAI) and right superior temporal sulcus (rSTS) connectivity with the intensity of repetitive…
- Trial name
- CNF-RNT (NCT06219681)
- Testing
- Active neurofeedback
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Laureate Institute for Brain Research, Inc.
New Daily Persistent Headache (NDPH)
Endogenous Modulation and Central Sensitization in New Daily Persistent Headache ( NDPH ) in Children
New daily persistent headache (NDPH) is a primary headache disorder characterized by the daily and unremitting headache pain patients experience with a distinct onset.
- Trial name
- EMCS-NDPH (NCT03447782)
- Testing
- Naltrexone HCl (Bulk) Powder
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Deep Brain Stimulation, PARKINSON DISEASE (Disorder)
Cortical Network Modulation by Subthalamic Nucleus DBS
Deep brain stimulation of the subthalamic nucleus (STN DBS) in Parkinson's disease (PD) can provide substantial motor benefit yet can also produce unwanted mood and cognitive side effects.
- Trial name
- NCT04922411
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Traumatic Brain Injury
Noninvasive Modulation of Motivational Brain Regions in Healthy Volunteers
21 healthy control participants will be recruited. On Day 1 they will complete reward-guided decision making tasks and questionnaires followed by a functional magnetic resonance imaging (fMRI) scan.
- Trial name
- NCT04972786
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Lewy Body Disease, Lewy Body Variant of Alzheimer Disease
Stimulation of Cingulo-opercular Alertness Network
Fluctuations in alertness are very common in persons with Lewy body dementias and are a major source of disability. Changes in a chemical messenger molecule called acetylcholine within certain brain regions may play a role in…
- Conditions
- Lewy Body Disease, Lewy Body Variant of Alzheimer Disease, Lewy Body Dementia With Behavioral Disturbance
- Trial name
- SCAN (NCT04817891)
- Testing
- HD-tDCS
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Michigan
Ischemic Stroke, Acute
MEXIDOL® in the Rehabilitation Treatment of Patients With Acute Cerebral Failure
The use of metabolic modulators creates prospects for increasing the efficiency of the rehabilitation treatment of patients with acute cerebral failure
- Trial name
- NCT06221826
- Testing
- Mexidol
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Pharmasoft
Parkinson's Disease With Dementia
The Impact of Pharmacological and Electric Modulation of NMDA Pathway on the Cognitive Flexibility and Volitional Movement Preparation in Patients With Parkinson's Disease
The project will investigate the effect of pharmacological and electric modulation of N-methyl-D-aspartate (NMDA) pathway on the cognitive flexibility and volitional movement preparation in patients with Parkinson's disease (PD).
- Trial name
- NCT01785628
- Testing
- Sarcosine Capsule
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- China Medical University Hospital
Stroke, Sensorimotor Impairment
Learning in Stroke
After a stroke, plasticity occurs in the brain from microscopic to network level with positive but also negative consequences for functional recovery.
- Trial name
- NCT05511467
- Testing
- Visuomotor learning task
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Glucose Metabolism Disorders
Glucose and Non-Invasive Brain Stimulation
Purpose: In this study, the investigators will delineate how brain network dynamics are modulated by experimentally induced elevated blood glucose levels and examine how glucose levels gate neuronal excitability measured by the…
- Trial name
- NCT04031404
- Testing
- Single-pulse TMS
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Tourette Syndrome
Response Inhibition in Tourette Syndrome
Tics are the hallmark symptoms in Tourette Syndrome. Patients with Tourette Syndrome have difficulties controlling unwanted movements.
- Trial name
- NCT03628703
- Testing
- Repetitive TMS
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
ADHD
Genetic Modulation of Working Memory in Attention Deficit Hyperactivity Disorder (ADHD)
In this study the investigators will measure the functional brain activity of adult Attention Deficit Hyperactivity Disorder (ADHD) patients, genotyped according to the COMT genotype, during a Working Memory Paradigm, before and…
- Trial name
- BEAS (NCT01351272)
- Testing
- Methylphenidate, non-retard
- Where
- Germany
- Volunteers
- 41 people
- Sponsor
- Wuerzburg University Hospital
Brain Function
Modulation of Spontaneous Cortical Activity by tDCS: BRAIN Initiative I
This study will determine whether transcranial direct current stimulation (tDCS) can be used alter the amplitude of spontaneous neural activity, and thereby modulate cognitive function in healthy adults
- Trial name
- NCT03672747
- Testing
- transcranial direct-current stimulation (tDCS)
- Where
- United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Parkinson Disease
Feasibility and Preliminary Effects of MR-005 in Persons With Parkinson Disease
The purpose of this clinical study is to evaluate the effects of music, tailored to the participant's cadence, on adherence, quality of life, gait speed, functional mobility, and walking activity in individuals with Parkinson…
- Trial name
- NCT04891107
- Testing
- Walking Program with a Music-based, Rhythm-modulating Wearable Sensor System
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- MedRhythms, Inc.
Alzheimer Disease
Effect of Modulating Gamma Oscillations Using tACS
This study aims to implement an intervention based on multiple, individualized multifocal tACS stimulation sessions based on individual PET and MRI information in patients with amyloid-positive PET with the hope that this leads…
- Trial name
- NCT03412604
- Testing
- Transcranial Alternating Current Stimulation (tACS)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Massachusetts General Hospital
Parkinson Disease
Modulation of GABA-A Receptors in Parkinson Disease-Transdermal Flumazenil Arm
The arm of this study evaluates possible GABA-A receptor target engagement effects of the FDA-approved medication, transdermal flumazenil (added 4/2020, replaced clarithromycin), in the setting of Parkinson's disease.
- Trial name
- GABA-A (NCT03440112)
- Testing
- Clarithromycin (Not used as of 4/2020), Transdermal flumazenil (Added 4/2020)
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Nicolaas Bohnen, MD, PhD
Parkinson Disease, Parkinson's Disease and Parkinsonism
STEM-PD Open Label Extension (OLE)
This study seeks to establish the safety and efficacy of extended twice daily time-varying caloric vestibular stimulation treatments for treating symptoms associated with Parkinson's disease.
- Trial name
- NCT04799418
- Testing
- Open Label Extension Study
- Where
- 15 sites in United States
- Volunteers
- 148 people
- Sponsor
- Scion NeuroStim